Detailed information for compound 133812

Basic information

Technical information
  • TDR Targets ID: 133812
  • Name: 4-pyrido[3,4-e][1,2,4]triazin-3-ylbenzonitril e
  • MW: 233.228 | Formula: C13H7N5
  • H donors: 0 H acceptors: 5 LogP: 0.93 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1)c1nnc2c(n1)cncc2
  • InChi: 1S/C13H7N5/c14-7-9-1-3-10(4-2-9)13-16-12-8-15-6-5-11(12)17-18-13/h1-6,8H
  • InChiKey: KVYRBRIPUAHYGR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(3-pyrido[3,4-e][1,2,4]triazinyl)benzonitrile
  • 4-pyrido[3,4-e][1,2,4]triazin-3-ylbenzenecarbonitrile
  • 121845-60-1
  • 4-Pyrido(3,4-e)(1,2,4)triazin-3-yl-benzonitrile
  • 4-Pyrido[3,4-e][1,2,4]triazin-3-yl-benzonitrile
  • AIDS-195847
  • AIDS195847

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0291 0.0291
Brugia malayi jmjC domain containing protein 0.0059 0.0826 0.1724
Entamoeba histolytica protein kinase, putative 0.0089 0.1418 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0034 0.0034
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0884 0.1845
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0409 0.0409
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0661 0.0661
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0409 0.0409
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0884 0.1845
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0034 0.0034
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0661 0.0661
Brugia malayi nuclear receptor NHR-88 0.0037 0.0409 0.0854
Brugia malayi hypothetical protein 0.0122 0.2046 0.4271
Echinococcus multilocularis muscleblind protein 0.0144 0.2473 0.2473
Brugia malayi Protein kinase domain containing protein 0.0089 0.1418 0.2959
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0034 0.0034
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0666 0.0666
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.0074 0.0074
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0074 0.0074
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0154 0.266 0.266
Brugia malayi photoreceptor-specific nuclear receptor 0.0265 0.4791 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0409 0.0409
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0154 0.266 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0101 0.164 0.5617
Loa Loa (eye worm) hypothetical protein 0.0089 0.14 0.2923
Brugia malayi TAR-binding protein 0.0062 0.0884 0.1845
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0409 0.0409
Schistosoma mansoni hypothetical protein 0.0031 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0072
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0409 0.0409
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0034 0.0072
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0034 0.0034
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0407 0.0407
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0661 0.0599
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0549 0.0549
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0549 0.0549
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0266 0.4814 0.4814
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0884 0.0884
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0034 0.0034
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0409 0.0409
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0409 0.0854
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.002 0.0074 0.0155
Loa Loa (eye worm) hypothetical protein 0.0026 0.0192 0.0401
Brugia malayi conserved hypotetical protein 0.0017 0.0034 0.0072
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0409 0.0409
Loa Loa (eye worm) acetyltransferase 0.0171 0.2987 0.6234
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0409 0.0409
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0034 0.0034
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.1568 0.3272
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0154 0.266 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0072
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0034 0.0034
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0826 0.1724
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0034 0.0072
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0661 1
Brugia malayi acetyltransferase, GNAT family protein 0.0171 0.2987 0.6234
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0661 0.0599
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0407 0.2871
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.4647 1
Schistosoma mansoni hypothetical protein 0.0536 1 1
Onchocerca volvulus Huntingtin homolog 0.0122 0.2046 0.6912
Schistosoma mansoni inositol monophosphatase 0.0037 0.0407 0.0407
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0409 0.0409
Schistosoma mansoni hypothetical protein 0.0066 0.0977 0.0977
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.4647 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0291 0.0607
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0089 0.1418 1
Brugia malayi nuclear receptor RXR 0.0017 0.0034 0.0072
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0666 0.0611
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0409 0.1288
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.0409 0.1288
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0101 0.164 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0154 0.266 1
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0034 0.0072
Loa Loa (eye worm) hypothetical protein 0.002 0.0074 0.0155
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0154 0.266 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0409 0.0409
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0409 0.0854
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0072
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0409 0.0409
Brugia malayi ecdysone receptor 0.0017 0.0034 0.0072
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0661 0.4663
Loa Loa (eye worm) hypothetical protein 0.0154 0.266 0.5551
Brugia malayi steroid hormone receptor 0.0037 0.0409 0.0854
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0053 0.0719 0.2705
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0407 0.0407
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0154 0.266 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0826 0.0826
Brugia malayi nuclear receptor NHR-67 0.0017 0.0034 0.0072
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0089 0.1418 1
Brugia malayi hypothetical protein 0.0017 0.0034 0.0072
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.1568 0.3272
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0034 0.0072
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0407 0.1531
Brugia malayi RNA binding protein 0.0062 0.0884 0.1845
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0291 0.0291
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0661 0.0599
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0661 0.0661
Onchocerca volvulus Huntingtin homolog 0.0122 0.2046 0.6912
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0409 0.0854
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0409 0.0409
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0034 0.0072
Plasmodium falciparum histone acetyltransferase GCN5 0.0046 0.0586 0.2202
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0053 0.0719 0.1661
Loa Loa (eye worm) hypothetical protein 0.0037 0.0409 0.0854
Loa Loa (eye worm) hypothetical protein 0.0122 0.2046 0.4271
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0074 0.0074
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0661 0.2486
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0661 0.4663
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0409 0.0854
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.4647 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0154 0.266 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0409 0.0854
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0409 0.0854
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.4647 1
Echinococcus multilocularis neuropeptide receptor A26 0.0451 0.8368 0.8368
Schistosoma mansoni inositol monophosphatase 0.0037 0.0407 0.0407
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0034 0.0072
Brugia malayi Muscleblind-like protein 0.0144 0.2473 0.5161
Loa Loa (eye worm) RNA binding protein 0.0062 0.0884 0.1845
Echinococcus granulosus peptidase Clp S14 family 0.0101 0.164 0.164
Brugia malayi tailless protein 0.0017 0.0034 0.0072
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0291 0.0291
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0549 0.0549
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0154 0.266 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0409 0.0854
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0034 0.0034
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.4647 1
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0034 0.0034
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0034 0.0072
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.0144 0.2473 0.5161
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0409 0.0409
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0291 0.0607
Entamoeba histolytica protein kinase domain containing protein 0.0089 0.1418 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0171 0.2987 0.2987
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0409 0.0854
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0072
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0826 0.0826
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0409 0.0409
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0409 0.0854
Brugia malayi nuclear hormone receptor 0.0037 0.0409 0.0854
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.2946 0.5987
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0192 0.0722
Loa Loa (eye worm) hypothetical protein 0.002 0.0074 0.0155
Brugia malayi hypothetical protein 0.002 0.0074 0.0155
Loa Loa (eye worm) hypothetical protein 0.0037 0.0409 0.0854
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0192 0.1355
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0034 0.0034
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0409 0.0854
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0409 0.0854
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1986 0.4146
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0034 0.0072
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0409 0.0409
Echinococcus granulosus dual specificity 0.0089 0.1418 0.1418
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0661 0.4663
Echinococcus granulosus tar DNA binding protein 0.0062 0.0884 0.0884
Entamoeba histolytica hypothetical protein 0.0089 0.1418 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0072
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0549 0.1145
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0192 0.1355
Loa Loa (eye worm) hypothetical protein 0.0037 0.0409 0.0854
Schistosoma mansoni hypothetical protein 0.0031 0.0291 0.0291
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0666 0.0611
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0154 0.266 1
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0409 0.0409
Brugia malayi Probable ClpP-like protease 0.0154 0.266 0.5551
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0034 0.0034
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0884 0.0884
Loa Loa (eye worm) hypothetical protein 0.0066 0.0977 0.2038
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0072
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0409 0.0409
Echinococcus multilocularis neuropeptide s receptor 0.0451 0.8368 0.8368
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0409 0.0854
Entamoeba histolytica protein kinase, putative 0.0089 0.1418 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0192 0.0722
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0101 0.164 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0154 0.266 0.266
Brugia malayi nuclear receptor RXR 0.002 0.0074 0.0155
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0884 0.0884
Brugia malayi hypothetical protein 0.0026 0.0192 0.0401
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.2946 0.5987
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0666 0.2505
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0072
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0154 0.266 0.5
Brugia malayi hypothetical protein 0.0017 0.0018 0.0037
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.0034 0.0034
Echinococcus multilocularis muscleblind protein 1 0.0144 0.2473 0.2473
Schistosoma mansoni retinoic acid receptor RXR 0.0037 0.0409 0.0409
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0409 0.0409
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0154 0.266 0.266
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0053 0.0719 0.2705
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0192 0.0722
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0409 0.0854
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0074 0.0155
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.2946 0.5987
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0122 0.2046 0.4271
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0266 0.4814 0.4814
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0089 0.1418 0.2959
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0407 0.2871
Schistosoma mansoni hypothetical protein 0.0031 0.0291 0.0291
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0089 0.1418 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0549 0.0549
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0409 0.0854
Schistosoma mansoni nuclear receptor 0.0017 0.0034 0.0034
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0409 0.0854
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0549 0.1145
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0154 0.266 1
Echinococcus granulosus muscleblind protein 0.0144 0.2473 0.2473
Loa Loa (eye worm) hypothetical protein 0.002 0.0074 0.0155
Echinococcus granulosus neuropeptide s receptor 0.0451 0.8368 0.8368
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.312 0.64
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0409 0.0409
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0409 0.0854
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.0074 0.0155
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0977 0.2038
Loa Loa (eye worm) hypothetical protein 0.0031 0.0291 0.0607
Entamoeba histolytica acetyltransferase, GNAT family 0.0046 0.0586 0.1768
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0661 0.4663
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.4647 1
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0409 0.0409
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0884 0.1845
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0409 0.0409
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0291 0.0291
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0034 0.0034
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0661 0.138
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.2946 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0826 0.0826
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0661 0.4663
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.312 0.64
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0409 0.0854
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0031 0.0291 0.0291
Toxoplasma gondii hypothetical protein 0.0053 0.0719 0.2705
Brugia malayi ecdysteroid receptor 0.0037 0.0409 0.0854
Echinococcus multilocularis geminin 0.0536 1 1
Schistosoma mansoni zinc finger protein 0.0017 0.0034 0.0034
Echinococcus multilocularis GPCR, family 2 0.0031 0.0291 0.0291
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0291 0.0607
Loa Loa (eye worm) DR-78 0.0017 0.0034 0.0072
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.4647 0.9698
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0034 0.0034
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0661 0.0661
Onchocerca volvulus 0.0037 0.0409 0.1288
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0034 0.0072
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0826 0.0826
Echinococcus granulosus GPCR family 2 0.0031 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0072
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0661 0.4663
Brugia malayi jmjC domain containing protein 0.0059 0.0826 0.1724
Loa Loa (eye worm) inositol-1 0.0037 0.0407 0.085
Echinococcus granulosus histone acetyltransferase KAT2B 0.0166 0.2895 0.2895
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.0074 0.0074
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0409 0.0854
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0072
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.2946 0.5987
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0192 0.1355
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0407 0.2871
Echinococcus multilocularis thyroid hormone receptor alpha 0.0037 0.0409 0.0409
Trypanosoma brucei protein kinase, putative 0.005 0.0661 0.4663
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.1568 0.3272
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1986 0.4146
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0072
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0192 0.0722
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0826 0.0826
Brugia malayi nuclear hormone receptor 0.0017 0.0034 0.0072
Loa Loa (eye worm) hypothetical protein 0.0037 0.0409 0.0854
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.1418 0.1418
Brugia malayi MH2 domain containing protein 0.0119 0.1986 0.4146
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0089 0.1418 1
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0074 0.0155
Brugia malayi hypothetical protein 0.002 0.0074 0.0155
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0666 0.2505
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0661 0.4663
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0661 0.0599
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.2946 0.5987
Schistosoma mansoni nuclear receptor 0.0017 0.0034 0.0034
Schistosoma mansoni coup transcription factor 0.0037 0.0409 0.0409
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0826 0.0826
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0037 0.0409 0.0409
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.2946 0.5987
Brugia malayi MAP kinase sur-1 0.005 0.0661 0.138
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0154 0.266 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0074 0.0155
Echinococcus multilocularis dual specificity 0.0089 0.1418 0.1418
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0884 0.0884
Loa Loa (eye worm) hypothetical protein 0.0037 0.0409 0.0854
Schistosoma mansoni hypothetical protein 0.0536 1 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0666 0.2505
Brugia malayi nuclear receptor NHR-88 0.0017 0.0034 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0409 0.0854
Echinococcus multilocularis peptidase Clp (S14 family) 0.0101 0.164 0.164
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0409 0.0409
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0409 0.1288
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0409 0.0409
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0034 0.0034
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0037 0.0409 0.0854
Brugia malayi hypothetical protein 0.0017 0.0034 0.0072
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0407 0.2871
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.4647 0.9698
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0409 0.0854
Loa Loa (eye worm) hypothetical protein 0.0144 0.2473 0.5161
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0661 0.0661
Loa Loa (eye worm) hypothetical protein 0.0037 0.0409 0.0854
Loa Loa (eye worm) hypothetical protein 0.0097 0.1568 0.3272
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0409 0.0409
Echinococcus granulosus neuropeptide receptor A26 0.0451 0.8368 0.8368
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0409 0.0409
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0171 0.2987 0.2987
Brugia malayi Inositol-1 0.0037 0.0407 0.085
Loa Loa (eye worm) hypothetical protein 0.0265 0.4791 1
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.2946 0.5987
Loa Loa (eye worm) hypothetical protein 0.0089 0.14 0.2923
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0409 0.0854
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0409 0.0854
Leishmania major hypothetical protein, conserved 0.0026 0.0192 0.1355
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0409 0.0854
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0072
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0826 0.0826
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0884 0.0884
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0884 0.0884
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0034 0.0034

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 2 ug ml-1 Antifungal activity of the compound against Trychophyton rubrum; Range is 2-4 ChEMBL. 2810336
MIC (functional) = 4 ug ml-1 Antifungal activity of the compound against Candida pseudotropicalis; Range is 4-8 ChEMBL. 2810336
MIC (functional) = 4 ug ml-1 Antifungal activity of the compound against Trychophyton mentagrophytes; Range is 4-8 ChEMBL. 2810336
MIC (functional) = 8 ug ml-1 Antifungal activity of the compound against Candida tropicalis; Range is 8-32 ChEMBL. 2810336
MIC (functional) = 64 ug ml-1 Antifungal activity of the compound against Candida albicans ChEMBL. 2810336
MIC (functional) = 64 ug ml-1 Antifungal activity of the compound against Candida parapsilosis ChEMBL. 2810336
MIC (functional) = 64 ug ml-1 Antifungal activity of the compound against Candida albicans ChEMBL. 2810336
MIC (functional) > 128 ug ml-1 Antifungal activity of the compound against Candida rugosa ChEMBL. 2810336
MIC (functional) = 128 ug ml-1 Antifungal activity of the compound against Candida stellatoidea ChEMBL. 2810336
MIC (functional) = 128 ug ml-1 Antifungal activity of the compound against Aspergillus niger ChEMBL. 2810336
MIC (functional) = 128 ug ml-1 Antifungal activity of the compound against Mucor fragilis ChEMBL. 2810336
MIC (functional) = 128 ug ml-1 Antifungal activity of the compound against Candida stellatoidea ChEMBL. 2810336

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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