Detailed information for compound 1338142

Basic information

Technical information
  • TDR Targets ID: 1338142
  • Name: N-[(3,4-dichlorophenyl)methyl]pyridine-3-carb oxamide
  • MW: 281.137 | Formula: C13H10Cl2N2O
  • H donors: 1 H acceptors: 2 LogP: 2.88 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccnc1)NCc1ccc(c(c1)Cl)Cl
  • InChi: 1S/C13H10Cl2N2O/c14-11-4-3-9(6-12(11)15)7-17-13(18)10-2-1-5-16-8-10/h1-6,8H,7H2,(H,17,18)
  • InChiKey: KMAXICOFKNOYDI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(3,4-dichlorophenyl)methyl]-3-pyridinecarboxamide
  • N-(3,4-dichlorobenzyl)nicotinamide
  • Oprea1_401357
  • MLS000113979
  • SMR000109869
  • AK-968/12121374
  • ZINC00460646
  • IVK/8073836

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania infantum ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans hypothetical protein Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana 6-phospho-1-fructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania donovani ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania braziliensis ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Brugia malayi hypothetical protein 0.0055 0.1794 0.2069
Onchocerca volvulus Neuropeptide F receptor homolog 0.0055 0.1794 0.5
Echinococcus multilocularis g protein coupled receptor 0.0055 0.1794 0.1794
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.1794 0.1794
Schistosoma mansoni neuropeptide receptor 0.0055 0.1794 0.1794
Echinococcus granulosus neuropeptide s receptor 0.0055 0.1794 0.1794
Brugia malayi Carboxylesterase family protein 0.0075 0.29 0.3346
Brugia malayi hypothetical protein 0.0055 0.1794 0.2069
Schistosoma mansoni amine GPCR 0.0055 0.1794 0.1794
Echinococcus granulosus muscleblind protein 0.018 0.8668 0.8668
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0701 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0055 0.1794 0.2069
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Loa Loa (eye worm) melatonin receptor type 1A 0.0055 0.1794 0.2069
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.1794 0.1794
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.5967 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.5967 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0701 0.5
Onchocerca volvulus 0.0055 0.1794 0.5
Schistosoma mansoni opsin-like receptor 0.0055 0.1794 0.1794
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0701 0.1175
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0055 0.1794 0.2069
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.1794 0.1794
Echinococcus granulosus neuropeptide FF receptor 2 0.0055 0.1794 0.1794
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.1794 0.1794
Loa Loa (eye worm) hypothetical protein 0.0075 0.29 0.3346
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.1794 0.2069
Loa Loa (eye worm) phosphofructokinase 0.0131 0.5967 0.6884
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Echinococcus granulosus g-protein coupled receptor 0.0055 0.1794 0.1794
Leishmania major ATP-dependent phosphofructokinase 0.0131 0.5967 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.1794 0.1794
Echinococcus granulosus G protein coupled receptor 139 0.0055 0.1794 0.1794
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.1794 0.2069
Brugia malayi ORL1-like opioid receptor 0.0055 0.1794 0.2069
Onchocerca volvulus 0.0055 0.1794 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0055 0.1794 0.1794
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Echinococcus multilocularis neuropeptide receptor A26 0.0055 0.1794 0.1794
Echinococcus granulosus tachykinin peptides receptor 99D 0.0055 0.1794 0.1794
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.1794 0.1794
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0055 0.1794 0.1794
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.1794 0.1794
Echinococcus granulosus acetylcholinesterase 0.0075 0.29 0.29
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.1794 0.1794
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.1794 0.1794
Onchocerca volvulus 0.0055 0.1794 0.5
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0701 0.1175
Loa Loa (eye worm) acetylcholinesterase 1 0.0075 0.29 0.3346
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.1794 0.1794
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0055 0.1794 0.1794
Brugia malayi G protein-coupled receptor F59B2.13 0.0055 0.1794 0.2069
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.1794 0.1794
Echinococcus multilocularis muscleblind protein 1 0.018 0.8668 0.8668
Echinococcus multilocularis neuropeptide s receptor 0.0055 0.1794 0.1794
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.1794 0.1794
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.1794 0.1794
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.1794 0.1794
Schistosoma mansoni biogenic amine receptor 0.0055 0.1794 0.1794
Brugia malayi Muscleblind-like protein 0.018 0.8668 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Brugia malayi Dopamine receptor protein 2 0.0055 0.1794 0.2069
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0131 0.5967 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.0701 1
Brugia malayi hypothetical protein 0.0055 0.1794 0.2069
Loa Loa (eye worm) TYRA-2 protein 0.0055 0.1794 0.2069
Echinococcus multilocularis orexin receptor type 2 0.0055 0.1794 0.1794
Echinococcus granulosus g protein coupled receptor 0.0055 0.1794 0.1794
Brugia malayi Cytochrome P450 family protein 0.003 0.0415 0.0479
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0055 0.1794 0.2069
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0055 0.1794 0.1794
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0055 0.1794 0.1794
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.1794 0.1794
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0055 0.1794 0.1794
Brugia malayi Dopamine receptor 0.0055 0.1794 0.2069
Echinococcus granulosus 6 phosphofructokinase 0.0131 0.5967 0.5967
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.012 0.5357 0.5357
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Echinococcus granulosus carboxylesterase 5A 0.0075 0.29 0.29
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.5967 0.5967
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.1794 0.1794
Echinococcus granulosus neuropeptide receptor A26 0.0055 0.1794 0.1794
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0701 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.1794 0.1794
Schistosoma mansoni opsin-like receptor 0.0055 0.1794 0.1794
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.1794 0.1794
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.5967 0.6884
Schistosoma mansoni neuropeptide receptor 0.0055 0.1794 0.1794
Onchocerca volvulus 0.0055 0.1794 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.1794 0.1794
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Echinococcus granulosus fmrfamide receptor 0.0055 0.1794 0.1794
Schistosoma mansoni lipoxygenase 0.012 0.5357 0.5357
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0055 0.1794 0.1794
Echinococcus multilocularis neuropeptide receptor 0.0055 0.1794 0.1794
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0055 0.1794 0.2069
Schistosoma mansoni hypothetical protein 0.0055 0.1794 0.1794
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0035 0.0701 0.1175
Brugia malayi G protein-coupled receptor 0.0055 0.1794 0.2069
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.1794 0.1794
Echinococcus granulosus neuropeptide receptor 0.0055 0.1794 0.1794
Brugia malayi Dopamine receptor protein 1 0.0055 0.1794 0.2069
Echinococcus granulosus peptide allatostatin:somatostatin 0.0055 0.1794 0.1794
Brugia malayi neuropeptide F receptor 0.0055 0.1794 0.2069
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.1794 0.1794
Onchocerca volvulus 0.0055 0.1794 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0055 0.1794 0.2069
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.1794 0.1794
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.5967 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Echinococcus multilocularis g protein coupled receptor 0.0055 0.1794 0.1794
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Schistosoma mansoni amine GPCR 0.0055 0.1794 0.1794
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0055 0.1794 0.2069
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.1794 0.1794
Schistosoma mansoni amine GPCR 0.0055 0.1794 0.1794
Loa Loa (eye worm) hypothetical protein 0.0075 0.29 0.3346
Brugia malayi phosphofructokinase 0.0131 0.5967 0.6884
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0027 0.0234 0.0234
Brugia malayi hypothetical protein 0.0055 0.1794 0.2069
Echinococcus granulosus g protein coupled receptor 0.0055 0.1794 0.1794
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.1794 0.1794
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0055 0.1794 0.1794
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0055 0.1794 0.5
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0701 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.1794 0.1794
Echinococcus granulosus hypothetical protein 0.0055 0.1794 0.1794
Schistosoma mansoni hypothetical protein 0.0205 1 1
Onchocerca volvulus 0.0055 0.1794 0.5
Brugia malayi GnHR receptor homolog 0.0055 0.1794 0.2069
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.1794 0.1794
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0055 0.1794 0.1794
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0701 0.1175
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.1794 0.1794
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.1794 0.1794
Brugia malayi sulfakinin receptor protein 0.0055 0.1794 0.2069
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.1794 0.1794
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.1794 0.1794
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.1794 0.1794
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0055 0.1794 0.1794
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.1794 0.1794
Brugia malayi Tachykinin-like peptides receptor 99D 0.0055 0.1794 0.2069
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0055 0.1794 0.1794
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.0701 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.1794 0.1794
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0131 0.5967 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0701 1
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.1794 0.2069
Brugia malayi hypothetical protein 0.0055 0.1794 0.2069
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.1794 0.1794
Brugia malayi hypothetical protein 0.0055 0.1794 0.2069
Schistosoma mansoni histamine h1 receptor 0.0055 0.1794 0.1794
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.5967 1
Schistosoma mansoni hypothetical protein 0.0055 0.1794 0.1794
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0701 0.1175
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0055 0.1794 0.1794
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Echinococcus multilocularis carboxylesterase 5A 0.0075 0.29 0.29
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.1794 0.1794
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0035 0.0701 0.1175
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Onchocerca volvulus 0.0055 0.1794 0.5
Echinococcus granulosus arachidonate 5 lipoxygenase 0.012 0.5357 0.5357
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.5967 0.6884
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.1794 0.1794
Schistosoma mansoni neuropeptide receptor 0.0055 0.1794 0.1794
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0055 0.1794 0.1794
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.1794 0.1794
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Brugia malayi Carboxylesterase family protein 0.0075 0.29 0.3346
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.1794 0.1794
Echinococcus multilocularis G-protein coupled receptor, putative 0.0055 0.1794 0.1794
Brugia malayi Melatonin receptor type 1A 0.0055 0.1794 0.2069
Schistosoma mansoni myosin xvIII 0.0055 0.1794 0.1794
Loa Loa (eye worm) hypothetical protein 0.018 0.8668 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.1794 0.1794
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.1794 0.1794
Onchocerca volvulus 0.0055 0.1794 0.5
Schistosoma mansoni amine GPCR 0.0055 0.1794 0.1794
Schistosoma mansoni lipoxygenase 0.0084 0.337 0.337
Echinococcus granulosus 7tm_1 domain containing protein 0.0055 0.1794 0.1794
Echinococcus multilocularis serotonin receptor 0.0055 0.1794 0.1794
Schistosoma mansoni biogenic amine receptor 0.0055 0.1794 0.1794
Echinococcus granulosus 7TM GPCR rhodopsin 0.0055 0.1794 0.1794
Schistosoma mansoni hypothetical protein 0.0055 0.1794 0.1794
Echinococcus granulosus g protein coupled receptor 0.0055 0.1794 0.1794
Echinococcus granulosus somatostatin receptor 0.0055 0.1794 0.1794
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.1794 0.1794
Onchocerca volvulus 0.0055 0.1794 0.5
Onchocerca volvulus 0.0055 0.1794 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Echinococcus multilocularis acetylcholinesterase 0.0075 0.29 0.29
Loa Loa (eye worm) carboxylesterase 0.0075 0.29 0.3346
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0701 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.0701 1
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.5967 1
Onchocerca volvulus 0.0055 0.1794 0.5
Echinococcus granulosus nmda type glutamate receptor 0.0027 0.0234 0.0234
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.1794 0.1794
Echinococcus multilocularis g-protein coupled receptor 0.0055 0.1794 0.1794
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Brugia malayi neuropeptide F receptor 0.0055 0.1794 0.2069
Brugia malayi hypothetical protein 0.0055 0.1794 0.2069
Schistosoma mansoni growth hormone secretagogue receptor 0.0055 0.1794 0.1794
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0055 0.1794 0.2069
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.1794 0.1794
Echinococcus multilocularis acetylcholinesterase 0.0075 0.29 0.29
Brugia malayi G-protein coupled receptor 0.0055 0.1794 0.2069
Brugia malayi hypothetical protein 0.0055 0.1794 0.2069
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.1794 0.2069
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Onchocerca volvulus 0.0055 0.1794 0.5
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0075 0.29 0.29
Echinococcus multilocularis dro:myosuppressin receptor 0.0055 0.1794 0.1794
Onchocerca volvulus 0.0055 0.1794 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.5967 1
Echinococcus granulosus dro:myosuppressin receptor 0.0055 0.1794 0.1794
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.1794 0.1794
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.5967 1
Echinococcus multilocularis fmrfamide receptor 0.0055 0.1794 0.1794
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Echinococcus multilocularis neuropeptide FF receptor 2 0.0055 0.1794 0.1794
Mycobacterium ulcerans 6-phosphofructokinase 0.0131 0.5967 1
Echinococcus multilocularis neuropeptide receptor 0.0055 0.1794 0.1794
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0055 0.1794 0.1794
Echinococcus granulosus serotonin receptor 0.0055 0.1794 0.1794
Echinococcus multilocularis fmrfamide receptor 0.0055 0.1794 0.1794
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.1794 0.1794
Onchocerca volvulus 0.0055 0.1794 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.0055 0.1794 0.1794
Echinococcus multilocularis G protein coupled receptor 139 0.0055 0.1794 0.1794
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0055 0.1794 0.1794
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.1794 0.1794
Brugia malayi Serotonin receptor 0.0055 0.1794 0.2069
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Echinococcus multilocularis 6 phosphofructokinase 0.0131 0.5967 0.5967
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0701 0.1175
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0131 0.5967 0.5
Echinococcus granulosus orexin receptor type 2 0.0055 0.1794 0.1794
Brugia malayi putative neuropeptide receptor 0.0055 0.1794 0.2069
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0055 0.1794 0.2069
Echinococcus multilocularis nmda type glutamate receptor 0.0027 0.0234 0.0234
Brugia malayi hypothetical protein 0.0055 0.1794 0.2069
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.1794 0.1794
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0701 0.1175
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Echinococcus granulosus sex peptide receptor 0.0055 0.1794 0.1794
Echinococcus multilocularis serotonin receptor 0.0055 0.1794 0.1794
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.1794 0.1794
Brugia malayi larval opioid receptor 0.0055 0.1794 0.2069
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.0701 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0055 0.1794 0.1794
Echinococcus granulosus alpha 1A adrenergic receptor 0.0055 0.1794 0.1794
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.1794 0.1794
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0055 0.1794 0.1794
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.1794 0.1794
Echinococcus granulosus allatostatin A receptor 0.0055 0.1794 0.1794
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.5967 0.5967
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0055 0.1794 0.1794
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.1794 0.1794
Echinococcus multilocularis somatostatin receptor 0.0055 0.1794 0.1794
Schistosoma mansoni biogenic amine receptor 0.0055 0.1794 0.1794
Loa Loa (eye worm) hypothetical protein 0.018 0.8668 1
Schistosoma mansoni amine GPCR 0.0055 0.1794 0.1794
Echinococcus granulosus acetylcholinesterase 0.0075 0.29 0.29
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.1794 0.1794
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0415 0.0479
Brugia malayi AKH receptor 0.0055 0.1794 0.2069
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.0701 0.1175
Schistosoma mansoni opsin-like receptor 0.0055 0.1794 0.1794
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Brugia malayi hypothetical protein 0.0055 0.1794 0.2069
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Onchocerca volvulus 0.0055 0.1794 0.5
Brugia malayi 6-phosphofructokinase 0.0131 0.5967 0.6884
Echinococcus multilocularis muscleblind protein 0.018 0.8668 0.8668
Echinococcus granulosus neuropeptide receptor 0.0055 0.1794 0.1794
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0055 0.1794 0.2069
Echinococcus multilocularis sex peptide receptor 0.0055 0.1794 0.1794
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Schistosoma mansoni adenoreceptor 0.0055 0.1794 0.1794
Schistosoma mansoni alpha-1 adrenergic receptor 0.0055 0.1794 0.1794
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Schistosoma mansoni neuropeptide receptor 0.0055 0.1794 0.1794
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Onchocerca volvulus 0.0055 0.1794 0.5
Schistosoma mansoni hypothetical protein 0.0205 1 1
Onchocerca volvulus 0.0055 0.1794 0.5
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0055 0.1794 0.1794
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.5967 1
Schistosoma mansoni hypothetical protein 0.0055 0.1794 0.1794
Echinococcus multilocularis geminin 0.0205 1 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0055 0.1794 0.1794
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Loa Loa (eye worm) hypothetical protein 0.0055 0.1794 0.2069
Brugia malayi follicle stimulating hormone receptor 0.0055 0.1794 0.2069
Brugia malayi G-protein coupled receptor 0.0055 0.1794 0.2069
Echinococcus multilocularis allatostatin A receptor 0.0055 0.1794 0.1794
Echinococcus multilocularis g protein coupled receptor 0.0055 0.1794 0.1794
Brugia malayi putative neuropeptide receptor NPR1 0.0055 0.1794 0.2069
Brugia malayi Serotonin receptor 0.0055 0.1794 0.2069
Brugia malayi RE15519p 0.0055 0.1794 0.2069
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.1794 0.1794
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0055 0.1794 0.2069
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.5967 1
Brugia malayi 6-phosphofructokinase 0.0131 0.5967 0.6884
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0055 0.1794 0.1794

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.122 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.8356 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 6.3096 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.4591 uM PUBCHEM_BIOASSAY: Tb PFK orthogonal confirmatory assay using ATP depletion (Kinase-Glo Plus) as an alternative measure of Tb PFK activity: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768] ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: Inhibitors of T. brucei phosphofructokinase: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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