Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Rattus norvegicus | Inositol monophosphatase 1 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0749 | 0.0749 |
Schistosoma mansoni | lamin | 0.0033 | 0.3788 | 0.529 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0749 | 0.0375 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.331 | 0.5 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0045 | 0.6494 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 0.6494 | 0.5 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0045 | 0.6494 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0749 | 0.0375 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0749 | 0.0749 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 0.6494 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 0.3788 | 0.5833 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 0.6494 | 0.5 |
Onchocerca volvulus | 0.0033 | 0.3788 | 0.5 | |
Brugia malayi | hypothetical protein | 0.003 | 0.331 | 0.3039 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 0.6494 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.5718 | 0.865 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.004 | 0.5443 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.331 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0749 | 0.1153 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5718 | 0.5718 |
Onchocerca volvulus | 0.0033 | 0.3788 | 0.5 | |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.6494 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0749 | 0.1153 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0045 | 0.6494 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.3788 | 0.3788 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0045 | 0.6494 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.331 | 0.331 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.3788 | 0.3788 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.331 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0749 | 0.1153 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0389 | 0.0389 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.6494 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.004 | 0.5443 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.3788 | 0.3788 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.3788 | 0.5833 |
Echinococcus multilocularis | lamin | 0.0033 | 0.3788 | 0.5833 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.3788 | 0.3537 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0045 | 0.6494 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.3654 | 0.3654 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0045 | 0.6494 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.6494 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.3788 | 0.5833 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 1 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0045 | 0.6494 | 0.6494 |
Schistosoma mansoni | lamin | 0.0033 | 0.3788 | 0.529 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0749 | 0.1153 |
Brugia malayi | Inositol-1 | 0.0045 | 0.6494 | 0.6352 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0749 | 0.1153 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0749 | 0.1153 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.3788 | 0.3537 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.6494 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.3788 | 0.529 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0045 | 0.6494 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.3788 | 0.5833 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.3788 | 0.5833 |
Brugia malayi | hypothetical protein | 0.002 | 0.0884 | 0.0516 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.5718 | 0.5545 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0158 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.0465 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.