Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.6655 | 0.6655 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0037 | 0.1885 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.6655 | 0.6655 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0037 | 0.1885 | 0.1885 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Loa Loa (eye worm) | CYP4Cod1 | 0.0037 | 0.1885 | 0.1885 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | TAR-binding protein | 0.0076 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.6655 | 0.6655 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Trypanosoma cruzi | cytochrome P450, putative | 0.0037 | 0.1885 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Leishmania major | cytochrome p450-like protein | 0.0037 | 0.1885 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0037 | 0.1885 | 0.1885 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.2745 | 0.2745 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2745 | 0.2745 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0037 | 0.1885 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.2745 | 0.2745 |
Brugia malayi | Cytochrome P450 family protein | 0.0037 | 0.1885 | 0.1885 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0037 | 0.1885 | 0.1885 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0028 | 0 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0037 | 0.1885 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.6655 | 0.6655 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.