Detailed information for compound 1335114

Basic information

Technical information
  • TDR Targets ID: 1335114
  • Name: 4-bromo-N-[(1,5-dimethylpyrazol-3-yl)methyl]- 5-ethylthiophene-2-carboxamide
  • MW: 342.255 | Formula: C13H16BrN3OS
  • H donors: 1 H acceptors: 2 LogP: 2.98 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1sc(cc1Br)C(=O)NCc1nn(c(c1)C)C
  • InChi: 1S/C13H16BrN3OS/c1-4-11-10(14)6-12(19-11)13(18)15-7-9-5-8(2)17(3)16-9/h5-6H,4,7H2,1-3H3,(H,15,18)
  • InChiKey: UVWOUPUKAMEOCW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-bromo-N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-ethyl-thiophene-2-carboxamide
  • 4-bromo-N-[(1,5-dimethyl-3-pyrazolyl)methyl]-5-ethyl-2-thiophenecarboxamide
  • 4-bromo-N-[(1,5-dimethyl-1H-pyrazol-3-yl)methyl]-5-ethyl-2-thiophenecarboxamide
  • MLS000065721
  • SMR000080389
  • ZINC01054044
  • IVK/4004852

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 15-lipoxygenase 662 aa 590 aa 23.9 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Bromodomain containing protein 0.0033 0.0007 0.0015
Schistosoma mansoni ets-related 0.022 0.1373 0.1373
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0029 0.0029
Trichomonas vaginalis glutaminase, putative 0.0273 0.1764 0.4845
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0057 0.0057
Onchocerca volvulus 0.0055 0.0173 0.0995
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0297 0.0297
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0297 0.0297
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0639 0.1403
Brugia malayi jmjC domain containing protein 0.0107 0.0551 0.1207
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0032 0.0009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0063
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0063
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0029 0.0029
Echinococcus multilocularis peregrin 0.0033 0.0007 0.0007
Toxoplasma gondii ABC1 family protein 0.0036 0.0029 0.0332
Schistosoma mansoni alpha glucosidase 0.0036 0.0032 0.0032
Brugia malayi hypothetical protein 0.0286 0.1855 0.4069
Mycobacterium tuberculosis Conserved hypothetical protein 0.0195 0.1191 0.3245
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0237 0.1501 0.3293
Onchocerca volvulus 0.0036 0.0029 0.0165
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0036
Entamoeba histolytica hypothetical protein 0.0039 0.0057 1
Onchocerca volvulus 0.0036 0.0029 0.0165
Mycobacterium tuberculosis Conserved hypothetical protein 0.0195 0.1191 0.3245
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1855 0.1855
Mycobacterium leprae Probable lipase LipE 0.0036 0.0029 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0032 1
Echinococcus multilocularis microtubule associated protein 2 0.14 1 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0029 0.0063
Loa Loa (eye worm) beta-lactamase 0.0036 0.0029 0.0063
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0063
Brugia malayi beta-lactamase family protein 0.0036 0.0029 0.0063
Entamoeba histolytica hypothetical protein 0.0039 0.0057 1
Schistosoma mansoni alpha-glucosidase 0.014 0.0792 0.0792
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.0668 0.0668
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0123 0.0668 0.1786
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0032 0.0009
Loa Loa (eye worm) hypothetical protein 0.0056 0.0178 0.0389
Brugia malayi Muscleblind-like protein 0.0656 0.4559 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0261 0.0573
Wolbachia endosymbiont of Brugia malayi trans-2-enoyl-ACP reductase, FabK 0.0526 0.3609 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0032 0.0009
Mycobacterium ulcerans hypothetical protein 0.0526 0.3609 1
Brugia malayi glutaminase DH11.1 0.0273 0.1764 0.3868
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.0255 0.0255
Brugia malayi Pre-SET motif family protein 0.0034 0.0017 0.0036
Entamoeba histolytica hypothetical protein 0.0039 0.0057 1
Mycobacterium ulcerans glutaminase 0.0273 0.1764 0.4845
Onchocerca volvulus 0.0034 0.0017 0.0095
Schistosoma mansoni glutaminase 0.0273 0.1764 0.1764
Brugia malayi Pre-SET motif family protein 0.0237 0.1501 0.3293
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0017 0.0017
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0032 0.0009
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0041 0.0069 0.0069
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0032 0.0378
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0057 0.0057
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0032 0.0009
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0032 0.0009
Brugia malayi beta-lactamase family protein 0.0036 0.0029 0.0063
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0029 0.0029
Trichomonas vaginalis set domain proteins, putative 0.027 0.1741 0.4781
Schistosoma mansoni hypothetical protein 0.0058 0.0194 0.0194
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0208 0.0456
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0107 0.0551 0.0551
Brugia malayi beta-lactamase 0.0036 0.0029 0.0063
Brugia malayi MH2 domain containing protein 0.0119 0.0639 0.1403
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0208 0.0456
Schistosoma mansoni hypothetical protein 0.0039 0.0057 0.0057
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0029 1
Mycobacterium ulcerans 2-nitropropane dioxygenase 0.0526 0.3609 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.0957 0.21
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.1435 0.3927
Plasmodium vivax SET domain protein, putative 0.0034 0.0017 0.4407
Echinococcus granulosus tumor protein p63 0.0379 0.2537 0.2537
Brugia malayi Fli-1 protein 0.022 0.1373 0.3011
Loa Loa (eye worm) hypothetical protein 0.0656 0.4559 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0007 0.0007
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0909 0.6414 0.6414
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0029 0.0063
Brugia malayi Ets-domain containing protein 0.0072 0.0297 0.065
Schistosoma mansoni hypothetical protein 0.0033 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0033 0.0007 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0017 0.0017
Brugia malayi Ets-domain containing protein 0.0072 0.0297 0.065
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.0668 0.0668
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0057 0.0057
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0069 0.0151
Plasmodium falciparum phd finger protein, putative 0.0033 0.0007 0.5
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0007 0.0007
Mycobacterium tuberculosis Possible oxidoreductase 0.0526 0.3609 1
Giardia lamblia PHD finger protein 15 0.0033 0.0007 0.5
Mycobacterium ulcerans hypothetical protein 0.0195 0.1191 0.3245
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0173 0.0173
Echinococcus multilocularis muscleblind protein 1 0.0656 0.4559 0.4559
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0957 0.0957
Leishmania major enoyl-[acyl-carrier-protein] reductase, putative 0.0526 0.3609 1
Onchocerca volvulus 0.0094 0.0456 0.2619
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.0957 0.21
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0057 0.0057
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0957 0.0957
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0297 0.065
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0194 0.0425
Schistosoma mansoni lipoxygenase 0.0067 0.0255 0.0255
Brugia malayi jmjC domain containing protein 0.004 0.0057 0.0125
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0032 0.0009
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0123 0.0668 0.0668
Onchocerca volvulus 0.027 0.1741 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0032 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0017 0.0146
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0017 0.0017
Echinococcus multilocularis muscleblind protein 0.0656 0.4559 0.4559
Loa Loa (eye worm) hypothetical protein 0.0041 0.0069 0.0151
Brugia malayi PHD-finger family protein 0.0033 0.0007 0.0015
Loa Loa (eye worm) hypothetical protein 0.0055 0.0173 0.038
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0107 0.0551 0.0551
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0032 0.0032
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0017 0.0017
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0062 0.022 0.0482
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0032 0.0009
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0032 0.0009
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0057 0.0057
Onchocerca volvulus 0.0036 0.0029 0.0165
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0007 0.0007
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0007 0.0015
Toxoplasma gondii aldehyde dehydrogenase 0.0123 0.0668 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0123 0.0668 0.0668
Schistosoma mansoni survival motor neuron protein 0.0058 0.0194 0.0194
Brugia malayi hypothetical protein 0.0039 0.0057 0.0124
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0063
Loa Loa (eye worm) fli-1 protein 0.022 0.1373 0.3011
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.006 0.0208 0.0456
Mycobacterium ulcerans hypothetical protein 0.0195 0.1191 0.3245
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0032 0.007
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0032 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0063
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.0668 0.1786
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.01 0.01
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.0668 0.1786
Schistosoma mansoni microtubule-associated protein tau 0.14 1 1
Loa Loa (eye worm) hypothetical protein 0.0656 0.4559 1
Loa Loa (eye worm) hypothetical protein 0.0286 0.1855 0.4069
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.0668 0.1786
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0208 0.0456
Echinococcus granulosus jumonji domain containing protein 0.0045 0.01 0.01
Echinococcus multilocularis tumor protein p63 0.0379 0.2537 0.2537
Onchocerca volvulus Alhambra homolog 0.0033 0.0007 0.0039
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0063
Mycobacterium tuberculosis Possible alanine rich oxidoreductase 0.0526 0.3609 1
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0057 0.0125
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0032 0.0009
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0032 0.007
Schistosoma mansoni jumonji domain containing protein 0.0085 0.039 0.039
Schistosoma mansoni alpha-glucosidase 0.014 0.0792 0.0792
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0029 0.5
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.0957 0.0957
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0123 0.0668 0.1786
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0017 0.0017
Loa Loa (eye worm) glutaminase 0.0273 0.1764 0.3868
Loa Loa (eye worm) glutaminase 2 0.0273 0.1764 0.3868
Echinococcus granulosus peregrin 0.0033 0.0007 0.0007
Echinococcus granulosus muscleblind protein 0.0656 0.4559 0.4559
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.0255 0.0255
Schistosoma mansoni gabp alpha 0.0072 0.0297 0.0297
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0639 0.1403
Mycobacterium tuberculosis Conserved protein 0.0195 0.1191 0.3245
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0017 0.0017
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0029 0.0029
Trichomonas vaginalis 2-nitropropane dioxygenase precursor, putative 0.0526 0.3609 1
Entamoeba histolytica hypothetical protein 0.0039 0.0057 1
Onchocerca volvulus 0.0058 0.0194 0.1112
Trypanosoma brucei glucosidase, putative 0.0036 0.0032 1
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1855 0.1855

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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