Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | RAB9A, member RAS oncogene family | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | ras-related protein Rab-5B | RAB9A, member RAS oncogene family | 201 aa | 165 aa | 30.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0124 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0124 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.3094 | 0.3094 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0124 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0124 | 1 | 1 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0124 | 1 | 0.5 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0124 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2564 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0124 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1662 | 0.6482 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0124 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2564 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2564 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.2564 | 0.2564 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2564 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0.2564 | 0.2564 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1662 | 0.1662 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0124 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0124 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0124 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2564 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.2564 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.3094 | 0.3094 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.3094 | 0.3094 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.2564 | 0.2564 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3094 | 0.3094 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1662 | 0.1662 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.7783 um | PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.9953 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 23.9341 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Potency (binding) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.