Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Brugia malayi | Muscleblind-like protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus multilocularis | muscleblind protein 1 | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus multilocularis | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0083 | 0.324 | 0.072 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0083 | 0.324 | 1 |
Schistosoma mansoni | chromobox protein | 0.0083 | 0.324 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0083 | 0.324 | 0.2731 |
Echinococcus granulosus | muscleblind protein | 0.018 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.005 | 0.0946 | 0.0969 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2715 | 0.2715 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.07 | 0.07 |
Trichomonas vaginalis | chromobox protein, putative | 0.0083 | 0.324 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2715 | 0.2167 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.07 | 0.7399 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2715 | 0.2167 |
Schistosoma mansoni | chromobox protein | 0.0083 | 0.324 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.005 | 0.0946 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2715 | 0.2715 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2715 | 0.2167 |
Echinococcus granulosus | chromobox protein 1 | 0.0083 | 0.324 | 0.072 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 1 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0083 | 0.324 | 0.072 |
Trichomonas vaginalis | chromobox protein, putative | 0.005 | 0.0946 | 0.0969 |
Echinococcus multilocularis | chromobox protein 1 | 0.0083 | 0.324 | 0.072 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0083 | 0.324 | 0.324 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2715 | 0.2715 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.73 ug ml-1 | Antileishmanial activity against promastigote form of Leishmania major after 72 hr by Neubauer counting analysis | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | 15.8489 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 30.1313 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Leishmania major | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.