Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | hydroxyprostaglandin dehydrogenase 15-(NAD) | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxyprostaglandin dehydrogenase 15-(NAD) | 266 aa | 216 aa | 22.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0871 | 0.1977 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.387 | 0.387 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0871 | 0.1977 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.387 | 0.387 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0871 | 0.1977 |
Echinococcus multilocularis | musashi | 0.0033 | 0.387 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.387 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.387 | 0.3537 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0871 | 0.0871 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.387 | 0.387 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5775 | 0.5775 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.5775 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.387 | 0.6116 |
Onchocerca volvulus | 0.0033 | 0.387 | 0.5 | |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.387 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.5775 | 0.5545 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.3738 | 0.3738 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0516 | 0.0516 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0871 | 0.1977 |
Echinococcus multilocularis | lamin | 0.0033 | 0.387 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0871 | 0.1977 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0871 | 0.0375 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0871 | 0.0375 |
Schistosoma mansoni | lamin | 0.0033 | 0.387 | 0.6116 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 0.387 | 0.5 | |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0871 | 0.1977 |
Echinococcus granulosus | lamin | 0.0033 | 0.387 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.387 | 0.6116 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0132 | 0.0132 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.387 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.387 | 0.3537 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0871 | 0.0871 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.