Ki (binding)
|
= -7.2
|
Binding affinity for imidazoline receptor I-2 in rabbit kidney homogenate (relative to [3H]-Idazoxan radioligand)
|
ChEMBL.
|
10737743
|
Ki (binding)
|
= 24 %
|
In Vitro binding affinity for imidazoline receptor I-1 of rabbit kidney at 10e-7 M
|
ChEMBL.
|
12723959
|
Ki (binding)
|
= 24 %
|
In Vitro binding affinity for imidazoline receptor I-1 of rabbit kidney at 10e-7 M
|
ChEMBL.
|
12723959
|
Ki (binding)
|
= 0.0000000047 M
|
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation
|
ChEMBL.
|
12723959
|
Ki (binding)
|
= 0.0000000047 M
|
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation
|
ChEMBL.
|
12723959
|
Ki (binding)
|
= 0.000000017 M
|
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation
|
ChEMBL.
|
12723959
|
Ki (binding)
|
= 0.000000017 M
|
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation
|
ChEMBL.
|
12723959
|
Ki (binding)
|
= 0.000000031 M
|
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation
|
ChEMBL.
|
12723959
|
Ki (binding)
|
= 0.000000031 M
|
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation
|
ChEMBL.
|
12723959
|
Ki (binding)
|
= 0.0000000329 M
|
In vitro alpha-2 adrenergic receptor binding affinity was determined on calf frontal cortex membrane preparation
|
ChEMBL.
|
12723959
|
Ki (binding)
|
= 0.000000057 M
|
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation
|
ChEMBL.
|
12723959
|
Ki (binding)
|
= 0.000000057 M
|
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation
|
ChEMBL.
|
12723959
|
Ki (binding)
|
= 0.00000006 M
|
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation
|
ChEMBL.
|
12723959
|
Ki (binding)
|
= 0.00000006 M
|
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation
|
ChEMBL.
|
12723959
|
Ki (binding)
|
= 0.0000000682 M
|
In vitro alpha-2 adrenergic receptor binding affinity was determined on calf frontal cortex membrane preparation
|
ChEMBL.
|
12723959
|
Ki (binding)
|
= 0.000000104 M
|
In vitro alpha-2 adrenergic receptor binding affinity was determined on calf frontal cortex membrane preparation
|
ChEMBL.
|
12723959
|
Ki (binding)
|
> 0.000001 M
|
In vitro alpha-1 adrenergic receptor binding affinity was determined on calf frontal cortex membrane preparation
|
ChEMBL.
|
12723959
|
Ki (binding)
|
= 0.00000254 M
|
In vitro alpha-1 adrenergic receptor binding affinity was determined on calf frontal cortex membrane preparation
|
ChEMBL.
|
12723959
|
Ki (binding)
|
= 0.00000591 M
|
In vitro alpha-1 adrenergic receptor binding affinity was determined on calf frontal cortex membrane preparation
|
ChEMBL.
|
12723959
|
Log Ki (binding)
|
= 7.2
|
Binding affinity for imidazoline receptor I-2 in rabbit kidney homogenate (relative to [3H]-Idazoxan radioligand)
|
ChEMBL.
|
10737743
|
Max delta HR (functional)
|
= -143 beats min-1
|
Effect at (25 mg/kg, ip) on heart rate in anesthetized spontaneously hypertensive rats
|
ChEMBL.
|
12723959
|
Max delta HR (functional)
|
= -139 beats min-1
|
Effect at (25 mg/kg, ip) on heart rate in anesthetized spontaneously hypertensive rats
|
ChEMBL.
|
12723959
|
Max delta HR (functional)
|
= -85 beats min-1
|
Effect at (25 mg/kg, ip) on heart rate in anesthetized spontaneously hypertensive rats
|
ChEMBL.
|
12723959
|
Max delta HR (functional)
|
= -61 beats min-1
|
Effect of the compound after 100 mg/kg,po, on heart rate in conscious spontaneously hypertensive rats
|
ChEMBL.
|
12723959
|
Max delta HR (functional)
|
= -43 beats min-1
|
Effect of the compound after 30 mg/kg,po, on heart rate in conscious spontaneously hypertensive rats
|
ChEMBL.
|
12723959
|
Max delta HR (functional)
|
= 25 beats min-1
|
Effect of the compound after 10 mg/kg,po, on heart rate in conscious spontaneously hypertensive rats
|
ChEMBL.
|
12723959
|
Max delta MAP (functional)
|
= -81 mmHg
|
Effect of the compound after 100 mg/kg,po, on mean arterial blood pressure in conscious spontaneously hypertensive rats
|
ChEMBL.
|
12723959
|
Max delta MAP (functional)
|
= -56 mmHg
|
Effect of the compound after 30 mg/kg,po, on mean arterial blood pressure in conscious spontaneously hypertensive rats
|
ChEMBL.
|
12723959
|
Max delta MAP (functional)
|
= -55 mmHg
|
Effect (25 mg/kg ip) on mean arterial blood pressure in anesthetized spontaneously hypertensive rats
|
ChEMBL.
|
12723959
|
Max delta MAP (functional)
|
= -50 mmHg
|
Effect (25 mg/kg ip) on mean arterial blood pressure in anesthetized spontaneously hypertensive rats
|
ChEMBL.
|
12723959
|
Max delta MAP (functional)
|
= -34 mmHg
|
Effect of the compound after 10 mg/kg,po, on mean arterial blood pressure in conscious spontaneously hypertensive rats
|
ChEMBL.
|
12723959
|
Max delta MAP (functional)
|
= -6 mmHg
|
Effect (25 mg/kg ip) on mean arterial blood pressure in anesthetized spontaneously hypertensive rats
|
ChEMBL.
|
12723959
|
Variation (functional)
|
= -45 %
|
Effect (25 mg/kg ip) on heart rate in anesthetized spontaneously hypertensive rats
|
ChEMBL.
|
12723959
|
Variation (functional)
|
= -44 %
|
Effect (25 mg/kg ip) on heart rate in anesthetized spontaneously hypertensive rats
|
ChEMBL.
|
12723959
|
Variation (functional)
|
= -44 %
|
Effect of the compound after 100 mg/kg,po, on mean arterial blood pressure in conscious spontaneously hypertensive rats
|
ChEMBL.
|
12723959
|
Variation (functional)
|
= -36 %
|
Effect (25 mg/kg ip) on mean arterial blood pressure in anesthetized spontaneously hypertensive rats
|
ChEMBL.
|
12723959
|
Variation (functional)
|
= -31 %
|
Effect (25 mg/kg ip) on mean arterial blood pressure in anesthetized spontaneously hypertensive rats
|
ChEMBL.
|
12723959
|
Variation (functional)
|
= -29 %
|
Effect of the compound after 30 mg/kg,po, on mean arterial blood pressure in conscious spontaneously hypertensive rats
|
ChEMBL.
|
12723959
|
Variation (functional)
|
= -28 %
|
Effect (25 mg/kg ip) on mean arterial blood pressure in anesthetized spontaneously hypertensive rats
|
ChEMBL.
|
12723959
|
Variation (functional)
|
= -25 %
|
Effect (25 mg/kg ip) on heart rate in anesthetized spontaneously hypertensive rats
|
ChEMBL.
|
12723959
|
Variation (functional)
|
= -18 %
|
Effect of the compound after 10 mg/kg,po, on mean arterial blood pressure in conscious spontaneously hypertensive rats
|
ChEMBL.
|
12723959
|
Variation (functional)
|
= -18 %
|
Effect of the compound after 100 mg/kg,po, on heart rate in conscious spontaneously hypertensive rats
|
ChEMBL.
|
12723959
|
Variation (functional)
|
= -12 %
|
Effect of the compound after 30 mg/kg,po, on heart rate in conscious spontaneously hypertensive rats
|
ChEMBL.
|
12723959
|
Variation (functional)
|
= 7 %
|
Effect of the compound after 10 mg/kg,po, on heart rate in conscious spontaneously hypertensive rats
|
ChEMBL.
|
12723959
|