Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0113 | 0.1841 | 0.5 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0203 | 0.8159 | 0.8159 |
Leishmania major | p450 reductase, putative | 0.0229 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0141 | 0.3805 | 0.3805 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0141 | 0.3805 | 0.2407 |
Giardia lamblia | Hypothetical protein | 0.0203 | 0.8159 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0087 | 0 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0229 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0229 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0229 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0141 | 0.3805 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0229 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0203 | 0.8159 | 0.8159 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0229 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0229 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0087 | 0 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0087 | 0 | 0.5 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0203 | 0.8159 | 0.8159 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0229 | 1 | 1 |
Treponema pallidum | flavodoxin | 0.0087 | 0 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0115 | 0.1964 | 0.0151 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0229 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0229 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0203 | 0.8159 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0229 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0229 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0141 | 0.3805 | 0.3805 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0229 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0113 | 0.1841 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0229 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0229 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0087 | 0 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0229 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0087 | 0 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0229 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0229 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0229 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0229 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0229 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.4668 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.