TDR Targets

Basic information

Technical information

TDR Targets ID: 1341286
Name: 3-(4-chlorophenyl)-1-[(3,4-dichlorophenyl)met hyl]-6,7-dihydro-5H-pyrrolo[2,1-b]imidazol-1- ium chloride
MW: 414.156 | Formula: C19H16Cl4N2
H donors: 0 H acceptors: 0 LogP: 6.45 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)c1c[n+](c2n1CCC2)Cc1ccc(c(c1)Cl)Cl.[Cl-]
InChi: 1S/C19H16Cl3N2.ClH/c20-15-6-4-14(5-7-15)18-12-23(19-2-1-9-24(18)19)11-13-3-8-16(21)17(22)10-13;/h3-8,10,12H,1-2,9,11H2;1H/q+1;/p-1
InChiKey: LYOGFICNDLJPRP-UHFFFAOYSA-M

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

3-(4-chlorophenyl)-1-(3,4-dichlorobenzyl)-6,7-dihydro-5H-pyrrolo[2,1-b]imidazol-1-ium chloride
3-(4-Chloro-phenyl)-1-(3,4-dichloro-benzyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-1-ium
MLS000331626
SMR000220684

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	Starlite/ChEMBL	No references
Trypanosoma brucei gambiense	ATP-dependent phosphofructokinase,6-phospho-1-fructokinase		No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	ATP-dependent phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Trichomonas vaginalis	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Trichomonas vaginalis	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C)	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania donovani	ATP-dependent 6-phosphofructokinase, glycosomal	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania braziliensis	ATP-dependent phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Brugia malayi	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Trypanosoma brucei gambiense	ATP-dependent phosphofructokinase,6-phospho-1-fructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C)	Get druggable targets OG5_126758	All targets in OG5_126758
Echinococcus multilocularis	6 phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	hypothetical protein	Get druggable targets OG5_126758	All targets in OG5_126758
Schistosoma japonicum	ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative	Get druggable targets OG5_126758	All targets in OG5_126758
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	Get druggable targets OG5_126758	All targets in OG5_126758
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	Get druggable targets OG5_126758	All targets in OG5_126758
Entamoeba histolytica	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Schistosoma mansoni	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Loa Loa (eye worm)	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C)	Get druggable targets OG5_126758	All targets in OG5_126758
Brugia malayi	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Echinococcus granulosus	6 phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Brugia malayi	phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Loa Loa (eye worm)	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania infantum	ATP-dependent phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Trypanosoma congolense	ATP-dependent 6-phosphofructokinase, glycosomal	Get druggable targets OG5_126758	All targets in OG5_126758
Entamoeba histolytica	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Trichomonas vaginalis	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Trichomonas vaginalis	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania mexicana	6-phospho-1-fructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C)	Get druggable targets OG5_126758	All targets in OG5_126758
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	Get druggable targets OG5_126758	All targets in OG5_126758
Entamoeba histolytica	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	Get druggable targets OG5_126758	All targets in OG5_126758
Mycobacterium ulcerans	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Loa Loa (eye worm)	phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Schistosoma mansoni	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	hypothetical protein, conserved	0.0029	0.0494	0.1216
Trypanosoma brucei	DNA polymerase IV, putative	0.0073	0.1986	0.4967
Trichomonas vaginalis	DNA polymerase eta, putative	0.008	0.221	0.3056
Trypanosoma cruzi	DNA damage repair protein, putative	0.0016	0.0081	0.016
Giardia lamblia	Sgs1 DNA helicase, putative	0.0029	0.0489	0.1618
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0579	0.0561
Trypanosoma brucei	DNA polymerase IV, putative	0.008	0.221	0.5548
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.1796	0.226
Trypanosoma brucei	chrX additional, unordered contigs	0.0016	0.0081	0.0036
Trypanosoma cruzi	DNA polymerase kappa, putative	0.008	0.221	0.5604
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0579	0.0515
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0053	0.1306	0.1247
Trypanosoma brucei	DNA polymerase eta, putative	0.0104	0.3	0.7593
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0037	0.0771	0.1821
Echinococcus multilocularis	dna polymerase eta	0.0104	0.3	0.2952
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0511	0.1148
Trypanosoma cruzi	polo-like protein kinase, putative	0.0092	0.2599	0.6598
Leishmania major	DNA polymerase eta, putative	0.0067	0.1775	0.4422
Mycobacterium tuberculosis	Conserved protein	0.0029	0.0494	0.0759
Brugia malayi	Importin beta-1 subunit	0.0029	0.0511	0.058
Loa Loa (eye worm)	transcription factor SMAD2	0.0237	0.7469	0.7465
Trichomonas vaginalis	phosphofructokinase, putative	0.0131	0.393	0.5812
Entamoeba histolytica	phosphofructokinase, putative	0.0131	0.393	1
Giardia lamblia	Kinase, PLK	0.0092	0.2599	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0494	0.0476
Entamoeba histolytica	recQ family DNA helicase	0.0015	0.0019	0.0047
Trypanosoma brucei	DNA polymerase kappa, putative	0.008	0.221	0.5548
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0092	0.2599	0.2914
Mycobacterium ulcerans	lipase LipD	0.0029	0.0494	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0494	0.0476
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0325	0.0784
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0023	0.0306	0.1633
Schistosoma mansoni	hypothetical protein	0.0037	0.0754	0.0736
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0053	0.1306	0.1247
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0035	0.0719	0.179
Trichomonas vaginalis	D-aminoacylase, putative	0.0029	0.0494	0.0306
Plasmodium falciparum	ataxin-2 like protein, putative	0.005	0.1206	0.7578
Brugia malayi	hypothetical protein	0.005	0.1206	0.1489
Trypanosoma brucei	hypothetical protein, conserved	0.0016	0.0081	0.0036
Mycobacterium ulcerans	DNA polymerase IV	0.008	0.221	0.3295
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0067	0.0278
Brugia malayi	MH2 domain containing protein	0.0237	0.7469	0.9677
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0022	0.0282	0.0216
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0035	0.0719	0.1829
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0029	0.0494	0.0476
Echinococcus granulosus	beta LACTamase domain containing family member	0.0029	0.0494	0.043
Plasmodium vivax	ataxin-2 like protein, putative	0.005	0.1206	1
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0016	0.0071	0.0004
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0029	0.0494	0.0476
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0304	0.0729
Schistosoma mansoni	hypothetical protein	0.0031	0.0579	0.0561
Loa Loa (eye worm)	MH2 domain-containing protein	0.0016	0.0071	0.0052
Brugia malayi	hypothetical protein	0.0138	0.4155	0.5344
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0071	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0494	0.0476
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.2599	0.3679
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0016	0.0071	0.0004
Trichomonas vaginalis	phosphofructokinase, putative	0.0131	0.393	0.5812
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0304	0.0729
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0304	0.0729
Echinococcus multilocularis	dna polymerase kappa	0.008	0.221	0.2157
Echinococcus multilocularis	tumor susceptibility gene 101 protein	0.0138	0.4155	0.4115
Trichomonas vaginalis	DNA helicase recq, putative	0.0069	0.1852	0.2482
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0325	0.0035
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0035	0.0719	0.4333
Loa Loa (eye worm)	fli-1 protein	0.0223	0.7008	0.7002
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.006	0.153	0.2601
Trichomonas vaginalis	penicillin-binding protein, putative	0.0029	0.0494	0.0306
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0312	1	1
Schistosoma mansoni	DNA polymerase eta	0.0104	0.3	0.2987
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.008	0.221	0.3056
Brugia malayi	hypothetical protein	0.0032	0.0612	0.0712
Loa Loa (eye worm)	glutaminase 2	0.0209	0.6543	0.6536
Loa Loa (eye worm)	beta-lactamase	0.0029	0.0494	0.0476
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0067	0.0278
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.2599	0.3679
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.0304	0.0729
Trichomonas vaginalis	phosphofructokinase, putative	0.0035	0.0719	0.0665
Trichomonas vaginalis	phosphofructokinase, putative	0.0035	0.0719	0.0665
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0053	0.1306	0.129
Trichomonas vaginalis	phosphofructokinase, putative	0.0131	0.393	0.5812
Entamoeba histolytica	tumor susceptibility gene 101 protein, putative	0.0094	0.2676	0.6809
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0029	0.0489	0.2676
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0022	0.0282	0.0216
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0046	0.1082	0.6051
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0037	0.0771	0.1821
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0131	0.393	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0029	0.0494	0.0306
Echinococcus multilocularis	Smad4	0.0016	0.0071	0.0004
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0304	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1796	0.1781
Schistosoma mansoni	6-phosphofructokinase	0.0131	0.393	0.3918
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0029	0.0494	0.0639
Brugia malayi	MH1 domain containing protein	0.0016	0.0071	0.0005
Brugia malayi	MH2 domain containing protein	0.0016	0.0071	0.0005
Echinococcus granulosus	bloom syndrome protein	0.0069	0.1852	0.1797
Entamoeba histolytica	phosphofructokinase, putative	0.0131	0.393	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0029	0.0494	0.0639
Trypanosoma brucei	unspecified product	0.0073	0.1986	0.4967
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0016	0.0071	0.0004
Schistosoma mansoni	DNA polymerase IV / kappa	0.0016	0.0081	0.0063
Schistosoma mansoni	Smad4	0.0016	0.0071	0.0052
Trypanosoma brucei	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0304	0.0612
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0092	0.2599	0.2549
Entamoeba histolytica	hypothetical protein	0.0023	0.0304	0.0772
Echinococcus granulosus	dna polymerase kappa	0.008	0.221	0.2157
Loa Loa (eye worm)	Smad1	0.0016	0.0071	0.0052
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0325	0.0035
Trypanosoma cruzi	DNA polymerase kappa, putative	0.008	0.221	0.5604
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0029	0.0489	0.0424
Schistosoma mansoni	blooms syndrome DNA helicase	0.0055	0.1364	0.1348
Trypanosoma brucei	DNA polymerase kappa, putative	0.006	0.153	0.3787
Mycobacterium tuberculosis	Conserved protein	0.0029	0.0494	0.0759
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0099	0.2845	0.3632
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0579	0.0515
Plasmodium vivax	DNA repair protein REV1, putative	0.0016	0.0081	0.0672
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0511	0.1148
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0016	0.0071	0.0052
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0073	0.1993	0.1978
Loa Loa (eye worm)	hypothetical protein	0.005	0.1206	0.119
Plasmodium vivax	6-phosphofructokinase, putative	0.0035	0.0719	0.5957
Trypanosoma cruzi	DNA polymerase eta, putative	0.0104	0.3	0.7623
Brugia malayi	beta-lactamase family protein	0.0029	0.0494	0.0558
Trypanosoma cruzi	DNA polymerase eta, putative	0.0067	0.1775	0.4491
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.1206	0.3037
Toxoplasma gondii	6-phosphofructokinase	0.0035	0.0719	0.3985
Schistosoma mansoni	glutaminase	0.0209	0.6543	0.6536
Loa Loa (eye worm)	pax transcription factor protein 2	0.0244	0.7716	0.7712
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0035	0.0719	0.3985
Schistosoma mansoni	ets-related	0.0223	0.7008	0.7002
Trichomonas vaginalis	CAMK family protein kinase	0.0045	0.1049	0.1195
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0131	0.393	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0579	0.0515
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0304	0.0729
Brugia malayi	MH1 domain containing protein	0.0016	0.0071	0.0005
Trypanosoma brucei	DNA polymerase kappa, putative	0.008	0.221	0.5548
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0016	0.0067	0.0559
Echinococcus granulosus	dna polymerase eta	0.0104	0.3	0.2952
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0092	0.2599	0.2585
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0047	0.11	0.9121
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0304	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0494	0.0476
Trichomonas vaginalis	phosphofructokinase, putative	0.0131	0.393	0.5812
Trichomonas vaginalis	glutaminase, putative	0.0209	0.6543	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0986	0.2377
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0029	0.0489	0.2803
Trichomonas vaginalis	penicillin-binding protein, putative	0.0029	0.0494	0.0306
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0304	0.0729
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.1206	0.3037
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0081	0.016
Schistosoma mansoni	hypothetical protein	0.0031	0.0579	0.0561
Brugia malayi	ImpB/MucB/SamB family protein	0.0104	0.3	0.3834
Brugia malayi	beta-lactamase family protein	0.0029	0.0494	0.0558
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0067	0.0125
Brugia malayi	RNA, U transporter 1	0.0083	0.2319	0.2944
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0035	0.0719	0.0665
Brugia malayi	6-phosphofructokinase	0.0131	0.393	0.5049
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0016	0.0067	0.0125
Trypanosoma brucei	DNA polymerase kappa, putative	0.008	0.221	0.5548
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0029	0.0494	0.043
Trypanosoma brucei	DNA damage repair protein, putative	0.0016	0.0081	0.0036
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0035	0.0719	0.2532
Loa Loa (eye worm)	MH1 domain-containing protein	0.0016	0.0071	0.0052
Trichomonas vaginalis	phosphofructokinase, putative	0.0035	0.0719	0.0665
Loa Loa (eye worm)	6-phosphofructokinase	0.0131	0.393	0.3918
Leishmania major	DNA damage repair protein, putative	0.0016	0.0081	0.0036
Trypanosoma cruzi	hypothetical protein, conserved	0.0029	0.0494	0.1216
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0029	0.0489	0.2676
Brugia malayi	beta-lactamase	0.0029	0.0494	0.0558
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0986	0.0969
Schistosoma mansoni	importin beta-1	0.0029	0.0511	0.0493
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0979	0.236
Trichomonas vaginalis	D-aminoacylase, putative	0.0029	0.0494	0.0306
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0754	0.0691
Echinococcus multilocularis	smad	0.0016	0.0071	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0099	0.2845	0.2832
Trypanosoma brucei	unspecified product	0.0037	0.0755	0.1779
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0092	0.2599	0.2549
Brugia malayi	ImpB/MucB/SamB family protein	0.0053	0.1306	0.1619
Trypanosoma brucei	hypothetical protein, conserved	0.0016	0.0081	0.0036
Trypanosoma brucei	DNA polymerase kappa, putative	0.008	0.221	0.5548
Brugia malayi	serine/threonine-protein kinase plk-2	0.0092	0.2599	0.331
Toxoplasma gondii	LsmAD domain-containing protein	0.005	0.1206	0.6761
Trichomonas vaginalis	phosphofructokinase, putative	0.0035	0.0719	0.0665
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0494	0.4097
Trichomonas vaginalis	esterase, putative	0.0029	0.0494	0.0306
Echinococcus granulosus	6 phosphofructokinase	0.0131	0.393	0.3888
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0053	0.1306	0.129
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0131	0.393	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0511	0.0493
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0304	0.0729
Trypanosoma brucei	DNA polymerase kappa, putative	0.008	0.221	0.5548
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0511	0.0446
Entamoeba histolytica	hypothetical protein	0.0023	0.0304	0.0772
Trypanosoma brucei	DNA polymerase kappa, putative	0.008	0.221	0.5548
Schistosoma mansoni	hypothetical protein	0.0031	0.0579	0.0561
Loa Loa (eye worm)	hypothetical protein	0.0257	0.8145	0.8141
Toxoplasma gondii	ABC1 family protein	0.0029	0.0494	0.2707
Trypanosoma cruzi	polo-like protein kinase, putative	0.0092	0.2599	0.6598
Entamoeba histolytica	phosphofructokinase, putative	0.0131	0.393	1
Schistosoma mansoni	tsg101-related	0.0094	0.2676	0.2662
Trypanosoma brucei	DNA polymerase IV, putative	0.008	0.221	0.5548
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0029	0.0494	0.0558
Schistosoma mansoni	DNA helicase recq5	0.0029	0.0489	0.0471
Schistosoma mansoni	hypothetical protein	0.0068	0.1796	0.1781
Leishmania major	ATP-dependent phosphofructokinase	0.0131	0.393	1
Echinococcus granulosus	Smad4	0.0016	0.0071	0.0004
Schistosoma mansoni	smad	0.0016	0.0071	0.0052
Loa Loa (eye worm)	STAT protein	0.0127	0.3803	0.3792
Trypanosoma brucei	hypothetical protein, conserved	0.0029	0.0494	0.1105
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0081	0.016
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0579	0.0561
Schistosoma mansoni	tsg101-related	0.0115	0.3381	0.3369
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0579	0.0515
Brugia malayi	Smad1	0.0016	0.0071	0.0005
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0029	0.0489	0.0551
Loa Loa (eye worm)	RecQ helicase	0.0069	0.1852	0.1837
Schistosoma mansoni	6-phosphofructokinase	0.0131	0.393	0.3918
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0986	0.2377
Trypanosoma cruzi	DNA damage repair protein, putative	0.0016	0.0081	0.016
Echinococcus multilocularis	6 phosphofructokinase	0.0131	0.393	0.3888
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0029	0.0494	0.0759
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0071	0.0052
Schistosoma mansoni	hypothetical protein	0.0031	0.0579	0.0561
Leishmania major	DNA polymerase eta, putative	0.0104	0.3	0.7593
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.2599	0.3679
Loa Loa (eye worm)	MH2 domain-containing protein	0.0237	0.7469	0.7465
Entamoeba histolytica	hypothetical protein	0.0037	0.0754	0.1918
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0071	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0489	0.0471
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0092	0.2599	0.6614
Schistosoma mansoni	kinase	0.0047	0.109	0.1073
Echinococcus granulosus	GPCR family 2	0.0031	0.0579	0.0515
Plasmodium falciparum	DNA repair protein REV1, putative	0.0016	0.0081	0.0091
Trypanosoma brucei	Vps23 core domain containing protein, putative	0.0044	0.1009	0.2438
Mycobacterium tuberculosis	Conserved protein	0.0029	0.0494	0.0759
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0127	0.3803	0.4884
Plasmodium falciparum	ataxin-2 like protein, putative	0.005	0.1206	0.7578
Loa Loa (eye worm)	hypothetical protein	0.0104	0.3	0.2987
Schistosoma mansoni	DNA helicase recq1	0.0029	0.0489	0.0471
Echinococcus granulosus	tumor susceptibility gene 101 protein	0.0138	0.4155	0.4115
Onchocerca volvulus		0.0244	0.7716	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0579	0.0669
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0979	0.236
Trypanosoma brucei	DNA polymerase kappa, putative	0.008	0.221	0.5548
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0029	0.0494	0.0759
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0494	0.0476
Trypanosoma brucei	PAB1-binding protein , putative	0.005	0.1206	0.2949
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0053	0.1306	0.129
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0754	0.0736
Brugia malayi	glutaminase DH11.1	0.0209	0.6543	0.8466
Mycobacterium ulcerans	DNA polymerase IV	0.008	0.221	0.3295
Mycobacterium tuberculosis	Probable lipase LipD	0.0029	0.0494	0.0759
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0579	0.0669
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0029	0.0489	0.0424
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0016	0.0081	0.0356
Brugia malayi	6-phosphofructokinase	0.0131	0.393	0.5049
Giardia lamblia	DINP protein human, muc B family	0.006	0.153	0.5755
Echinococcus multilocularis	bloom syndrome protein	0.0069	0.1852	0.1797
Echinococcus multilocularis	GA binding protein alpha chain	0.0073	0.1993	0.1939
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0184	0.569	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0035	0.0719	0.0665
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0304	0.0729
Echinococcus granulosus	smad	0.0016	0.0071	0.0004
Mycobacterium tuberculosis	Probable hydrolase	0.0029	0.0494	0.0759
Schistosoma mansoni	hypothetical protein	0.0312	1	1
Brugia malayi	Bloom's syndrome protein homolog	0.0069	0.1852	0.2333
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0511	0.4234
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0035	0.0719	0.5
Mycobacterium tuberculosis	Probable esterase LipL	0.0029	0.0494	0.0759
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0067	0.0049
Mycobacterium ulcerans	glutaminase	0.0209	0.6543	1
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.006	0.153	0.3787
Entamoeba histolytica	hypothetical protein	0.0024	0.0325	0.0828
Entamoeba histolytica	hypothetical protein	0.0023	0.0304	0.0772
Trypanosoma cruzi	DNA polymerase kappa, putative	0.008	0.221	0.5604
Entamoeba histolytica	recQ family helicase, putative	0.0037	0.0771	0.1961
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0325	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0494	0.0476
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0053	0.1306	0.3323
Brugia malayi	Ets-domain containing protein	0.0073	0.1993	0.2518
Loa Loa (eye worm)	phosphofructokinase	0.0131	0.393	0.3918
Entamoeba histolytica	hypothetical protein	0.0037	0.0754	0.1918
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0029	0.0489	0.0471
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0511	0.2802
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.0304	0.0729
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0131	0.393	1
Entamoeba histolytica	hypothetical protein	0.0037	0.0754	0.1918
Plasmodium falciparum	importin beta, putative	0.0029	0.0511	0.295
Brugia malayi	hypothetical protein	0.0037	0.0754	0.0897
Leishmania major	DNA polymerase kappa, putative	0.006	0.153	0.3787
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.2599	0.3679
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0325	0.0035
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0099	0.2845	0.3632
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0029	0.0494	0.0476
Schistosoma mansoni	gabp alpha	0.0073	0.1993	0.1978
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0754	0.0691
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0304	0.0729
Leishmania major	hypothetical protein, conserved	0.0029	0.0494	0.1105
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0099	0.2845	0.2832
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.2599	0.3679
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.2599	0.3679
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0067	0.1775	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0029	0.0494	0.0759
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1636	0.162
Trichomonas vaginalis	DNA helicase recq1, putative	0.0069	0.1852	0.2482
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0067	0.0049
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0131	0.393	0.6869
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0304	0.0729
Brugia malayi	Ets-domain containing protein	0.0073	0.1993	0.2518
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0579	0.0515
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0029	0.0489	0.0424
Loa Loa (eye worm)	6-phosphofructokinase	0.0131	0.393	0.3918
Mycobacterium ulcerans	6-phosphofructokinase	0.0131	0.393	0.5956
Trichomonas vaginalis	hypothetical protein	0.0067	0.1783	0.2371
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0029	0.0494	0.0759
Brugia malayi	MH2 domain containing protein	0.0016	0.0071	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0092	0.2599	0.2585
Trypanosoma brucei	DNA damage repair protein, putative	0.0016	0.0081	0.0036
Trypanosoma brucei	DNA polymerase kappa, putative	0.008	0.221	0.5548
Echinococcus granulosus	mothers against decapentaplegic 5	0.0016	0.0071	0.0004
Trypanosoma brucei	unspecified product	0.0037	0.0755	0.1779
Echinococcus multilocularis	snurportin 1	0.0312	1	1
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0061	0.157	1
Trypanosoma brucei	polo-like protein kinase	0.0092	0.2599	0.6555
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0037	0.0771	0.1923
Brugia malayi	polk-prov protein	0.0043	0.0986	0.12
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0035	0.0719	0.4333
Entamoeba histolytica	hypothetical protein	0.0037	0.0754	0.1918
Trichomonas vaginalis	DNA helicase recq, putative	0.0037	0.0771	0.0749
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0029	0.0489	0.0424
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0979	0.236
Trichomonas vaginalis	phosphofructokinase, putative	0.0035	0.0719	0.0665
Entamoeba histolytica	hypothetical protein	0.0023	0.0304	0.0772
Loa Loa (eye worm)	glutaminase	0.0209	0.6543	0.6536
Schistosoma mansoni	hypothetical protein	0.0022	0.0282	0.0264
Schistosoma mansoni	tsg101-related	0.0115	0.3381	0.3369
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0035	0.0719	0.5
Mycobacterium ulcerans	hypothetical protein	0.0029	0.0494	0.0639
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.2599	0.3679
Brugia malayi	Pax transcription factor protein 2	0.0244	0.7716	1
Toxoplasma gondii	phosphofructokinase PFKII	0.0035	0.0719	0.3985
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0053	0.1306	0.2202
Loa Loa (eye worm)	hypothetical protein	0.0138	0.4155	0.4144
Mycobacterium ulcerans	beta-lactamase	0.0029	0.0494	0.0639
Trichomonas vaginalis	CAMK family protein kinase	0.0045	0.1049	0.1195
Brugia malayi	phosphofructokinase	0.0131	0.393	0.5049
Brugia malayi	Fli-1 protein	0.0223	0.7008	0.9074
Trypanosoma cruzi	Vps23 core domain containing protein, putative	0.0044	0.1009	0.2532
Plasmodium vivax	6-phosphofructokinase, putative	0.0035	0.0719	0.5957
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0092	0.2599	0.6555
Leishmania major	hypothetical protein, conserved	0.005	0.1206	0.2949
Leishmania major	hypothetical protein, conserved	0.0044	0.1009	0.2438
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0029	0.0489	0.0551
Leishmania major	DNA polymerase kappa, putative	0.0016	0.0081	0.0036
Trypanosoma cruzi	DNA polymerase kappa, putative	0.008	0.221	0.5604
Trypanosoma brucei	DNA polymerase kappa, putative	0.008	0.221	0.5548
Echinococcus granulosus	GA binding protein alpha chain	0.0073	0.1993	0.1939
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0511	0.0446

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.2617 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	0.5858 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	11.9955 uM	PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961]	ChEMBL.	No reference
Potency (functional)	= 22.3872 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845]	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 44.6684 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1482742

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1341286