TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 652.164 | Formula: C31H34ClN7O5S
H donors: 1 H acceptors: 7 LogP: 4.87 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: CCCOc1ccc(cc1c1nc(O)c2c(n1)c1cn(nc1nc2Cl)Cc1ccc(cc1)OC)S(=O)(=O)N1CC[C@H](C1)N(C)C
InChi: 1S/C31H34ClN7O5S/c1-5-14-44-25-11-10-22(45(41,42)39-13-12-20(17-39)37(2)3)15-23(25)29-33-27-24-18-38(16-19-6-8-21(43-4)9-7-19)36-30(24)34-28(32)26(27)31(40)35-29/h6-11,15,18,20H,5,12-14,16-17H2,1-4H3,(H,33,35,40)/t20-/m1/s1
InChiKey: LKRDLYGCRSZOTL-HXUWFJFHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 5A, cGMP-specific	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania donovani	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.0415	0.1019
Trichomonas vaginalis	set domain proteins, putative	0.0724	0.3447	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0074	0.0289	0.0717
Loa Loa (eye worm)	jmjC domain-containing protein	0.0131	0.0569	0.136
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0036	0.0108	0.0093
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0289	0.0717
Brugia malayi	jmjC domain containing protein	0.0034	0.0097	0.0237
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0074	0.0289	0.0696
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.005	0.0175	0.0382
Brugia malayi	hypothetical protein	0.0405	0.19	0.4668
Schistosoma mansoni	tar DNA-binding protein	0.0139	0.0604	0.0598
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.0289	0.0717
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.014	0.033
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0342	0.1594	0.3849
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0289	0.0717
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0224	0.1021	0.1008
Mycobacterium tuberculosis	Hypothetical protein	0.0405	0.19	0.4609
Echinococcus multilocularis	phd:f box containing protein	0.0034	0.0097	0.0082
Echinococcus multilocularis	jumonji domain containing 1A	0.0034	0.0097	0.0082
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0103	0.0096
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0103	0.0088
Schistosoma mansoni	jumonji domain containing protein	0.0128	0.0551	0.0546
Brugia malayi	Bromodomain containing protein	0.0077	0.0307	0.0755
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0289	0.0717
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0088	0.0358	0.0343
Schistosoma mansoni	zinc finger protein	0.0021	0.0035	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0131	0.028
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0342	0.1594	0.3849
Echinococcus multilocularis	JmjC domain containing protein 4	0.0034	0.0097	0.0082
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0043	0.014	0.5
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0118	0.0504	0.2907
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0103	0.0143
Leishmania major	hypothetical protein, conserved	0.0035	0.0103	0.0237
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0224	0.1021	0.2425
Brugia malayi	jmjC domain containing protein	0.0131	0.0569	0.1398
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0342	0.1594	0.1582
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.0289	0.0717
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.005	0.0044
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0289	0.0717
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0092	0.0377	0.0371
Schistosoma mansoni	hypothetical protein	0.0415	0.1948	0.1943
Trichomonas vaginalis	ferritin, putative	0.0026	0.0057	0.0036
Schistosoma mansoni	hypothetical protein	0.0198	0.0891	0.0885
Echinococcus granulosus	GPCR family 2	0.0032	0.0084	0.0069
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0033	0.0089	0.0129
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0289	0.0717
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0103	0.0143
Schistosoma mansoni	jumonji domain containing protein	0.0034	0.0097	0.009
Echinococcus multilocularis	cpg binding protein	0.0033	0.009	0.0075
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0034	0.0097	0.0222
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0852	0.407	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0065	0.0248	0.0242
Echinococcus multilocularis	tar DNA binding protein	0.0139	0.0604	0.059
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.014	0.033
Toxoplasma gondii	hypothetical protein	0.0065	0.0245	0.0497
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0036	0.0108	0.0093
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0103	0.0143
Brugia malayi	Probable ClpP-like protease	0.0342	0.1594	0.3917
Echinococcus granulosus	expressed protein	0.0026	0.0057	0.0042
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0289	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0084	0.0164
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0074	0.0289	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0278	0.0643
Brugia malayi	beta-lactamase	0.0035	0.0103	0.0252
Loa Loa (eye worm)	thymidylate synthase	0.0852	0.407	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0342	0.1594	0.5
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0015	0.0009
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0074	0.0289	0.0696
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0193	0.0868	0.0854
Schistosoma mansoni	ferritin	0.0026	0.0057	0.0051
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0224	0.1021	0.2425
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.005	0.0175	0.0415
Schistosoma mansoni	tar DNA-binding protein	0.0139	0.0604	0.0598
Echinococcus granulosus	cpg binding protein	0.0033	0.009	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0103	0.0209
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0074	0.0289	0.0696
Brugia malayi	beta-lactamase family protein	0.0035	0.0103	0.0252
Trichomonas vaginalis	esterase, putative	0.0035	0.0103	0.0169
Onchocerca volvulus		0.0035	0.0103	0.0075
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0103	0.0209
Onchocerca volvulus		0.0852	0.407	1
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0405	0.19	0.466
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0092	0.0377	0.0371
Toxoplasma gondii	hypothetical protein	0.0118	0.0504	0.114
Echinococcus multilocularis	microtubule associated protein 2	0.2073	1	1
Echinococcus multilocularis	inositol monophosphatase 1	0.0043	0.014	0.0126
Echinococcus granulosus	dnaJ subfamily B	0.0415	0.1948	0.1936
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0097	0.0194
Mycobacterium ulcerans	lipase LipD	0.0035	0.0103	0.0143
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0103	0.0143
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.0289	0.0717
Brugia malayi	beta-lactamase family protein	0.0035	0.0103	0.0252
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.0289	0.0717
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0109	0.0461	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0461	0.1093
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0043	0.014	0.0237
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0074	0.0289	0.0717
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0103	0.0143
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0109	0.0461	0.0446
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0074	0.0289	0.0717
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0852	0.407	1
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0034	0.0097	0.0128
Brugia malayi	thymidylate synthase	0.0852	0.407	1
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0852	0.407	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0128	0.0551	0.0537
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0193	0.0868	0.0854
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0289	0.0717
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0193	0.0868	0.2132
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0073	0.0179
Plasmodium vivax	SET domain protein, putative	0.0092	0.0377	0.0824
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.014	0.033
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0852	0.407	1
Trichomonas vaginalis	inositol monophosphatase, putative	0.0043	0.014	0.028
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.0289	0.0717
Onchocerca volvulus		0.0035	0.0103	0.0075
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.0032	0.0036
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.005	0.0035
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0103	0.0237
Echinococcus multilocularis	lysine specific demethylase 5A	0.0128	0.0551	0.0537
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0103	0.0143
Schistosoma mansoni	ferritin light chain	0.0026	0.0057	0.0051
Brugia malayi	follicle stimulating hormone receptor	0.027	0.1243	0.3055
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0033	0.0089	0.0219
Mycobacterium ulcerans	bacterioferritin BfrA	0.0026	0.0057	0.003
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0245	0.0588
Brugia malayi	jmjC domain containing protein	0.0034	0.0097	0.0237
Echinococcus granulosus	inositol monophosphatase 1	0.0043	0.014	0.0126
Brugia malayi	jmjC domain containing protein	0.0034	0.0097	0.0237
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0342	0.1594	0.3849
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0109	0.0461	0.0455
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0245	0.0588
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0084	0.0207
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0103	0.0237
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0034	0.0097	0.0222
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0062	0.0232	0.0218
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0193	0.0868	0.0862
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.0262	0.0643
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0033	0.0089	0.0074
Schistosoma mansoni	ferritin	0.0026	0.0057	0.0051
Schistosoma mansoni	hypothetical protein	0.0021	0.0032	0.0026
Onchocerca volvulus		0.0035	0.0103	0.0075
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0092	0.0377	0.0824
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0074	0.0289	0.0717
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0074	0.0289	0.0717
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0062	0.0232	0.0218
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0038	0.0114	0.0099
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0074	0.0289	0.0717
Schistosoma mansoni	apoferritin-2	0.0026	0.0057	0.0051
Mycobacterium ulcerans	thymidylate synthase	0.0852	0.407	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0103	0.0143
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0103	0.0143
Loa Loa (eye worm)	jmjC domain-containing protein	0.0034	0.0097	0.0194
Schistosoma mansoni	tar DNA-binding protein	0.0139	0.0604	0.0598
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0119	0.0251
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0103	0.0143
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0852	0.407	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0103	0.0169
Echinococcus granulosus	zinc finger protein	0.0021	0.0035	0.002
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0043	0.014	0.0237
Echinococcus granulosus	lysine specific demethylase 5A	0.0131	0.0569	0.0555
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0033	0.0089	0.0074
Schistosoma mansoni	cpg binding protein	0.0029	0.0073	0.0067
Leishmania major	hypothetical protein, conserved	0.0034	0.0097	0.0222
Loa Loa (eye worm)	inositol-1	0.0043	0.014	0.0302
Schistosoma mansoni	cpg binding protein	0.0033	0.009	0.0084
Echinococcus multilocularis	geminin	0.0198	0.0891	0.0877
Echinococcus granulosus	thymidylate synthase	0.0852	0.407	0.4061
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0342	0.1594	0.3849
Mycobacterium ulcerans	bacterioferritin BfrB	0.0026	0.0057	0.003
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0342	0.1594	0.1582
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0103	0.0143
Echinococcus multilocularis	thymidylate synthase	0.0852	0.407	0.4061
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0118	0.0504	0.114
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0103	0.0143
Onchocerca volvulus		0.0092	0.0377	0.0761
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0193	0.0868	0.2098
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0852	0.407	1
Echinococcus granulosus	jumonji domain containing 1A	0.0034	0.0097	0.0082
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0034	0.0097	0.009
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0103	0.0209
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0074	0.0289	0.0717
Schistosoma mansoni	hypothetical protein	0.0032	0.0084	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0097	0.0194
Brugia malayi	jmjC domain containing protein	0.0034	0.0097	0.0237
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0034	0.0097	0.0222
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0245	0.0588
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0118	0.0504	0.114
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0074	0.0289	0.0717
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0084	0.0164
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0342	0.1594	1
Loa Loa (eye worm)	hypothetical protein	0.0342	0.1594	0.389
Schistosoma mansoni	ferritin light chain	0.0026	0.0057	0.0051
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0289	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0103	0.0209
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0103	0.0237
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0289	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0089	0.0176
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0118	0.0504	0.114
Schistosoma mansoni	bromodomain containing protein	0.0066	0.025	0.0244
Schistosoma mansoni	tar DNA-binding protein	0.0139	0.0604	0.0598
Schistosoma mansoni	protein phosphatase 2C	0.0034	0.0097	0.009
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0131	0.0569	0.0563
Trichomonas vaginalis	conserved hypothetical protein	0.0405	0.19	0.5452
Echinococcus granulosus	JmjC domain containing protein 4	0.0034	0.0097	0.0082
Loa Loa (eye worm)	hypothetical protein	0.01	0.0415	0.0979
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0033	0.0089	0.0129
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0039	0.0118	0.0182
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.0415	0.1019
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0043	0.014	0.054
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0193	0.0868	0.0854
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0224	0.1021	0.2425
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0034	0.0097	0.0128
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0289	0.0717
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0074	0.0289	0.0696
Echinococcus multilocularis	ferritin	0.0026	0.0057	0.0042
Schistosoma mansoni	phd/f-box containing protein	0.0034	0.0097	0.009
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0103	0.0143
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0852	0.407	0.4066
Brugia malayi	TAR-binding protein	0.0139	0.0604	0.1485
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0045	0.0067
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0852	0.407	1
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0038	0.0114	0.0099
Schistosoma mansoni	hypothetical protein	0.0068	0.0262	0.0256
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.0026	0.0057	0.003
Brugia malayi	Bromodomain containing protein	0.0039	0.0119	0.0293
Loa Loa (eye worm)	RNA binding protein	0.0139	0.0604	0.1448
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0342	0.1594	0.3849
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.014	0.033
Brugia malayi	RNA recognition motif domain containing protein	0.0139	0.0604	0.1485
Echinococcus multilocularis	dnaJ subfamily B	0.0415	0.1948	0.1936
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0149	0.0323
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.0415	0.0979
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0033	0.0089	0.0219
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0193	0.0868	0.0862
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0103	0.0143
Brugia malayi	PHD-finger family protein	0.0027	0.0061	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0097	0.0194
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.027	0.1243	0.3024
Schistosoma mansoni	cpg binding protein	0.0033	0.009	0.0084
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0043	0.014	0.028
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0103	0.0143
Echinococcus granulosus	geminin	0.0198	0.0891	0.0877
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0103	0.0169
Schistosoma mansoni	ferritin	0.0026	0.0057	0.0051
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0092	0.0377	0.0363
Echinococcus granulosus	ferritin	0.0026	0.0057	0.0042
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0103	0.0252
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0039	0.0118	0.0182
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0342	0.1594	0.3849
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0262	0.0602
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0084	0.0069
Schistosoma mansoni	peptidase Clp (S14 family)	0.0342	0.1594	0.1589
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0034	0.0097	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0103	0.0209
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0193	0.0868	0.0854
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0033	0.0089	0.0083
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0128	0.0551	0.0537
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0074	0.0289	0.0283
Brugia malayi	Pre-SET motif family protein	0.0092	0.0377	0.0926
Echinococcus multilocularis	expressed protein	0.0026	0.0057	0.0042
Brugia malayi	Pre-SET motif family protein	0.0636	0.3021	0.7423
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.005	0.0175	0.0382
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0103	0.0169
Brugia malayi	Inositol-1	0.0043	0.014	0.0345
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0103	0.0088
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0289	0.0717
Echinococcus granulosus	phd:f box containing protein	0.0034	0.0097	0.0082
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.0026	0.0057	0.003
Schistosoma mansoni	microtubule-associated protein tau	0.2073	1	1
Plasmodium vivax	JmjC domain containing protein	0.0034	0.0097	0.0128
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0084	0.0069
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0015	0.0009
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0289	0.0717
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0103	0.0096
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.0026	0.0057	0.003
Schistosoma mansoni	hypothetical protein	0.0198	0.0891	0.0885
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0033	0.0089	0.0129
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0084	0.0069
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0342	0.1594	0.3849
Brugia malayi	jmjC domain containing protein	0.0128	0.0551	0.1355
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0061	0.0227	0.0453
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0103	0.0209
Toxoplasma gondii	ABC1 family protein	0.0035	0.0103	0.0143
Loa Loa (eye worm)	jmjC domain-containing protein	0.0034	0.0097	0.0194
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0074	0.0289	0.0696
Schistosoma mansoni	hypothetical protein	0.0032	0.0084	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0103	0.0209
Schistosoma mansoni	ferritin	0.0026	0.0057	0.0051
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0289	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0103	0.0209
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0636	0.3021	0.7411
Echinococcus multilocularis	zinc finger protein	0.0021	0.0035	0.002
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0103	0.0143
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0073	0.0135
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0103	0.0169
Schistosoma mansoni	phosphatidylserine receptor	0.0034	0.0097	0.009
Echinococcus granulosus	peptidase Clp S14 family	0.0224	0.1021	0.1008
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0852	0.407	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0074	0.0289	0.0717
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0103	0.0143
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0074	0.0289	0.0275
Schistosoma mansoni	hypothetical protein	0.0032	0.0084	0.0078
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0193	0.0868	0.0862
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0342	0.1594	0.5
Schistosoma mansoni	hypothetical protein	0.0032	0.0084	0.0078
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0043	0.014	0.028
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0139	0.0604	0.1448
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0289	0.0717
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0084	0.0069
Schistosoma mansoni	inositol monophosphatase	0.0043	0.014	0.0134
Schistosoma mansoni	apoferritin-2	0.0026	0.0057	0.0051
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0103	0.0169
Onchocerca volvulus		0.0724	0.3447	0.8443
Schistosoma mansoni	inositol monophosphatase	0.0043	0.014	0.0134
Loa Loa (eye worm)	TAR-binding protein	0.0139	0.0604	0.1448
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0289	0.0717
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0084	0.0207
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0103	0.0143
Brugia malayi	RNA binding protein	0.0139	0.0604	0.1485
Echinococcus granulosus	lysine specific demethylase 6a	0.0034	0.0097	0.0082
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0131	0.0569	0.0563
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0342	0.1594	1
Echinococcus granulosus	tar DNA binding protein	0.0139	0.0604	0.059
Echinococcus granulosus	histone lysine methyltransferase setb	0.0109	0.0461	0.0446
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0226	0.1027	0.2439
Schistosoma mansoni	tar DNA-binding protein	0.0139	0.0604	0.0598
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.005	0.0035
Echinococcus multilocularis	lysine specific demethylase 6a	0.0034	0.0097	0.0082
Loa Loa (eye worm)	jmjC domain-containing protein	0.0034	0.0097	0.0194
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0084	0.0069

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 13 nM	Inhibition of PDE5 from human platelets	ChEMBL.	11549447
IC50 (binding)	= 13 nM	Inhibition of PDE5 from human platelets	ChEMBL.	11549447
Ratio (binding)	= 17	Relative inhibition of PDE6 from bovine retina and PDE5 from human platelets	ChEMBL.	11549447
Ratio (binding)	= 130	Relative inhibition of PDE1 from bovine heart and PDE5 from human platelets	ChEMBL.	11549447
Ratio (binding)	= 310	Relative inhibition of PDE4 from rat kidney and PDE5 from human platelets	ChEMBL.	11549447
Ratio (binding)	= 1100	Relative inhibition of PDE3 and PDE5 from human platelets	ChEMBL.	11549447
Ratio (binding)	= 1200	Relative inhibition of PDE2 from rat kidney and PDE5 from human platelets	ChEMBL.	11549447

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL76827

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 133611