Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | RAB9A, member RAS oncogene family | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | ras-related protein Rab-5B | RAB9A, member RAS oncogene family | 201 aa | 165 aa | 30.9 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | animal heme peroxidase | 0.012 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 0.3185 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2086 | 1 |
Schistosoma mansoni | peroxidasin | 0.012 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.012 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.012 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.3307 | 0.3307 |
Loa Loa (eye worm) | animal heme peroxidase | 0.012 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.2086 | 0.2086 |
Onchocerca volvulus | Dual oxidase homolog | 0.012 | 1 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.3307 | 0.3307 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 0.3185 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 1 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 0.3185 | 0.3185 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.012 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.012 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3307 | 0.3307 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 0.3185 | 0.3185 |
Schistosoma mansoni | peroxidasin | 0.012 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.3307 | 0.3307 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.012 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.2086 | 0.2086 |
Brugia malayi | Animal haem peroxidase family protein | 0.012 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2086 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.012 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.2086 | 0.2086 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0 | 0.5 |
Onchocerca volvulus | 0.012 | 1 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.012 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.012 | 1 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.1521 | 0.4775 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3307 | 0.3307 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2086 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.2086 | 0.2086 |
Onchocerca volvulus | Peroxidase homolog | 0.012 | 1 | 0.5 |
Brugia malayi | Peroxidasin | 0.012 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.1521 | 0.4775 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.3307 | 0.3307 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 0.3185 | 0.3185 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.012 | 1 | 0.5 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.1521 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3307 | 0.3307 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.3307 | 0.3307 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.3307 | 0.3307 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 0.3185 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2086 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.012 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.012 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0054 | 0.3185 | 0.3185 |
Onchocerca volvulus | 0.012 | 1 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2086 | 0.2086 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.3185 | 0.3185 |
Onchocerca volvulus | 0.012 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.92 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 1.2589 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 20.5878 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.