Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hydroxyprostaglandin dehydrogenase 15-(NAD) | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific demethylase 4E | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxyprostaglandin dehydrogenase 15-(NAD) | 266 aa | 216 aa | 22.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lysine specific demethylase 6a | 0.0019 | 0.056 | 0.056 |
Brugia malayi | jmjC domain containing protein | 0.0019 | 0.056 | 0.0279 |
Echinococcus multilocularis | JmjC domain containing protein 4 | 0.0019 | 0.056 | 0.056 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.2925 | 0.2506 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.2925 | 0.2925 |
Echinococcus multilocularis | lamin | 0.0033 | 0.2925 | 0.2925 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2925 | 0.3047 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0071 | 0.96 | 0.96 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0071 | 0.96 | 0.96 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0071 | 0.96 | 0.96 |
Echinococcus multilocularis | jumonji domain containing 1A | 0.0019 | 0.056 | 0.056 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.2925 | 0.2506 |
Brugia malayi | jmjC domain containing protein | 0.0019 | 0.056 | 0.0279 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0071 | 0.96 | 1 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0019 | 0.056 | 0.5 |
Echinococcus multilocularis | phd:f box containing protein | 0.0019 | 0.056 | 0.056 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 1 | 1 |
Plasmodium vivax | JmjC domain containing protein | 0.0019 | 0.056 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.2925 | 0.3047 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0019 | 0.056 | 0.5 |
Echinococcus granulosus | JmjC domain containing protein 4 | 0.0019 | 0.056 | 0.056 |
Onchocerca volvulus | 0.0033 | 0.2925 | 0.5 | |
Echinococcus granulosus | jumonji domain containing 1A | 0.0019 | 0.056 | 0.056 |
Echinococcus multilocularis | lysine specific demethylase 6a | 0.0019 | 0.056 | 0.056 |
Brugia malayi | jmjC domain containing protein | 0.0071 | 0.96 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.2925 | 0.2925 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.2925 | 0.3047 |
Echinococcus granulosus | phd:f box containing protein | 0.0019 | 0.056 | 0.056 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.056 | 0.0583 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0071 | 0.96 | 0.9577 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.2925 | 0.2822 |
Brugia malayi | jmjC domain containing protein | 0.0019 | 0.056 | 0.0279 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Plasmodium falciparum | JmjC domain-containing protein, putative | 0.0019 | 0.056 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.056 | 0.0583 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.2925 | 0.2925 |
Echinococcus granulosus | lamin | 0.0033 | 0.2925 | 0.2925 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0019 | 0.056 | 0.0583 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.03 | 0.0313 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0019 | 0.056 | 0.056 |
Schistosoma mansoni | lamin | 0.0033 | 0.2925 | 0.2506 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0019 | 0.056 | 0.0583 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0071 | 0.96 | 0.96 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0019 | 0.056 | 0.0583 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0071 | 0.96 | 0.9577 |
Brugia malayi | jmjC domain containing protein | 0.0071 | 0.96 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0019 | 0.056 | 0.0279 |
Onchocerca volvulus | 0.0033 | 0.2925 | 0.5 | |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 1 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0071 | 0.96 | 0.9577 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.2925 | 0.2822 |
Trypanosoma brucei | JmjC domain, hydroxylase, putative | 0.0019 | 0.056 | 0.5 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0019 | 0.056 | 0.056 |
Echinococcus multilocularis | musashi | 0.0033 | 0.2925 | 0.2925 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.2821 | 0.2939 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.056 | 0.0583 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.1 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.