Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4518 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.4518 | 1 |
Brugia malayi | RNA binding protein | 0.007 | 0.4518 | 0.4518 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3627 | 0.3627 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.4518 | 0.4518 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4518 | 1 |
Brugia malayi | TAR-binding protein | 0.007 | 0.4518 | 0.4518 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.4518 | 0.4518 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4518 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4518 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.4518 | 0.4518 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.4518 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0133 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4518 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0133 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1948 | 0.4312 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.4518 | 0.4518 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1948 | 0.1948 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3627 | 0.3627 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3627 | 0.3627 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1948 | 0.1948 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3627 | 0.3627 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.