Detailed information for compound 134097

Basic information

Technical information
  • TDR Targets ID: 134097
  • Name: methyl N-[(2S)-3-methyl-1-oxo-1-[(2S)-2-[[(3S )-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl]c arbamoyl]pyrrolidin-1-yl]butan-2-yl]carbamate
  • MW: 423.427 | Formula: C18H28F3N3O5
  • H donors: 2 H acceptors: 4 LogP: 2.94 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C)C(C)C
  • InChi: 1S/C18H28F3N3O5/c1-9(2)12(14(25)18(19,20)21)22-15(26)11-7-6-8-24(11)16(27)13(10(3)4)23-17(28)29-5/h9-13H,6-8H2,1-5H3,(H,22,26)(H,23,28)/t11-,12-,13-/m0/s1
  • InChiKey: ZYLBZJKJNAYAFU-AVGNSLFASA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • methyl N-[(1S)-2-methyl-1-[(2S)-2-[[(1S)-3,3,3-trifluoro-1-isopropyl-2-oxo-propyl]carbamoyl]pyrrolidine-1-carbonyl]propyl]carbamate
  • N-[(1S)-2-methyl-1-[oxo-[(2S)-2-[oxo-[[(1S)-3,3,3-trifluoro-1-isopropyl-2-oxopropyl]amino]methyl]-1-pyrrolidinyl]methyl]propyl]carbamic acid methyl ester
  • methyl N-[(2S)-3-methyl-1-oxo-1-[(2S)-2-[[(3S)-1,1,1-trifluoro-4-methyl-2-oxo-pentan-3-yl]carbamoyl]pyrrolidin-1-yl]butan-2-yl]carbamate
  • N-[(1S)-2-methyl-1-[(2S)-2-[[(1S)-3,3,3-trifluoro-1-isopropyl-2-keto-propyl]carbamoyl]pyrrolidine-1-carbonyl]propyl]carbamic acid methyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Elastase 2A Starlite/ChEMBL References
Homo sapiens chymotrypsin C (caldecrin) Starlite/ChEMBL References
Homo sapiens elastase, neutrophil expressed Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis glycoprotein Antigen 5 Elastase 2A   269 aa 310 aa 26.5 %
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Elastase 2A   269 aa 247 aa 36.0 %
Echinococcus granulosus Mastin Elastase 2A   269 aa 308 aa 27.6 %
Drosophila melanogaster CG30083 gene product from transcript CG30083-RB Elastase 2A   269 aa 265 aa 33.6 %
Drosophila melanogaster CG31267 gene product from transcript CG31267-RA Elastase 2A   269 aa 241 aa 28.6 %
Echinococcus granulosus transmembrane protease serine 3 elastase, neutrophil expressed 267 aa 236 aa 27.5 %
Drosophila melanogaster Spatzle-Processing Enzyme Elastase 2A   269 aa 265 aa 30.9 %
Drosophila melanogaster CG33458 gene product from transcript CG33458-RA Elastase 2A   269 aa 255 aa 31.4 %
Drosophila melanogaster CG4914 gene product from transcript CG4914-RA Elastase 2A   269 aa 244 aa 33.6 %
Onchocerca volvulus Elastase 2A   269 aa 257 aa 27.2 %
Schistosoma mansoni aminopeptidase PILS (M01 family) Elastase 2A   269 aa 314 aa 24.8 %
Onchocerca volvulus Elastase 2A   269 aa 237 aa 26.2 %
Drosophila melanogaster CG11313 gene product from transcript CG11313-RC Elastase 2A   269 aa 259 aa 30.5 %
Onchocerca volvulus Elastase 2A   269 aa 242 aa 23.6 %
Echinococcus granulosus enteropeptidase Elastase 2A   269 aa 287 aa 27.2 %
Drosophila melanogaster CG31326 gene product from transcript CG31326-RA Elastase 2A   269 aa 254 aa 29.9 %
Drosophila melanogaster CG5909 gene product from transcript CG5909-RA Elastase 2A   269 aa 272 aa 30.5 %
Drosophila melanogaster CG30287 gene product from transcript CG30287-RA Elastase 2A   269 aa 265 aa 30.9 %
Drosophila melanogaster CG18420 gene product from transcript CG18420-RA Elastase 2A   269 aa 255 aa 30.6 %
Onchocerca volvulus Elastase 2A   269 aa 260 aa 26.5 %
Drosophila melanogaster CG31220 gene product from transcript CG31220-RB Elastase 2A   269 aa 285 aa 30.2 %
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Elastase 2A   269 aa 248 aa 34.7 %
Echinococcus granulosus glycoprotein Antigen 5 Elastase 2A   269 aa 312 aa 25.6 %
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Elastase 2A   269 aa 259 aa 32.0 %
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) Elastase 2A   269 aa 314 aa 27.1 %
Loa Loa (eye worm) hypothetical protein Elastase 2A   269 aa 258 aa 25.6 %
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family Elastase 2A   269 aa 314 aa 27.1 %
Drosophila melanogaster CG13744 gene product from transcript CG13744-RA Elastase 2A   269 aa 287 aa 30.7 %
Drosophila melanogaster CG33465 gene product from transcript CG33465-RC Elastase 2A   269 aa 241 aa 22.0 %
Schistosoma japonicum ko:K09637 transmembrane protease, serine 6, putative Elastase 2A   269 aa 267 aa 31.8 %
Echinococcus multilocularis enteropeptidase Elastase 2A   269 aa 287 aa 26.8 %
Drosophila melanogaster CG34436 gene product from transcript CG34436-RA Elastase 2A   269 aa 222 aa 25.2 %
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Elastase 2A   269 aa 317 aa 27.1 %
Schistosoma japonicum Enteropeptidase, putative Elastase 2A   269 aa 271 aa 29.2 %
Brugia malayi hypothetical protein Elastase 2A   269 aa 234 aa 23.5 %
Brugia malayi Trypsin family protein Elastase 2A   269 aa 231 aa 23.8 %
Schistosoma japonicum ko:K01346 pancreatic elastase II [EC3.4.21.71], putative Elastase 2A   269 aa 306 aa 28.1 %
Echinococcus granulosus transmembrane protease serine 3 Elastase 2A   269 aa 236 aa 31.8 %
Brugia malayi Trypsin family protein Elastase 2A   269 aa 243 aa 24.7 %
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Elastase 2A   269 aa 248 aa 34.3 %
Echinococcus multilocularis Mastin Elastase 2A   269 aa 305 aa 29.2 %
Brugia malayi Trypsin family protein chymotrypsin C (caldecrin) 268 aa 236 aa 21.6 %
Drosophila melanogaster CG30288 gene product from transcript CG30288-RC Elastase 2A   269 aa 272 aa 31.6 %
Onchocerca volvulus Elastase 2A   269 aa 253 aa 24.5 %
Drosophila melanogaster Jonah 99Ci Elastase 2A   269 aa 240 aa 30.4 %
Drosophila melanogaster Jonah 65Aiii Elastase 2A   269 aa 280 aa 34.6 %
Drosophila melanogaster CG9733 gene product from transcript CG9733-RB Elastase 2A   269 aa 275 aa 32.0 %
Echinococcus multilocularis transmembrane protease serine 3 Elastase 2A   269 aa 236 aa 32.6 %
Drosophila melanogaster CG14990 gene product from transcript CG14990-RA Elastase 2A   269 aa 264 aa 28.8 %
Brugia malayi Trypsin family protein Elastase 2A   269 aa 257 aa 23.7 %
Drosophila melanogaster CG3505 gene product from transcript CG3505-RA Elastase 2A   269 aa 254 aa 29.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0243 0.1444 0.1912
Plasmodium vivax endoplasmin, putative 0.1195 0.7477 1
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.0844 0.1129
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0028 0.0012
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0028 0.0012
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0126 0.0145
Onchocerca volvulus 0.0025 0.006 0.0025
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0126 0.0145
Echinococcus granulosus snurportin 1 0.0312 0.188 0.2514
Echinococcus multilocularis heat shock protein 0.1195 0.7477 0.7477
Echinococcus granulosus adam 0.0032 0.0103 0.0138
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0126 0.0169
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0028 0.0012
Onchocerca volvulus 0.0036 0.0126 0.0114
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0028 0.0012
Trichomonas vaginalis endoplasmin, putative 0.0733 0.4548 0.6073
Schistosoma mansoni ap endonuclease 0.0019 0.0019 0.0025
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0951 0.5934 0.7918
Leishmania major hypothetical protein, conserved 0.0036 0.0126 0.0145
Brugia malayi beta-lactamase 0.0036 0.0126 0.0169
Echinococcus granulosus Mastin 0.0022 0.0042 0.0056
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0178 0.0238
Loa Loa (eye worm) hypothetical protein 0.0243 0.1444 0.1931
Trichomonas vaginalis heat shock protein, putative 0.0489 0.3005 0.4004
Trypanosoma brucei developmentally regulated phosphoprotein 0.0243 0.1444 0.1911
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0019 0.0019
Loa Loa (eye worm) thymidylate synthase 0.1193 0.747 0.999
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0243 0.1444 0.2409
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0056
Schistosoma mansoni importin beta-1 0.0029 0.0086 0.0115
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0087 0.045 0.0602
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0042 0.0056
Mycobacterium leprae Probable lipase LipE 0.0036 0.0126 0.0042
Mycobacterium leprae Probable two-component sensor kinase 0.0243 0.1444 0.1828
Trypanosoma brucei Heat shock protein 83, putative 0.1195 0.7477 1
Trypanosoma brucei heat shock protein 90, putative 0.1195 0.7477 1
Loa Loa (eye worm) hypothetical protein 0.0243 0.1444 0.1931
Echinococcus granulosus enteropeptidase 0.0022 0.0042 0.0056
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0243 0.1444 0.1912
Schistosoma mansoni heat shock protein 0.1195 0.7477 1
Plasmodium vivax heat shock protein 86, putative 0.1195 0.7477 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0051 0.0043
Echinococcus multilocularis thymidylate synthase 0.1193 0.747 0.747
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0087 0.045 0.0602
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0243 0.1444 0.1911
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0042 0.0056
Schistosoma mansoni heat shock protein 0.0489 0.3005 0.4019
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0028 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0126 0.0169
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0774 0.1035
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0042 0.0056
Echinococcus granulosus heat shock protein 90 0.0951 0.5934 0.7936
Entamoeba histolytica hypothetical protein 0.0076 0.0379 0.0484
Mycobacterium ulcerans hypothetical protein 0.0036 0.0126 0.0145
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0126 0.0042
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0273 0.0365
Brugia malayi hypothetical protein 0.0076 0.0379 0.0508
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0018 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0034 0.0115 0.0154
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0184 0.1065 0.1424
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0489 0.3005 0.3005
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0243 0.1444 0.1911
Toxoplasma gondii DNA topoisomerase 2, putative 0.0243 0.1444 0.1911
Trichomonas vaginalis heat shock protein, putative 0.0951 0.5934 0.7931
Schistosoma mansoni intermediate filament proteins 0.0054 0.0245 0.0328
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0037 0.0049
Plasmodium vivax heat shock protein, putative 0.0489 0.3005 0.4004
Brugia malayi Trypsin family protein 0.0022 0.0042 0.0056
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0245 0.0328
Echinococcus multilocularis endoplasmin 0.0951 0.5934 0.5934
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0028 0.0012
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0243 0.1444 0.1911
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0019 0.0025
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0243 0.1444 0.1912
Trypanosoma brucei heat shock protein, putative 0.1195 0.7477 1
Brugia malayi Matrixin family protein 0.0025 0.006 0.0081
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0031 0.0095 0.0103
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.1193 0.747 0.999
Brugia malayi heat shock protein 90 0.1195 0.7477 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0042 0.0056
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0056
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0243 0.1444 0.1828
Trypanosoma brucei DNA topoisomerase ii 0.0243 0.1444 0.1911
Echinococcus multilocularis lamin dm0 0.0054 0.0245 0.0245
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0215 0.0287
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0037 0.0049
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0019 0.0025
Entamoeba histolytica hypothetical protein 0.0024 0.0051 0.0043
Schistosoma mansoni hypothetical protein 0.0036 0.0127 0.017
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0126 0.0169
Leishmania major importin beta-1 subunit, putative 0.0024 0.0051 0.0043
Echinococcus granulosus disintegrin and metalloproteinase 0.0018 0.0017 0.0022
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.0818 0.1094
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0042 0.0042
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0243 0.1444 0.1911
Schistosoma mansoni dihydroceramide desaturase 0.0018 0.0017 0.0022
Schistosoma mansoni hypothetical protein 0.0312 0.188 0.2514
Leishmania major heat shock protein 83-1 0.1195 0.7477 1
Echinococcus multilocularis glycoprotein Antigen 5 0.0022 0.0042 0.0042
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0178 0.0214
Trichomonas vaginalis heat shock protein, putative 0.0951 0.5934 0.7931
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0042 0.0056
Brugia malayi hypothetical protein 0.0022 0.0042 0.0056
Brugia malayi Cytochrome P450 family protein 0.0024 0.0051 0.0068
Brugia malayi Disintegrin family protein 0.0018 0.0017 0.0022
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0037 0.0025
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0031 0.0095 0.0127
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0028 0.0012
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0243 0.1444 0.2409
Trichomonas vaginalis heat shock protein, putative 0.0733 0.4548 0.6073
Loa Loa (eye worm) heat shock protein 90 0.1195 0.7477 1
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.1193 0.747 0.999
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0086 0.0086
Echinococcus multilocularis heat shock protein 90 0.1195 0.7477 0.7477
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0951 0.5934 0.7931
Brugia malayi beta-lactamase family protein 0.0036 0.0126 0.0169
Leishmania major heat shock protein 83-1 0.1195 0.7477 1
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0086 0.009
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0178 0.0214
Echinococcus multilocularis enteropeptidase 0.0022 0.0042 0.0042
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0028 0.0012
Leishmania major heat shock protein 83-1 0.1195 0.7477 1
Trypanosoma cruzi heat shock protein, putative 0.0489 0.3005 0.4004
Echinococcus multilocularis snurportin 1 0.0312 0.188 0.188
Mycobacterium tuberculosis Conserved protein 0.0036 0.0126 0.0145
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0115 0.0631 0.0844
Brugia malayi RNA, U transporter 1 0.0083 0.0428 0.0572
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0215 0.0287
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0243 0.1444 0.1912
Schistosoma mansoni hypothetical protein 0.0052 0.0233 0.0312
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0243 0.1444 0.1912
Mycobacterium ulcerans beta-lactamase 0.0036 0.0126 0.0145
Onchocerca volvulus 0.0036 0.0126 0.0114
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0087 0.045 0.045
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0022 0.0042 0.0056
Leishmania major heat shock protein, putative 0.0489 0.3005 0.4004
Plasmodium falciparum DNA topoisomerase 2 0.0243 0.1444 0.1911
Trypanosoma cruzi heat shock protein 85, putative 0.1195 0.7477 1
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0092 0.0482 0.0482
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0126 0.0145
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0025 0.006 0.0081
Loa Loa (eye worm) matrixin family protein 0.0061 0.0287 0.0384
Leishmania major heat shock protein 83-1 0.1195 0.7477 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0028 0.0012
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0028 0.0012
Leishmania major mitochondrial DNA topoisomerase II 0.0243 0.1444 0.1911
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0273 0.0341
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0174 0.1007 0.1299
Mycobacterium ulcerans putative regultory protein 0.0243 0.1444 0.1912
Leishmania major heat shock protein 83-1 0.1195 0.7477 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0056
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0489 0.3005 0.3989
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0042 0.0056
Toxoplasma gondii heat shock protein 75, putative 0.0489 0.3005 0.4004
Treponema pallidum heat shock protein 90 0.0951 0.5934 1
Loa Loa (eye worm) matrix metalloproteinase 0.0025 0.006 0.0081
Echinococcus granulosus importin subunit beta 1 0.0029 0.0086 0.0115
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0243 0.1444 0.1887
Echinococcus multilocularis Mastin 0.0022 0.0042 0.0042
Echinococcus multilocularis adam 17 protease 0.0184 0.1065 0.1065
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0951 0.5934 0.7939
Loa Loa (eye worm) matrixin family protein 0.0056 0.0255 0.0341
Echinococcus multilocularis heat shock protein 90 0.0951 0.5934 0.5934
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.1193 0.747 1
Mycobacterium tuberculosis Conserved protein 0.0243 0.1444 0.1912
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0051 0.0043
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0018 0.0017 0.0022
Brugia malayi Probable DNA topoisomerase II 0.0243 0.1444 0.1931
Loa Loa (eye worm) hypothetical protein 0.0053 0.0239 0.032
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0243 0.1444 0.2409
Loa Loa (eye worm) endoplasmin 0.1195 0.7477 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0028 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0126 0.0169
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0243 0.1444 0.1931
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0028 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0568 0.3501 0.467
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0051 0.0068
Entamoeba histolytica heat shock protein 90, putative 0.1195 0.7477 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0056
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0951 0.5934 0.7936
Entamoeba histolytica DNA topoisomerase II, putative 0.0243 0.1444 0.1911
Echinococcus granulosus dna polymerase eta 0.002 0.0028 0.0037
Trypanosoma brucei unspecified product 0.002 0.0028 0.0012
Loa Loa (eye worm) hypothetical protein 0.0243 0.1444 0.1931
Trichomonas vaginalis heat shock protein, putative 0.1195 0.7477 1
Leishmania major heat shock protein 83-1 0.1195 0.7477 1
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0243 0.1444 0.1912
Mycobacterium ulcerans heat shock protein 90 0.0951 0.5934 0.7939
Leishmania major heat shock protein 83-1 0.1195 0.7477 1
Brugia malayi kinase, mitochondrial precursor 0.0243 0.1444 0.1931
Echinococcus granulosus heat shock protein 0.1195 0.7477 1
Schistosoma mansoni hypothetical protein 0.0022 0.0042 0.0056
Schistosoma mansoni hypothetical protein 0.0528 0.3247 0.4343
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0042 0.0056
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0243 0.1444 0.1912
Trichomonas vaginalis heat shock protein, putative 0.0951 0.5934 0.7931
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0067 0.0089
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0028 0.0012
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.1193 0.747 0.999
Loa Loa (eye worm) hypothetical protein 0.0036 0.0126 0.0169
Brugia malayi intermediate filament protein 0.0054 0.0245 0.0328
Brugia malayi N-terminal motif family protein 0.0174 0.1007 0.1346
Entamoeba histolytica Ran family GTPase 0.0022 0.0037 0.0025
Echinococcus multilocularis dna polymerase kappa 0.002 0.0028 0.0028
Mycobacterium tuberculosis Hypothetical protein 0.0568 0.3501 0.4674
Leishmania major DNA polymerase kappa, putative 0.002 0.0028 0.0012
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0178 0.0214
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0243 0.1444 0.1912
Giardia lamblia Heat shock protein HSP 90-alpha 0.0951 0.5934 0.7931
Chlamydia trachomatis DNA gyrase subunit B 0.0243 0.1444 0.5
Mycobacterium ulcerans thymidylate synthase 0.1193 0.747 1
Schistosoma mansoni heat shock protein 0.1195 0.7477 1
Plasmodium vivax importin-beta 2, putative 0.0029 0.0086 0.009
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0273 0.0341
Echinococcus multilocularis geminin 0.0528 0.3247 0.3247
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0951 0.5934 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0273 0.0365
Onchocerca volvulus 0.0036 0.0127 0.0115
Plasmodium falciparum endoplasmin, putative 0.0733 0.4548 0.6073
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0774 0.1035
Brugia malayi follicle stimulating hormone receptor 0.0235 0.139 0.1859
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0037 0.0037
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0037 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0126 0.0145
Brugia malayi Trypsin-like protease protein 5 0.0022 0.0042 0.0056
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0243 0.1444 0.1912
Mycobacterium ulcerans hydrolase 0.0031 0.0095 0.0103
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0126 0.0145
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0273 0.0341
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0056
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0019 0.0025
Leishmania major heat shock protein 83-1 0.1195 0.7477 1
Loa Loa (eye worm) beta-lactamase 0.0036 0.0126 0.0169
Echinococcus granulosus transmembrane protease serine 3 0.0022 0.0042 0.0056
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0243 0.1444 0.1828
Loa Loa (eye worm) hypothetical protein 0.0386 0.2347 0.3139
Trypanosoma brucei heat shock protein, putative 0.1195 0.7477 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0273 0.0273
Echinococcus granulosus adam 17 protease 0.0202 0.1181 0.1579
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0243 0.1444 0.1911
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0126 0.0145
Giardia lamblia Grp94/Hsp90 0.0951 0.5934 0.7931
Echinococcus granulosus endoplasmin 0.0951 0.5934 0.7936
Loa Loa (eye worm) reprolysin 0.0018 0.0017 0.0022
Leishmania major developmentally regulated phosphoprotein-like protein 0.0243 0.1444 0.1911
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0243 0.1444 0.1911
Loa Loa (eye worm) hypothetical protein 0.0025 0.006 0.0081
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0022 0.0042 0.0042
Brugia malayi Endoplasmin precursor 0.1195 0.7477 1
Onchocerca volvulus Matrix metalloproteinase homolog 0.0056 0.0255 0.0287
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0245 0.0328
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0243 0.1444 0.1912
Chlamydia trachomatis DNA gyrase subunit B 0.0243 0.1444 0.5
Trypanosoma brucei heat shock protein 90, putative 0.1195 0.7477 1
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0243 0.1444 0.2409
Mycobacterium tuberculosis Possible two component sensor kinase 0.0243 0.1444 0.1912
Schistosoma mansoni hypothetical protein 0.0528 0.3247 0.4343
Echinococcus granulosus heat shock protein 90 0.1195 0.7477 1
Loa Loa (eye worm) trypsin family protein 0.0022 0.0042 0.0056
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0085 0.0114
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0028 0.0012
Leishmania major GTP-binding protein, putative 0.0022 0.0037 0.0025
Echinococcus multilocularis lamin 0.0054 0.0245 0.0245
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0037 0.0025
Trypanosoma cruzi heat shock protein 90, putative 0.0705 0.4372 0.5838
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0243 0.1444 0.1911
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0243 0.1444 0.1911
Mycobacterium ulcerans lipase LipD 0.0036 0.0126 0.0145
Onchocerca volvulus Matrilysin homolog 0.0056 0.0255 0.0287
Plasmodium falciparum heat shock protein 90, putative 0.0489 0.3005 0.4004
Brugia malayi Trypsin family protein 0.0022 0.0042 0.0056
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.0774 0.1035
Trypanosoma brucei heat shock protein, putative 0.1195 0.7477 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0774 0.0774
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0243 0.1444 0.1444
Loa Loa (eye worm) hypothetical protein 0.005 0.0215 0.0287
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0774 0.1035
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0489 0.3005 0.4019
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0126 0.0126
Trichomonas vaginalis esterase, putative 0.0036 0.0126 0.0145
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.0774 0.1035
Loa Loa (eye worm) hypothetical protein 0.0026 0.0067 0.0089
Schistosoma mansoni hypothetical protein 0.0034 0.0115 0.0154
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0126 0.0145
Plasmodium vivax DNA topoisomerase II, putative 0.0243 0.1444 0.1911
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0037 0.0025
Plasmodium vivax hypothetical protein, conserved 0.0243 0.1444 0.1911
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.1344 0.1779
Loa Loa (eye worm) hypothetical protein 0.0025 0.006 0.0081
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0126 0.0145
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0028 0.0012
Schistosoma mansoni endoplasmin 0.1195 0.7477 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0243 0.1444 0.1911
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0243 0.1444 0.1912
Leishmania major heat shock protein 83-1 0.1195 0.7477 1
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0243 0.1444 0.1912
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0028 0.0012
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0273 0.0341
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.1193 0.747 0.999
Schistosoma mansoni lamin 0.0054 0.0245 0.0328
Echinococcus granulosus lamin dm0 0.0054 0.0245 0.0328
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0178 0.0214
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.1193 0.747 0.999
Echinococcus multilocularis adam 0.0032 0.0103 0.0103
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0126 0.0169
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0489 0.3005 0.4004
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0042 0.0056
Leishmania major DNA topoisomerase ii 0.0243 0.1444 0.1911
Leishmania major heat shock protein 83-1 0.1195 0.7477 1
Toxoplasma gondii heat shock protein HSP90 0.1195 0.7477 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0235 0.139 0.1859
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0115 0.0154
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0243 0.1444 0.1911
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0273 0.0341
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0243 0.1444 0.1912
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0022 0.0042 0.0056
Brugia malayi beta-lactamase family protein 0.0036 0.0126 0.0169
Leishmania major heat shock protein 83-1 0.1195 0.7477 1
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0243 0.1444 0.1931
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0243 0.1444 0.1911
Loa Loa (eye worm) heat shock protein 75 0.0489 0.3005 0.4019
Loa Loa (eye worm) hypothetical protein 0.0036 0.0126 0.0169
Schistosoma mansoni pyruvate dehydrogenase 0.0243 0.1444 0.1931
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0067 0.0067
Brugia malayi hypothetical protein 0.0032 0.0103 0.0138
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0022 0.0042 0.0056
Entamoeba histolytica hypothetical protein 0.0076 0.0379 0.0484
Schistosoma mansoni ran 0.0022 0.0037 0.0049
Brugia malayi Trypsin family protein 0.0022 0.0042 0.0056
Leishmania major dihydrofolate reductase-thymidylate synthase 0.1193 0.747 0.999
Leishmania major DNA polymerase eta, putative 0.002 0.0028 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0028 0.0012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0774 0.0774
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0087 0.045 0.0602
Loa Loa (eye worm) hypothetical protein 0.0031 0.0095 0.0127
Schistosoma mansoni endoplasmin 0.1195 0.7477 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.0844 0.0844
Trypanosoma cruzi heat shock protein 85, putative 0.0951 0.5934 0.7931
Echinococcus granulosus geminin 0.0528 0.3247 0.4343
Trypanosoma brucei heat shock protein, putative 0.1195 0.7477 1
Schistosoma mansoni lamin 0.0054 0.0245 0.0328
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0273 0.0365
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0042 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0126 0.0145
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0028 0.0012
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0126 0.0145
Trichomonas vaginalis sensor histidine kinase, putative 0.0243 0.1444 0.1911
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0243 0.1444 0.5
Toxoplasma gondii ABC1 family protein 0.0036 0.0126 0.0145
Leishmania major heat shock protein 83-1 0.1195 0.7477 1
Brugia malayi hypothetical protein 0.0568 0.3501 0.4683
Loa Loa (eye worm) TOPoisomerase family member 0.0243 0.1444 0.1931
Schistosoma mansoni ran 0.0022 0.0037 0.0049
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0126 0.0145
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0243 0.1444 0.1912
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0028 0.0037
Trypanosoma cruzi heat shock protein 85, putative 0.1195 0.7477 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0774 0.1035
Loa Loa (eye worm) hypothetical protein 0.0025 0.006 0.0081
Mycobacterium tuberculosis Conserved protein 0.0036 0.0126 0.0145
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0243 0.1444 0.1911
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0126 0.0145
Echinococcus granulosus lamin 0.0054 0.0245 0.0328
Brugia malayi Matrixin family protein 0.0061 0.0287 0.0384
Trichomonas vaginalis receptor histidine kinase, putative 0.0243 0.1444 0.1911
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0243 0.1444 0.1912
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0042 0.0056
Entamoeba histolytica heat shock protein 90, putative 0.1195 0.7477 1
Trypanosoma brucei heat shock protein 84, putative 0.0489 0.3005 0.4004
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0215 0.0287
Schistosoma mansoni hypothetical protein 0.0022 0.0042 0.0056
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0028 0.0037
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0155 0.0183
Loa Loa (eye worm) hypothetical protein 0.0036 0.0126 0.0169
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0042 0.0056
Trypanosoma brucei heat shock protein, putative 0.1195 0.7477 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0086 0.009
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0037 0.0049
Loa Loa (eye worm) hypothetical protein 0.0174 0.1007 0.1346
Onchocerca volvulus 0.1193 0.747 1
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0243 0.1444 0.1444
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0028 0.0012
Mycobacterium leprae Probable two component sensor kinase MprB 0.0243 0.1444 0.1828
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0243 0.1444 0.1912
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0042 0.0056
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0126 0.0145
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0115 0.0631 0.0631
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0243 0.1444 0.1931
Trypanosoma cruzi Heat shock protein 83, putative 0.1195 0.7477 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0037 0.0025
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0028 0.0012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0056
Brugia malayi Matrixin family protein 0.0025 0.006 0.0081
Plasmodium vivax DNA gyrase subunit B, putative 0.0243 0.1444 0.1911
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0028 0.0012
Onchocerca volvulus 0.0054 0.0245 0.0274
Trypanosoma cruzi DNA topoisomerase II, putative 0.0243 0.1444 0.1911
Echinococcus multilocularis transmembrane protease serine 3 0.0022 0.0042 0.0042
Giardia lamblia DINP protein human, muc B family 0.002 0.0028 0.0012
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0243 0.1444 0.1887
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0042 0.0056
Brugia malayi Hsp90 protein 0.0489 0.3005 0.4019
Trypanosoma cruzi heat shock protein 85, putative 0.1195 0.7477 1
Brugia malayi Importin beta-1 subunit 0.0029 0.0086 0.0115
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0379 0.0379
Leishmania major hypothetical protein, conserved 0.0243 0.1444 0.1911
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0037 0.0025
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0028 0.0028
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0126 0.0145
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0155 0.0183
Mycobacterium ulcerans two component regulator - sensor kinase 0.0243 0.1444 0.1912
Schistosoma mansoni ap endonuclease 0.0019 0.0019 0.0025
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0042 0.0056
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0056
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0379 0.0508
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.1193 0.747 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0178 0.0214
Echinococcus multilocularis dna polymerase eta 0.002 0.0028 0.0028
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0126 0.0169
Echinococcus multilocularis musashi 0.0054 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0036 0.0126 0.0169
Trypanosoma cruzi heat shock protein 90, putative 0.0951 0.5934 0.7931
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0774 0.1035
Plasmodium falciparum heat shock protein 90, putative 0.0489 0.3005 0.4004
Leishmania major heat shock protein 83-1 0.1195 0.7477 1
Schistosoma mansoni DNA topoisomerase II 0.0243 0.1444 0.1931
Trypanosoma brucei heat shock protein, putative 0.1195 0.7477 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.188 0.2514
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0243 0.1444 0.1887
Leishmania major heat shock protein 83-1 0.1195 0.7477 1
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0155 0.0183
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0126 0.0169
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0245 0.0328
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0243 0.1444 0.1911
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0243 0.1444 0.1931
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0243 0.1444 0.1912
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0243 0.1444 0.1911
Loa Loa (eye worm) hypothetical protein 0.0029 0.0086 0.0115
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0243 0.1444 0.1911
Echinococcus granulosus thymidylate synthase 0.1193 0.747 0.999
Echinococcus granulosus glycoprotein Antigen 5 0.0022 0.0042 0.0056
Brugia malayi Trypsin family protein 0.0022 0.0042 0.0056
Leishmania major heat shock protein 83-1 0.1195 0.7477 1
Mycobacterium tuberculosis Probable two component sensor kinase 0.0243 0.1444 0.1912
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0051 0.0043
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0042 0.0056
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.0844 0.1129
Plasmodium falciparum DNA gyrase subunit B 0.0243 0.1444 0.1911
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0243 0.1444 0.1911
Loa Loa (eye worm) acetyltransferase 0.0149 0.0844 0.1129
Loa Loa (eye worm) hypothetical protein 0.0025 0.0061 0.0081
Onchocerca volvulus 0.0036 0.0126 0.0114
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0126 0.0145
Trichomonas vaginalis ran, putative 0.0022 0.0037 0.0025
Onchocerca volvulus 0.0054 0.0245 0.0274
Mycobacterium ulcerans hypothetical protein 0.0022 0.0042 0.0031
Mycobacterium tuberculosis Conserved protein 0.0036 0.0126 0.0145
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0568 0.3501 0.467
Toxoplasma gondii Hsp90 domain-containing protein 0.0489 0.3005 0.4004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0273 0.0341
Trichomonas vaginalis receptor histidine kinase, putative 0.0243 0.1444 0.1911
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0028 0.0012
Giardia lamblia Pms1-like protein 0.0243 0.1444 0.1911
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0243 0.1444 0.1912
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0243 0.1444 0.2409
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0022 0.0042 0.0056
Schistosoma mansoni DNA polymerase eta 0.002 0.0028 0.0037
Entamoeba histolytica hypothetical protein 0.0076 0.0379 0.0484
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0243 0.1444 0.1912
Brugia malayi Matrixin family protein 0.0025 0.006 0.0081
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0028 0.0012
Trypanosoma brucei heat shock protein, putative 0.1195 0.7477 1
Plasmodium falciparum importin beta, putative 0.0029 0.0086 0.009
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0243 0.1444 0.1444
Entamoeba histolytica hypothetical protein 0.0076 0.0379 0.0484
Trypanosoma brucei heat shock protein, putative 0.1195 0.7477 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0028 0.0037
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0379 0.0508
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0042 0.0056
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0028 0.0012
Plasmodium vivax heat shock protein 90, putative 0.0489 0.3005 0.4004
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0126 0.0145
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0037 0.0025
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0028 0.0037
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0086 0.009
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0018 0.0017 0.0022
Leishmania major heat shock protein 83-1 0.1195 0.7477 1
Toxoplasma gondii heat shock protein 90, putative 0.1195 0.7477 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0042 0.0056
Loa Loa (eye worm) hypothetical protein 0.0054 0.0245 0.0328
Leishmania major heat shock protein 83-1 0.1195 0.7477 1
Brugia malayi Matrixin family protein 0.0025 0.006 0.0081
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0022
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0126 0.0145
Echinococcus granulosus intermediate filament protein 0.0054 0.0245 0.0328
Mycobacterium ulcerans two component sensor kinase MprB 0.0243 0.1444 0.1912
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0018 0.0017 0.0022
Echinococcus multilocularis disintegrin and metalloproteinase 0.0018 0.0017 0.0017
Brugia malayi Hemopexin family protein 0.0036 0.0127 0.017
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0032 0.0103 0.0138
Plasmodium falciparum heat shock protein 90 0.1195 0.7477 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0028 0.0012
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0051 0.0043
Schistosoma mansoni hypothetical protein 0.0076 0.0379 0.0508
Giardia lamblia Heat shock protein HSP 90-alpha 0.1195 0.7477 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0042 0.0056
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.1193 0.747 0.999
Loa Loa (eye worm) hypothetical protein 0.0025 0.0061 0.0081
Echinococcus granulosus dna polymerase kappa 0.002 0.0028 0.0037
Trypanosoma cruzi heat shock protein 90, putative 0.1195 0.7477 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0028 0.0037
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0028 0.0037
Brugia malayi thymidylate synthase 0.1193 0.747 0.999
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0028 0.0012
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0126 0.0145
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0243 0.1444 0.1911
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0085 0.0114
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0092 0.0482 0.0644
Trichomonas vaginalis DNA topoisomerase II, putative 0.0243 0.1444 0.1911
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0028 0.0012
Mycobacterium ulcerans DNA gyrase subunit B 0.0243 0.1444 0.1912
Onchocerca volvulus Matrilysin homolog 0.0025 0.006 0.0025

Activities

Activity type Activity value Assay description Source Reference
AUC (ADMET) = 2160 ng hr ml-1 Oral integrated area under the concentration vs time curve, for compound in hamster plasma ChEMBL. 9379436
AUC (ADMET) = 2890 ng hr ml-1 Intravenous integrated area under the concentration vs time curve, for compound in hamster plasma ChEMBL. 9379436
AUC (ADMET) = 5480 ng hr ml-1 Oral integrated area under the concentration vs time curve, for compound in rat plasma ChEMBL. 9379436
AUC (ADMET) = 6540 ng hr ml-1 Intravenous integrated area under the concentration vs time curve, for compound in rat plasma ChEMBL. 9379436
AUC (ADMET) = 6540 ng hr ml-1 Oral integrated area under the concentration vs time curve, for compound in dog plasma ChEMBL. 9379436
AUC (ADMET) = 9366 ng hr ml-1 Intravenous integrated area under the concentration vs time curve, for compound in dog plasma ChEMBL. 9379436
Bioavailabiility (ADMET) = 75 % oral bioavailability of the compound in Hamsters ChEMBL. 10669559
Cmax (ADMET) = 1460 ng ml-1 Maximum concentration of the unchanged compound in hamster plasma, recorded in the period 0-6 h post dose. ChEMBL. 9379436
Cmax (ADMET) = 3690 ng ml-1 Maximum concentration of the unchanged compound in rat plasma, recorded in the period 0-6 h post dose. ChEMBL. 9379436
Cmax (ADMET) = 5440 ng ml-1 Maximum concentration of the unchanged compound in dog plasma, recorded in the period 0-6 h post dose. ChEMBL. 9379436
ED50 (functional) = 0.51 mg kg-1 The in vivo activity of the compound ED50 (oral) ChEMBL. 10669559
ED50 (functional) = 0.51 mg kg-1 Effective dose of the compound in the Acute Hemarrhagic Assay model after i.v. administration ChEMBL. 9379436
ED50 (functional) = 2 mg kg-1 The in vivo activity of the compound ED50 (iv) ChEMBL. 10669559
ED50 (functional) = 2 mg kg-1 Effective dose of the compound in the Acute Hemarrhagic Assay model after oral administration ChEMBL. 9379436
F (ADMET) = 70 % Oral bioavailability in dog ChEMBL. 10669559
F (ADMET) = 70 % Ratio of intravenous to oral integrated area under the concentration vs time curve, for compound in dog plasma ChEMBL. 9379436
F (ADMET) = 75 % Bioavailability in hamster ChEMBL. 9379436
F (ADMET) = 84 % Oral bioavailability in rat ChEMBL. 10669559
F (ADMET) = 84 % Bioavailability in rat ChEMBL. 9379436
IC50 (binding) > 10 nM Compound was evaluated in vitro for the inhibitory activity in human whole blood (HWB) elastase ChEMBL. 11206469
IC50 (binding) > 10 nM Compound was evaluated in vitro for the inhibitory activity in human whole blood (HWB) elastase ChEMBL. 11206469
Inhibition (functional) = 92 % Percent inhibition of elastase-induced lung damage by 10 mg/kg dosed orally, 30 minutes prior to the instillation of 50 ug of elastase ChEMBL. 9379436
Ki (binding) nM Binding affinity of the compound for human erythrocyte Acetylcholinesterase; Not tested ChEMBL. 9379436
Ki (binding) nM Binding affinity of the compound for human plasma monoamine oxidase; No inhibition at 188 microM (highest concentration tested) ChEMBL. 9379436
Ki (binding) nM Binding affinity of the compound for carboxypeptidase A; No inhibition at 188 microM (highest concentration tested) ChEMBL. 9379436
Ki (binding) nM Binding affinity of the compound for human plasma thrombin; No inhibition at 188 microM (highest concentration tested) ChEMBL. 9379436
Ki (binding) nM Binding affinity of the compound for papaya papain; No inhibition at 188 microM (highest concentration tested) ChEMBL. 9379436
Ki (binding) nM Binding affinity of the compound for bovine spleen cathepsin L; No inhibition at 188 microM (highest concentration tested) ChEMBL. 9379436
Ki (binding) nM Binding affinity of the compound for human urine kallikrein; No inhibition at 188 microM (highest concentration tested) ChEMBL. 9379436
Ki (binding) nM Binding affinity of the compound for human plasma kallikrein; No inhibition at 188 microM (highest concentration tested) ChEMBL. 9379436
Ki (binding) nM Binding affinity of the compound for human leukocyte cathepsin G; No inhibition at 188 microM (highest concentration tested) ChEMBL. 9379436
Ki (binding) nM Binding affinity of the compound for rabbit lung Angiotensin I converting enzyme; No inhibition at 188 microM (highest concentration tested) ChEMBL. 9379436
Ki (binding) NI 0 nM Binding affinity of the compound for human plasma thrombin; No inhibition at 188 microM (highest concentration tested) ChEMBL. 9379436
Ki (binding) NI 0 nM Binding affinity of the compound for human plasma kallikrein; No inhibition at 188 microM (highest concentration tested) ChEMBL. 9379436
Ki (binding) NI 0 nM Binding affinity of the compound for human urine kallikrein; No inhibition at 188 microM (highest concentration tested) ChEMBL. 9379436
Ki (binding) NI 0 nM Binding affinity of the compound for human leukocyte cathepsin G; No inhibition at 188 microM (highest concentration tested) ChEMBL. 9379436
Ki (binding) NI 0 nM Binding affinity of the compound for papaya papain; No inhibition at 188 microM (highest concentration tested) ChEMBL. 9379436
Ki (binding) NI 0 nM Binding affinity of the compound for bovine spleen cathepsin L; No inhibition at 188 microM (highest concentration tested) ChEMBL. 9379436
Ki (binding) NI 0 nM Binding affinity of the compound for rabbit lung Angiotensin I converting enzyme; No inhibition at 188 microM (highest concentration tested) ChEMBL. 9379436
Ki (binding) NI 0 nM Binding affinity of the compound for carboxypeptidase A; No inhibition at 188 microM (highest concentration tested) ChEMBL. 9379436
Ki (binding) 0 nM Binding affinity of the compound for human erythrocyte Acetylcholinesterase; Not tested ChEMBL. 9379436
Ki (binding) NI 0 nM Binding affinity of the compound for human plasma monoamine oxidase; No inhibition at 188 microM (highest concentration tested) ChEMBL. 9379436
Ki (binding) = 13 nM oral activity of the compound ChEMBL. 10669559
Ki (binding) = 13 nM Binding affinity for human leukocyte elastase ChEMBL. 9379436
Ki (binding) = 13 nM Binding affinity of the compound for porcine Pancreatic elastase ChEMBL. 9379436
Ki (binding) = 13 nM oral activity of the compound ChEMBL. 10669559
Ki (binding) = 13 nM Binding affinity for human leukocyte elastase ChEMBL. 9379436
Ki (binding) = 13 nM Binding affinity of the compound for porcine Pancreatic elastase ChEMBL. 9379436
Ki (binding) = 149 nM Binding affinity of the compound for human pancreatic Chymotrypsinogen ChEMBL. 9379436
Ki (binding) = 149 nM Binding affinity of the compound for human pancreatic Chymotrypsinogen ChEMBL. 9379436
Ki (binding) = 66600 nM Binding affinity of the compound for human pancreatic trypsin ChEMBL. 9379436
Ki (binding) = 66600 nM Binding affinity of the compound for human pancreatic trypsin ChEMBL. 9379436
Ratio (binding) = 11 Selectivity ratio refers to the ratio K1 [porcine pancreatic elastase)/Ki(HLE)] ChEMBL. 9379436
Ratio (binding) = 5123 Selectivity ratio refers to the ratio K1 [human pancreatic chymotrypsin)/Ki(HLE)] ChEMBL. 9379436
T max (ADMET) = 0.25 hr Time of maximum concentration of compound in hamster plasma. ChEMBL. 9379436
T max (ADMET) = 0.33 hr Time of maximum concentration of compound in dog plasma. ChEMBL. 9379436
T max (ADMET) = 0.5 hr Time of maximum concentration of compound in rat plasma. ChEMBL. 9379436
T1/2 (ADMET) = 0.81 hr Half-life of compound in plasma of dog ChEMBL. 9379436
T1/2 (ADMET) = 1.3 hr Half-life of compound in plasma of rat ChEMBL. 9379436
T1/2 (ADMET) = 2 hr Half-life of compound in plasma of hamster ChEMBL. 9379436

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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