TDR Targets

Basic information

Technical information

TDR Targets ID: 1337697
Name: 5-(4-methoxy-2,3-dimethylphenyl)-4-methyl-N-p henyl-1,3,4-thiadiazol-4-ium-2-amine chloride
MW: 361.889 | Formula: C18H20ClN3OS
H donors: 1 H acceptors: 1 LogP: 6.11 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(c(c1C)C)c1sc(n[n+]1C)Nc1ccccc1.[Cl-]
InChi: 1S/C18H20N3OS.ClH/c1-12-13(2)16(22-4)11-10-15(12)17-21(3)20-18(23-17)19-14-8-6-5-7-9-14;/h5-11H,1-4H3,(H,19,20);1H/q+1;/p-1
InChiKey: QGXLHEYXIKTRLG-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-(4-methoxy-2,3-dimethyl-phenyl)-4-methyl-N-phenyl-1,3,4-thiadiazol-4-ium-2-amine chloride
[5-(4-methoxy-2,3-dimethyl-phenyl)-4-methyl-1,3,4-thiadiazol-4-ium-2-yl]-phenyl-amine chloride

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	Rap guanine nucleotide exchange factor (GEF) 4	Starlite/ChEMBL	No references
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131726	All targets in OG5_131726
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	Get druggable targets OG5_131726	All targets in OG5_131726
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	N-terminal motif family protein	Get druggable targets OG5_131726	All targets in OG5_131726

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0008	0.0014	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1338	0.1703
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.1338	0.523
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.1338	0.5
Loa Loa (eye worm)	DIX domain-containing protein	0.0011	0.0128	0.0146
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.1338	0.5
Brugia malayi	ecdysteroid receptor	0.0012	0.0182	0.0217
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0182	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0182	0.0217
Toxoplasma gondii	ABC1 family protein	0.0043	0.1338	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0182	0.0217
Brugia malayi	hypothetical protein	0.0011	0.0128	0.0146
Brugia malayi	TAR-binding protein	0.0076	0.2559	0.3273
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0008	0.0014	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0182	0.0217
Onchocerca volvulus		0.0043	0.1338	0.1703
Onchocerca volvulus		0.0012	0.0182	0.0217
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.2559	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0182	0.0662
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0182	0.0662
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2559	1
Mycobacterium leprae	Probable lipase LipE	0.0043	0.1338	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0182	0.0217
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0218	0.779	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0128	0.0146
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0182	0.0712
Mycobacterium ulcerans	beta-lactamase	0.0043	0.1338	0.5
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0008	0.0014	0.5
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0011	0.0128	0.0146
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0182	0.0662
Mycobacterium ulcerans	lipase LipD	0.0043	0.1338	0.5
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0011	0.0128	0.0447
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.2559	0.3273
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0182	0.0712
Echinococcus multilocularis	segment polarity protein dishevelled	0.0011	0.0128	0.0447
Brugia malayi	beta-lactamase family protein	0.0043	0.1338	0.1703
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0008	0.0014	0.0054
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0182	0.0712
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0182	0.0217
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0182	0.0662
Brugia malayi	steroid hormone receptor	0.0012	0.0182	0.0217
Brugia malayi	DIX domain containing protein	0.0011	0.0128	0.0146
Schistosoma mansoni	dep domain containing protein	0.0011	0.0128	0.0499
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0182	0.0217
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0182	0.0217
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0008	0.0014	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0182	0.0217
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0182	0.0217
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0008	0.0014	0.5
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0182	0.0712
Onchocerca volvulus		0.0043	0.1338	0.1703
Echinococcus granulosus	segment polarity protein dishevelled	0.0011	0.0128	0.0447
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0011	0.0128	0.0447
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0182	0.0217
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0182	0.0712
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.1338	1
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0011	0.0128	0.0499
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0182	0.0712
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0182	0.0217
Leishmania major	hypothetical protein, conserved	0.0043	0.1338	0.5
Schistosoma mansoni	guanine-nucleotide-exchange-factor	0.0008	0.0014	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0182	0.0217
Onchocerca volvulus	Bile acid receptor homolog	0.0012	0.0182	0.0217
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0182	0.0217
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0182	0.0217
Trichomonas vaginalis	esterase, putative	0.0043	0.1338	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0182	0.0662
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0182	0.0712
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0182	0.0662
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.1338	0.5204
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.1338	1
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.2559	0.3273
Echinococcus granulosus	tar DNA binding protein	0.0076	0.2559	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0182	0.0712
Loa Loa (eye worm)	RNA binding protein	0.0076	0.2559	0.3273
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0182	0.0662
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1338	0.1703
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0182	0.0662
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0128	0.0146
Schistosoma mansoni	dishevelled	0.0011	0.0128	0.0499
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.1338	0.5
Echinococcus granulosus	regulator of G protein signaling 7	0.0011	0.0128	0.0447
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2559	1
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0008	0.0014	0.5
Brugia malayi	beta-lactamase family protein	0.0043	0.1338	0.1703
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0182	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1338	0.1703
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.1338	1
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.2559	0.3273
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.1338	0.1703
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0182	0.0662
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0182	0.0217
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0011	0.0128	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0182	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0182	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0182	0.0217
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0182	0.0217
Loa Loa (eye worm)	beta-lactamase	0.0043	0.1338	0.1703
Schistosoma mansoni	regulator of G protein signaling	0.0011	0.0128	0.0499
Echinococcus multilocularis	regulator of G protein signaling 7	0.0011	0.0128	0.0447
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0182	0.0217
Brugia malayi	hypothetical protein	0.0011	0.0128	0.0146
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.1338	1
Schistosoma mansoni	ras GTP exchange factor	0.0008	0.0014	0.0054
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0008	0.0014	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2559	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0182	0.0662
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0182	0.0662
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0182	0.0712
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0008	0.0014	0.5
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0008	0.0014	0.5
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0182	0.0662
Brugia malayi	regulator of G-protein signaling egl-10	0.0011	0.0128	0.0146
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0008	0.0014	0.5
Brugia malayi	N-terminal motif family protein	0.0218	0.779	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0182	0.0662
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0008	0.0014	0.5
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1338	0.1703
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1338	0.1703
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0182	0.0662
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0008	0.0014	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0182	0.0217
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2559	1
Onchocerca volvulus		0.0043	0.1338	0.1703
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2559	1
Echinococcus granulosus	segment polarity protein dishevelled	0.0011	0.0128	0.0447
Echinococcus granulosus	regulator of G protein signaling 7	0.0011	0.0128	0.0447
Brugia malayi	RNA binding protein	0.0076	0.2559	0.3273
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0182	0.0712
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0182	0.0662
Brugia malayi	beta-lactamase	0.0043	0.1338	0.1703
Mycobacterium ulcerans	hypothetical protein	0.0043	0.1338	0.5
Schistosoma mansoni	coup transcription factor	0.0012	0.0182	0.0712
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0182	0.0217
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0182	0.0712
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0008	0.0014	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0128	0.0146
Entamoeba histolytica	hypothetical protein	0.0008	0.0014	0.5
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1338	0.1703
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0182	0.0217
Brugia malayi	nuclear hormone receptor	0.0012	0.0182	0.0217
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.1338	0.5204
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0008	0.0014	0.5
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.1338	0.523
Echinococcus multilocularis	segment polarity protein dishevelled	0.0011	0.0128	0.0447
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.1338	0.1703
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.1338	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0182	0.0662
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0011	0.0128	0.0146
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0182	0.0662
Schistosoma mansoni	z-protein (S1r protein)	0.0011	0.0128	0.0499
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0182	0.0217
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0182	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0218	0.779	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0182	0.0217
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.1338	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.1338	1
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0182	0.0217
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.0182	0.0217
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0182	0.0217
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.1338	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0182	0.0217
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.1338	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0182	0.0712
Schistosoma mansoni	dishevelled	0.0011	0.0128	0.0499
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0182	0.0662
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0008	0.0014	0.5
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0011	0.0128	0.0146
Onchocerca volvulus		0.0011	0.0128	0.0146
Echinococcus multilocularis	regulator of G protein signaling 7	0.0011	0.0128	0.0447
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0182	0.0217
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.0182	0.0217
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0182	0.0217

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.5623 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	20.5962 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	125.8925 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1437670

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1337697