Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.6715 | 1 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.0166 | 0.0166 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.036 | 0.036 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0235 | 0.035 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1117 | 0.097 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2152 | 0.3205 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2798 | 0.2798 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1399 | 0.2083 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1679 | 0.2501 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.3033 | 0.3033 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1239 | 0.1239 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.004 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1554 | 0.2314 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1117 | 0.1117 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1239 | 0.1239 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.6715 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2152 | 0.3205 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.036 | 0.036 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.3522 | 0.5245 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0166 | 0.0166 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1117 | 0.1664 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.6715 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.0166 | 0.0166 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2798 | 0.2798 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2152 | 0.264 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.1394 | 0.1417 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.3802 | 0.5302 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.036 | 0.036 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2152 | 0.264 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0235 | 0.0235 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1636 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.122 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 1.4125 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 | ||
Saccharomyces cerevisiae | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.