Detailed information for compound 134145

Basic information

Technical information
  • TDR Targets ID: 134145
  • Name: 2-[4-[(3,5-dichloropyridin-4-yl)methyl]-7-met hoxyphthalazin-1-yl]-1,3-thiazole
  • MW: 403.285 | Formula: C18H12Cl2N4OS
  • H donors: 0 H acceptors: 4 LogP: 3.94 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)c(nnc2Cc1c(Cl)cncc1Cl)c1nccs1
  • InChi: 1S/C18H12Cl2N4OS/c1-25-10-2-3-11-12(6-10)17(18-22-4-5-26-18)24-23-16(11)7-13-14(19)8-21-9-15(13)20/h2-6,8-9H,7H2,1H3
  • InChiKey: PHOOWFUDCZCEGK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-[(3,5-dichloro-4-pyridyl)methyl]-7-methoxy-phthalazin-1-yl]thiazole
  • 2-[4-[(3,5-dichloro-4-pyridyl)methyl]-7-methoxy-1-phthalazinyl]thiazole
  • 2-[4-[(3,5-dichloropyridin-4-yl)methyl]-7-methoxy-phthalazin-1-yl]-1,3-thiazole
  • 1-[(3,5-dichloropyridin-4-yl)methyl]-6-methoxy-4-(1,3-thiazol-2-yl)phthalazine
  • 1-[(3,5-dichloro-4-pyridyl)methyl]-6-methoxy-4-thiazol-2-yl-phthalazine
  • 1-[(3,5-dichloro-4-pyridyl)methyl]-6-methoxy-4-(2-thiazolyl)phthalazine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 4A, cAMP-specific References
Homo sapiens phosphodiesterase 4C, cAMP-specific References
Homo sapiens phosphodiesterase 4D, cAMP-specific Starlite/ChEMBL References
Homo sapiens phosphodiesterase 4B, cAMP-specific References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium parvum membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Neospora caninum cAMP-specific phosphodiesterase, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing Get druggable targets OG5_128242 All targets in OG5_128242
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B Get druggable targets OG5_128242 All targets in OG5_128242
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0054 0.0192 0.0054
Echinococcus multilocularis geminin 0.0166 0.1354 0.1354
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0054 0.0192 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0094 0.0094
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0192 0.0032
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0192 0.0054
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0192 0.0032
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0054 0.0192 1
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0999 1 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0054 0.0192 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.0635 0.0635
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0054 0.0192 0.0437
Loa Loa (eye worm) hypothetical protein 0.0054 0.0192 0.0192
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0094 0.0094
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0054 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0051 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0053 0.0179 0.0179
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.2605 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0094 0.0094
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0054 0.0192 0.0192
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0054 0.0192 0.0437
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0192 0.0054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0094 0.0094
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0091 0.057 0.057
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0687 0.1563
Loa Loa (eye worm) hypothetical protein 0.0053 0.0179 0.0179
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0192 0.0054
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0118 0.0118
Echinococcus multilocularis GPCR, family 2 0.0047 0.0118 0.0118
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0054 0.0192 0.0437
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0192 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0054 0.0192 0.0437
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0447 0.4263 0.4263
Echinococcus granulosus GPCR family 2 0.0047 0.0118 0.0118
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0053 0.0179 0.0179
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0118 0.0118
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0192 0.0054
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0091 0.057 0.057
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0192 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0054 0.0192 0.0192
Echinococcus multilocularis jun protein 0.0091 0.057 0.057
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0054 0.0192 0.0054
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0054 0.0192 0.0192
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0192 0.0032
Schistosoma mansoni jun-related protein 0.0074 0.0393 0.0393
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0192 0.0032
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0999 1 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0054 0.0192 0.0054
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0127 0.0951 0.0951
Loa Loa (eye worm) hypothetical protein 0.0102 0.0687 0.0687
Plasmodium falciparum phosphodiesterase delta, putative 0.0054 0.0192 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0192 0.0192
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.2605 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.2605 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.1177 0.2678
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0192 0.0032
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0054 0.0192 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0192 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0392 0.3699 0.3699
Onchocerca volvulus 0.0236 0.2079 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0447 0.4263 0.4263
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0192 0.0032
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0192 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0054 0.0192 1
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0118 0.0269
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0054 0.0192 0.0054
Leishmania major cAMP-specific phosphodiesterase, putative 0.0054 0.0192 1
Brugia malayi Peptidase family M1 containing protein 0.0053 0.0179 0.0407
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0094 0.0094
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0192 0.0054
Loa Loa (eye worm) hypothetical protein 0.0149 0.1177 0.1177
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0054 0.0192 0.0192
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0054 0.0192 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0192 0.0032
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0054 0.0192 0.0437
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0175 0.0175
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.0635 0.0635
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0056 0.0056
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0118 0.0118
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0054 0.0192 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0447 0.4263 0.4263
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0192 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.2605 0.5927
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0054 0.0192 0.0192
Brugia malayi hypothetical protein 0.0053 0.0179 0.0407
Echinococcus granulosus jun protein 0.0091 0.057 0.057
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0192 0.0032
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0053 0.0179 0.0179
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0054 0.0192 1
Schistosoma mansoni hypothetical protein 0.0166 0.1354 0.1354
Loa Loa (eye worm) hypothetical protein 0.0088 0.0544 0.0544
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0192 1
Schistosoma mansoni lipoxygenase 0.0089 0.0553 0.0553
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0192 0.0032
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.1177 0.2678
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0192 0.0032
Schistosoma mansoni hypothetical protein 0.0074 0.0393 0.0393
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Schistosoma mansoni hypothetical protein 0.0166 0.1354 0.1354
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0054 0.0192 0.0192
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0054 0.0192 0.0437
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0053 0.0179 0.0179
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0192 0.0032
Schistosoma mansoni hypothetical protein 0.0047 0.0118 0.0118
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0053 0.0179 0.0179
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.2605 1
Echinococcus granulosus aminopeptidase N 0.0053 0.0179 0.0179
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0192 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0192 0.0054
Loa Loa (eye worm) TATA binding protein associated factor 0.0053 0.0179 0.0179
Echinococcus granulosus geminin 0.0166 0.1354 0.1354
Schistosoma mansoni hypothetical protein 0.0102 0.0687 0.0687
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Brugia malayi Peptidase family M1 containing protein 0.0053 0.0179 0.0407
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0192 0.0054
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0054 0.0192 0.0054
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0054 0.0192 1
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0447 0.4263 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0054 0.0192 0.0192
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0094 0.0213
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0263 0.0263
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0118 0.0118
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0054 0.0192 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0447 0.4263 0.4263
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0192 0.0032
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0192 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.2605 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0192 0.0054
Schistosoma mansoni aminopeptidase A (M01 family) 0.0053 0.0179 0.0179
Trichomonas vaginalis set domain proteins, putative 0.0236 0.2079 0.7832
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0054 0.0192 0.0192
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0192 0.0032
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0192 0.0032
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0053 0.0179 0.0179
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0054 0.0192 0.0192
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.2605 1
Loa Loa (eye worm) peptidase family M1 containing protein 0.0053 0.0179 0.0179
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.1177 0.1177
Plasmodium falciparum phosphodiesterase gamma, putative 0.0054 0.0192 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0118 0.0118
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0053 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0418 0.3967 0.3967
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0054 0.0192 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0054 0.0192 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.1971 1
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0999 1 1
Brugia malayi TATA binding protein associated factor 0.0053 0.0179 0.0407
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0054 0.0192 0.0054
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0392 0.3699 0.3699
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0053 0.0179 0.0179
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0054 0.0192 0.0192
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0054 0.0192 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0447 0.4263 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0053 0.0179 0.0179
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.2605 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Loa Loa (eye worm) hypothetical protein 0.0053 0.0179 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0192 0.0054
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0054 0.0192 0.0192
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0192 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0192 0.0054
Brugia malayi hypothetical protein 0.0071 0.0367 0.0836
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0053 0.0179 0.0179
Brugia malayi hypothetical protein 0.0459 0.4396 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0118 0.0269
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Schistosoma mansoni lipoxygenase 0.0127 0.0951 0.0951
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0447 0.4263 0.4263
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0192 1
Trypanosoma brucei hypothetical protein, conserved 0.0054 0.0192 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0054 0.0192 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0054 0.0192 0.0192
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0094 0.0094
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0053 0.0179 0.0179
Brugia malayi Cytochrome P450 family protein 0.0053 0.0175 0.0398
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0054 0.0192 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0192 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0054 0.0192 0.0192
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0054 0.0192 0.0054
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0054 0.0192 0.0192
Loa Loa (eye worm) aminopeptidase N 0.0053 0.0179 0.0179
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Loa Loa (eye worm) hypothetical protein 0.0447 0.4263 0.4263
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0054 0.0192 0.0192
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0192 0.0054
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.0192 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0053 0.0179 0.0179
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0054 0.0192 0.0192
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0054 0.0192 0.0192
Brugia malayi hypothetical protein 0.0053 0.0179 0.0407
Echinococcus multilocularis aminopeptidase N 0.0053 0.0179 0.0179
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0054 0.0192 1
Brugia malayi Pre-SET motif family protein 0.0207 0.1781 0.4052
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0428 0.0428
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0054 0.0192 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0054 0.0192 0.0192
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.2605 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0053 0.0179 0.0179
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0054 0.0192 0.0192
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0054 0.0192 0.0192
Leishmania major hypothetical protein, conserved 0.0054 0.0192 1
Brugia malayi Dopamine receptor protein 1 0.0418 0.3967 0.9023
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.2605 0.5
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0192 1
Brugia malayi Peptidase family M1 containing protein 0.0053 0.0179 0.0407
Brugia malayi jmjC domain containing protein 0.0097 0.0635 0.1444
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0192 0.0032
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0127 0.0951 0.0951
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0053 0.0179 0.0179
Plasmodium vivax phosphodiesterase gamma, putative 0.0054 0.0192 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.1781 0.1781
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0054 0.0192 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0094 0.0094
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0392 0.3699 0.8413
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0053 0.0179 0.0179
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0054 0.0192 0.0192
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.1082 0.5
Brugia malayi bZIP transcription factor family protein 0.0091 0.057 0.1296
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0392 0.3699 0.3699
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0054 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0047 0.0118 0.0118
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.2605 1
Schistosoma mansoni hypothetical protein 0.0047 0.0118 0.0118
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0053 0.0179 0.0179
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.0192 0.0032
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0192 0.0054
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.2605 1
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0054 0.0192 0.0192
Loa Loa (eye worm) PDE1B protein 0.0054 0.0192 0.0192
Onchocerca volvulus 0.0071 0.0367 0.0993
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.1082 1
Schistosoma mansoni hypothetical protein 0.0047 0.0118 0.0118
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0094 0.0094
Leishmania major hypothetical protein, conserved 0.0054 0.0192 1
Schistosoma mansoni hypothetical protein 0.0047 0.0118 0.0118

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = -7.85 Inhibitory concentration against phosphodiesterase 4. ChEMBL. 12852946
IC50 (functional) = 8 nM Inhibition of TNF-alpha synthesis in human monocytes ChEMBL. 11140727
IC50 (functional) = 8 nM Inhibition of TNF-alpha synthesis in human monocytes ChEMBL. 11140727
IC50 (binding) = 14 nM In vitro inhibitory concentration against phosphodiesterase 4. ChEMBL. 12852946
IC50 (binding) = 14 nM Inhibition of human Phosphodiesterase 4 ChEMBL. 11140727
IC50 (binding) = 14 nM In vitro inhibitory concentration against phosphodiesterase 4. ChEMBL. 12852946
IC50 (binding) = 14 nM Inhibition of human Phosphodiesterase 4 ChEMBL. 11140727
Ki (binding) = 34 nM Inhibition of rolipram binding to PDE4 ChEMBL. 11140727
Ki (binding) = 34 nM Inhibition of rolipram binding to PDE4 ChEMBL. 11140727
Log IC50 (binding) = 7.85 Inhibitory concentration against phosphodiesterase 4. ChEMBL. 12852946

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 11140727

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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