Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 1 | 1 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0132 | 0.3248 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0132 | 0.3248 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0132 | 0.3248 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0132 | 0.3248 | 1 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0132 | 0.3248 | 1 |
Schistosoma mansoni | dihydropteridine reductase | 0.0115 | 0.2499 | 1 |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0132 | 0.3248 | 1 |
Leishmania major | pteridine reductase 1 | 0.0132 | 0.3248 | 1 |
Leishmania major | oxidoreductase-like protein | 0.0132 | 0.3248 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 1 | 1 |
Mycobacterium leprae | 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI | 0.0115 | 0.2499 | 0.5 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0132 | 0.3248 | 1 |
Onchocerca volvulus | 0.0132 | 0.3248 | 1 | |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0115 | 0.2499 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0115 | 0.2499 | 0.5 |
Onchocerca volvulus | 0.0115 | 0.2499 | 0.7692 | |
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | 0.0115 | 0.2499 | 0.5 |
Mycobacterium leprae | POSSIBLE OXIDOREDUCTASE | 0.0115 | 0.2499 | 0.5 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0115 | 0.2499 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 1 | 1 |
Chlamydia trachomatis | oxoacy-ACP reductase | 0.0115 | 0.2499 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0115 | 0.2499 | 0.2499 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] reductase, putative | 0.0115 | 0.2499 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0115 | 0.2499 | 0.5 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0115 | 0.2499 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | Short-chain alcohol dehydrogenase family enzyme | 0.0115 | 0.2499 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0115 | 0.2499 | 0.5 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0115 | 0.2499 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0115 | 0.2499 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0115 | 0.2499 | 0.2499 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0132 | 0.3248 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0045 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 199.5262 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.