Detailed information for compound 1340133

Basic information

Technical information
  • TDR Targets ID: 1340133
  • Name: 2-[(4-fluorophenyl)sulfonylamino]-N-(oxolan-2 -ylmethyl)benzamide
  • MW: 378.418 | Formula: C18H19FN2O4S
  • H donors: 2 H acceptors: 3 LogP: 2.78 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)S(=O)(=O)Nc1ccccc1C(=O)NCC1CCCO1
  • InChi: 1S/C18H19FN2O4S/c19-13-7-9-15(10-8-13)26(23,24)21-17-6-2-1-5-16(17)18(22)20-12-14-4-3-11-25-14/h1-2,5-10,14,21H,3-4,11-12H2,(H,20,22)
  • InChiKey: FJDLISLMTRJPPZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4-fluorophenyl)sulfonylamino]-N-(tetrahydrofuran-2-ylmethyl)benzamide
  • 2-[(4-fluorophenyl)sulfonylamino]-N-(2-tetrahydrofuranylmethyl)benzamide
  • 2-[(4-fluorophenyl)sulfonylamino]-N-(tetrahydrofurfuryl)benzamide
  • T0505-4438

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi steroid hormone receptor vitamin D (1,25- dihydroxyvitamin D3) receptor 427 aa 416 aa 24.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0218 0.0235
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0869 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0218 0.1945
Loa Loa (eye worm) hypothetical protein 0.0012 0.0218 0.0235
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.027 0.2434
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0218 0.1945
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0218 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0218 0.0235
Schistosoma mansoni DNA helicase recq1 0.0012 0.021 0.1959
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.021 0.5
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.107 1
Plasmodium vivax SET domain protein, putative 0.0036 0.107 1
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0218 0.2039
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0335 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0218 0.2039
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0218 0.0235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0218 0.0235
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0218 0.2039
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.876 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0218 0.1945
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0218 0.2039
Loa Loa (eye worm) hypothetical protein 0.0012 0.0218 0.0235
Trichomonas vaginalis set domain proteins, putative 0.0286 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0218 0.0235
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0218 0.2039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.107 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.021 0.1959
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0218 0.1945
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.021 0.1865
Brugia malayi hypothetical protein 0.003 0.0869 0.098
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0218 0.1945
Leishmania major hypothetical protein, conserved 0.003 0.0869 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0869 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0218 0.0235
Brugia malayi Pre-SET motif family protein 0.0036 0.107 0.1209
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0218 0.0235
Schistosoma mansoni hypothetical protein 0.0014 0.027 0.2522
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0218 0.2039
Echinococcus granulosus bloom syndrome protein 0.0029 0.0818 0.7615
Brugia malayi Pre-SET motif family protein 0.0251 0.876 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0218 0.0235
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0218 0.1945
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0012 0.0116
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0218 0.2039
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0218 0.1945
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0869 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.107 1
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0218 0.1945
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0692 0.7309
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0869 0.6589
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0818 0.7615
Schistosoma mansoni DNA helicase recq5 0.0012 0.021 0.1959
Onchocerca volvulus 0.0036 0.107 0.0871
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0218 0.0235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0218 0.0235
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0218 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0218 0.0235
Schistosoma mansoni coup transcription factor 0.0012 0.0218 0.2039
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0869 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0218 0.0235
Brugia malayi ecdysteroid receptor 0.0012 0.0218 0.0235
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0218 0.1945
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0218 0.0235
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.1022 0.9552
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.107 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.021 0.0225
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.021 0.1865
Loa Loa (eye worm) hypothetical protein 0.0012 0.021 0.0225
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0218 0.1945
Loa Loa (eye worm) hypothetical protein 0.0012 0.0218 0.0235
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.021 0.1959
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0818 0.0499
Brugia malayi hypothetical protein 0.002 0.0484 0.0539
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0218 0.2039
Brugia malayi steroid hormone receptor 0.0012 0.0218 0.0235
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.107 1
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0218 0.1945
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0218 0.1945
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0818 0.0499
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0218 0.1945
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.021 0.1865
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0869 1
Brugia malayi nuclear hormone receptor 0.0012 0.0218 0.0235
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0474 0.4431
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0218 0.1945
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.021 0.0225
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.107 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0218 0.0235
Loa Loa (eye worm) hypothetical protein 0.0012 0.0218 0.0235
Loa Loa (eye worm) hypothetical protein 0.0146 0.4995 0.5696
Loa Loa (eye worm) hypothetical protein 0.003 0.0869 0.098
Loa Loa (eye worm) hypothetical protein 0.0012 0.0218 0.0235
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0218 0.0235
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0218 0.0235
Loa Loa (eye worm) RecQ helicase 0.0029 0.0818 0.0921
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.107 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.06 0.5606
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0218 0.0235
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0218 0.1945
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0218 0.1945
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0218 0.0235
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.021 0.0225
Loa Loa (eye worm) hypothetical protein 0.0012 0.0218 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0218 0.0235
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0218 0.0235
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0218 0.2039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0218 0.0235
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0218 0.2039
Loa Loa (eye worm) hypothetical protein 0.0036 0.107 0.1209
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0869 0.8127
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0218 0.2039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0218 0.0235
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0218 0.2039
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0218 0.1945
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0818 0.0921
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.021 0.1865
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0218 0.1945
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0218 0.0235
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0012 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0218 0.0235
Brugia malayi nuclear receptor NHR-88 0.0012 0.0218 0.0235
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.027 0.2434
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.107 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3323 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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