Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Echinococcus granulosus | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Echinococcus multilocularis | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | calcium/calmodulin-dependent protein kinase subunit type II alpha | 0.0129 | 0.2154 | 0.211 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0202 | 0.4493 | 0.6756 |
Brugia malayi | protein kinase C II. | 0.0269 | 0.6624 | 0.925 |
Trichomonas vaginalis | AGC family protein kinase | 0.0063 | 0.0055 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.7156 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0063 | 0.0055 | 1 |
Brugia malayi | Protein kinase c protein 2 | 0.0141 | 0.2534 | 0.3491 |
Trichomonas vaginalis | AGC family protein kinase | 0.0063 | 0.0055 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.7986 | 0.7975 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.6908 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.7156 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0063 | 0.0055 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0063 | 0.0055 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.0107 | 0.147 | 0.1993 |
Trichomonas vaginalis | AGC family protein kinase | 0.0063 | 0.0055 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.7986 | 0.7975 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0269 | 0.6624 | 0.925 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.7156 | 0.7141 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0158 | 0.3077 | 0.4256 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0269 | 0.6624 | 0.6605 |
Schistosoma mansoni | protein kinase | 0.0148 | 0.2767 | 0.4129 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0148 | 0.2767 | 0.3819 |
Toxoplasma gondii | AGC kinase | 0.0063 | 0.0055 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0157 | 0.3068 | 0.4244 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0148 | 0.2767 | 0.3819 |
Trichomonas vaginalis | AGC family protein kinase | 0.0063 | 0.0055 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0063 | 0.0055 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0202 | 0.4493 | 0.6249 |
Brugia malayi | hypothetical protein | 0.0286 | 0.7156 | 1 |
Onchocerca volvulus | 0.0312 | 0.7986 | 0.5 | |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0096 | 0.1118 | 0.1069 |
Loa Loa (eye worm) | hypothetical protein | 0.0356 | 0.9402 | 0.9399 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0089 | 0.0883 | 0.1166 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0269 | 0.6624 | 1 |
Echinococcus granulosus | protein kinase c iota type | 0.0107 | 0.147 | 0.1993 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0219 | 0.5027 | 0.7002 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0883 | 0.0833 |
Trichomonas vaginalis | AGC family protein kinase | 0.0063 | 0.0055 | 1 |
Echinococcus granulosus | protein kinase C gamma type | 0.0158 | 0.3077 | 0.4256 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0089 | 0.0883 | 0.1166 |
Schistosoma mansoni | protein kinase | 0.0148 | 0.2767 | 0.4129 |
Trichomonas vaginalis | AGC family protein kinase | 0.0063 | 0.0055 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0063 | 0.0055 | 1 |
Schistosoma mansoni | protein kinase | 0.0148 | 0.2767 | 0.4129 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0202 | 0.4493 | 0.6249 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0157 | 0.3068 | 1 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0063 | 0.0055 | 0.5 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0269 | 0.6624 | 0.925 |
Brugia malayi | Calcium/calmodulin-dependent protein kinase type II alpha chain | 0.0129 | 0.2154 | 0.2955 |
Schistosoma mansoni | atypical protein kinase C | 0.0107 | 0.147 | 0.2155 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0202 | 0.4493 | 0.6756 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.7986 | 0.7975 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0089 | 0.0883 | 0.1166 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.2298 | 0.2256 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.