Detailed information for compound 133587

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 554.616 | Formula: C17H28K3O7P3
  • H donors: 0 H acceptors: 6 LogP: 1.92 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: C/C(=C\CC1P(=O)([O-])CP(=O)(OP1(=O)[O-])[O-])/CC/C=C(/CCC=C(C)C)\C.[K+].[K+].[K+]
  • InChi: 1S/C17H31O7P3.3K/c1-14(2)7-5-8-15(3)9-6-10-16(4)11-12-17-25(18,19)13-26(20,21)24-27(17,22)23;;;/h7,9,11,17H,5-6,8,10,12-13H2,1-4H3,(H,18,19)(H,20,21)(H,22,23);;;/q;3*+1/p-3/b15-9+,16-11+;;;
  • InChiKey: YIPGLFPRVIIECR-FLZBTYJPSA-K  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans beta-lactamase 0.0035 0.04 0.0306
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0548 0.8177 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0155 0.0577
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.084 0.0817
Schistosoma mansoni purine nucleoside phosphorylase 0.0548 0.8177 0.8172
Leishmania major methylthioadenosine phosphorylase, putative 0.0113 0.1591 1
Echinococcus multilocularis muscleblind protein 0.0307 0.4526 0.4525
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0113 0.1591 0.3585
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0062 0.0061
Echinococcus multilocularis purine nucleoside phosphorylase 0.0548 0.8177 0.8176
Schistosoma mansoni DNA polymerase eta 0.0019 0.0155 0.0129
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0083 0.0102
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.04 0.1707
Brugia malayi transcription factor E74 isoform 0.001 0.0025 0.0031
Echinococcus granulosus uridine phosphorylase 1 0.0113 0.1591 0.159
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.4161 0.4995
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0155 0.0153
Loa Loa (eye worm) beta-lactamase 0.0035 0.04 0.0617
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0267 0.0411
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0113 0.1591 0.1791
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0025 0.0037
Echinococcus granulosus purine nucleoside phosphorylase 0.0548 0.8177 0.8176
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0155 0.0577
Brugia malayi uridine phosphorylase family protein 0.0113 0.1591 0.1946
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0113 0.1591 0.2462
Schistosoma mansoni microtubule-associated protein tau 0.0668 1 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0155 0.0153
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.084 0.1028
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0113 0.1591 0.1791
Brugia malayi Fli-1 protein 0.0213 0.3098 0.3789
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.04 0.0398
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.1967 0.2015
Trichomonas vaginalis esterase, putative 0.0035 0.04 0.0306
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0113 0.1591 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0155 0.0129
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.084 0.4773
Brugia malayi MTAP 0.0113 0.1591 0.1946
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0155 0.0237
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0113 0.1591 0.3585
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.0934 0.1445
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0025 0.0037
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0155 0.0577
Echinococcus granulosus purine nucleoside phosphorylase 0.0548 0.8177 0.8176
Leishmania major nucleoside phosphorylase-like protein 0.0113 0.1591 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.04 0.0306
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.04 0.0398
Loa Loa (eye worm) hypothetical protein 0.0026 0.0267 0.0411
Loa Loa (eye worm) hypothetical protein 0.0035 0.04 0.0617
Onchocerca volvulus 0.0028 0.0293 0.0033
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0025 0.0024
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0083 0.0126
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0113 0.1591 0.1791
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0113 0.1591 0.1791
Mycobacterium tuberculosis Conserved hypothetical protein 0.0113 0.1591 0.1791
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0155 0.0577
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.4161 0.4995
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.4161 0.4995
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0548 0.8177 1
Brugia malayi beta-lactamase family protein 0.0035 0.04 0.0489
Echinococcus granulosus purine nucleoside phosphorylase 0.0548 0.8177 0.8176
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.4161 0.4995
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0025 0.0024
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.04 0.0306
Schistosoma mansoni methylthioadenosine phosphorylase 0.0113 0.1591 0.157
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.1967 0.2259
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0113 0.1591 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0155 0.0189
Onchocerca volvulus 0.0035 0.04 0.0168
Echinococcus multilocularis lamin dm0 0.0026 0.0267 0.0265
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0548 0.8177 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.4161 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0548 0.8177 0.8176
Echinococcus granulosus purine nucleoside phosphorylase 0.0548 0.8177 0.8176
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0155 0.0577
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0765 0.0742
Loa Loa (eye worm) hypothetical protein 0.0035 0.04 0.0617
Chlamydia trachomatis AMP nucleosidase 0.0113 0.1591 0.5
Brugia malayi beta-lactamase 0.0035 0.04 0.0489
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0025 0.0024
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.5875 0.5874
Echinococcus multilocularis musashi 0.0026 0.0267 0.0265
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0267 0.0327
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0025 0.0024
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0113 0.1591 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0548 0.8177 0.8176
Echinococcus granulosus lamin dm0 0.0026 0.0267 0.0265
Echinococcus multilocularis protein C ets 2 0.001 0.0025 0.0024
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0113 0.1591 0.3585
Loa Loa (eye worm) fli-1 protein 0.0213 0.3098 0.4797
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0155 0.0577
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.04 0.2185
Brugia malayi Ets-domain containing protein 0.007 0.0934 0.1142
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0062 0.0061
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.4161 0.4995
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.084 0.1711
Loa Loa (eye worm) hypothetical protein 0.0013 0.0062 0.0094
Loa Loa (eye worm) hypothetical protein 0.0307 0.4526 0.7009
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.084 0.0839
Echinococcus granulosus dna polymerase eta 0.0019 0.0155 0.0153
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.4161 1
Schistosoma mansoni cpg binding protein 0.0028 0.0293 0.0268
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.04 0.0306
Echinococcus granulosus intermediate filament protein 0.0026 0.0267 0.0265
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.04 0.1707
Echinococcus granulosus GA binding protein alpha chain 0.007 0.0934 0.0933
Loa Loa (eye worm) hypothetical protein 0.0012 0.0055 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0155 0.0577
Loa Loa (eye worm) uridine phosphorylase 0.0113 0.1591 0.2462
Echinococcus granulosus protein C ets 2 0.001 0.0025 0.0024
Mycobacterium ulcerans hypothetical protein 0.0035 0.04 0.0306
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.04 0.0306
Loa Loa (eye worm) hypothetical protein 0.0012 0.0055 0.0083
Trypanosoma brucei uridine phosphorylase 0.0113 0.1591 1
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0113 0.1591 0.1791
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0113 0.1591 0.1791
Mycobacterium tuberculosis Conserved protein 0.0035 0.04 0.0306
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0113 0.1591 0.3585
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0037
Brugia malayi CXXC zinc finger family protein 0.0028 0.0293 0.0358
Echinococcus granulosus purine nucleoside phosphorylase 0.0548 0.8177 0.8176
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0113 0.1591 0.1791
Echinococcus granulosus methylthioadenosine phosphorylase 0.0113 0.1591 0.159
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0155 0.0577
Echinococcus multilocularis purine nucleoside phosphorylase 0.0434 0.6457 0.6456
Onchocerca volvulus 0.0035 0.04 0.0168
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.084 0.4773
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.4161 0.4995
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0155 0.0577
Schistosoma mansoni ets-related 0.0213 0.3098 0.3081
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0155 0.0189
Echinococcus multilocularis purine nucleoside phosphorylase 0.0548 0.8177 0.8176
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0293 0.0451
Mycobacterium leprae probable uridine phosphorylase 0.0113 0.1591 0.1532
Mycobacterium tuberculosis Conserved protein 0.0035 0.04 0.0306
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.04 0.0617
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0025 0.0024
Plasmodium falciparum purine nucleoside phosphorylase 0.0113 0.1591 0.5
Brugia malayi beta-lactamase family protein 0.0035 0.04 0.0489
Echinococcus multilocularis dna polymerase eta 0.0019 0.0155 0.0153
Schistosoma mansoni purine nucleoside phosphorylase 0.0548 0.8177 0.8172
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0548 0.8177 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.1967 0.2259
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.04 0.0306
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.4161 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.04 0.0375
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0155 0.0153
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0113 0.1591 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0155 0.0577
Echinococcus multilocularis muscleblind protein 1 0.0307 0.4526 0.4525
Loa Loa (eye worm) hypothetical protein 0.0035 0.04 0.0617
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.4161 0.4995
Echinococcus multilocularis ets variant gene 4 0.001 0.0025 0.0024
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0025 0.0037
Schistosoma mansoni lamin 0.0026 0.0267 0.0242
Loa Loa (eye worm) hypothetical protein 0.0035 0.04 0.0617
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0113 0.1591 1
Entamoeba histolytica hypothetical protein 0.0113 0.1591 0.3585
Leishmania major hypothetical protein, conserved 0.0035 0.04 0.1707
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0113 0.1591 0.1791
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.04 0.0489
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0113 0.1591 0.1791
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.04 0.0306
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.04 0.0375
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0025 0.0024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.4161 0.4995
Echinococcus granulosus dnaJ subfamily B 0.0396 0.5875 0.5874
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.084 0.0839
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0025 0.0024
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0113 0.1591 1
Echinococcus multilocularis uridine phosphorylase 1 0.0113 0.1591 0.159
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.4161 0.4995
Toxoplasma gondii phosphorylase family protein 0.0113 0.1591 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0548 0.8177 0.8176
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0155 0.0577
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0113 0.1591 0.1791
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0025 0.0024
Onchocerca volvulus 0.0035 0.04 0.0168
Echinococcus multilocularis cpg binding protein 0.0029 0.0317 0.0315
Echinococcus granulosus cpg binding protein 0.0029 0.0317 0.0315
Echinococcus multilocularis lamin 0.0026 0.0267 0.0265
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.04 0.0306
Schistosoma mansoni cpg binding protein 0.0029 0.0317 0.0292
Mycobacterium tuberculosis Hypothetical protein 0.0113 0.1591 0.1791
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0432 0.043
Echinococcus granulosus purine nucleoside phosphorylase 0.0548 0.8177 0.8176
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.04 0.0306
Schistosoma mansoni uridine phosphorylase 0.0113 0.1591 0.157
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.1591 0.1791
Brugia malayi Muscleblind-like protein 0.0307 0.4526 0.5535
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.084 0.5074
Loa Loa (eye worm) hypothetical protein 0.0307 0.4526 0.7009
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0025 0.0024
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0155 0.0129
Schistosoma mansoni uridine phosphorylase 0.0113 0.1591 0.157
Loa Loa (eye worm) hypothetical protein 0.0434 0.6457 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.084 0.4773
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.067 0.2268
Loa Loa (eye worm) hypothetical protein 0.006 0.078 0.1206
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0113 0.1591 0.3585
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0113 0.1591 0.3585
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0113 0.1591 0.1791
Schistosoma mansoni methylthioadenosine phosphorylase 0.0113 0.1591 0.157
Brugia malayi Ets-domain containing protein 0.007 0.0934 0.1142
Toxoplasma gondii Purine nucleoside phosphorylase 0.0113 0.1591 1
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.04 0.0306
Mycobacterium ulcerans lipase LipD 0.0035 0.04 0.0306
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0113 0.1591 0.1791
Echinococcus granulosus lamin 0.0026 0.0267 0.0265
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.04 0.0306
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0548 0.8177 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0434 0.6457 0.6456
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0548 0.8177 1
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.04 0.0306
Echinococcus granulosus dna polymerase kappa 0.0019 0.0155 0.0153
Loa Loa (eye worm) hypothetical protein 0.0035 0.04 0.0617
Brugia malayi intermediate filament protein 0.0026 0.0267 0.0327
Loa Loa (eye worm) hypothetical protein 0.0019 0.0155 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.1591 0.1791
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0548 0.8177 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0155 0.0577
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.3248 0.3856
Echinococcus multilocularis purine nucleoside phosphorylase 0.0548 0.8177 0.8176
Schistosoma mansoni intermediate filament proteins 0.0026 0.0267 0.0242
Loa Loa (eye worm) hypothetical protein 0.0035 0.04 0.0617
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0025 0.0024
Schistosoma mansoni lamin 0.0026 0.0267 0.0242
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0113 0.1591 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.04 0.0306
Echinococcus multilocularis purine nucleoside phosphorylase 0.0548 0.8177 0.8176
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0025 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0155 0.0577
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0025 0.0037
Echinococcus multilocularis microtubule associated protein 2 0.0668 1 1
Schistosoma mansoni gabp alpha 0.007 0.0934 0.0911
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0025 0.0024
Echinococcus multilocularis purine nucleoside phosphorylase 0.0548 0.8177 0.8176
Loa Loa (eye worm) hypothetical protein 0.0026 0.026 0.04
Toxoplasma gondii phosphorylase family protein 0.0113 0.1591 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.084 0.1299
Schistosoma mansoni hypothetical protein 0.0396 0.5875 0.5864
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0432 0.043
Trypanosoma brucei unspecified product 0.0019 0.0155 0.0577
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0025 0.0024
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.04 0.0306
Schistosoma mansoni methylthioadenosine phosphorylase 0.0113 0.1591 0.157
Brugia malayi Ets-domain containing protein 0.001 0.0025 0.0031
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0113 0.1591 0.159
Giardia lamblia UPL-1 0.0113 0.1591 0.1791
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.04 0.0306
Schistosoma mansoni cpg binding protein 0.0029 0.0317 0.0292
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0037
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0434 0.6457 0.6456
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0267 0.0411
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0155 0.0577
Mycobacterium tuberculosis Conserved protein 0.0035 0.04 0.0306
Echinococcus granulosus muscleblind protein 0.0307 0.4526 0.4525
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.0934 0.0933

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 34.2 uM Inhibition of Farnesyl Transferase ChEMBL. No reference
IC50 (binding) = 34.2 uM Inhibition of Farnesyl Transferase ChEMBL. No reference
IC50 (binding) = 46.4 uM Inhibition of Squalene Synthase ChEMBL. No reference
IC50 (binding) = 46.4 uM Inhibition of Squalene Synthase LITERATURE. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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