TDR Targets

Basic information

Technical information

TDR Targets ID: 1338081
Name: 1-(4-methylphenyl)sulfonyl-4-[1-phenyl-3-[[3- (trifluoromethyl)phenyl]methoxy]propan-2-yl]- 1,4-diazepan-5-one
MW: 560.628 | Formula: C29H31F3N2O4S
H donors: 0 H acceptors: 3 LogP: 4.89 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: Cc1ccc(cc1)S(=O)(=O)N1CCC(=O)N(CC1)C(Cc1ccccc1)COCc1cccc(c1)C(F)(F)F
InChi: 1S/C29H31F3N2O4S/c1-22-10-12-27(13-11-22)39(36,37)33-15-14-28(35)34(17-16-33)26(19-23-6-3-2-4-7-23)21-38-20-24-8-5-9-25(18-24)29(30,31)32/h2-13,18,26H,14-17,19-21H2,1H3
InChiKey: FEDINYRJSNZBFK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(4-methylphenyl)sulfonyl-4-[1-(phenylmethyl)-2-[[3-(trifluoromethyl)phenyl]methoxy]ethyl]-1,4-diazepan-5-one
4-[1-(benzyl)-2-[3-(trifluoromethyl)benzyl]oxy-ethyl]-1-(4-methylphenyl)sulfonyl-1,4-diazepan-5-one
SMR000128907
KUC100115
MLS000518515

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Starlite/ChEMBL	No references
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	Heat shock protein 70 (HSP70)	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium yoelii	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	heat shock protein 70 related	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein 70 (HSP70)-4, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Cryptosporidium hominis	heat shock protein 70 precursor	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	70 kDa heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium falciparum	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania mexicana	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Plasmodium vivax	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei gambiense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania donovani	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 71 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania major	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma cruzi	heat shock protein 70 (hsp70), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Neospora caninum	Heat shock protein 70, related	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania major	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania donovani	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma mansoni	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium knowlesi	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma cruzi	heat shock protein 70 (hsp70), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70 family	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein kDa	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Giardia lamblia	Cytosolic HSP70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein kDa heat shock kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	heat shock 70 kDa protein 1A:1B	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock 70 kDa protein 1	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	similar to Heat shock 70 kDa protein homolog, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania mexicana	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania major	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein 70kD, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	Cytoplasmic chaperone	Get druggable targets OG5_126588	All targets in OG5_126588
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	heat shock protein 71 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Onchocerca volvulus		Get druggable targets OG5_126588	All targets in OG5_126588
Theileria parva	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	heat shock 70kDa protein 5	Get druggable targets OG5_126588	All targets in OG5_126588
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Toxoplasma gondii	heat shock protein HSP70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma mansoni	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	Heat Shock protein family member hsp 3	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Giardia lamblia	Bip	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania donovani	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium falciparum	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	HSP70	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70 related	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium falciparum	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	3'partial\|5'partial\|heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium vivax	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock kda protein	Get druggable targets OG5_126588	All targets in OG5_126588
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma brucei	heat shock protein 70 (hsp70), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei gambiense	glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein 70 (HSP70)-4, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	microsomal stress 70 protein ATPase core precursor, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70 related	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 71 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Babesia bovis	heat shock protein 70 precursor, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	Heat Shock protein family member (hsp 3)	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania mexicana	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock 70 kda protein 1a	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei gambiense	glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania major	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Plasmodium berghei	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Entamoeba histolytica	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K09490 heat shock 70kDa protein 5, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Babesia bovis	dnaK protein	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania braziliensis	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein 70kD, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis		Get druggable targets OG5_126588	All targets in OG5_126588
Brugia malayi	heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Cryptosporidium hominis	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	Cytoplasmic chaperone	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock kda protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium berghei	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70b	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania donovani	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania mexicana	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania braziliensis	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein kDa heat shock kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Brugia malayi	heat shock 70 kDa protein C precursor	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium yoelii	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	HSP70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70 family	Get druggable targets OG5_126588	All targets in OG5_126588
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium knowlesi	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Neospora caninum	Heat shock protein 70 (Precursor), related	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	similar to Heat shock 70 kDa protein cognate 4, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein 70 (HSP70)-4, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Cryptosporidium parvum	heat shock 70 (HSP70) protein	Get druggable targets OG5_126588	All targets in OG5_126588
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania infantum	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis		Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis		Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70 related	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70b	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Toxoplasma gondii	chaperonin protein BiP	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania braziliensis	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Candida albicans	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma cruzi	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Theileria parva	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 71 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Cryptosporidium parvum	heat shock protein, Hsp70	Get druggable targets OG5_126588	All targets in OG5_126588

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Plasmodium falciparum	heat shock protein 70	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	654 aa	613 aa	51.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0033	0.387	0.387
Echinococcus granulosus	GPCR family 2	0.0019	0.0871	0.1977
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.387	0.387
Onchocerca volvulus		0.0033	0.387	0.5
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.387	0.387
Echinococcus granulosus	lamin	0.0033	0.387	1
Echinococcus granulosus	intermediate filament protein	0.0033	0.387	1
Schistosoma mansoni	hypothetical protein	0.0041	0.5775	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.5775	0.5775
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.387	0.3537
Loa Loa (eye worm)	hypothetical protein	0.006	1	1
Onchocerca volvulus		0.0033	0.387	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.3738	0.3738
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	1	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0871	0.0871
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	1	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0871	0.0375
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0871	0.1977
Schistosoma mansoni	lamin	0.0033	0.387	0.6116
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0132	0.0132
Schistosoma mansoni	intermediate filament proteins	0.0033	0.387	0.6116
Schistosoma mansoni	lamin	0.0033	0.387	0.6116
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0871	0.0375
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0871	0.1977
Echinococcus multilocularis	musashi	0.0033	0.387	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.5775	0.5545
Echinococcus granulosus	lamin dm0	0.0033	0.387	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0871	0.1977
Echinococcus multilocularis	lamin	0.0033	0.387	1
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0871	0.1977
Echinococcus multilocularis	lamin dm0	0.0033	0.387	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0516	0.0516
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0871	0.0871
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0871	0.1977
Brugia malayi	intermediate filament protein	0.0033	0.387	0.3537

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	3.6964 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	6.5733 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	7.9433 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	14.1254 uM	PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	16.3601 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 50.1187 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1424319

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1338081