Detailed information for compound 133575

Basic information

Technical information
  • TDR Targets ID: 133575
  • Name: N-(1-adamantyl)-N'-[4-[4-(1-adamantylamino)bu tylamino]butyl]butane-1,4-diamine
  • MW: 498.83 | Formula: C32H58N4
  • H donors: 4 H acceptors: 0 LogP: 6 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 1
  • SMILES: C(CNCCCCNC12CC3CC(C2)CC(C1)C3)CCNCCCCNC12CC3CC(C2)CC(C1)C3
  • InChi: 1S/C32H58N4/c1(7-33-9-3-5-11-35-31-19-25-13-26(20-31)15-27(14-25)21-31)2-8-34-10-4-6-12-36-32-22-28-16-29(23-32)18-30(17-28)24-32/h25-30,33-36H,1-24H2
  • InChiKey: FEXNVNVPGQVKBO-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-adamantyl-[4-[4-[4-(1-adamantylamino)butylamino]butylamino]butyl]amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0488 0.4274 1
Loa Loa (eye worm) heterochromatin protein 1 0.0442 0.3858 0.3854
Echinococcus granulosus lysine specific demethylase 6a 0.0079 0.0511 0.0623
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0031 0.0072 0.0056
Schistosoma mansoni hypothetical protein 0.0878 0.7865 0.9705
Echinococcus granulosus phd:f box containing protein 0.0079 0.0511 0.0623
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0522 0.0506
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0332 0.2844 0.284
Loa Loa (eye worm) hypothetical protein 0.003 0.0059 0.0053
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0031 0.0072 0.0131
Echinococcus multilocularis chromobox protein 2 0.0072 0.0451 0.0549
Echinococcus granulosus jumonji domain containing 1A 0.0079 0.0511 0.0623
Brugia malayi CXXC zinc finger family protein 0.0063 0.0368 0.0368
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0033 0.0086 0.0164
Echinococcus granulosus Chromobox protein 3 0.0072 0.0451 0.0549
Plasmodium vivax heterochromatin protein 1, putative 0.0072 0.0451 0.2107
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.1109 1 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0296 0.251 0.3092
Trypanosoma brucei Heat shock protein 83, putative 0.0154 0.12 0.2686
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0043 0.0183 0.0218
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0033 0.0086 0.0037
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0854 0.7644 0.7642
Echinococcus granulosus peregrin 0.0262 0.2196 0.2704
Trypanosoma cruzi heat shock protein 85, putative 0.0154 0.12 0.2779
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.044 0.3835 0.4729
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0662 0.0647
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0072 0.0451 0.2128
Plasmodium falciparum DNA topoisomerase 2 0.0031 0.0072 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0451 0.0435
Echinococcus granulosus importin subunit beta 1 0.0031 0.0071 0.008
Schistosoma mansoni bromodomain containing protein 0.0035 0.0105 0.013
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0079 0.0511 0.1048
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0031 0.0072 0.0131
Loa Loa (eye worm) helicase 0.0072 0.0451 0.0445
Loa Loa (eye worm) hypothetical protein 0.0072 0.0451 0.0445
Leishmania major heat shock protein 83-1 0.0154 0.12 0.2779
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.0662 0.0753
Loa Loa (eye worm) TOPoisomerase family member 0.0031 0.0072 0.0066
Trypanosoma cruzi heat shock protein, putative 0.0063 0.0364 0.0817
Leishmania major heat shock protein 83-1 0.0154 0.12 0.2779
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0662 0.0647
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0072 0.0451 0.102
Trypanosoma brucei ISWI complex protein 0.0112 0.0814 0.1767
Entamoeba histolytica heat shock protein 90, putative 0.0154 0.12 0.2779
Schistosoma mansoni chromobox protein 0.0442 0.3858 0.476
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0079 0.0512 0.0496
Trichomonas vaginalis sensor histidine kinase, putative 0.0031 0.0072 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0451 0.0435
Plasmodium falciparum heterochromatin protein 1 0.0072 0.0451 0.198
Loa Loa (eye worm) hypothetical protein 0.0978 0.8792 0.8791
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0031 0.0072 0.0082
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0042 0.0172 0.0464
Echinococcus multilocularis jumonji domain containing protein 0.034 0.2919 0.3597
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0097 0.0673 0.0823
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0072 0.0451 0.198
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0118 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0248 0.2067 0.2054
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.1237 0.1223
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0488 0.4274 1
Leishmania major heat shock protein 83-1 0.0154 0.12 0.2779
Echinococcus granulosus transcription factor Dp 1 0.0282 0.2383 0.2935
Trichomonas vaginalis DNA topoisomerase II, putative 0.0031 0.0072 0.0056
Echinococcus granulosus histone lysine methyltransferase setb 0.0248 0.207 0.2549
Leishmania major heat shock protein 83-1 0.0154 0.12 0.2779
Brugia malayi Probable DNA topoisomerase II 0.0031 0.0072 0.0072
Trichomonas vaginalis chromobox protein, putative 0.0267 0.2241 0.2228
Schistosoma mansoni jumonji/arid domain-containing protein 0.0314 0.2672 0.3297
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0072 0.0451 0.0451
Schistosoma mansoni hypothetical protein 0.0112 0.0814 0.1004
Schistosoma mansoni lozenge 0.0123 0.0914 0.1128
Giardia lamblia Grp94/Hsp90 0.0122 0.0911 0.3516
Chlamydia trachomatis DNA gyrase subunit B 0.0031 0.0072 0.5
Trichomonas vaginalis DNA helicase recq, putative 0.0033 0.0086 0.007
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0031 0.0072 0.0056
Schistosoma mansoni phd/f-box containing protein 0.0079 0.0511 0.0631
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.1103 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0087 0.0583 0.0568
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.0662 0.081
Toxoplasma gondii PHD-finger domain-containing protein 0.008 0.052 0.2473
Brugia malayi Associated with TFs and helicases family protein 0.0072 0.0451 0.0451
Loa Loa (eye worm) jmjC domain-containing protein 0.0314 0.2672 0.2668
Brugia malayi Pre-SET motif family protein 0.0124 0.0922 0.0922
Brugia malayi Bromodomain containing protein 0.0552 0.4865 0.4865
Giardia lamblia Pms1-like protein 0.0031 0.0072 0.0054
Echinococcus multilocularis Chromobox protein 3 0.0072 0.0451 0.0549
Echinococcus multilocularis dnaJ subfamily B 0.0904 0.8104 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0158 0.1237 0.2775
Echinococcus multilocularis transcription factor Dp 1 0.0282 0.2383 0.2935
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.003 0.0059 0.0065
Echinococcus granulosus Chromo domain 0.0072 0.0451 0.0549
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0042 0.0172 0.0204
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.044 0.3835 0.4729
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0158 0.1237 0.2867
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.0982 0.0976
Trypanosoma brucei heat shock protein 90, putative 0.0154 0.12 0.2686
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0031 0.0072 0.0082
Schistosoma mansoni hypothetical protein 0.0878 0.7865 0.9705
Trichomonas vaginalis set domain proteins, putative 0.0971 0.8728 0.8726
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0451 0.2107
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.008 0.052 0.2473
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0196 0.1589 0.1961
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0072 0.0451 0.198
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0172 0.0155
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0267 0.2241 0.2549
Loa Loa (eye worm) hypothetical protein 0.0194 0.1574 0.1569
Trypanosoma brucei heat shock protein, putative 0.0154 0.12 0.2686
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0063 0.0364 0.0817
Brugia malayi MH2 domain containing protein 0.013 0.0982 0.0982
Loa Loa (eye worm) hypothetical protein 0.0079 0.0511 0.0505
Trichomonas vaginalis chromobox protein, putative 0.0442 0.3858 0.3847
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0031 0.0072 0.0131
Leishmania major heat shock protein 83-1 0.0154 0.12 0.2779
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0031 0.0072 0.0082
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0118 0.0139
Loa Loa (eye worm) hypothetical protein 0.0419 0.3646 0.3642
Brugia malayi jmjC domain containing protein 0.0314 0.2672 0.2672
Plasmodium vivax ataxin-2 like protein, putative 0.0081 0.053 0.25
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0042 0.0172 0.0166
Loa Loa (eye worm) jmjC domain-containing protein 0.0079 0.0511 0.0505
Plasmodium falciparum heat shock protein 90, putative 0.0063 0.0364 0.1542
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0662 0.0817
Echinococcus multilocularis peregrin 0.0262 0.2196 0.2704
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0031 0.0072 0.0082
Onchocerca volvulus 0.0072 0.0451 0.0513
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.053 0.238
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0662 0.0647
Schistosoma mansoni microtubule-associated protein tau 0.0694 0.6179 0.7624
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0079 0.0511 0.2427
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0042 0.0172 0.0364
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.008 0.052 0.1069
Echinococcus multilocularis microtubule associated protein 2 0.0694 0.6179 0.7622
Trypanosoma brucei heat shock protein, putative 0.0154 0.12 0.2686
Plasmodium vivax endoplasmin, putative 0.0154 0.12 0.5835
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0031 0.0072 0.0072
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.009 0.0613 0.0749
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0189 0.0173
Brugia malayi exodeoxyribonuclease III family protein 0.0042 0.0172 0.0172
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0079 0.0511 0.1162
Schistosoma mansoni inositol transporter 0.0043 0.0183 0.0225
Loa Loa (eye worm) PHD-finger family protein 0.0245 0.2036 0.2032
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0063 0.0364 0.0414
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.2483 0.5793
Echinococcus granulosus dnaJ subfamily B 0.0904 0.8104 1
Leishmania major heat shock protein 83-1 0.0154 0.12 0.2779
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.2483 0.2471
Brugia malayi Protein cec-1. 0.0072 0.0451 0.0451
Trichomonas vaginalis Heterochromatin protein, putative 0.0072 0.0451 0.0435
Echinococcus granulosus heat shock protein 90 0.0122 0.0911 0.1118
Mycobacterium ulcerans heat shock protein 90 0.0122 0.0911 0.3788
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0451 0.2107
Trichomonas vaginalis glucosylceramidase, putative 0.1109 1 1
Leishmania major heat shock protein 83-1 0.0154 0.12 0.2779
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.1237 0.1223
Loa Loa (eye worm) hypothetical protein 0.0098 0.0682 0.0676
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0488 0.4274 1
Brugia malayi PHD-finger family protein 0.0186 0.1494 0.1494
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.053 0.1206
Loa Loa (eye worm) hypothetical protein 0.0315 0.2688 0.2683
Loa Loa (eye worm) hypothetical protein 0.0031 0.0071 0.0065
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.1237 0.1223
Leishmania major heat shock protein 83-1 0.0154 0.12 0.2779
Loa Loa (eye worm) hypothetical protein 0.0072 0.0451 0.0445
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.003 0.0059 0.0065
Trypanosoma cruzi DNA topoisomerase II, putative 0.0031 0.0072 0.0131
Schistosoma mansoni high-affinity choline transporter 0.0392 0.3398 0.4193
Schistosoma mansoni endoplasmin 0.0154 0.12 0.148
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0031 0.0072 0.0131
Leishmania major hypothetical protein, conserved 0.0081 0.053 0.1206
Brugia malayi jmjC domain containing protein 0.0801 0.7161 0.7161
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0072 0.0223
Plasmodium vivax heat shock protein 86, putative 0.0154 0.12 0.5835
Toxoplasma gondii heat shock protein HSP90 0.0154 0.12 0.5846
Trichomonas vaginalis heat shock protein, putative 0.0063 0.0364 0.0348
Echinococcus granulosus endoplasmin 0.0122 0.0911 0.1118
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0488 0.4274 0.5274
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0263 0.2202 0.2712
Trichomonas vaginalis conserved hypothetical protein 0.0248 0.2067 0.2054
Schistosoma mansoni blooms syndrome DNA helicase 0.0029 0.0049 0.0061
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0511 0.0631
Plasmodium vivax hypothetical protein, conserved 0.0084 0.0556 0.263
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0087 0.0583 0.0568
Loa Loa (eye worm) hypothetical protein 0.0072 0.0451 0.0445
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0072 0.0451 0.0435
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0031 0.0072 0.0056
Echinococcus multilocularis endoplasmin 0.0122 0.0911 0.1118
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0041 0.0162 0.0522
Trypanosoma cruzi heat shock protein 90, putative 0.0122 0.0911 0.2102
Echinococcus granulosus lysine specific demethylase 5A 0.0314 0.2672 0.3292
Loa Loa (eye worm) jmjC domain-containing protein 0.0079 0.0511 0.0505
Loa Loa (eye worm) jmjC domain-containing protein 0.0505 0.4435 0.4431
Schistosoma mansoni chromobox protein 0.0442 0.3858 0.476
Treponema pallidum fructose-bisphosphate aldolase 0.0293 0.2483 1
Treponema pallidum heat shock protein 90 0.0122 0.0911 0.3481
Entamoeba histolytica hypothetical protein 0.0072 0.0451 0.102
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0072 0.0451 0.2128
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.1103 0.4651
Plasmodium falciparum endoplasmin, putative 0.0094 0.0652 0.3001
Loa Loa (eye worm) hypothetical protein 0.0298 0.2526 0.2521
Plasmodium falciparum heat shock protein 90 0.0154 0.12 0.5769
Schistosoma mansoni ap endonuclease 0.0042 0.0172 0.0212
Brugia malayi Valyl-tRNA synthetase 0.0072 0.0451 0.0451
Leishmania major heat shock protein 83-1 0.0154 0.12 0.2779
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0042 0.0172 0.0448
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.2483 0.2471
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.0662 0.1516
Schistosoma mansoni jumonji/arid domain-containing protein 0.0314 0.2672 0.3297
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0168 0.1335 0.1647
Trypanosoma cruzi heat shock protein 85, putative 0.0154 0.12 0.2779
Echinococcus granulosus jumonji domain containing protein 0.034 0.2919 0.3597
Trypanosoma brucei DNA topoisomerase ii 0.0031 0.0072 0.0004
Echinococcus multilocularis phd:f box containing protein 0.0079 0.0511 0.0623
Leishmania major hypothetical protein, conserved 0.0112 0.0814 0.1872
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0042 0.0172 0.024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0087 0.0583 0.0568
Echinococcus multilocularis chromobox protein 1 0.0442 0.3858 0.4756
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.2483 0.2471
Brugia malayi hypothetical protein 0.0072 0.0451 0.0451
Plasmodium vivax heat shock protein 90, putative 0.0063 0.0364 0.1676
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0158 0.1237 0.2867
Loa Loa (eye worm) hypothetical protein 0.0043 0.0183 0.0177
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0042 0.0172 0.0364
Brugia malayi Pre-SET motif family protein 0.0854 0.7644 0.7644
Trypanosoma brucei protein kinase, putative 0.0158 0.1237 0.2775
Brugia malayi hypothetical protein 0.0978 0.8792 0.8792
Schistosoma mansoni cpg binding protein 0.0063 0.0368 0.0454
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0158 0.1237 0.2867
Echinococcus granulosus high affinity choline transporter 1 0.0392 0.3398 0.4188
Entamoeba histolytica heat shock protein 90, putative 0.0154 0.12 0.2779
Schistosoma mansoni hypothetical protein 0.0904 0.8104 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0488 0.4274 0.5271
Brugia malayi GH02984p 0.0392 0.3398 0.3398
Trichomonas vaginalis glucosylceramidase, putative 0.1109 1 1
Schistosoma mansoni heat shock protein 0.0154 0.12 0.148
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0451 0.0435
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0097 0.0673 0.0823
Trypanosoma brucei heat shock protein, putative 0.0154 0.12 0.2686
Leishmania major hypothetical protein, conserved 0.0031 0.0072 0.0131
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.2483 0.2471
Echinococcus multilocularis Chromo domain 0.0072 0.0451 0.0549
Echinococcus granulosus cpg binding protein 0.0081 0.053 0.0647
Echinococcus multilocularis solute carrier family 5 0.0043 0.0183 0.0218
Trichomonas vaginalis glucosylceramidase, putative 0.1109 1 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0158 0.1237 0.152
Echinococcus granulosus sodium:glucose cotransporter 2 0.0043 0.0183 0.0218
Echinococcus granulosus mitogen activated protein kinase 0.0158 0.1237 0.152
Schistosoma mansoni sodium/solute symporter 0.0043 0.0183 0.0225
Echinococcus multilocularis heat shock protein 0.0154 0.12 0.1474
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0072 0.0451 0.102
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0071 0.008
Echinococcus granulosus ATP dependent DNA helicase Q5 0.003 0.0059 0.0065
Echinococcus granulosus chromobox protein 1 0.0442 0.3858 0.4756
Trichomonas vaginalis heat shock protein, putative 0.0122 0.0911 0.0897
Echinococcus granulosus snurportin 1 0.0332 0.2844 0.3504
Echinococcus multilocularis snurportin 1 0.0332 0.2844 0.3504
Loa Loa (eye worm) hypothetical protein 0.0248 0.2067 0.2063
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0031 0.0072 0.0082
Mycobacterium ulcerans glutaminase 0.0272 0.2287 1
Trichomonas vaginalis hypothetical protein 0.0072 0.0451 0.0435
Loa Loa (eye worm) hypothetical protein 0.0245 0.2036 0.2032
Loa Loa (eye worm) hypothetical protein 0.0072 0.0451 0.0445
Echinococcus multilocularis high affinity choline transporter 1 0.0392 0.3398 0.4188
Leishmania major hypothetical protein, conserved 0.0079 0.0511 0.1162
Trypanosoma cruzi heat shock protein 90, putative 0.0154 0.12 0.2779
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0122 0.0911 0.2102
Brugia malayi Bloom's syndrome protein homolog 0.0044 0.0189 0.0189
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0043 0.0183 0.0218
Loa Loa (eye worm) hypothetical protein 0.0072 0.0451 0.0445
Trichomonas vaginalis glucosylceramidase, putative 0.0767 0.6848 0.6843
Trypanosoma cruzi heat shock protein 85, putative 0.0122 0.0911 0.2102
Trypanosoma brucei heat shock protein, putative 0.0154 0.12 0.2686
Plasmodium falciparum DNA gyrase subunit B 0.0031 0.0072 0.0067
Trichomonas vaginalis chromobox protein, putative 0.0267 0.2241 0.2228
Brugia malayi hypothetical protein 0.0052 0.0265 0.0265
Trichomonas vaginalis glucosylceramidase, putative 0.0728 0.6487 0.6481
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0158 0.1237 0.2867
Trypanosoma brucei polo-like protein kinase 0.0095 0.0662 0.1407
Loa Loa (eye worm) CHromoDomain protein family member 0.009 0.0613 0.0607
Schistosoma mansoni heat shock protein 0.0154 0.12 0.148
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.0662 0.081
Schistosoma mansoni methyl-cpg binding protein mbd 0.0125 0.0932 0.115
Schistosoma mansoni hypothetical protein 0.0245 0.2036 0.2513
Loa Loa (eye worm) hypothetical protein 0.0072 0.0451 0.0445
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0084 0.0556 0.2512
Brugia malayi Importin beta-1 subunit 0.0031 0.0071 0.0071
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.0982 0.0976
Trichomonas vaginalis glucosylceramidase, putative 0.1109 1 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0263 0.2202 0.2712
Trypanosoma cruzi heat shock protein 85, putative 0.0154 0.12 0.2779
Loa Loa (eye worm) bromodomain containing protein 0.0129 0.0973 0.0967
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0087 0.0583 0.0568
Brugia malayi kinase, mitochondrial precursor 0.0031 0.0072 0.0072
Trichomonas vaginalis glucosylceramidase, putative 0.0728 0.6487 0.6481
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0451 0.0435
Echinococcus multilocularis bloom syndrome protein 0.0044 0.0189 0.0226
Brugia malayi Bromodomain containing protein 0.0262 0.2196 0.2196
Schistosoma mansoni glutaminase 0.0272 0.2287 0.2822
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.0662 0.1516
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0139 0.1064 0.1314
Loa Loa (eye worm) hypothetical protein 0.0081 0.053 0.0524
Giardia lamblia Heat shock protein HSP 90-alpha 0.0154 0.12 0.4706
Chlamydia trachomatis DNA gyrase subunit B 0.0031 0.0072 0.5
Onchocerca volvulus 0.0043 0.0183 0.0208
Brugia malayi heat shock protein 90 0.0154 0.12 0.12
Toxoplasma gondii PHD-finger domain-containing protein 0.0245 0.2036 1
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0451 0.0435
Toxoplasma gondii histone lysine methyltransferase SET1 0.0142 0.1091 0.5309
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0662 0.0647
Echinococcus multilocularis JmjC domain containing protein 4 0.0079 0.0511 0.0623
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0063 0.0364 0.0442
Leishmania major heat shock protein 83-1 0.0154 0.12 0.2779
Echinococcus multilocularis neuropeptide receptor A26 0.0448 0.3913 0.4825
Schistosoma mansoni DNA topoisomerase II 0.0031 0.0072 0.0089
Brugia malayi Bromodomain containing protein 0.028 0.2362 0.2362
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0043 0.0183 0.0796
Toxoplasma gondii Hsp90 domain-containing protein 0.0063 0.0364 0.1698
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0662 0.1516
Trichomonas vaginalis receptor histidine kinase, putative 0.0031 0.0072 0.0056
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0059 0.0184
Onchocerca volvulus 0.0971 0.8728 0.9927
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0072 0.0451 0.2128
Plasmodium falciparum phd finger protein, putative 0.0245 0.2036 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0087 0.0583 0.0568
Onchocerca volvulus 0.0063 0.0368 0.0419
Echinococcus granulosus microtubule associated protein 2 0.0694 0.6179 0.7622
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0031 0.0072 0.0249
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0662 0.1516
Brugia malayi hypothetical protein 0.0081 0.053 0.053
Brugia malayi jmjC domain containing protein 0.0079 0.0511 0.0511
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0801 0.7161 0.8836
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0042 0.0172 0.1183
Echinococcus granulosus zinc finger protein 0.0147 0.1135 0.1394
Echinococcus multilocularis Protein lozenge 0.0123 0.0914 0.1121
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0122 0.0911 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0168 0.1335 0.164
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.053 0.238
Toxoplasma gondii heat shock protein 90, putative 0.0154 0.12 0.5846
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0168 0.1335 0.164
Brugia malayi MAP kinase sur-1 0.0158 0.1237 0.1237
Echinococcus multilocularis cpg binding protein 0.0081 0.053 0.0647
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.2483 0.2471
Onchocerca volvulus 0.0978 0.8792 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0031 0.0072 0.0082
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.008 0.0522 0.0506
Schistosoma mansoni chromodomain helicase DNA binding protein 0.009 0.0613 0.0756
Schistosoma mansoni kinase 0.0049 0.0237 0.0292
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0172 0.0717
Trypanosoma brucei heat shock protein, putative 0.0154 0.12 0.2686
Trichomonas vaginalis endoplasmin, putative 0.0094 0.0652 0.0637
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0072 0.0451 0.102
Plasmodium vivax hypothetical protein, conserved 0.0245 0.2036 1
Leishmania major heat shock protein 83-1 0.0154 0.12 0.2779
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0488 0.4274 1
Echinococcus multilocularis jumonji domain containing 1A 0.0079 0.0511 0.0623
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.2483 0.2471
Loa Loa (eye worm) hypothetical protein 0.0392 0.3398 0.3394
Leishmania major heat shock protein 83-1 0.0154 0.12 0.2779
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0125 0.0932 0.1143
Trichomonas vaginalis heat shock protein, putative 0.0122 0.0911 0.0897
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0122 0.0911 0.8145
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0488 0.4274 0.4271
Echinococcus granulosus chromobox protein 2 0.0072 0.0451 0.0549
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0042 0.0172 0.0364
Echinococcus granulosus bloom syndrome protein 0.0044 0.0189 0.0226
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0031 0.0072 0.0004
Echinococcus granulosus neuropeptide receptor A26 0.0448 0.3913 0.4825
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0072 0.0451 0.0556
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0031 0.0072 0.0056
Loa Loa (eye worm) hypothetical protein 0.0079 0.0511 0.0505
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0087 0.0583 0.0568
Giardia lamblia Fructose-bisphosphate aldolase 0.0293 0.2483 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0245 0.2036 0.2507
Plasmodium vivax SET domain protein, putative 0.0124 0.0922 0.4454
Schistosoma mansoni chromobox protein 0.0072 0.0451 0.0556
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0059 0.0059
Brugia malayi jmjC domain containing protein 0.0079 0.0511 0.0511
Schistosoma mansoni cpg binding protein 0.0081 0.053 0.0654
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0122 0.0911 0.8145
Brugia malayi Hsp90 protein 0.0063 0.0364 0.0364
Echinococcus granulosus mitogen activated protein kinase 3 0.0158 0.1237 0.152
Echinococcus granulosus heat shock protein 90 0.0154 0.12 0.1474
Loa Loa (eye worm) heat shock protein 90 0.0154 0.12 0.1194
Trichomonas vaginalis glucosylceramidase, putative 0.0728 0.6487 0.6481
Schistosoma mansoni DNA helicase recq5 0.003 0.0059 0.0073
Trichomonas vaginalis heat shock protein, putative 0.0154 0.12 0.1185
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0801 0.7161 0.8836
Schistosoma mansoni hypothetical protein 0.0072 0.0451 0.0556
Loa Loa (eye worm) jmjC domain-containing protein 0.0079 0.0511 0.0505
Trypanosoma cruzi DNA topoisomerase II, putative 0.0031 0.0072 0.0131
Loa Loa (eye worm) hypothetical protein 0.028 0.2366 0.2362
Trichomonas vaginalis conserved hypothetical protein 0.0176 0.1401 0.1387
Loa Loa (eye worm) hypothetical protein 0.0031 0.0072 0.0066
Brugia malayi Endoplasmin precursor 0.0154 0.12 0.12
Trypanosoma brucei developmentally regulated phosphoprotein 0.0031 0.0072 0.0004
Schistosoma mansoni bromodomain containing protein 0.0466 0.4076 0.503
Brugia malayi jmjC domain containing protein 0.0079 0.0511 0.0511
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0031 0.0072 0.0056
Trichomonas vaginalis receptor histidine kinase, putative 0.0031 0.0072 0.0056
Trypanosoma cruzi ISWI complex protein 0.0112 0.0814 0.1872
Echinococcus granulosus ATP dependent DNA helicase Q1 0.003 0.0059 0.0065
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0031 0.0072 0.0067
Trypanosoma cruzi ISWI complex protein 0.0112 0.0814 0.1872
Leishmania major DNA topoisomerase ii 0.0031 0.0072 0.0131
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0079 0.0511 0.2427
Echinococcus granulosus neuropeptide s receptor 0.0448 0.3913 0.4825
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.0662 0.0656
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0042 0.0172 0.0204
Trichomonas vaginalis glucosylceramidase, putative 0.1109 1 1
Leishmania major heat shock protein 83-1 0.0154 0.12 0.2779
Loa Loa (eye worm) hypothetical protein 0.0517 0.4544 0.454
Schistosoma mansoni serine/threonine protein kinase 0.0158 0.1237 0.1527
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0451 0.0435
Leishmania major heat shock protein 83-1 0.0154 0.12 0.2779
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0662 0.0647
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0031 0.0072 0.5
Echinococcus multilocularis chromobox protein 1 0.0442 0.3858 0.4756
Giardia lamblia Heat shock protein HSP 90-alpha 0.0122 0.0911 0.3516
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0248 0.2067 0.2352
Echinococcus granulosus sodium:myo inositol cotransporter 0.0043 0.0183 0.0218
Plasmodium vivax DNA gyrase subunit B, putative 0.0031 0.0072 0.0223
Schistosoma mansoni phosphatidylserine receptor 0.0079 0.0511 0.0631
Schistosoma mansoni zinc finger protein 0.0147 0.1135 0.14
Echinococcus granulosus JmjC domain containing protein 4 0.0079 0.0511 0.0623
Brugia malayi RNA, U transporter 1 0.0089 0.0599 0.0599
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0031 0.0072 0.0249
Brugia malayi PHD-finger family protein 0.0245 0.2036 0.2036
Giardia lamblia PHD finger protein 15 0.0245 0.2036 0.8157
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0451 0.0435
Trypanosoma cruzi heat shock protein 90, putative 0.0091 0.062 0.1417
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0662 0.0647
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.2483 0.5793
Echinococcus multilocularis zinc finger protein 0.0147 0.1135 0.1394
Schistosoma mansoni cpg binding protein 0.0081 0.053 0.0654
Schistosoma mansoni DNA helicase recq1 0.003 0.0059 0.0073
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0488 0.4274 0.4274
Loa Loa (eye worm) PHD-finger family protein 0.0151 0.1173 0.1167
Loa Loa (eye worm) glutaminase 0.0272 0.2287 0.2283
Entamoeba histolytica hypothetical protein 0.0072 0.0451 0.102
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0248 0.207 0.2554
Schistosoma mansoni hypothetical protein 0.0151 0.1173 0.1447
Loa Loa (eye worm) ATP-dependent DNA helicase 0.003 0.0059 0.0053
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0158 0.1237 0.2867
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0087 0.0583 0.0568
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0031 0.0072 0.0249
Toxoplasma gondii DNA topoisomerase 2, putative 0.0031 0.0072 0.0249
Trichomonas vaginalis heat shock protein, putative 0.0122 0.0911 0.0897
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0031 0.0072 0.0004
Loa Loa (eye worm) hypothetical protein 0.0131 0.0994 0.0988
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0079 0.0511 0.1162
Onchocerca volvulus 0.0194 0.1574 0.179
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0059 0.0184
Schistosoma mansoni endoplasmin 0.0154 0.12 0.148
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0451 0.0435
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0158 0.1237 0.1232
Entamoeba histolytica DNA topoisomerase II, putative 0.0031 0.0072 0.0131
Plasmodium falciparum importin beta, putative 0.0031 0.0071 0.0058
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0172 0.0155
Brugia malayi Sodium:solute symporter family protein 0.0043 0.0183 0.0183
Schistosoma mansoni pyruvate dehydrogenase 0.0031 0.0072 0.0089
Echinococcus multilocularis neuropeptide s receptor 0.0448 0.3913 0.4825
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0172 0.0568
Trichomonas vaginalis DNA helicase recq1, putative 0.0044 0.0189 0.0173
Onchocerca volvulus 0.0072 0.0451 0.0513
Leishmania major developmentally regulated phosphoprotein-like protein 0.0031 0.0072 0.0131
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0862 0.7724 0.9531
Echinococcus granulosus sodium:glucose cotransporter 0.0043 0.0183 0.0218
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.053 0.1206
Echinococcus granulosus methyl CpG binding domain protein 2 0.0125 0.0932 0.1143
Echinococcus granulosus solute carrier family 5 0.0043 0.0183 0.0218
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0072 0.0451 0.0549
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0072 0.0451 0.0556
Echinococcus granulosus chromobox protein 1 0.0442 0.3858 0.4756
Loa Loa (eye worm) hypothetical protein 0.0978 0.8792 0.8791
Loa Loa (eye worm) hypothetical protein 0.0035 0.0105 0.0099
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0033 0.0086 0.0164
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0158 0.1237 0.6032
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0122 0.0911 0.1118
Plasmodium vivax JmjC domain containing protein 0.0079 0.0511 0.2407
Loa Loa (eye worm) hypothetical protein 0.0031 0.0072 0.0066
Schistosoma mansoni protein phosphatase 2C 0.0079 0.0511 0.0631
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0488 0.4274 1
Schistosoma mansoni hypothetical protein 0.008 0.052 0.0642
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0071 0.0241
Loa Loa (eye worm) hypothetical protein 0.0072 0.0451 0.0445
Trichomonas vaginalis glucosylceramidase, putative 0.0728 0.6487 0.6481
Plasmodium falciparum heat shock protein 90, putative 0.0063 0.0364 0.1542
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0488 0.4274 0.5271
Schistosoma mansoni mixed-lineage leukemia protein mll 0.01 0.0707 0.0872
Entamoeba histolytica recQ family helicase, putative 0.0033 0.0086 0.0164
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0059 0.0059
Treponema pallidum exodeoxyribonuclease (exoA) 0.0042 0.0172 0.0412
Leishmania major mitochondrial DNA topoisomerase II 0.0031 0.0072 0.0131
Brugia malayi jmjC domain containing protein 0.0079 0.0511 0.0511
Trichomonas vaginalis glucosylceramidase, putative 0.1109 1 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0079 0.0511 0.2285
Schistosoma mansoni jumonji domain containing protein 0.0636 0.5645 0.6966
Schistosoma mansoni methyl-cpg binding protein mbd 0.0125 0.0932 0.115
Toxoplasma gondii PHD-finger domain-containing protein 0.0245 0.2036 1
Onchocerca volvulus Glucosylceramidase homolog 0.0728 0.6487 0.7378
Trypanosoma brucei PAB1-binding protein , putative 0.0081 0.053 0.1092
Toxoplasma gondii exonuclease III APE 0.0042 0.0172 0.0742
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.2483 0.2471
Brugia malayi M-phase phosphoprotein, mpp8 0.0072 0.0451 0.0451
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0043 0.0183 0.0218
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0072 0.0451 0.0435
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0124 0.0922 0.4468
Leishmania major heat shock protein 83-1 0.0154 0.12 0.2779
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0042 0.0172 0.0364
Onchocerca volvulus 0.0196 0.1589 0.1807
Loa Loa (eye worm) runx1 0.0123 0.0914 0.0908
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0158 0.1237 0.2867
Loa Loa (eye worm) RecQ helicase 0.0044 0.0189 0.0183
Brugia malayi SET domain containing protein 0.0078 0.0505 0.0505
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0225 0.0209
Schistosoma mansoni heat shock protein 0.0063 0.0364 0.0449
Giardia lamblia Kinase, CMGC MAPK 0.0158 0.1237 0.486
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0087 0.0583 0.0568
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.2483 0.2471
Trichomonas vaginalis glutaminase, putative 0.0272 0.2287 0.2275
Brugia malayi PHD-finger family protein 0.0098 0.0682 0.0682
Schistosoma mansoni chromobox protein 0.0072 0.0451 0.0556
Leishmania major heat shock protein, putative 0.0063 0.0364 0.0817
Trichomonas vaginalis conserved hypothetical protein 0.0176 0.1401 0.1387
Echinococcus multilocularis heat shock protein 90 0.0122 0.0911 0.1118
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0072 0.0451 0.0435
Trypanosoma cruzi Heat shock protein 83, putative 0.0154 0.12 0.2779
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0072 0.0451 0.0549
Trichomonas vaginalis glucosylceramidase, putative 0.0767 0.6848 0.6843
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0031 0.0072 0.0072
Trypanosoma brucei heat shock protein 90, putative 0.0154 0.12 0.2686
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.009 0.0613 0.0749
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0451 0.0435
Plasmodium vivax DNA topoisomerase II, putative 0.0031 0.0072 0.0223
Brugia malayi CHD4 protein 0.009 0.0613 0.0613
Echinococcus multilocularis heat shock protein 90 0.0154 0.12 0.1474
Leishmania major heat shock protein 83-1 0.0154 0.12 0.2779
Onchocerca volvulus Alhambra homolog 0.0245 0.2036 0.2316
Trypanosoma brucei heat shock protein, putative 0.0154 0.12 0.2686
Echinococcus granulosus heat shock protein 0.0154 0.12 0.1474
Echinococcus multilocularis mitogen activated protein kinase 0.0158 0.1237 0.152
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0451 0.0435
Trypanosoma brucei heat shock protein 84, putative 0.0063 0.0364 0.0698
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0248 0.207 0.2554
Loa Loa (eye worm) endoplasmin 0.0154 0.12 0.1194
Trichomonas vaginalis chromobox protein, putative 0.0442 0.3858 0.3847
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0079 0.0511 0.0631
Brugia malayi glutaminase DH11.1 0.0272 0.2287 0.2287
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.1103 1
Trichomonas vaginalis glucosylceramidase, putative 0.0728 0.6487 0.6481
Trichomonas vaginalis glucosylceramidase, putative 0.0728 0.6487 0.6481
Brugia malayi chromobox protein homolog 3 0.0248 0.2067 0.2067
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0118 0.0868 0.1064
Brugia malayi AF-10 protein 0.008 0.052 0.052
Schistosoma mansoni hypothetical protein 0.0332 0.2844 0.3509
Toxoplasma gondii LsmAD domain-containing protein 0.0081 0.053 0.252
Brugia malayi F/Y-rich N-terminus family protein 0.0118 0.0869 0.0869
Loa Loa (eye worm) hypothetical protein 0.0248 0.207 0.2065
Plasmodium vivax importin-beta 2, putative 0.0031 0.0071 0.0215
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0248 0.207 0.2549
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.008 0.052 0.1069
Trichomonas vaginalis glucosylceramidase, putative 0.0728 0.6487 0.6481
Giardia lamblia Kinase, PLK 0.0095 0.0662 0.2488
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0072 0.0451 0.0556
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0124 0.0922 0.1131
Schistosoma mansoni hypothetical protein 0.0036 0.0118 0.0146
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.1237 0.1223
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.0662 0.0662
Loa Loa (eye worm) heat shock protein 75 0.0063 0.0364 0.0358
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0042 0.0172 0.0963
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0031 0.0072 0.0082
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0662 0.0647
Brugia malayi Heterochromatin protein 1 0.0442 0.3858 0.3858
Schistosoma mansoni ap endonuclease 0.0042 0.0172 0.0212
Trichomonas vaginalis heat shock protein, putative 0.0094 0.0652 0.0637
Trypanosoma brucei heat shock protein, putative 0.0154 0.12 0.2686
Toxoplasma gondii heat shock protein 75, putative 0.0063 0.0364 0.1698
Echinococcus granulosus PHD finger protein rhinoceros 0.0245 0.2036 0.2507
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0063 0.0364 0.0442
Loa Loa (eye worm) glutaminase 2 0.0272 0.2287 0.2283
Plasmodium vivax heat shock protein, putative 0.0063 0.0364 0.1676
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0043 0.0183 0.0218
Echinococcus multilocularis lysine specific demethylase 6a 0.0079 0.0511 0.0623
Loa Loa (eye worm) hypothetical protein 0.0031 0.0072 0.0066
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.0922 0.1138
Echinococcus granulosus geminin 0.0878 0.7865 0.9705
Schistosoma mansoni importin beta-1 0.0031 0.0071 0.0087
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0245 0.2036 0.2513
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0031 0.0072 0.0004
Schistosoma mansoni inositol transporter 0.0043 0.0183 0.0225
Echinococcus multilocularis geminin 0.0878 0.7865 0.9705
Trypanosoma brucei heat shock protein, putative 0.0154 0.12 0.2686
Entamoeba histolytica hypothetical protein 0.0072 0.0451 0.102
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0031 0.0072 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0451 0.0435
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0225 0.0209
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0368 0.0362
Leishmania major heat shock protein 83-1 0.0154 0.12 0.2779
Schistosoma mansoni zinc finger protein 0.0112 0.0814 0.1004

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) = 2 uM Ability to competitively inhibit uptake of radiolabelled spermidine in L1210 cells ChEMBL. 8691443
Ki (functional) = 2 uM Ability to competitively inhibit uptake of radiolabelled spermidine in L1210 cells ChEMBL. 8691443

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 8691443

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.