Detailed information for compound 1335045

Basic information

Technical information
  • TDR Targets ID: 1335045
  • Name: N-(furan-2-ylmethyl)cyclooctanamine
  • MW: 207.312 | Formula: C13H21NO
  • H donors: 1 H acceptors: 0 LogP: 3.28 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CCCCC(CC1)NCc1ccco1
  • InChi: 1S/C13H21NO/c1-2-4-7-12(8-5-3-1)14-11-13-9-6-10-15-13/h6,9-10,12,14H,1-5,7-8,11H2
  • InChiKey: LVIUTUZVSHHXQO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-furylmethyl)cyclooctanamine
  • cyclooctyl-(2-furylmethyl)amine
  • BAS 07571592
  • SBB009615
  • Cyclooctyl-furan-2-ylmethyl-amine
  • MLS000075563
  • SMR000014677
  • TimTec1_008174

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0957 0.0957
Loa Loa (eye worm) hypothetical protein 0.0681 0.9508 0.9508
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.011 0.1137 0.1137
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0054 0.0054
Brugia malayi Inositol-1 0.0111 0.1159 0.1159
Trypanosoma cruzi cytochrome P450, putative 0.0062 0.0429 0.37
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0035 0.0043 0.0121
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0054 0.0097
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0102 0.1021 0.1021
Leishmania major alpha glucosidase II subunit, putative 0.0106 0.1085 0.834
Echinococcus granulosus nAChR subunit 0.0055 0.0331 0.0331
Loa Loa (eye worm) beta-lactamase 0.0043 0.0163 0.0163
Schistosoma mansoni nAChR subunit 0.0102 0.1021 0.1831
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0121 0.1301 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0215
Onchocerca volvulus 0.0043 0.0163 0.0171
Loa Loa (eye worm) RNA binding protein 0.0063 0.0442 0.0442
Loa Loa (eye worm) CYP4Cod1 0.0062 0.0429 0.0429
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0111 0.1159 0.8908
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0107 0.0287
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0107 0.0287
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0215
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.3596 1
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0163 0.1251
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0102 0.1021 0.1021
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0047 0.0215 0.0215
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0035 0.0043 0.0333
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0035 0.0043 0.0121
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.1085 0.9363
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0102 0.1021 0.1021
Brugia malayi TAR-binding protein 0.0063 0.0442 0.0442
Schistosoma mansoni hypothetical protein 0.0036 0.0046 0.0083
Echinococcus multilocularis lysosomal alpha glucosidase 0.048 0.6554 0.6554
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.01 0.0988 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0102 0.1021 0.1831
Plasmodium falciparum pyruvate kinase 0.0032 0 0.5
Onchocerca volvulus 0.0102 0.1021 0.1074
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0101 0.0182
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0102 0.1021 0.1021
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0101 0.0182
Onchocerca volvulus 0.0055 0.0331 0.0348
Loa Loa (eye worm) hypothetical protein 0.0102 0.1021 0.1021
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1226 0.1226
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0047 0.0215 0.0215
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0102 0.1021 0.1021
Loa Loa (eye worm) hypothetical protein 0.0043 0.0163 0.0163
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0442 0.0793
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0681 0.9508 0.9508
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0035 0.0043 0.0333
Echinococcus granulosus FTZ F1 alpha 0.0408 0.5497 0.5497
Brugia malayi Pre-SET motif family protein 0.0036 0.0054 0.0054
Onchocerca volvulus 0.0047 0.0215 0.0227
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0111 0.1159 1
Onchocerca volvulus 0.0048 0.0232 0.0244
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0035 0.0043 0.0374
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0442 0.0442
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0102 0.1021 0.1021
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0035 0.0035
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0102 0.1021 0.1831
Trichomonas vaginalis alpha-glucosidase, putative 0.0106 0.1085 0.292
Loa Loa (eye worm) hypothetical protein 0.0043 0.0163 0.0163
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0106 0.1085 0.292
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0047 0.0215 0.0215
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0035 0.0043 0.0121
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0055 0.0331 0.0331
Schistosoma mansoni hypothetical protein 0.0146 0.1662 0.2981
Echinococcus granulosus glycine receptor subunit alpha 1 0.0102 0.1021 0.1021
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.1301 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0335 0.0335
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0101 0.0101
Loa Loa (eye worm) inositol-1 0.0111 0.1159 0.1159
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0163 0.0438
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0102 0.1021 0.1021
Leishmania major cytochrome p450-like protein 0.0035 0.0043 0.0333
Brugia malayi hypothetical protein 0.0047 0.0215 0.0215
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0101 0.0874
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0102 0.1021 0.1021
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0215
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0102 0.1021 0.1021
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0101 0.0101
Schistosoma mansoni alpha glucosidase 0.0106 0.1085 0.1947
Loa Loa (eye worm) hypothetical protein 0.0102 0.1021 0.1021
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0047 0.0215 0.0215
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0035 0.0043 0.0333
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0047 0.0215 0.0215
Loa Loa (eye worm) cytochrome P450 0.0035 0.0043 0.0043
Brugia malayi MH2 domain containing protein 0.0116 0.1226 0.1226
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0163 0.0453
Chlamydia trachomatis pyruvate kinase 0.0032 0 0.5
Mycobacterium ulcerans hypothetical protein 0.0043 0.0163 0.1251
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.004 0.0107 0.092
Brugia malayi follicle stimulating hormone receptor 0.0229 0.2875 0.2875
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0102 0.1021 0.1021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0054 0.0097
Onchocerca volvulus Putative nachr subunit 0.0681 0.9508 1
Trypanosoma brucei cytochrome P450, putative 0.0062 0.0429 0.37
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0163 0.0163
Trichomonas vaginalis sucrase-isomaltase, putative 0.0106 0.1085 0.292
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0101 0.0101
Echinococcus multilocularis nAChR subunit 0.0055 0.0331 0.0331
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0035 0.0043 0.0121
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0035 0.0043 0.0121
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0047 0.0215 0.0215
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0102 0.1021 0.1831
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0111 0.1159 0.5
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.1301 0.2334
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0101 0.0778
Trichomonas vaginalis alpha-glucosidase, putative 0.0106 0.1085 0.292
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0215
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0101 0.0101
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0102 0.1021 0.1021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.011 0.1137 0.1137
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0102 0.1021 0.1831
Echinococcus granulosus survival motor neuron protein 1 0.0715 1 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.1021 0.1021
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0102 0.1021 0.1021
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0163 0.0438
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0054 0.0054
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0035 0.0043 0.0333
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0035 0.0043 0.0333
Trichomonas vaginalis alpha-glucosidase, putative 0.0106 0.1085 0.292
Brugia malayi Cation transporter family protein 0.0102 0.1021 0.1021
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0102 0.1021 0.1021
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0047 0.0215 0.0215
Brugia malayi excitatory GABA receptor EXP-1A 0.0102 0.1021 0.1021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0054 0.0097
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0776 0.1391
Brugia malayi beta-lactamase family protein 0.0043 0.0163 0.0163
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.3208 0.3208
Loa Loa (eye worm) hypothetical protein 0.0043 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0102 0.1021 0.1021
Loa Loa (eye worm) hypothetical protein 0.0102 0.1021 0.1021
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0215
Echinococcus granulosus glycine receptor subunit beta 0.0102 0.1021 0.1021
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0106 0.1085 0.292
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0111 0.1159 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0215
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0106 0.1085 0.834
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0163 0.1251
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0106 0.1085 0.9336
Onchocerca volvulus 0.0043 0.0163 0.0171
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0215
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0146 0.1662 0.1662
Onchocerca volvulus 0.0102 0.1021 0.1074
Loa Loa (eye worm) cytochrome P450 family protein 0.013 0.1431 0.1431
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0035 0.0043 0.0121
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0055 0.0331 0.0594
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0062 0.0429 0.3296
Schistosoma mansoni nAChR subunit 0.0102 0.1021 0.1831
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0047 0.0215 0.0215
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0102 0.1021 0.1021
Echinococcus multilocularis glycine receptor subunit beta 0.0102 0.1021 0.1021
Mycobacterium leprae putative cytochrome p450 0.0035 0.0043 0.0439
Brugia malayi Cytochrome P450 family protein 0.0035 0.0043 0.0043
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0035 0.0043 0.0374
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0035 0.0043 0.0333
Loa Loa (eye worm) acetylcholine receptor protein 0.0047 0.0215 0.0215
Echinococcus multilocularis neutral alpha glucosidase AB 0.0106 0.1085 0.1085
Loa Loa (eye worm) ACC-1 protein 0.0102 0.1021 0.1021
Schistosoma mansoni nAChR subunit 0.0102 0.1021 0.1831
Mycobacterium tuberculosis Conserved protein 0.0043 0.0163 0.0453
Echinococcus granulosus glycine receptor subunit alpha 1 0.0102 0.1021 0.1021
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0776 0.0776
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0681 0.9508 0.9508
Echinococcus multilocularis FTZ F1 alpha 0.011 0.1137 0.1137
Loa Loa (eye worm) hypothetical protein 0.0055 0.0331 0.0331
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0442 0.0793
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0111 0.1159 0.3119
Echinococcus granulosus lysosomal alpha glucosidase 0.048 0.6554 0.6554
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0163 0.0453
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0046 0.0083
Mycobacterium tuberculosis Conserved protein 0.0043 0.0163 0.0453
Loa Loa (eye worm) hypothetical protein 0.0085 0.0776 0.0776
Trypanosoma brucei glucosidase, putative 0.0106 0.1085 0.9363
Schistosoma mansoni hypothetical protein 0.0067 0.0504 0.0904
Echinococcus multilocularis nAChR subunit 0.0102 0.1021 0.1021
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0035 0.0043 0.0333
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0681 0.9508 0.9508
Brugia malayi Pre-SET motif family protein 0.0251 0.3208 0.3208
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0035 0.0043 0.0121
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0055 0.0331 0.0331
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0102 0.1021 0.1021
Echinococcus granulosus tumor protein p63 0.0329 0.4352 0.4352
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0054 0.0415
Schistosoma mansoni alpha-glucosidase 0.0413 0.5576 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0055 0.0331 0.0331
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0163 0.0453
Echinococcus multilocularis survival motor neuron protein 1 0.0715 1 1
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0442 0.0442
Loa Loa (eye worm) LGC-31 protein 0.0102 0.1021 0.1021
Loa Loa (eye worm) hypothetical protein 0.0055 0.0331 0.0331
Brugia malayi beta-lactamase family protein 0.0043 0.0163 0.0163
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0335 0.0335
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0035 0.0043 0.0121
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0101 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.1021 0.1021
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0035 0.0043 0.0333
Loa Loa (eye worm) hypothetical protein 0.0055 0.0331 0.0331
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0047 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0098 0.0957 0.0957
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0163 0.1405
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0102 0.1021 0.1021
Echinococcus granulosus nAChR subunit 0.0102 0.1021 0.1021
Schistosoma mansoni acetylcholine receptor subunit beta 0.0047 0.0215 0.0386
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0035 0.0043 0.0333
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0163 0.0453
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0047 0.0215 0.0215
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0429 0.0429
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0335 0.0335
Brugia malayi hypothetical protein 0.0047 0.0215 0.0215
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0035 0.0043 0.0121
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0035 0.0043 0.0374
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0054 0.0097
Schistosoma mansoni alpha-glucosidase 0.0413 0.5576 1
Schistosoma mansoni hypothetical protein 0.008 0.0701 0.1258
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0102 0.1021 0.1831
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0102 0.1021 0.1831
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0035 0.0043 0.0333
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.2875 0.2875
Onchocerca volvulus 0.0102 0.1021 0.1074
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0111 0.1159 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0101 0.0273
Brugia malayi hypothetical protein 0.0047 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.011 0.1137 0.1137
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0102 0.1021 0.1021
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0035 0.0043 0.0333
Mycobacterium leprae Conserved hypothetical protein 0.0035 0.0043 0.0439
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0163 0.0292
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0102 0.1021 0.1021
Schistosoma mansoni nAChR subunit 0.0102 0.1021 0.1831
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0232 0.0417
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0035 0.0043 0.0333
Schistosoma mansoni nAChR subunit 0.0102 0.1021 0.1831
Onchocerca volvulus 0.0146 0.1662 0.1748
Loa Loa (eye worm) hypothetical protein 0.0102 0.1021 0.1021
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0102 0.1021 0.1021
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0035 0.0043 0.0333
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0957 0.0957
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0215
Onchocerca volvulus 0.0277 0.3591 0.3777
Trichomonas vaginalis esterase, putative 0.0043 0.0163 0.0438
Onchocerca volvulus 0.0047 0.0215 0.0227
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0055 0.0331 0.0594
Schistosoma mansoni nAChR subunit 0.0047 0.0215 0.0386
Echinococcus granulosus cytochrome P450 2K1 0.0035 0.0043 0.0043
Mycobacterium tuberculosis Conserved protein 0.0043 0.0163 0.0453
Toxoplasma gondii aldehyde dehydrogenase 0.0121 0.1301 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0163 0.0438
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.011 0.1137 0.1137
Onchocerca volvulus 0.0102 0.1021 0.1074
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0035 0.0043 0.0121
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0681 0.9508 0.9508
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0442 0.0793
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0215
Echinococcus granulosus glycine receptor subunit alpha 1 0.0102 0.1021 0.1021
Echinococcus multilocularis tumor protein p63 0.0329 0.4352 0.4352
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0035 0.0043 0.0333
Schistosoma mansoni nAChR subunit 0.0102 0.1021 0.1831
Trypanosoma cruzi cytochrome P450, putative 0.0062 0.0429 0.37
Loa Loa (eye worm) hypothetical protein 0.0043 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0043 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0055 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0215
Brugia malayi Cation transporter family protein 0.0102 0.1021 0.1021
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0035 0.0043 0.0121
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0035 0.0043 0.0121
Loa Loa (eye worm) hypothetical protein 0.0055 0.0331 0.0331
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.004 0.0107 0.092
Onchocerca volvulus 0.0286 0.3717 0.3909
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0054
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0043 0.0163 0.0163
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0163 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0106 0.1085 0.9336
Leishmania major glycosyl hydrolase-like protein 0.004 0.0107 0.082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0335 0.0601
Echinococcus multilocularis lysosomal alpha glucosidase 0.048 0.6554 0.6554
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0101 0.0874
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0111 0.1159 0.8908
Loa Loa (eye worm) hypothetical protein 0.0039 0.0101 0.0101
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0035 0.0043 0.0121
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0121 0.1301 0.362
Loa Loa (eye worm) ACC-1 protein 0.0102 0.1021 0.1021
Echinococcus granulosus tar DNA binding protein 0.0063 0.0442 0.0442
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0957 0.0957
Brugia malayi Glycosyl hydrolases family 31 protein 0.0106 0.1085 0.1085
Brugia malayi RNA binding protein 0.0063 0.0442 0.0442
Schistosoma mansoni inositol monophosphatase 0.0111 0.1159 0.2079
Onchocerca volvulus 0.0055 0.0331 0.0348
Loa Loa (eye worm) hypothetical protein 0.0715 1 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0035 0.0043 0.0374
Schistosoma mansoni hypothetical protein 0.0035 0.0043 0.0078
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0101 0.0273
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0035 0.0043 0.0333
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0101 0.0496
Plasmodium vivax SET domain protein, putative 0.0036 0.0054 0.3315
Echinococcus granulosus inositol monophosphatase 1 0.0111 0.1159 0.1159
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0035 0.0043 0.0121
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0102 0.1021 0.1021
Trichomonas vaginalis inositol monophosphatase, putative 0.0111 0.1159 0.3119
Loa Loa (eye worm) hypothetical protein 0.0102 0.1021 0.1021
Schistosoma mansoni cytochrome P450 0.0035 0.0043 0.0078
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0035 0.0043 0.0333
Brugia malayi hypothetical protein 0.0047 0.0215 0.0215
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0106 0.1085 0.1085
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0047 0.0215 0.0215
Toxoplasma gondii cytochrome p450 superfamily protein 0.0035 0.0043 0.0333
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0107 0.0287
Trichomonas vaginalis alpha-glucosidase, putative 0.0106 0.1085 0.292
Loa Loa (eye worm) hypothetical protein 0.0102 0.1021 0.1021
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0035 0.0043 0.0121
Loa Loa (eye worm) hypothetical protein 0.0055 0.0331 0.0331
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0102 0.1021 0.1021
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0102 0.1021 0.1021
Brugia malayi Cytochrome P450 family protein 0.0062 0.0429 0.0429
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0163 0.0438
Loa Loa (eye worm) hypothetical protein 0.0102 0.1021 0.1021
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0102 0.1021 0.1021
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0429 0.0429
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0776 0.0776
Schistosoma mansoni acetylcholine receptor-related 0.0047 0.0215 0.0386
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0102 0.1021 0.1021
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0035 0.0043 0.0121
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0035 0.0043 0.0333
Toxoplasma gondii ABC1 family protein 0.0043 0.0163 0.1251
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.01 0.0988 0.2748
Brugia malayi hypothetical protein 0.0047 0.0215 0.0215
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0442 0.0442
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0035 0.0043 0.0333
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0163 0.0292
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0681 0.9508 0.9508
Mycobacterium ulcerans lipase LipD 0.0043 0.0163 0.1251
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.1085 0.9363
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0163 0.0438
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0102 0.1021 0.1021
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0102 0.1021 0.1021
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0121 0.1301 0.1301
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0681 0.9508 0.9508
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0215
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0035 0.0043 0.0121
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0215
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0055 0.0331 0.0331
Brugia malayi hypothetical protein 0.0036 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0055 0.0331 0.0331
Echinococcus granulosus neutral alpha glucosidase AB 0.0106 0.1085 0.1085
Loa Loa (eye worm) hypothetical protein 0.0102 0.1021 0.1021
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.004 0.0107 0.0112
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0101 0.0273
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.1301 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0331 0.0331
Echinococcus multilocularis inositol monophosphatase 1 0.0111 0.1159 0.1159
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0047 0.0215 0.0215
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0335 0.0335
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0102 0.1021 0.1021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.011 0.1137 0.1137
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0107 0.0287
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0111 0.1159 0.3119
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0035 0.0043 0.0121
Onchocerca volvulus 0.0102 0.1021 0.1074
Schistosoma mansoni neurotransmitter gated ion channel 0.0047 0.0215 0.0386
Schistosoma mansoni neurotransmitter gated ion channel 0.0047 0.0215 0.0386
Loa Loa (eye worm) hypothetical protein 0.0102 0.1021 0.1021
Brugia malayi Glycosyl hydrolases family 31 protein 0.048 0.6554 0.6554
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0035 0.0043 0.0121
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.1301 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0035 0.0043 0.0333
Loa Loa (eye worm) hypothetical protein 0.0102 0.1021 0.1021
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0102 0.1021 0.1021
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0215
Schistosoma mansoni inositol monophosphatase 0.0111 0.1159 0.2079
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0163 0.1405
Leishmania major hypothetical protein, conserved 0.0043 0.0163 0.1251
Leishmania major cytochrome p450-like protein 0.0062 0.0429 0.3296
Echinococcus multilocularis 0.0035 0.0043 0.0043
Onchocerca volvulus 0.0036 0.0054 0.0057
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0442 0.0442
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0102 0.1021 0.1021
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.1301 0.2334
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0681 0.9508 0.9508
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.048 0.6554 0.6554
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0681 0.9508 0.9508
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0442 0.0793
Schistosoma mansoni survival motor neuron protein 0.0146 0.1662 0.2981
Onchocerca volvulus 0.0085 0.0776 0.0816
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0107 0.0287
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0776 0.0776
Brugia malayi Cation transporter family protein 0.0102 0.1021 0.1021
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0215
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0047 0.0215 0.0215
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0163 0.1405
Loa Loa (eye worm) hypothetical protein 0.0048 0.0232 0.0232
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0107 0.0287
Trichomonas vaginalis alpha-glucosidase, putative 0.0106 0.1085 0.292
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0335 0.0335
Leishmania major cytochrome p450-like protein 0.0035 0.0043 0.0333
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0111 0.1159 0.8908
Brugia malayi Cytochrome P450 family protein 0.0062 0.0429 0.0429
Trypanosoma brucei glycosyl hydrolase-like protein 0.004 0.0107 0.092
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0102 0.1021 0.1021
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0163 0.0453
Brugia malayi beta-lactamase 0.0043 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0102 0.1021 0.1021
Loa Loa (eye worm) GABA receptor subunit 0.0055 0.0331 0.0331
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0107 0.0544
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0035 0.0043 0.0333
Loa Loa (eye worm) hypothetical protein 0.0067 0.0504 0.0504
Trichomonas vaginalis set domain proteins, putative 0.0286 0.3717 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0107 0.0107
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0107 0.0107
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0335 0.0601
Brugia malayi Cytochrome P450 family protein 0.013 0.1431 0.1431
Onchocerca volvulus 0.0102 0.1021 0.1074
Mycobacterium ulcerans beta-lactamase 0.0043 0.0163 0.1251
Onchocerca volvulus 0.0043 0.0163 0.0171
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0035 0.0043 0.0121
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0102 0.1021 0.1021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0335 0.0601
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1226 0.1226
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0102 0.1021 0.1021
Mycobacterium leprae Probable lipase LipE 0.0043 0.0163 0.1648
Onchocerca volvulus 0.0047 0.0215 0.0227
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0163 0.0163
Schistosoma mansoni neurotransmitter gated ion channel 0.0055 0.0331 0.0594
Echinococcus multilocularis glycine receptor subunit beta 0.0102 0.1021 0.1021
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0121 0.1301 0.1301
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0102 0.1021 0.1021
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0442 0.0793
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0111 0.1159 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0101 0.0101
Entamoeba histolytica hypothetical protein 0.0055 0.0331 0.2561
Loa Loa (eye worm) hypothetical protein 0.0102 0.1021 0.1021
Brugia malayi cytochrome P450 0.0035 0.0043 0.0043
Echinococcus granulosus glycine receptor subunit beta 0.0102 0.1021 0.1021
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0035 0.0043 0.0333
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0504 0.0504
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0102 0.1021 0.1021
Schistosoma mansoni nAChR subunit 0.0102 0.1021 0.1831
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0163 0.0453
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0101 0.0874
Loa Loa (eye worm) hypothetical protein 0.0055 0.0331 0.0331
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0107 0.0287
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0163 0.1648
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0107 0.0287
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0163 0.0453
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0335 0.0335
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0102 0.1021 0.1021
Schistosoma mansoni nAChR subunit 0.0047 0.0215 0.0386
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0163 0.0163
Trichomonas vaginalis maltase-glucoamylase, putative 0.0106 0.1085 0.292
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.011 0.1137 0.2039
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0163 0.0163

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter. (Class of assay: confirmatory) [Related pubchem assays: 2281 (Summary of qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a), 463106 (LOPAC Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a)] ChEMBL. No reference
Potency (functional) 29.9349 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 95.2834 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.