Detailed information for compound 1334905

Basic information

Technical information
  • TDR Targets ID: 1334905
  • Name: ethyl 1-[2-[5-[(2-fluorophenyl)methyl]-4-oxop yridazino[5,4-b]indol-3-yl]acetyl]piperidine- 4-carboxylate
  • MW: 490.526 | Formula: C27H27FN4O4
  • H donors: 0 H acceptors: 3 LogP: 3.24 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1CCN(CC1)C(=O)Cn1ncc2c(c1=O)n(Cc1ccccc1F)c1c2cccc1
  • InChi: 1S/C27H27FN4O4/c1-2-36-27(35)18-11-13-30(14-12-18)24(33)17-32-26(34)25-21(15-29-32)20-8-4-6-10-23(20)31(25)16-19-7-3-5-9-22(19)28/h3-10,15,18H,2,11-14,16-17H2,1H3
  • InChiKey: PYJIJUQVQRTUIX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 1-[2-[5-[(2-fluorophenyl)methyl]-4-oxo-pyridazino[5,4-b]indol-3-yl]acetyl]piperidine-4-carboxylate
  • 1-[2-[5-[(2-fluorophenyl)methyl]-4-oxo-3-pyridazino[5,4-b]indolyl]-1-oxoethyl]-4-piperidinecarboxylic acid ethyl ester
  • 1-[2-[5-(2-fluorobenzyl)-4-keto-pyridazino[5,4-b]indol-3-yl]acetyl]isonipecotic acid ethyl ester
  • ethyl 1-[2-[5-[(2-fluorophenyl)methyl]-4-oxo-pyridazino[5,4-b]indol-3-yl]ethanoyl]piperidine-4-carboxylate
  • C880-2359
  • NCGC00114036-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0139 0.032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 1
Leishmania major cysteine peptidase A (CPA) 0.002 0.159 0.0155
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0601 0.2084
Entamoeba histolytica cysteine proteinase, putative 0.002 0.159 0.595
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 1
Onchocerca volvulus Cathepsin L homolog 0.002 0.159 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0139 0.032
Leishmania major cathepsin L-like protease 0.002 0.159 0.0155
Brugia malayi Cathepsin L-like precursor 0.002 0.159 1
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0139 0.0521
Onchocerca volvulus 0.002 0.159 1
Entamoeba histolytica recQ family helicase, putative 0.0019 0.1458 0.5454
Trypanosoma cruzi cysteine peptidase, putative 0.0077 1 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.1458 0.1337
Plasmodium vivax vivapain-3 0.001 0.0139 0.0876
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.1458 0.9087
Entamoeba histolytica cysteine protease, putative 0.001 0.0139 0.0521
Entamoeba histolytica cysteine protease, putative 0.001 0.0139 0.0521
Leishmania major cathepsin L-like protease 0.002 0.159 0.0155
Plasmodium vivax vivapain-1 0.001 0.0139 0.0876
Entamoeba histolytica cysteine protease, putative 0.001 0.0139 0.0521
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.159 0.5727
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.159 0.5727
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.159 0.5727
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.159 0.5727
Brugia malayi Cathepsin L-like precursor 0.0014 0.0601 0.3182
Onchocerca volvulus Cathepsin F homolog 0.002 0.159 1
Leishmania major cathepsin L-like protease 0.0077 1 1
Brugia malayi Cathepsin L-like precursor 0.002 0.159 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.159 1
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0028 0.2673 0.2632
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.159 0.5727
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.159 1
Entamoeba histolytica hypothetical protein, conserved 0.0028 0.2673 1
Trypanosoma cruzi cruzipain precursor, putative 0.0077 1 1
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0139 0.0521
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.159 0.5727
Loa Loa (eye worm) hypothetical protein 0.001 0.0055 0.0000000076842
Entamoeba histolytica cysteine protease, putative 0.001 0.0139 0.0521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0601 0.3554
Trypanosoma cruzi cysteine protease, putative 0.001 0.0139 0.0084
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0028 0.2673 0.1422
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.159 0.5727
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.159 0.5727
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.159 0.5727
Leishmania major cathepsin L-like protease 0.002 0.159 0.0155
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0139 0.032
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.159 0.1543
Entamoeba histolytica cysteine protease, putative 0.001 0.0139 0.0521
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.2673 1
Entamoeba histolytica cysteine protease, putative 0.001 0.0139 0.0521
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0028 0.2673 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 1
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0028 0.2673 0.2632
Toxoplasma gondii cathepsin CPL 0.002 0.159 1
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0139 0.0084
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.1458 0.9087
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.1458 0.5204
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0055 0.5
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.1458 0.5204
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.159 1
Plasmodium vivax unspecified product 0.001 0.0139 0.0876
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.1458 0.9087
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.159 0.5727
Loa Loa (eye worm) fibroinase 0.002 0.159 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.1458 0.9087
Giardia lamblia Rrm3p helicase 0.0028 0.2673 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.159 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.159 0.5727
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0028 0.2673 0.2569
Loa Loa (eye worm) cysteine protease 0.002 0.159 1
Entamoeba histolytica cysteine proteinase 2 0.001 0.0139 0.0521
Plasmodium vivax vivapain-2 0.002 0.159 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0601 0.3554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.159 0.5727
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.159 0.5727
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.159 0.5727
Entamoeba histolytica cysteine protease, putative 0.001 0.0139 0.0521
Onchocerca volvulus 0.002 0.159 1
Loa Loa (eye worm) hypothetical protein 0.002 0.159 1
Entamoeba histolytica cysteine protease, putative 0.002 0.159 0.595
Echinococcus multilocularis bloom syndrome protein 0.0019 0.1458 0.5204
Echinococcus multilocularis cysteine protease 0.002 0.159 0.5727
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.159 0.5727
Trypanosoma cruzi cysteine peptidase, putative 0.0077 1 1
Loa Loa (eye worm) ctsf protein 0.002 0.159 1
Schistosoma mansoni hypothetical protein 0.0028 0.2673 1
Schistosoma mansoni DNA helicase recq1 0.0019 0.1458 0.5358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.159 0.5727
Entamoeba histolytica cysteine protease, putative 0.001 0.0139 0.0521
Schistosoma mansoni DNA helicase recq5 0.0019 0.1458 0.5358
Entamoeba histolytica cysteine protease, putative 0.001 0.0139 0.0521
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.159 0.5727
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.9011 0.9005
Onchocerca volvulus 0.002 0.159 1
Loa Loa (eye worm) RecQ helicase 0.0019 0.1458 0.9137
Echinococcus granulosus bloom syndrome protein 0.0019 0.1458 0.5204
Entamoeba histolytica recQ family DNA helicase 0.001 0.0055 0.0208
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0028 0.2673 1
Entamoeba histolytica cysteine protease, putative 0.001 0.0139 0.0521
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.159 0.5727
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0139 0.0521
Onchocerca volvulus 0.002 0.159 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0055 0.0349
Onchocerca volvulus Cathepsin L homolog 0.002 0.159 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.159 0.5727
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0139 0.0521
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.1458 0.141
Echinococcus granulosus cathepsin l1 0.002 0.159 0.5727
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 1
Brugia malayi Cathepsin L-like precursor 0.002 0.159 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0601 0.3182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.159 0.5727
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.159 0.5727
Trypanosoma cruzi cysteine peptidase, putative 0.0077 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.0139 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 1
Brugia malayi cathepsin L-like precursor 0.0014 0.0601 0.3182
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.1458 0.5204
Entamoeba histolytica cysteine protease, putative 0.001 0.0139 0.0521
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.1458 0.9137
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0055 0.0349
Onchocerca volvulus 0.002 0.159 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.159 0.5727
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.159 0.5727
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.159 0.5727
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.1458 0.5204
Entamoeba histolytica cysteine protease, putative 0.001 0.0139 0.0521
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0028 0.2673 0.1422
Echinococcus multilocularis cysteine protease 0.002 0.159 0.5727
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.159 0.5864
Entamoeba histolytica DNA repair and recombination protein, putative 0.0028 0.2673 1
Onchocerca volvulus 0.002 0.159 1
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0139 0.0084
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.1458 0.5204
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.1458 0.9167
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0601 0.2248
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.159 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.159 0.5727
Brugia malayi Papain family cysteine protease containing protein 0.002 0.159 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.1458 0.9137
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.001 0.0139 0.0084
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.1458 0.9167
Leishmania major cathepsin L-like protease 0.002 0.159 0.0155
Echinococcus granulosus cathepsin l1 0.0014 0.0601 0.1822
Entamoeba histolytica cysteine proteinase 1, putative 0.001 0.0139 0.0521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0601 0.1822
Leishmania major cathepsin L-like protease 0.0077 1 1
Brugia malayi Cathepsin L-like precursor 0.002 0.159 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.1458 0.9087
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0028 0.2673 0.2632
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.159 0.5727
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.159 0.5864
Brugia malayi Cathepsin L-like precursor 0.002 0.159 1
Plasmodium vivax vivapain-2 0.002 0.159 1
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0028 0.2673 0.2569
Brugia malayi Cathepsin L-like precursor 0.0014 0.0601 0.3182
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.1458 0.5204
Brugia malayi Cathepsin L-like precursor 0.002 0.159 1
Entamoeba histolytica cysteine protease, putative 0.001 0.0139 0.0521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 1
Leishmania major cathepsin L-like protease 0.002 0.159 0.0155
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.159 0.5727
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.159 0.5727
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 1
Onchocerca volvulus 0.002 0.159 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.159 0.5727
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.159 0.5727
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.756 0.7546
Entamoeba histolytica cysteine proteinase, putative 0.002 0.159 0.595
Loa Loa (eye worm) hypothetical protein 0.0014 0.0601 0.3554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.159 0.5727
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0601 0.1822
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.1458 0.5204

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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