Detailed information for compound 1339055

Basic information

Technical information
  • TDR Targets ID: 1339055
  • Name: 2-[(5-bromothiophen-2-yl)sulfonylamino]-N-(2- methoxyethyl)benzamide
  • MW: 419.314 | Formula: C14H15BrN2O4S2
  • H donors: 2 H acceptors: 3 LogP: 3.17 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCNC(=O)c1ccccc1NS(=O)(=O)c1ccc(s1)Br
  • InChi: 1S/C14H15BrN2O4S2/c1-21-9-8-16-14(18)10-4-2-3-5-11(10)17-23(19,20)13-7-6-12(15)22-13/h2-7,17H,8-9H2,1H3,(H,16,18)
  • InChiKey: IVFLTOSIHDAZJY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(5-bromo-2-thienyl)sulfonylamino]-N-(2-methoxyethyl)benzamide
  • SMR000136106
  • 2-{[(5-bromo-2-thienyl)sulfonyl]amino}-N-(2-methoxyethyl)benzamide
  • MLS000531128
  • ZINC02857497

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0031 0.0642 0.0642
Giardia lamblia Dynamin 0.0038 0.0875 0.5
Echinococcus granulosus glycine receptor subunit beta 0.0031 0.0642 0.1113
Schistosoma mansoni hypothetical protein 0.0017 0.0152 0.0263
Loa Loa (eye worm) hypothetical protein 0.0031 0.0642 0.0642
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0031 0.0642 0.0642
Mycobacterium tuberculosis Hypothetical protein 0.007 0.1981 0.4188
Echinococcus granulosus glycine receptor subunit alpha 1 0.0031 0.0642 0.1113
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1203 0.2086
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0067
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1624 0.1624
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0014 0.007 0.007
Mycobacterium ulcerans carboxylesterase, LipT 0.0015 0.0087 0.0037
Echinococcus multilocularis GPCR, family 2 0.0019 0.0223 0.0386
Echinococcus multilocularis dynamin 1 0.0041 0.0975 0.1692
Brugia malayi hypothetical protein 0.0014 0.0067 0.0067
Onchocerca volvulus 0.0014 0.0067 0.0111
Toxoplasma gondii dynamin-related protein DRPA 0.0038 0.0875 0.0708
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0223 0.0386
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0088 0.2609 0.4526
Echinococcus multilocularis dynamin 0.0038 0.0875 0.1518
Loa Loa (eye worm) acetylcholine receptor protein 0.0014 0.0067 0.0067
Brugia malayi hypothetical protein 0.0014 0.0067 0.0067
Trichomonas vaginalis mgm1, putative 0.0038 0.0875 0.416
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0097 0.2901 0.5031
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0223 0.0386
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0031 0.0642 0.0642
Schistosoma mansoni tyrosine kinase 0.0097 0.2901 0.5031
Loa Loa (eye worm) hypothetical protein 0.0031 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0067
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0223 0.0386
Brugia malayi Carboxylesterase family protein 0.0015 0.0087 0.0087
Schistosoma mansoni acetylcholine receptor subunit beta 0.0014 0.0067 0.0115
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0067
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0017 0.0149 0.0259
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0015 0.0087 0.0151
Brugia malayi Carboxylesterase family protein 0.0015 0.0087 0.0087
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0031 0.0642 0.1113
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0642 0.0642
Schistosoma mansoni nAChR subunit 0.0031 0.0642 0.1113
Onchocerca volvulus 0.0102 0.3066 0.5109
Brugia malayi thymidylate synthase 0.0147 0.4635 0.4635
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.0642 0.0642
Brugia malayi hypothetical protein 0.0014 0.0067 0.0067
Onchocerca volvulus 0.0017 0.0149 0.0249
Loa Loa (eye worm) hypothetical protein 0.0041 0.0975 0.0975
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0014 0.0067 0.0115
Loa Loa (eye worm) hypothetical protein 0.0031 0.0642 0.0642
Echinococcus granulosus acetylcholinesterase 0.0088 0.2609 0.4526
Brugia malayi Matrixin family protein 0.0029 0.0559 0.0559
Loa Loa (eye worm) hypothetical protein 0.0017 0.0149 0.0149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1203 0.2086
Schistosoma mansoni tyrosine kinase 0.0097 0.2901 0.5031
Loa Loa (eye worm) carboxylesterase 0.0015 0.0087 0.0087
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0031 0.0642 0.0642
Loa Loa (eye worm) TK/EGFR protein kinase 0.018 0.5766 0.5766
Echinococcus multilocularis BC026374 protein (S09 family) 0.0015 0.0087 0.0151
Echinococcus multilocularis carboxylesterase 5A 0.0088 0.2609 0.4526
Echinococcus granulosus dynamin 1 0.0041 0.0975 0.1692
Echinococcus granulosus dihydrofolate reductase 0.006 0.1638 0.284
Loa Loa (eye worm) hypothetical protein 0.0017 0.0149 0.0149
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0014 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0031 0.0642 0.0642
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0031 0.0642 0.1113
Schistosoma mansoni tyrosine kinase 0.018 0.5766 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0031 0.0642 0.1113
Schistosoma mansoni tyrosine kinase 0.0096 0.2866 0.497
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0031 0.0642 0.1113
Echinococcus multilocularis thymidylate synthase 0.0147 0.4635 0.8038
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0208 0.6698 1
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0028 0.0541 0.0939
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0014 0.0067 0.0115
Echinococcus granulosus neuroligin 0.0015 0.0087 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.007 0.1981 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0642 0.0642
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0031 0.0642 0.1113
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0014 0.0067 0.0115
Loa Loa (eye worm) hypothetical protein 0.0031 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0031 0.0642 0.0642
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0208 0.6698 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.1203 0.1203
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0067
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0642 0.0642
Schistosoma mansoni acetylcholinesterase 0.0015 0.0087 0.0151
Brugia malayi Cation transporter family protein 0.0031 0.0642 0.0642
Onchocerca volvulus 0.0014 0.0067 0.0111
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0642 0.0642
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0015 0.0087 0.0037
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0031 0.0642 0.1113
Schistosoma mansoni tyrosine kinase 0.0096 0.2866 0.497
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1624 0.1624
Schistosoma mansoni hypothetical protein 0.0019 0.0223 0.0386
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.006 0.1638 0.3434
Brugia malayi Dynamin 0.0041 0.0975 0.0975
Echinococcus granulosus GPCR family 2 0.0019 0.0223 0.0386
Echinococcus multilocularis nAChR subunit 0.0017 0.0149 0.0259
Schistosoma mansoni neuroligin 3 (S09 family) 0.0015 0.0087 0.0151
Echinococcus multilocularis neuroligin 0.0015 0.0087 0.0151
Echinococcus multilocularis acetylcholinesterase 0.0088 0.2609 0.4526
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0187 0.6003 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0087 0.0087
Schistosoma mansoni tyrosine kinase 0.0058 0.1553 0.2693
Entamoeba histolytica dynamin-like protein 0.0038 0.0875 1
Brugia malayi Cation transporter family protein 0.0031 0.0642 0.0642
Echinococcus granulosus carboxylesterase 5A 0.0088 0.2609 0.4526
Brugia malayi Carboxylesterase family protein 0.0088 0.2609 0.2609
Schistosoma mansoni hypothetical protein 0.0041 0.0975 0.1691
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0031 0.0642 0.1113
Schistosoma mansoni dynamin 0.0038 0.0875 0.1518
Onchocerca volvulus Matrilysin homolog 0.0026 0.0477 0.0795
Brugia malayi Dynamin 0.0041 0.0975 0.0975
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0014 0.0067 0.0067
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0031 0.0642 0.1113
Loa Loa (eye worm) hypothetical protein 0.0017 0.0149 0.0149
Echinococcus multilocularis dynamin 1 protein 0.0038 0.0875 0.1518
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1203 0.2086
Onchocerca volvulus 0.0015 0.0087 0.0145
Loa Loa (eye worm) hypothetical protein 0.0031 0.0642 0.0642
Schistosoma mansoni nAChR subunit 0.0031 0.0642 0.1113
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0031 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.006 0.1624 0.1624
Loa Loa (eye worm) acetylcholinesterase 1 0.0088 0.2609 0.2609
Loa Loa (eye worm) thymidylate synthase 0.0147 0.4635 0.4635
Loa Loa (eye worm) hypothetical protein 0.0017 0.0149 0.0149
Echinococcus multilocularis insulin receptor 0.0058 0.1553 0.2693
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0019 0.0223 0.0386
Brugia malayi sulfakinin receptor protein 0.0304 1 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.2574 0.2574
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.1203 0.1203
Echinococcus granulosus glycine receptor subunit beta 0.0031 0.0642 0.1113
Schistosoma mansoni dynamin 0.0041 0.0975 0.1692
Trichomonas vaginalis interferon-induced GTP-binding protein mx, putative 0.0038 0.0875 0.416
Echinococcus granulosus para nitrobenzyl esterase 0.0015 0.0087 0.0151
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0147 0.4635 1
Echinococcus multilocularis glycine receptor subunit beta 0.0031 0.0642 0.1113
Echinococcus granulosus epidermal growth factor receptor 0.018 0.5766 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0031 0.0642 0.1113
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0014 0.0067 0.0115
Echinococcus multilocularis dihydrofolate reductase 0.006 0.1638 0.284
Echinococcus multilocularis epidermal growth factor receptor 0.0097 0.2901 0.5031
Loa Loa (eye worm) hypothetical protein 0.0014 0.007 0.007
Onchocerca volvulus 0.0014 0.0067 0.0111
Brugia malayi hypothetical protein 0.0014 0.0067 0.0067
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0147 0.4635 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0223 0.0223
Schistosoma mansoni hypothetical protein 0.0019 0.0223 0.0386
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0067 0.0067
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0015 0.0087 0.0151
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0017 0.0149 0.0259
Loa Loa (eye worm) hypothetical protein 0.0031 0.0642 0.0642
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0014 0.0067 0.0067
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0031 0.0642 0.1113
Echinococcus granulosus nAChR subunit 0.0017 0.0149 0.0259
Trichomonas vaginalis dynamin, putative 0.0038 0.0875 0.416
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0014 0.0067 0.0115
Loa Loa (eye worm) hypothetical protein 0.0031 0.0642 0.0642
Onchocerca volvulus 0.0031 0.0642 0.1069
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.006 0.1638 0.3434
Chlamydia trachomatis dihydrofolate reductase 0.006 0.1638 0.5
Onchocerca volvulus 0.0015 0.0087 0.0145
Loa Loa (eye worm) hypothetical protein 0.0015 0.0087 0.0087
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0223 0.0223
Brugia malayi hypothetical protein 0.0014 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0017 0.0149 0.0149
Loa Loa (eye worm) transcription factor SMAD2 0.0143 0.4483 0.4483
Schistosoma mansoni nAChR subunit 0.0031 0.0642 0.1113
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0031 0.0642 0.1113
Brugia malayi Dynamin central region family protein 0.0038 0.0875 0.0875
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0642 0.0642
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0102 0.3066 0.5319
Schistosoma mansoni BC026374 protein (S09 family) 0.0015 0.0087 0.0151
Echinococcus multilocularis nAChR subunit 0.0031 0.0642 0.1113
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.0642 0.0642
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0067 0.0067
Echinococcus granulosus dynamin 1 protein 0.0038 0.0875 0.1518
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0017 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0015 0.0087 0.0087
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0031 0.0642 0.1113
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0031 0.0642 0.1113
Trichomonas vaginalis dynamin, putative 0.0038 0.0875 0.416
Loa Loa (eye worm) hypothetical protein 0.0304 1 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0017 0.0149 0.0259
Schistosoma mansoni acetylcholine receptor-related 0.0014 0.0067 0.0115
Brugia malayi Hemopexin family protein 0.0017 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0067
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0017 0.0149 0.0149
Echinococcus granulosus thymidylate synthase 0.0147 0.4635 0.8038
Echinococcus multilocularis glycine receptor subunit beta 0.0031 0.0642 0.1113
Loa Loa (eye worm) hypothetical protein 0.0102 0.3066 0.3066
Trichomonas vaginalis dynamin, putative 0.0038 0.0875 0.416
Trichomonas vaginalis dynamin, putative 0.0038 0.0875 0.416
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0031 0.0642 0.0642
Onchocerca volvulus 0.0147 0.4635 0.7721
Onchocerca volvulus 0.0015 0.0087 0.0145
Echinococcus granulosus nAChR subunit 0.0031 0.0642 0.1113
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0017 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0067
Brugia malayi hypothetical protein 0.0015 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0067
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1203 0.2086
Loa Loa (eye worm) DRP-1 protein 0.0038 0.0875 0.0875
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0975 0.0975
Schistosoma mansoni gliotactin 0.0015 0.0087 0.0151
Echinococcus granulosus BC026374 protein S09 family 0.0015 0.0087 0.0151
Loa Loa (eye worm) hypothetical protein 0.0031 0.0642 0.0642
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0031 0.0642 0.1113
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0147 0.4635 0.8038
Loa Loa (eye worm) ACC-1 protein 0.0031 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0019 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0187 0.6003 0.6003
Loa Loa (eye worm) MH2 domain-containing protein 0.0143 0.4483 0.4483
Loa Loa (eye worm) dihydrofolate reductase 0.006 0.1638 0.1638
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0642 0.0642
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0031 0.0642 0.0642
Schistosoma mansoni nAChR subunit 0.0014 0.0067 0.0115
Schistosoma mansoni nAChR subunit 0.0031 0.0642 0.1113
Echinococcus multilocularis epidermal growth factor receptor 0.018 0.5766 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0067
Schistosoma mansoni nAChR subunit 0.0031 0.0642 0.1113
Loa Loa (eye worm) hypothetical protein 0.0088 0.2609 0.2609
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0031 0.0642 0.0642
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0031 0.0642 0.1113
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0208 0.6698 1
Schistosoma mansoni hypothetical protein 0.0019 0.0223 0.0386
Brugia malayi dihydrofolate reductase family protein 0.006 0.1638 0.1638
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.0642 0.0642
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0031 0.0642 0.1113
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0031 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0015 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0031 0.0642 0.0642
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1203 0.2086
Onchocerca volvulus 0.0031 0.0642 0.1069
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0031 0.0642 0.0642
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0208 0.6698 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0067
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0031 0.0642 0.0642
Brugia malayi Dihydrofolate reductase 0.006 0.1638 0.1638
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0031 0.0642 0.0642
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0017 0.0149 0.0149
Onchocerca volvulus Matrix metalloproteinase homolog 0.0026 0.0477 0.0795
Echinococcus granulosus dynamin 0.0038 0.0875 0.1518
Trichomonas vaginalis dynamin, putative 0.0038 0.0875 0.416
Onchocerca volvulus 0.0102 0.3066 0.5109
Onchocerca volvulus 0.0102 0.3066 0.5109
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0015 0.0087 0.0151
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0058 0.1553 0.2693
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0067
Schistosoma mansoni tyrosine kinase 0.0058 0.1553 0.2693
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.007 0.1981 0.19
Loa Loa (eye worm) hypothetical protein 0.0015 0.0087 0.0087
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0058 0.1553 0.2693
Onchocerca volvulus Putative nachr subunit 0.0031 0.0642 0.1069
Loa Loa (eye worm) hypothetical protein 0.0015 0.0087 0.0087
Entamoeba histolytica dynamin-1-like protein, putative 0.0038 0.0875 1
Loa Loa (eye worm) LGC-31 protein 0.0031 0.0642 0.0642
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0102 0.3066 0.5319
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0014 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0102 0.3066 0.3066
Trichomonas vaginalis dynamin, putative 0.0038 0.0875 0.416
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0067
Schistosoma mansoni neurotransmitter gated ion channel 0.0014 0.0067 0.0115
Brugia malayi Carboxylesterase family protein 0.0088 0.2609 0.2609
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0015 0.0087 0.0037
Brugia malayi Carboxylesterase family protein 0.0015 0.0087 0.0087
Echinococcus granulosus insulin receptor 0.0058 0.1553 0.2693
Brugia malayi Carboxylesterase family protein 0.0015 0.0087 0.0087
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.006 0.1638 0.3434
Schistosoma mansoni tyrosine kinase 0.0096 0.2866 0.497
Loa Loa (eye worm) carboxylesterase 0.0015 0.0087 0.0087
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0043 0.1055 0.183
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1203 0.2086
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0067 0.0067
Onchocerca volvulus 0.0017 0.0152 0.0252
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0208 0.6698 1
Loa Loa (eye worm) matrixin family protein 0.0029 0.0559 0.0559
Echinococcus granulosus epidermal growth factor receptor 0.0097 0.2901 0.5031
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0031 0.0642 0.1113
Loa Loa (eye worm) hypothetical protein 0.0017 0.0149 0.0149
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0223 0.0386
Brugia malayi Cation transporter family protein 0.0102 0.3066 0.3066
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0043 0.1055 0.183
Onchocerca volvulus 0.0015 0.0087 0.0145
Loa Loa (eye worm) hypothetical protein 0.0041 0.0975 0.0975
Echinococcus multilocularis 0.0056 0.149 0.2585
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0067
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0031 0.0642 0.0642
Loa Loa (eye worm) GABA receptor subunit 0.0017 0.0149 0.0149
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0031 0.0642 0.1113
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0031 0.0642 0.1113
Brugia malayi Protein kinase domain containing protein 0.0058 0.1553 0.1553
Loa Loa (eye worm) hypothetical protein 0.0031 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0017 0.0149 0.0149
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0015 0.0087 0.0151
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0031 0.0642 0.1113
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0031 0.0642 0.1113
Schistosoma mansoni dihydrofolate reductase 0.006 0.1638 0.284
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0067
Onchocerca volvulus 0.0017 0.0149 0.0249
Loa Loa (eye worm) hypothetical protein 0.0031 0.0642 0.0642
Onchocerca volvulus 0.0031 0.0642 0.1069
Schistosoma mansoni dynamin 0.0041 0.0975 0.1692
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0642 0.0642
Brugia malayi Furin-like cysteine rich region family protein 0.018 0.5766 0.5766
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0031 0.0642 0.0642
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0031 0.0642 0.1113
Mycobacterium tuberculosis Carboxylesterase LipT 0.0015 0.0087 0.0037
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1203 0.2086
Echinococcus multilocularis acetylcholinesterase 0.0088 0.2609 0.4526
Loa Loa (eye worm) hypothetical protein 0.0015 0.0087 0.0087
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0208 0.6698 1
Mycobacterium ulcerans thymidylate synthase 0.0147 0.4635 1
Schistosoma mansoni nAChR subunit 0.0031 0.0642 0.1113
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0014 0.0067 0.0067
Onchocerca volvulus 0.0015 0.0087 0.0145
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0031 0.0642 0.1113
Loa Loa (eye worm) hypothetical protein 0.0031 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0088 0.2609 0.2609
Loa Loa (eye worm) hypothetical protein 0.0017 0.0149 0.0149
Schistosoma mansoni neurotransmitter gated ion channel 0.0014 0.0067 0.0115
Loa Loa (eye worm) TK/INSR protein kinase 0.0058 0.1553 0.1553
Loa Loa (eye worm) ACC-1 protein 0.0031 0.0642 0.0642
Echinococcus granulosus glycine receptor subunit alpha 1 0.0031 0.0642 0.1113
Brugia malayi hypothetical protein 0.007 0.1981 0.1981
Brugia malayi N-terminal motif family protein 0.0187 0.6003 0.6003
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1624 0.1624
Schistosoma mansoni nAChR subunit 0.0031 0.0642 0.1113
Loa Loa (eye worm) hypothetical protein 0.0031 0.0642 0.0642
Schistosoma mansoni nAChR subunit 0.0014 0.0067 0.0115
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0015 0.0087 0.0151
Brugia malayi MH2 domain containing protein 0.0143 0.4483 0.4483
Loa Loa (eye worm) matrixin family protein 0.0026 0.0477 0.0477
Echinococcus granulosus acetylcholinesterase 0.0088 0.2609 0.4526
Brugia malayi excitatory GABA receptor EXP-1A 0.0031 0.0642 0.0642
Loa Loa (eye worm) carboxylesterase 0.0088 0.2609 0.2609
Toxoplasma gondii dynamin-related protein DRPB 0.0038 0.0875 0.0708
Echinococcus multilocularis para nitrobenzyl esterase 0.0015 0.0087 0.0151

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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