Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lamin | 0.0033 | 0.4732 | 0.4732 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.1218 | 0.1218 |
Onchocerca volvulus | 0.0033 | 0.4732 | 1 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.4593 | 0.4593 |
Onchocerca volvulus | 0.0033 | 0.4732 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0816 | 0.0816 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.4732 | 0.4732 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.4732 | 0.4732 |
Echinococcus granulosus | lamin | 0.0033 | 0.4732 | 0.4732 |
Schistosoma mansoni | lamin | 0.0033 | 0.4732 | 0.4732 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.0816 | 0.0816 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0678 | 0.0678 |
Echinococcus multilocularis | lamin | 0.0033 | 0.4732 | 0.4732 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.4732 | 0.4732 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.4732 | 0.4732 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.4732 | 0.4732 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.4732 | 0.4732 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.4732 | 0.4732 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.0816 | 0.0816 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.4732 | 0.4732 |
Echinococcus multilocularis | musashi | 0.0033 | 0.4732 | 0.4732 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.1218 | 0.1218 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0678 | 0.0678 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.4732 | 0.4732 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.4125 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 8.9125 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.