Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2624 | 0.2624 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3624 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0098 | 0.0098 |
Onchocerca volvulus | 0.0033 | 0.0928 | 0.5 | |
Echinococcus multilocularis | musashi | 0.0033 | 0.0928 | 0.0838 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3624 | 0.3624 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1455 | 0.1455 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0098 | 0.0098 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1455 | 0.3848 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3624 | 0.3624 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3624 | 0.3561 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0098 | 0.0098 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.0928 | 0.2353 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3624 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3624 | 0.3624 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3624 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0928 | 0.0838 |
Onchocerca volvulus | 0.0033 | 0.0928 | 0.5 | |
Brugia malayi | RNA binding protein | 0.0076 | 0.3624 | 0.3624 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0928 | 0.0928 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1455 | 0.1455 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2624 | 0.2624 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0928 | 0.0838 |
Echinococcus granulosus | muscleblind protein | 0.018 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3624 | 0.3624 |
Echinococcus granulosus | lamin | 0.0033 | 0.0928 | 0.0838 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3624 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0891 | 0.0891 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0928 | 0.0838 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0928 | 0.0838 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0928 | 0.0928 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0098 | 0.0098 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3624 | 0.3561 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3624 | 0.3624 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0928 | 0.0928 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0928 | 0.0928 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2624 | 0.2624 |
Schistosoma mansoni | lamin | 0.0033 | 0.0928 | 0.2353 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2624 | 0.2624 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0928 | 0.2353 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3624 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0928 | 0.0928 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 15.8489 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.