TDR Targets

Basic information

Technical information

TDR Targets ID: 1340284
Name: N-[2-(phenoxy)cyclohexyl]benzenesulfonamide
MW: 331.429 | Formula: C18H21NO3S
H donors: 1 H acceptors: 2 LogP: 3.89 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=S(=O)(c1ccccc1)NC1CCCCC1Oc1ccccc1
InChi: 1S/C18H21NO3S/c20-23(21,16-11-5-2-6-12-16)19-17-13-7-8-14-18(17)22-15-9-3-1-4-10-15/h1-6,9-12,17-19H,7-8,13-14H2
InChiKey: MSPOMUWFJZWNBR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

Enamine_003055
Benzenesulfonamide, N-(2-phenoxycyclohexyl)-
A3637/0154342
MLS000416696
SMR000241679

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	thyroid hormone receptor, beta	Starlite/ChEMBL	No references
Homo sapiens	aldehyde dehydrogenase 1 family, member A1	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Aldehyde dehydrogenase X, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	expressed protein	Get druggable targets OG5_134830	All targets in OG5_134830
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	thyroid hormone receptor	Get druggable targets OG5_134830	All targets in OG5_134830
Leishmania braziliensis	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Neospora caninum	hypothetical protein	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania mexicana	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma japonicum	Aldehyde dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	Get druggable targets OG5_134830	All targets in OG5_134830
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania infantum	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma japonicum	Thyroid hormone receptor alpha, putative	Get druggable targets OG5_134830	All targets in OG5_134830
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Retinal dehydrogenase 1, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Toxoplasma gondii	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma japonicum	Thyroid hormone receptor alpha, putative	Get druggable targets OG5_134830	All targets in OG5_134830
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Leishmania donovani	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	thyroid hormone receptor	Get druggable targets OG5_134830	All targets in OG5_134830
Echinococcus multilocularis	thyroid hormone receptor alpha	Get druggable targets OG5_134830	All targets in OG5_134830

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	aldehyde dehydrogenase 1 family, member A1	501 aa	456 aa	33.3 %
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Brugia malayi	photoreceptor-specific nuclear receptor	thyroid hormone receptor, beta	461 aa	414 aa	24.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0152	0.6669	0.6669
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0014	0.0044	0.0044
Onchocerca volvulus		0.0024	0.0513	0.0471
Echinococcus granulosus	lamin	0.0027	0.067	0.067
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0513	0.034
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.6292	0.6292
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0221	1	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0014	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0044	0.0044
Trichomonas vaginalis	aldo-keto reductase, putative	0.0221	1	1
Echinococcus multilocularis	lamin dm0	0.0027	0.067	0.067
Entamoeba histolytica	aldose reductase, putative	0.0221	1	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0014	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0044	0.0044
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0513	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0044	0.0044
Echinococcus granulosus	aldo keto reductase	0.0221	1	1
Echinococcus granulosus	aldo keto reductase	0.0221	1	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0059	0.0059
Trichomonas vaginalis	aldo/keto reductase, putative	0.0221	1	1
Schistosoma mansoni	aldo-keto reductase	0.0221	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0221	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0221	1	1
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.067	0.067
Echinococcus multilocularis	plexin a4	0.004	0.1312	0.1312
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0152	0.6669	0.6669
Onchocerca volvulus		0.0064	0.2453	0.2419
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.003	0.0793	0.0793
Echinococcus granulosus	aldehyde reductase	0.0157	0.6923	0.6923
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0221	1	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.2893	0.2729
Brugia malayi	intermediate filament protein	0.0027	0.067	0.0628
Schistosoma mansoni	pol-related	0.0221	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0221	1	1
Schistosoma mansoni	coup transcription factor	0.003	0.0793	0.0752
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.003	0.0793	0.0793
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0221	1	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0069	0.0069
Echinococcus multilocularis	aldo keto reductase	0.0221	1	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0044	0.0044
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0016	0.0124	0.0124
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0513	0.0471
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0221	1	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.003	0.0793	0.0752
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0513	0.034
Echinococcus granulosus	semaphorin 1A	0.0014	0.0059	0.0059
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0793	0.0793
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0069	0.0025
Schistosoma mansoni	hypothetical protein	0.0152	0.6669	0.6654
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0513	0.0513
Trichomonas vaginalis	aldo-keto reductase, putative	0.0221	1	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0124	0.0124
Trichomonas vaginalis	aldo-keto reductase, putative	0.0221	1	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0.2893	0.2763
Schistosoma mansoni	steroid hormone receptor ad4bp	0.003	0.0793	0.0752
Schistosoma mansoni	hypothetical protein	0.0014	0.0059	0.0015
Onchocerca volvulus		0.0221	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0221	1	1
Onchocerca volvulus		0.0221	1	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.003	0.0793	0.0793
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0014	0.0044	0.0044
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0221	1	1
Mycobacterium tuberculosis	Conserved protein	0.0064	0.2453	0.2315
Plasmodium vivax	aldehyde reductase, putative	0.0064	0.2453	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0221	1	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.003	0.0793	0.0793
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.2893	0.2893
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0064	0.2453	0.2044
Loa Loa (eye worm)	hypothetical protein	0.003	0.0793	0.0793
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.003	0.0793	0.0752
Plasmodium falciparum	aldo-keto reductase, putative	0.0064	0.2453	1
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0513	0.0471
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0226	0.0226
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.003	0.0793	0.0752
Onchocerca volvulus		0.003	0.0793	0.0752
Echinococcus multilocularis	FTZ F1 alpha	0.003	0.0793	0.0793
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.6292	0.6292
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0226	0.0226
Schistosoma mansoni	hypothetical protein	0.002	0.0328	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0027	0.067	0.067
Schistosoma mansoni	intermediate filament proteins	0.0027	0.067	0.0628
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.003	0.0793	0.0793
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0124	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0221	1	1
Echinococcus multilocularis	aldo keto reductase	0.0221	1	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0793	0.0793
Echinococcus granulosus	hypothetical protein	0.0221	1	1
Onchocerca volvulus		0.0221	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.003	0.0793	0.0752
Trypanosoma brucei	prostaglandin f synthase	0.0221	1	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0226	0.0047
Trypanosoma cruzi	aldo-keto reductase	0.0221	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.003	0.0793	0.0752
Onchocerca volvulus	Protein ultraspiracle homolog	0.003	0.0793	0.0752
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.2893	0.2862
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0793	0.0793
Schistosoma mansoni	thyroid hormone receptor	0.0182	0.8086	0.8078
Trichomonas vaginalis	aldo/keto reductase, putative	0.0221	1	1
Loa Loa (eye worm)	oxidoreductase	0.0221	1	1
Brugia malayi	MH2 domain containing protein	0.0144	0.6292	0.6275
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.003	0.0793	0.0793
Giardia lamblia	Aldose reductase	0.0221	1	0.5
Giardia lamblia	Aldose reductase	0.0221	1	0.5
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0064	0.2453	0.2044
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.003	0.0793	0.0793
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0064	0.2453	0.2453
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.003	0.0793	0.0793
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.003	0.0793	0.0752
Schistosoma mansoni	hypothetical protein	0.0014	0.0059	0.0015
Schistosoma mansoni	lamin	0.0027	0.067	0.0628
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0221	1	1
Schistosoma mansoni	plexin	0.002	0.0328	0.0285
Loa Loa (eye worm)	DR-78	0.0014	0.0044	0.0044
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0221	1	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.067	0.067
Mycobacterium ulcerans	oxidoreductase	0.0221	1	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0646	0.0646
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.003	0.0793	0.0793
Trichomonas vaginalis	aldo-keto reductase, putative	0.0221	1	1
Schistosoma mansoni	plexin	0.0034	0.1012	0.0973
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0793	0.0793
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0064	0.2453	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.003	0.0793	0.0752
Leishmania major	aldo-keto reductase-like protein	0.0221	1	1
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0513	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0124	0.0124
Loa Loa (eye worm)	hypothetical protein	0.003	0.0793	0.0793
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.003	0.0793	0.0752
Loa Loa (eye worm)	hypothetical protein	0.002	0.0328	0.0328
Brugia malayi	Sema domain containing protein	0.0014	0.0059	0.0015
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.067	0.0628
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0124	0.0124
Mycobacterium ulcerans	hypothetical protein	0.0064	0.2453	0.2279
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0044	0.0044
Brugia malayi	Plexin repeat family protein	0.0034	0.1012	0.0973
Trichomonas vaginalis	aldo-keto reductase, putative	0.0221	1	1
Brugia malayi	hypothetical protein	0.0016	0.0124	0.0081
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.2893	0.2729
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0226	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.003	0.0793	0.0793
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0044	0.0044
Echinococcus granulosus	nuclear receptor nhr 48	0.0014	0.0044	0.0044
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0064	0.2453	0.2044
Loa Loa (eye worm)	hypothetical protein	0.003	0.0793	0.0793
Onchocerca volvulus		0.0034	0.1012	0.0973
Onchocerca volvulus		0.0027	0.067	0.0628
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.003	0.0793	0.0752
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0014	0.0044	0.0044
Entamoeba histolytica	aldose reductase, putative	0.0221	1	1
Echinococcus multilocularis	aldehyde reductase	0.0157	0.6923	0.6923
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0513	0.0294
Trichomonas vaginalis	aldo-keto reductase, putative	0.0221	1	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0221	1	1
Brugia malayi	Sema domain containing protein	0.0014	0.0059	0.0015
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0014	0.0044	0.0044
Schistosoma mansoni	RAR-like nuclear receptor	0.003	0.0793	0.0752
Echinococcus granulosus	ecdysone induced protein 78C	0.003	0.0793	0.0793
Plasmodium falciparum	aldehyde reductase, putative	0.0064	0.2453	1
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0016	0.0124	0.0124
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0014	0.0044	0.0044
Trichomonas vaginalis	aldo-keto reductase, putative	0.0221	1	1
Leishmania major	prostaglandin f synthase, putative	0.0221	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0221	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.003	0.0793	0.0752
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.003	0.0793	0.0793
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0513	0.0513
Schistosoma mansoni	aldo-keto reductase	0.0221	1	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0059	0.0059
Brugia malayi	nuclear hormone receptor	0.003	0.0793	0.0752
Onchocerca volvulus		0.0027	0.067	0.0628
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0226	0.0226
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.003	0.0793	0.0752
Trichomonas vaginalis	aldo-keto reductase, putative	0.0221	1	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.2893	0.2729
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0221	1	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.003	0.0793	0.0793
Brugia malayi	nuclear receptor NHR-88	0.003	0.0793	0.0752
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.003	0.0793	0.0752
Schistosoma mansoni	nuclear hormone receptor	0.003	0.0793	0.0752
Schistosoma mansoni	semaphorin 5-related	0.0014	0.0059	0.0015
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0221	1	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.003	0.0793	0.0793
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.2893	0.2508
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.003	0.0793	0.0752
Echinococcus granulosus	plexin a4	0.004	0.1312	0.1312
Loa Loa (eye worm)	plexin A	0.004	0.1312	0.1312
Loa Loa (eye worm)	oxidoreductase	0.0221	1	1
Schistosoma mansoni	hypothetical protein	0.0217	0.9775	0.9774
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0513	0.0294
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0064	0.2453	0.2419
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0059	0.0059
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0221	1	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.2893	0.0583
Entamoeba histolytica	aldose reductase, putative	0.0221	1	1
Echinococcus multilocularis	aldo keto reductase	0.0221	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0221	1	1
Schistosoma mansoni	hypothetical protein	0.0052	0.1858	0.1822
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0014	0.0044	0.0044
Loa Loa (eye worm)	oxidoreductase	0.0221	1	1
Onchocerca volvulus		0.0221	1	1
Echinococcus granulosus	aldo keto reductase	0.0221	1	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0044	0.0044
Echinococcus multilocularis	ecdysone induced protein 78C	0.003	0.0793	0.0793
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0182	0.8086	0.8086
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.003	0.0793	0.0793
Brugia malayi	hypothetical protein	0.0016	0.0124	0.0081
Onchocerca volvulus		0.0221	1	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0014	0.0044	0.0044
Brugia malayi	Nuclear hormone receptor-like 1	0.0016	0.0124	0.0081
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0064	0.2453	0.2453
Loa Loa (eye worm)	hypothetical protein	0.003	0.0793	0.0793
Schistosoma mansoni	potassium channel beta	0.0064	0.2453	0.2419
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0513	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0044	0.0044
Loa Loa (eye worm)	sema domain-containing protein	0.0014	0.0059	0.0059
Trypanosoma brucei	RNA helicase, putative	0.0217	0.9775	0.9701
Trichomonas vaginalis	aldo-keto reductase, putative	0.0221	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0182	0.8086	0.8078
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0513	0.0513
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0513	0.0294
Echinococcus multilocularis	hypothetical protein	0.0014	0.0059	0.0059
Echinococcus granulosus	FTZ F1 alpha	0.003	0.0793	0.0793
Echinococcus multilocularis	nuclear receptor nhr 48	0.0014	0.0044	0.0044
Brugia malayi	Nuclear hormone receptor-like 1	0.003	0.0793	0.0752
Schistosoma mansoni	retinoic acid receptor RXR	0.003	0.0793	0.0752
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.003	0.0793	0.0752
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.003	0.0793	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0226	0.0226
Onchocerca volvulus		0.0014	0.0059	0.0015
Brugia malayi	steroid hormone receptor	0.003	0.0793	0.0752
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.2893	0.2893
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.003	0.0793	0.0793
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0221	1	1
Brugia malayi	nuclear receptor RXR	0.0016	0.0124	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0044	0.0044
Brugia malayi	plexin A	0.004	0.1312	0.1274
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0016	0.0124	0.0081
Brugia malayi	NADH-dependent xylose reductase	0.0064	0.2453	0.2419
Echinococcus multilocularis	lamin	0.0027	0.067	0.067
Brugia malayi	Nuclear hormone receptor-like 1	0.0016	0.0124	0.0081
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0793	0.0793
Loa Loa (eye worm)	oxidoreductase	0.0221	1	1
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0221	1	1
Trypanosoma brucei	aldo-keto reductase, putative	0.0221	1	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.003	0.0793	0.0752
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.003	0.0793	0.0793
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0221	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0226	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0044	0.0044
Onchocerca volvulus		0.0221	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0014	0.0044	0.0044
Trichomonas vaginalis	aldo-keto reductase, putative	0.0221	1	1
Echinococcus granulosus	semaphorin 5B	0.0014	0.0059	0.0059
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.003	0.0793	0.0752
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0221	1	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0016	0.0124	0.0124
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0221	1	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0221	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0221	1	1
Echinococcus multilocularis	semaphorin 5B	0.0014	0.0059	0.0059
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.003	0.0793	0.0752
Mycobacterium leprae	Conserved hypothetical protein	0.0157	0.6923	0.6756
Loa Loa (eye worm)	steroid hormone receptor	0.003	0.0793	0.0793
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.003	0.0793	0.0752
Echinococcus multilocularis	musashi	0.0027	0.067	0.067
Echinococcus granulosus	thyroid hormone receptor alpha	0.0014	0.0044	0.0044
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0221	1	1
Schistosoma mansoni	lamin	0.0027	0.067	0.0628
Onchocerca volvulus	Bile acid receptor homolog	0.003	0.0793	0.0752
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0513	0.0294
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0014	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.003	0.0793	0.0793
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0513	0.0471
Brugia malayi	hypothetical protein	0.0014	0.0059	0.0015
Trichomonas vaginalis	aldo/keto reductase, putative	0.0221	1	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0221	1	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0513	0.0294
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.003	0.0793	0.0752
Trichomonas vaginalis	aldo-keto reductase, putative	0.0221	1	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1012	0.1012
Echinococcus granulosus	voltage gated potassium channel subunit	0.0064	0.2453	0.2453
Echinococcus multilocularis	aldo keto reductase	0.0221	1	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.003	0.0793	0.0793
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0221	1	1
Echinococcus granulosus	lamin dm0	0.0027	0.067	0.067
Loa Loa (eye worm)	oxidoreductase	0.0221	1	1
Mycobacterium leprae	Possible oxidoreductase	0.0064	0.2453	0.2044
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0064	0.2453	0.2453
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0014	0.0044	0.0044
Trypanosoma cruzi	aldo/keto reductase, putative	0.0221	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0221	1	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.003	0.0793	0.0793
Brugia malayi	Steroid receptor seven-up type 2	0.003	0.0793	0.0752
Echinococcus granulosus	intermediate filament protein	0.0027	0.067	0.067
Mycobacterium tuberculosis	Probable oxidoreductase	0.0221	1	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0016	0.0124	0.0081
Brugia malayi	hypothetical protein	0.0014	0.0059	0.0015
Toxoplasma gondii	aldose reductase, putative	0.0221	1	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.2893	0.2862
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0044	0.0044
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0221	1	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0124	0.0124
Brugia malayi	ecdysteroid receptor	0.003	0.0793	0.0752
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.003	0.0793	0.0752
Loa Loa (eye worm)	sema domain-containing protein	0.0014	0.0059	0.0059

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.0028 um	PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	2.8184 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	3.1623 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1484923

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1340284