Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Inositol monophosphatase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.301 | 0.301 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.215 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.4367 | 0.3431 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.215 | 0.3907 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0129 | 1 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 0.215 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.215 | 1 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0022 | 0 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 0.215 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 0.215 | 0.3907 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.004 | 0.1715 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.4367 | 0.7936 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.4367 | 0.7936 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0045 | 0.215 | 0.4924 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.1425 | 0.1425 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.4367 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0045 | 0.215 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.215 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0045 | 0.215 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.4367 | 1 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0023 | 0.017 | 0.0309 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.4367 | 0.7936 |
Giardia lamblia | Ribonuclease H | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.301 | 0.1849 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1425 | 0.2589 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0045 | 0.215 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.004 | 0.1715 | 0.5 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.017 | 0.0309 |
Brugia malayi | RNA binding protein | 0.0068 | 0.4367 | 0.4367 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0023 | 0.017 | 0.0309 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.4367 | 0.4367 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.301 | 0.301 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 0.215 | 0.3907 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0045 | 0.215 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0023 | 0.017 | 0.0309 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.4367 | 0.7936 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.4367 | 0.3431 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.4367 | 0.4367 |
Brugia malayi | Inositol-1 | 0.0045 | 0.215 | 0.215 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0023 | 0.017 | 0.0309 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0045 | 0.215 | 0.4924 |
Trypanosoma brucei | RNA helicase, putative | 0.0081 | 0.5503 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0045 | 0.215 | 0.0846 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0045 | 0.215 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.4367 | 0.7936 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.5503 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.301 | 0.1849 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0129 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.4367 | 0.3431 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.2332 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 0.5012 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.