Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.3289 | 0.3289 |
Brugia malayi | RNase H family protein | 0.0025 | 0.0878 | 0.0878 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0642 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.0642 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4591 | 0.6139 |
Brugia malayi | RNase H family protein | 0.0025 | 0.0878 | 0.0878 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.3743 | 0.8151 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.3289 | 0.3289 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.0642 | 0.1399 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.3743 | 0.8151 |
Trypanosoma brucei | unspecified product | 0.0027 | 0.1082 | 0.0643 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0025 | 0.0878 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0642 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3743 | 0.5004 |
Schistosoma mansoni | phosphoglucomutase | 0.0025 | 0.0878 | 0.1174 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1767 | 0.2362 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0027 | 0.1082 | 0.0643 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.4591 | 1 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0025 | 0.0878 | 1 |
Schistosoma mansoni | phosphoglucomutase | 0.0025 | 0.0878 | 0.1174 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 1 | 1 |
Schistosoma mansoni | phosphoglucomutase | 0.0025 | 0.0878 | 0.1174 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0642 | 0.5 |
Echinococcus granulosus | ribonuclease H1 | 0.0025 | 0.0878 | 0.1913 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0027 | 0.1082 | 0.0643 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0025 | 0.0878 | 1 |
Toxoplasma gondii | ribonuclease HI protein | 0.0025 | 0.0878 | 1 |
Brugia malayi | RNase H family protein | 0.0025 | 0.0878 | 0.0878 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0642 | 0.0642 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4591 | 0.6139 |
Leishmania major | ribonuclease H1, putative | 0.0025 | 0.0878 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.1767 | 0.1767 |
Trypanosoma brucei | ribonuclease H1 | 0.0025 | 0.0878 | 0.0345 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0642 | 0.0859 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4591 | 0.6139 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.748 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.4591 | 0.4591 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.3743 | 0.8151 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.4591 | 0.4591 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0642 | 0.1399 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.4591 | 0.4591 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3743 | 0.5004 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0025 | 0.0878 | 1 |
Echinococcus multilocularis | ribonuclease H1 | 0.0025 | 0.0878 | 0.1913 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0027 | 0.1082 | 0.0643 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0642 | 0.0859 |
Brugia malayi | RNA binding protein | 0.0064 | 0.4591 | 0.4591 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0642 | 0.0642 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.3743 | 0.3743 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.3743 | 0.3743 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.3289 | 0.3289 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3743 | 0.5004 |
Giardia lamblia | Ribonuclease H | 0.0025 | 0.0878 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0094 | 0.748 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4591 | 0.6139 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.4591 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4591 | 0.6139 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.4591 | 0.4591 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0027 | 0.1082 | 0.0643 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.3743 | 0.8151 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.4591 | 0.4591 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0025 | 0.0878 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0642 | 0.5 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0025 | 0.0878 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1767 | 0.1767 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0178 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.122 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 23.3228 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.