Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | relaxin/insulin-like family peptide receptor 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2988 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0505 | 0.1674 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.1674 | 0.1674 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.1674 | 0.1674 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0505 | 0.1674 | 0.1674 |
Loa Loa (eye worm) | carboxylesterase | 0.0505 | 0.1674 | 0.1674 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0505 | 0.1674 | 0.1674 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.1674 | 0.1674 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0505 | 0.1674 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.1674 | 0.1674 |
Echinococcus granulosus | carboxylesterase 5A | 0.2988 | 1 | 1 |
Onchocerca volvulus | 0.0505 | 0.1674 | 1 | |
Echinococcus multilocularis | neuroligin | 0.0505 | 0.1674 | 0.1674 |
Echinococcus multilocularis | acetylcholinesterase | 0.2988 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0505 | 0.1674 | 0.1674 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.1674 | 0.1674 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2988 | 1 | 1 |
Onchocerca volvulus | 0.0505 | 0.1674 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.2988 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0505 | 0.1674 | 0.1674 |
Echinococcus granulosus | neuroligin | 0.0505 | 0.1674 | 0.1674 |
Echinococcus granulosus | acetylcholinesterase | 0.2988 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.2988 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0505 | 0.1674 | 0.1674 |
Brugia malayi | Carboxylesterase family protein | 0.0505 | 0.1674 | 0.1674 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0505 | 0.1674 | 0.1674 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0505 | 0.1674 | 0.1674 |
Onchocerca volvulus | 0.0505 | 0.1674 | 1 | |
Schistosoma mansoni | acetylcholinesterase | 0.0505 | 0.1674 | 0.1674 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0505 | 0.1674 | 0.1674 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0505 | 0.1674 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0505 | 0.1674 | 0.1674 |
Brugia malayi | Carboxylesterase family protein | 0.2988 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0505 | 0.1674 | 0.1674 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.1674 | 0.1674 |
Echinococcus multilocularis | acetylcholinesterase | 0.2988 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2988 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0505 | 0.1674 | 0.1674 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0505 | 0.1674 | 0.1674 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0505 | 0.1674 | 0.1674 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2988 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0505 | 0.1674 | 0.1674 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.1674 | 0.1674 |
Loa Loa (eye worm) | hypothetical protein | 0.2988 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0505 | 0.1674 | 0.1674 |
Schistosoma mansoni | gliotactin | 0.0505 | 0.1674 | 0.1674 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0505 | 0.1674 | 0.5 |
Onchocerca volvulus | 0.0505 | 0.1674 | 1 | |
Onchocerca volvulus | 0.0505 | 0.1674 | 1 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0505 | 0.1674 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0505 | 0.1674 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0505 | 0.1674 | 0.1674 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.