Detailed information for compound 1337709

Basic information

Technical information
  • TDR Targets ID: 1337709
  • Name: 1-[[5-(1,3-benzodioxol-5-yl)-1,3,4-oxadiazol- 2-yl]methyl]-4-(3-methoxyphenyl)piperazine
  • MW: 394.424 | Formula: C21H22N4O4
  • H donors: 0 H acceptors: 2 LogP: 2.66 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)N1CCN(CC1)Cc1nnc(o1)c1ccc2c(c1)OCO2
  • InChi: 1S/C21H22N4O4/c1-26-17-4-2-3-16(12-17)25-9-7-24(8-10-25)13-20-22-23-21(29-20)15-5-6-18-19(11-15)28-14-27-18/h2-6,11-12H,7-10,13-14H2,1H3
  • InChiKey: WIIZLRSNEVLHPR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • C301-4794
  • NCGC00107415-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0724 0.1969
Giardia lamblia PHD finger protein 15 0.0032 0.0724 0.1499
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0069 0.2036 0.4068
Trypanosoma cruzi hypothetical protein, conserved 0.0231 0.7697 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0239 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0049 0.00000000015598
Loa Loa (eye worm) hypothetical protein 0.0027 0.0574 0.0574
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0034 0.079 0.0904
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0528 0.0481
Loa Loa (eye worm) hypothetical protein 0.0012 0.0049 0.0049
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0101 0.3158 0.5218
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0239 0.0553
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.3204 0.3171
Loa Loa (eye worm) hypothetical protein 0.0054 0.1515 0.1515
Echinococcus multilocularis chromobox protein 1 0.0076 0.2263 0.3738
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0239 0.0239
Schistosoma mansoni chromobox protein 0.0012 0.0049 0.0049
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0049 0.00000000015598
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0049 0.00000000049196
Echinococcus granulosus geminin 0.0184 0.6053 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0103 0.3204 0.5294
Loa Loa (eye worm) helicase 0.0012 0.0049 0.0049
Echinococcus granulosus chromobox protein 1 0.0076 0.2263 0.3738
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.1212 0.3783
Brugia malayi glucose-6-phosphate dehydrogenase 0.0101 0.3158 0.3158
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0574 0.1531
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.3204 0.4084
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0239 0.0178
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.1412 0.398
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.1354 0.1354
Plasmodium falciparum thioredoxin reductase 0.0018 0.0239 0.0553
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.1392 0.135
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0957 0.158
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0049 0.0049
Plasmodium falciparum glutathione reductase 0.0051 0.1412 0.398
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.2292 0.2292
Brugia malayi hypothetical protein 0.0012 0.0049 0.0049
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0027 0.0547 0.0316
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0239 0.0178
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0035 0.0845 0.1372
Trypanosoma brucei polo-like protein kinase 0.0103 0.3204 0.4084
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0101 0.3158 1
Mycobacterium tuberculosis Probable oxidoreductase 0.013 0.417 0.8899
Onchocerca volvulus 0.0012 0.0049 0.0154
Trichomonas vaginalis chromobox protein, putative 0.0076 0.2263 0.2224
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0239 0.019
Loa Loa (eye worm) glutaminase 2 0.0297 1 1
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0101 0.3158 0.3158
Echinococcus granulosus tar DNA binding protein 0.0076 0.2292 0.3786
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0239 0.0553
Loa Loa (eye worm) glutathione reductase 0.0051 0.1412 0.1412
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0117 0.3713 0.7858
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.1354 0.2236
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0049 0.00000000015598
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0239 0.0178
Schistosoma mansoni hypothetical protein 0.0184 0.6053 0.6053
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.11 0.1056
Echinococcus multilocularis chromobox protein 1 0.0076 0.2263 0.3738
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.3204 0.4084
Brugia malayi SET domain containing protein 0.0012 0.0049 0.0049
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.3713 0.7864
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0225 0.0514
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0724 0.1195
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0049 0.00000000015598
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0049 0.00000000049196
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0239 0.0553
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0239 0.0178
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0103 0.0171
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.1412 0.2656
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0724 0.0724
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0336 0.0336
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0957 0.158
Brugia malayi chromobox protein homolog 3 0.0042 0.11 0.11
Echinococcus multilocularis chromobox protein 2 0.0012 0.0049 0.0081
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0101 0.3158 0.5218
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0239 0.0178
Trichomonas vaginalis chromobox protein, putative 0.0076 0.2263 0.2224
Schistosoma mansoni chromobox protein 0.0076 0.2263 0.2263
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.0049 0.00000000045326
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.1412 0.2333
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0103 0.0054
Onchocerca volvulus 0.0011 0.0005 0.0015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.1354 0.2236
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.3204 0.3171
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0239 0.0553
Brugia malayi glutathione reductase 0.0051 0.1412 0.1412
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.1354 0.1354
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0104 0.3243 0.5358
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0239 0.0178
Brugia malayi Bromodomain containing protein 0.0032 0.0724 0.0724
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0027 0.0547 0.0697
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0103 0.3204 0.3204
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0239 0.0178
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0049 0.00000000049196
Schistosoma mansoni chromobox protein 0.0012 0.0049 0.0049
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0046 0.0075
Echinococcus granulosus Chromo domain 0.0012 0.0049 0.0081
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0574 0.0619
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0528 0.0528
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0528 0.0481
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.011 0.3474 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.3713 0.7864
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0239 0.5
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.1412 0.1412
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0032 0.0724 0.0724
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0239 0.0178
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.3204 0.3171
Loa Loa (eye worm) heterochromatin protein 1 0.0076 0.2263 0.2263
Echinococcus granulosus chromobox protein 2 0.0012 0.0049 0.0081
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.3204 0.3204
Loa Loa (eye worm) hypothetical protein 0.0131 0.4206 0.4206
Echinococcus multilocularis citrate lyase subunit beta protein 0.0027 0.0547 0.0903
Loa Loa (eye worm) hypothetical protein 0.0012 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0012 0.0049 0.0049
Plasmodium vivax glutathione reductase, putative 0.0051 0.1412 0.398
Giardia lamblia Kinase, PLK 0.0103 0.3204 0.9167
Brugia malayi TAR-binding protein 0.0076 0.2292 0.2292
Brugia malayi PHD-finger family protein 0.0032 0.0724 0.0724
Onchocerca volvulus 0.0012 0.0049 0.0154
Brugia malayi Protein cec-1. 0.0012 0.0049 0.0049
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0239 0.0178
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.013 0.417 0.8899
Schistosoma mansoni glutaminase 0.0297 1 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0103 0.3204 0.3204
Echinococcus multilocularis geminin 0.0184 0.6053 1
Schistosoma mansoni hypothetical protein 0.0032 0.0724 0.0724
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0239 0.0178
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0239 0.0178
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0101 0.3158 0.3158
Echinococcus granulosus Chromobox protein 3 0.0012 0.0049 0.0081
Trichomonas vaginalis chromobox protein, putative 0.0046 0.1212 0.1169
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0033 0.0756 0.0859
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.1354 0.1354
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.011 0.3474 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0103 0.3204 0.4084
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0049 0.0049
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0049 0.00000000015598
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0049 0.0049
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2292 0.2292
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.3204 0.3171
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0101 0.3158 0.4023
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0066 0.193 0.1732
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0049 0.0081
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0073 0.0073
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.2292 0.2292
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0239 0.0394
Mycobacterium ulcerans glutaminase 0.0297 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0957 0.0957
Onchocerca volvulus Serine\/threonine kinase homolog 0.0103 0.3204 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0049 0.0049
Brugia malayi jmjC domain containing protein 0.0104 0.3243 0.3243
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0239 0.0178
Loa Loa (eye worm) CHromoDomain protein family member 0.0012 0.0049 0.0049
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0066 0.193 0.5491
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.1392 0.135
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2292 0.2292
Onchocerca volvulus Alhambra homolog 0.0032 0.0724 0.2258
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0239 0.0553
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0049 0.00000000015598
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0574 0.0619
Schistosoma mansoni chromobox protein 0.0076 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0033 0.0779 0.0779
Schistosoma mansoni hypothetical protein 0.0012 0.0046 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0666 0.062
Loa Loa (eye worm) hypothetical protein 0.0012 0.0049 0.0049
Echinococcus granulosus citrate lyase subunit beta protein 0.0027 0.0547 0.0903
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0101 0.3158 0.2991
Onchocerca volvulus 0.0012 0.0049 0.0154
Onchocerca volvulus 0.0033 0.0779 0.2431
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0957 0.0957
Mycobacterium tuberculosis Conserved protein 0.0027 0.0547 0.0697
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0144 0.4657 1
Schistosoma mansoni kinase 0.0052 0.144 0.144
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0239 0.019
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0027 0.0547 0.0316
Brugia malayi RNA binding protein 0.0076 0.2292 0.2292
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0049 0.00000000045326
Entamoeba histolytica serine/threonine protein kinase, putative 0.0103 0.3204 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0049 0.0049
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.3713 0.7864
Leishmania major hypothetical protein, conserved 0.0231 0.7697 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0239 0.0178
Echinococcus multilocularis peregrin 0.0032 0.0724 0.1195
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0049 0.0049
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.3204 0.3171
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0724 0.0724
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0046 0.0075
Loa Loa (eye worm) RNA binding protein 0.0076 0.2292 0.2292
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0724 0.1969
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0239 0.0553
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0101 0.3158 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2292 0.2292
Trypanosoma cruzi hypothetical protein, conserved 0.0231 0.7697 1
Brugia malayi hypothetical protein 0.0027 0.0574 0.0574
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0574 0.0619
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0049 0.00000000015598
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.3713 0.7864
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0103 0.3204 0.5294
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0239 0.0178
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0239 0.0239
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0049 0.00000000015598
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.3204 0.3171
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.1354 0.2236
Schistosoma mansoni hypothetical protein 0.0012 0.0049 0.0049
Brugia malayi Thioredoxin reductase 0.0051 0.1412 0.1412
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0027 0.0547 0.05
Loa Loa (eye worm) hypothetical protein 0.0042 0.11 0.11
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2292 0.2292
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0049 0.00000000015598
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0101 0.3158 0.4023
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0239 0.0394
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0012 0.0049 0.0081
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0049 0.0049
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0574 0.1531
Mycobacterium tuberculosis Probable reductase 0.0117 0.3713 0.7864
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0547 0.0584
Plasmodium falciparum thioredoxin reductase 0.0051 0.1412 0.398
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.011 0.3474 1
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0547 0.0584
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0049 0.00000000015598
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.11 0.3432
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.1412 0.1724
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0027 0.0547 0.0316
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0049 0.00000000015598
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0049 0.0081
Brugia malayi jmjC domain containing protein 0.0038 0.0957 0.0957
Echinococcus multilocularis Chromo domain 0.0012 0.0049 0.0081
Toxoplasma gondii thioredoxin reductase 0.0051 0.1412 0.398
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0049 0.00000000015598
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0239 0.0178
Loa Loa (eye worm) glutaminase 0.0297 1 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0012 0.0049 0.0081
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.013 0.417 1
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.011 0.3474 0.3441
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.11 0.1056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.1354 0.1354
Trypanosoma brucei trypanothione reductase 0.0051 0.1412 0.1724
Loa Loa (eye worm) RecQ helicase 0.0026 0.0528 0.0528
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.013 0.417 0.8899
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0049 0.0049
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0049 0.00000000045326
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0239 0.0178
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0049 0.0049
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.1903 0.1903
Mycobacterium ulcerans lipoprotein LpqF 0.0069 0.2036 0.1841
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.1412 0.2333
Loa Loa (eye worm) hypothetical protein 0.0012 0.0049 0.0049
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0724 0.1195
Plasmodium falciparum phd finger protein, putative 0.0032 0.0724 0.1969
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0049 0.0049
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.3713 0.7864
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0233 0.0536
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0724 0.1969
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.011 0.3474 0.3441
Schistosoma mansoni hypothetical protein 0.0184 0.6053 0.6053
Echinococcus granulosus peregrin 0.0032 0.0724 0.1195
Echinococcus multilocularis tar DNA binding protein 0.0076 0.2292 0.3786
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0417 0.1075
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0528 0.0872
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0144 0.4657 0.4527
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.3204 0.3171
Brugia malayi hypothetical protein 0.0018 0.0234 0.0234
Trypanosoma brucei hypothetical protein, conserved 0.0231 0.7697 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0239 0.0178
Brugia malayi Heterochromatin protein 1 0.0076 0.2263 0.2263
Echinococcus granulosus bloom syndrome protein 0.0026 0.0528 0.0872
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0957 0.0957
Mycobacterium ulcerans hypothetical protein 0.0027 0.0547 0.0316
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0027 0.0547 0.0584
Mycobacterium ulcerans hypothetical protein 0.0027 0.0547 0.0316
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0666 0.062
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0049 0.00000000015598
Trypanosoma brucei beta lactamase 0.0069 0.2036 0.2545
Echinococcus granulosus jumonji domain containing protein 0.0044 0.1157 0.1912
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0574 0.1531
Trichomonas vaginalis glutaminase, putative 0.0297 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0574 0.1531
Schistosoma mansoni jumonji domain containing protein 0.0082 0.2498 0.2498
Leishmania major hypothetical protein, conserved 0.0027 0.0574 0.0619
Leishmania major trypanothione reductase 0.0051 0.1412 0.1724
Plasmodium falciparum glutathione reductase 0.0018 0.0239 0.0553
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0049 0.0081
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0104 0.3243 0.5358
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.1354 0.1354
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.011 0.3474 0.3441
Brugia malayi CHD4 protein 0.0012 0.0049 0.0049
Echinococcus granulosus chromobox protein 1 0.0076 0.2263 0.3738
Loa Loa (eye worm) TAR-binding protein 0.0076 0.2292 0.2292
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0101 0.3158 0.4023
Entamoeba histolytica hypothetical protein 0.0012 0.0049 0.00000000049196
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2292 0.2292
Loa Loa (eye worm) hypothetical protein 0.0012 0.0049 0.0049
Trichomonas vaginalis chromobox protein, putative 0.0046 0.1212 0.1169
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.1157 0.1912
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.1354 0.2236
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.011 0.3474 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3162 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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