Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.2889 | 0.2251 |
Treponema pallidum | bacterioferrin (TpF1) | 0.001 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0823 | 0.168 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.001 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.001 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.4899 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.4669 | 0.4191 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0823 | 0.168 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0823 | 0.168 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.4669 | 0.4191 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.4669 | 0.4191 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2889 | 0.2251 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0823 | 0.168 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0823 | 0.168 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0823 | 0.168 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.4899 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0823 | 0.168 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.4899 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.4899 | 0.4442 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.4899 | 0.4442 |
Trichomonas vaginalis | ferritin, putative | 0.001 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.4899 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.4899 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.2889 | 0.5897 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.001 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.4899 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.4899 | 0.4442 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.4899 | 0.4442 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0823 | 0.168 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.4899 | 1 |
Brugia malayi | RNA binding protein | 0.0063 | 0.4899 | 0.4442 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0823 | 0.168 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.4899 | 0.4442 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0823 | 0.168 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.4669 | 0.4191 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.