Detailed information for compound 1336195

Basic information

Technical information
  • TDR Targets ID: 1336195
  • Name: 4-(2-fluorophenyl)-1-[(5-phenyl-1,3,4-oxadiaz ol-2-yl)methyl]piperidin-4-ol
  • MW: 353.39 | Formula: C20H20FN3O2
  • H donors: 1 H acceptors: 3 LogP: 2.54 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccccc1C1(O)CCN(CC1)Cc1nnc(o1)c1ccccc1
  • InChi: 1S/C20H20FN3O2/c21-17-9-5-4-8-16(17)20(25)10-12-24(13-11-20)14-18-22-23-19(26-18)15-6-2-1-3-7-15/h1-9,25H,10-14H2
  • InChiKey: RCSDCLFJRJGWED-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2-fluorophenyl)-1-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-4-piperidinol
  • MLS000075605
  • SMR000000532
  • ASN 09037938
  • 4-(2-Fluoro-phenyl)-1-(5-phenyl-[1,3,4]oxadiazol-2-ylmethyl)-piperidin-4-ol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0066 0.0978
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0221 1
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.1043 0.1043
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0217 0.447
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0109 0.0602 0.8921
Chlamydia trachomatis metal transport ATPase 0.0009 0 0.5
Trichomonas vaginalis modulator of drug activity B, putative 0.0182 0.1043 0.1043
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0066 0.2986
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0217 0.2076
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.014 0.6336
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0107 0.4843
Loa Loa (eye worm) hypothetical protein 0.0035 0.0156 0.231
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0066 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.014 1
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0107 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0217 0.447
Trichomonas vaginalis conserved hypothetical protein 0.0426 0.2505 0.2505
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0107 0.4843
Echinococcus granulosus dna polymerase eta 0.0045 0.0221 0.3651
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0045 0.0736
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0066 1
Mycobacterium leprae Probable metal cation-transporting P-type ATPase C CtpC 0.0009 0 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.2986
Schistosoma mansoni flap endonuclease-1 0.0024 0.0092 0.1894
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0217 0.9804
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0217 0.321
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.1043 0.1043
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0066 0.109
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0227 0.3748
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0217 0.3579
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0221 0.3274
Trichomonas vaginalis modulator of drug activity B, putative 0.0182 0.1043 0.1043
Loa Loa (eye worm) hypothetical protein 0.0045 0.0217 0.321
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0156 0.231
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0426 0.2505 0.2505
Echinococcus granulosus GPCR family 2 0.0016 0.0045 0.0736
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0227 0.4681
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.1043 0.1043
Schistosoma mansoni eyes absent homolog 0.0089 0.0485 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0182 0.1043 0.1043
Trichomonas vaginalis conserved hypothetical protein 0.0426 0.2505 0.2505
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.2986
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0066 0.0978
Entamoeba histolytica hypothetical protein 0.0182 0.1043 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0066 0.2986
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0182 0.1043 1
Trichomonas vaginalis conserved hypothetical protein 0.0426 0.2505 0.2505
Leishmania major DNA polymerase eta, putative 0.0045 0.0221 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0182 0.1043 0.1043
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0045 0.066
Trichomonas vaginalis modulator of drug activity B, putative 0.0182 0.1043 0.1043
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.2986
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.2986
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0066 0.2986
Trypanosoma brucei unspecified product 0.0013 0.003 0.1337
Echinococcus granulosus transcription factor eb 0.0109 0.0605 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0182 0.1043 0.1043
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0066 0.0632
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0066 0.2986
Echinococcus granulosus flap endonuclease 1 0.0026 0.0107 0.1768
Trichomonas vaginalis conserved hypothetical protein 0.0426 0.2505 0.2505
Loa Loa (eye worm) hypothetical protein 0.0089 0.0485 0.7182
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.1043 0.1043
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0919
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0675 1
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0107 0.1586
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0252 0.3732
Loa Loa (eye worm) hypothetical protein 0.0109 0.0602 0.8921
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0919
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0066 0.1361
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0217 0.3579
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0066 0.2986
Treponema pallidum cation-transporting ATPase, P-type 0.0009 0 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0227 0.3361
Giardia lamblia NADPH oxidoreductase, putative 0.0426 0.2505 1
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0009 0 0.5
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0217 0.0217
Trypanosoma brucei unspecified product 0.002 0.0066 0.2986
Trichomonas vaginalis conserved hypothetical protein 0.0426 0.2505 0.2505
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.2986
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0675 1
Trichomonas vaginalis conserved hypothetical protein 0.0426 0.2505 0.2505
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0107 0.1025
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0045 0.066
Plasmodium falciparum flap endonuclease 1 0.0026 0.0107 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0066 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0244 0.141 0.141
Onchocerca volvulus 0.0009 0 0.5
Trichomonas vaginalis modulator of drug activity B, putative 0.0182 0.1043 0.1043
Brugia malayi Flap endonuclease-1 0.0026 0.0107 0.1586
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.003 0.1337
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0227 0.3748
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.1043 0.1043
Brugia malayi hypothetical protein 0.0089 0.0485 0.7182
Trichomonas vaginalis conserved hypothetical protein 0.0426 0.2505 0.2505
Echinococcus multilocularis GPCR, family 2 0.0016 0.0045 0.0736
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0221 1
Trichomonas vaginalis conserved hypothetical protein 0.0426 0.2505 0.2505
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0182 0.1043 0.1043
Giardia lamblia DINP protein human, muc B family 0.002 0.0066 0.0263
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0107 0.7644
Treponema pallidum hypothetical protein 0.0009 0 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0066 0.2986
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0217 0.3579
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0066 0.2986
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0066 0.1361
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0107 0.0107
Leishmania major DNA polymerase kappa, putative 0.002 0.0066 0.2986
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.1043 0.1043
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0217 0.0217
Mycobacterium leprae PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB 0.0009 0 0.5
Trichomonas vaginalis modulator of drug activity B, putative 0.0182 0.1043 0.1043
Echinococcus multilocularis transcription factor eb 0.0109 0.0605 1
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0107 0.1768
Trichomonas vaginalis conserved hypothetical protein 0.0426 0.2505 0.2505
Trichomonas vaginalis modulator of drug activity B, putative 0.0182 0.1043 0.1043
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0107 0.4843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0227 0.3748
Trichomonas vaginalis modulator of drug activity B, putative 0.0182 0.1043 0.1043
Trichomonas vaginalis modulator of drug activity B, putative 0.0182 0.1043 0.1043
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0217 0.3579
Giardia lamblia NADPH oxidoreductase, putative 0.0426 0.2505 1
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.1043 0.1043
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0066 0.0066
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0066 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0217 0.9804
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0252 0.3732
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0227 0.3748
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.1675 1 1
Schistosoma mansoni DNA polymerase eta 0.0045 0.0221 0.4559
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0107 0.0427
Trichomonas vaginalis modulator of drug activity B, putative 0.0182 0.1043 0.1043
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0182 0.1043 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0066 0.2986
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0109 0.0605 0.8968
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.003 0.1337
Trichomonas vaginalis modulator of drug activity B, putative 0.0182 0.1043 0.1043
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0426 0.2505 0.2505
Loa Loa (eye worm) hypothetical protein 0.0089 0.0485 0.7182
Giardia lamblia NADPH oxidoreductase, putative 0.0426 0.2505 1
Echinococcus multilocularis dna polymerase eta 0.0045 0.0221 0.3651
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.2986
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.1043 0.1043
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0045 0.0736
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0426 0.2505 0.2505
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.2986
Trichomonas vaginalis conserved hypothetical protein 0.0426 0.2505 0.2505
Leishmania major DNA polymerase eta, putative 0.0032 0.014 0.6336
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0217 0.3579
Loa Loa (eye worm) hypothetical protein 0.0051 0.0252 0.3732
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.2986
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0919
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0217 0.0217
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0045 0.0736
Echinococcus granulosus dna polymerase kappa 0.002 0.0066 0.109
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0217 0.0865
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.2986
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.0919
Trypanosoma brucei unspecified product 0.0013 0.003 0.1337
Schistosoma mansoni hypothetical protein 0.0035 0.0156 0.3217
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0217 0.9804
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0217 0.3579
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0252 0.3732
Trichomonas vaginalis conserved hypothetical protein 0.0426 0.2505 0.2505
Trichomonas vaginalis modulator of drug activity B, putative 0.0182 0.1043 0.1043
Trichomonas vaginalis modulator of drug activity B, putative 0.0182 0.1043 0.1043
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0066 0.2986
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.003 0.1337
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0227 0.4681
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0227 0.3361
Loa Loa (eye worm) hypothetical protein 0.0045 0.0221 0.3274
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0045 0.066
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0066 0.109
Trichomonas vaginalis modulator of drug activity B, putative 0.0182 0.1043 0.1043
Trichomonas vaginalis conserved hypothetical protein 0.0426 0.2505 0.2505
Trichomonas vaginalis modulator of drug activity B, putative 0.0182 0.1043 0.1043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0227 0.4681
Brugia malayi MH2 domain containing protein 0.0121 0.0675 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0066 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0182 0.1043 0.1043
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0045 0.0736
Echinococcus multilocularis dna polymerase kappa 0.002 0.0066 0.109
Trichomonas vaginalis conserved hypothetical protein 0.0426 0.2505 0.2505
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0217 0.9804
Trichomonas vaginalis modulator of drug activity B, putative 0.0182 0.1043 0.1043
Trichomonas vaginalis modulator of drug activity B, putative 0.0182 0.1043 0.1043
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.1043 0.1043
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.066

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 23.7558 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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