Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.3785 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3785 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3785 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3785 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3785 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3785 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.3785 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3785 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3785 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3785 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.3785 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.3785 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.3785 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.3785 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.3785 | 0.5 | 0.5 |
Onchocerca volvulus | 0.3785 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.3785 | 0.5 | 0.5 |
Onchocerca volvulus | 0.3785 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.3785 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.3785 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.3785 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.3785 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.3785 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.3785 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3785 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.3785 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.3785 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.3785 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3785 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3785 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.3785 | 0.5 | 0.5 |
Onchocerca volvulus | 0.3785 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.3785 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.3785 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3785 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.3785 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3785 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.3785 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.3785 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.