Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Human immunodeficiency virus 1 | Aberrant vpr protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus multilocularis | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus multilocularis | muscleblind protein 1 | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Brugia malayi | Muscleblind-like protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0606 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0606 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0773 | 0.0773 |
Loa Loa (eye worm) | carboxylesterase | 0.0606 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0606 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0606 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0606 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0606 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0773 | 0.0773 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0773 | 0.0773 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0773 | 0.0773 |
Echinococcus granulosus | acetylcholinesterase | 0.0606 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0773 | 0.0773 |
Echinococcus multilocularis | acetylcholinesterase | 0.0606 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0102 | 0.0773 | 0.0773 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0606 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0102 | 0.0773 | 0.5 |
Brugia malayi | hypothetical protein | 0.0102 | 0.0773 | 0.0773 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.2203 | 0.2203 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.2203 | 0.2203 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0102 | 0.0773 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0606 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0606 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.2203 | 0.155 |
Loa Loa (eye worm) | carboxylesterase | 0.0102 | 0.0773 | 0.0773 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0102 | 0.0773 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0773 | 0.0773 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0773 | 0.0773 |
Onchocerca volvulus | 0.0102 | 0.0773 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0102 | 0.0773 | 0.5 |
Onchocerca volvulus | 0.0102 | 0.0773 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0102 | 0.0773 | 0.5 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.2203 | 0.2203 |
Brugia malayi | Carboxylesterase family protein | 0.0102 | 0.0773 | 0.0773 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.2203 | 0.155 |
Onchocerca volvulus | 0.0102 | 0.0773 | 0.5 | |
Onchocerca volvulus | 0.0102 | 0.0773 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0102 | 0.0773 | 0.0773 |
Onchocerca volvulus | 0.0102 | 0.0773 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0102 | 0.0773 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.2203 | 0.155 |
Brugia malayi | Carboxylesterase family protein | 0.0102 | 0.0773 | 0.0773 |
Brugia malayi | Carboxylesterase family protein | 0.0102 | 0.0773 | 0.0773 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.8184 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | 19.9526 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.