Detailed information for compound 1341908

Basic information

Technical information
  • TDR Targets ID: 1341908
  • Name: 2-[(5-oxo-2-propyl-[1,3,4]thiadiazolo[3,2-a]p yrimidin-7-yl)methylsulfanyl]-N-(5-propan-2-y l-1,3,4-thiadiazol-2-yl)acetamide
  • MW: 424.564 | Formula: C16H20N6O2S3
  • H donors: 1 H acceptors: 4 LogP: 2.35 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1nn2c(s1)nc(cc2=O)CSCC(=O)Nc1nnc(s1)C(C)C
  • InChi: 1S/C16H20N6O2S3/c1-4-5-12-21-22-13(24)6-10(17-16(22)26-12)7-25-8-11(23)18-15-20-19-14(27-15)9(2)3/h6,9H,4-5,7-8H2,1-3H3,(H,18,20,23)
  • InChiKey: NTNGNWHGMFYMJG-UHFFFAOYSA-N  

Network

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Synonyms

  • N-(5-isopropyl-1,3,4-thiadiazol-2-yl)-2-[(5-oxo-2-propyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)methylsulfanyl]acetamide
  • N-(5-isopropyl-1,3,4-thiadiazol-2-yl)-2-[(5-oxo-2-propyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)methylthio]acetamide
  • N-(5-isopropyl-1,3,4-thiadiazol-2-yl)-2-[(5-keto-2-propyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)methylthio]acetamide
  • 2-[(5-oxo-2-propyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)methylsulfanyl]-N-(5-propan-2-yl-1,3,4-thiadiazol-2-yl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0017 0.0063
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.001 0.0016 0.0627
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0032 0.0341
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0149 0.0133
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0016 0.0627
Trypanosoma brucei trypanothione reductase 0.0104 0.0489 1
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.017 0.0712
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0017 0.0016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0106 0.0496 0.2168
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Trichomonas vaginalis rotamase, putative 0.0039 0.0165 0.633
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0056 0.0249 0.4934
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0017 0.0045
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.001 0.0016 0.0003
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0149 0.0706
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0032 0.0061
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0026 0.0099 0.0421
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0149 0.2803
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Mycobacterium ulcerans hypothetical protein 0.0013 0.0032 0.0016
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0032 0.0357
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Schistosoma mansoni Smad4 0.0008 0.0009 0.0024
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0059 0.0261 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0179 0.0192
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0058 0.0218
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.0259 0.5138
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0149 0.2803
Schistosoma mansoni hypothetical protein 0.0396 0.1949 0.8557
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0149 0.0641
Schistosoma mansoni hypothetical protein 0.0373 0.1833 0.8049
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.001 0.0016 0.0059
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0058 0.0241
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0149 0.2803
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0251 0.122
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0032 0.0341
Schistosoma mansoni hypothetical protein 0.0018 0.0058 0.0241
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0175 0.3349
Brugia malayi glutamate synthase 0.001 0.0016 0.004
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.017 0.0813
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0106 0.0496 0.0539
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.001 0.0016 0.0017
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0017 0.0045
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0058 0.026 0.9947
Echinococcus granulosus GPCR family 2 0.0018 0.0058 0.0241
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0032 0.0341
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0149 0.2803
Giardia lamblia hypothetical protein 0.0056 0.0249 0.1031
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0016 0.0627
Schistosoma mansoni coup transcription factor 0.001 0.0017 0.0063
Schistosoma mansoni hypothetical protein 0.0018 0.0058 0.0241
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0108 0.0437
Loa Loa (eye worm) Smad1 0.0018 0.0058 0.0218
Schistosoma mansoni Smad4 0.0008 0.0009 0.0024
Plasmodium falciparum DNA repair protein REV1, putative 0.0013 0.0032 0.0341
Schistosoma mansoni smad1 5 8 and 0.0018 0.0058 0.0242
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0017 0.0063
Plasmodium falciparum thioredoxin reductase 0.0036 0.0149 0.2803
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0012 0.0013
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0149 0.2816
Loa Loa (eye worm) transcription factor SMAD2 0.0263 0.1282 0.5615
Toxoplasma gondii ImpB/MucB/SamB family protein 0.004 0.0168 0.055
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.4942
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0179 0.0772
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0056 0.0249 0.4934
Trypanosoma brucei unspecified product 0.0041 0.0175 0.3349
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0058 0.0242
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0064 0.2003
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0017 0.0016
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0017 0.0045
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0056 0.0249 0.4934
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0111 0.1995
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.001 0.0016 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0249 0.4934
Entamoeba histolytica hypothetical protein 0.0042 0.0179 0.6682
Echinococcus granulosus smad 0.0018 0.0058 0.0242
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0165 0.3151
Giardia lamblia DNA damage repair protein 0.0013 0.0032 0.0071
Loa Loa (eye worm) programmed cell death 8 0.001 0.0016 0.0035
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0058 0.026 0.9947
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.001 0.0016 0.0015
Leishmania major DNA polymerase eta, putative 0.004 0.0168 0.322
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0032 0.0341
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0175 0.0221
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0238 0.1155 0.1592
Schistosoma mansoni hypothetical protein 0.0018 0.0058 0.0241
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0032 0.0341
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2008 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0149 0.2803
Echinococcus granulosus FTZ F1 alpha 0.001 0.0017 0.0063
Entamoeba histolytica hypothetical protein 0.0042 0.0179 0.6682
Echinococcus granulosus mothers against decapentaplegic 6 0.0008 0.0009 0.0024
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0032 0.0129
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0032 0.0341
Echinococcus multilocularis glutamate synthase 0.001 0.0016 0.0015
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0264 0.1288 0.1777
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0058 0.026 0.9947
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0249 0.9555
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0026 0.0099 0.0105
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.001 0.0016 0.004
Loa Loa (eye worm) hypothetical protein 0.0057 0.0251 0.1069
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0175 0.0188
Schistosoma mansoni DNA helicase recq5 0.0019 0.0064 0.027
Trypanosoma cruzi DNA polymerase eta, putative 0.0068 0.0311 0.6228
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0106 0.0496 0.2149
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0058 0.0248
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.001 0.0016 0.0003
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0012 0.0037
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0149 0.2803
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0059 0.0261 0.0883
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0059 0.0261 1
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.001 0.0016 0.0034
Brugia malayi glutathione reductase 0.0104 0.0489 0.2417
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0039
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0058 0.026 0.9947
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0017 0.0039
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.003 0.0284
Trichomonas vaginalis rotamase, putative 0.004 0.017 0.6511
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0017 0.0063
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0406 0.1996 1
Loa Loa (eye worm) glutathione reductase 0.0104 0.0489 0.2118
Brugia malayi MH1 domain containing protein 0.001 0.0018 0.0048
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0462 0.2277 1
Schistosoma mansoni DNA polymerase eta 0.0068 0.0311 0.1353
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0016 0.0627
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0149 0.57
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0056 0.0249 0.1084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0017 0.0039
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0032 0.0341
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0251 0.1069
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0149 0.2803
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0058 0.026 0.9947
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0056 0.0249 0.1212
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0566 0.2797 0.2785
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0249 0.1084
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0064 0.1018
Brugia malayi hypothetical protein 0.0038 0.0156 0.0743
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0017 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0017 0.0039
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0064 0.2468
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0017 0.0016
Giardia lamblia Hypothetical protein 0.0056 0.0249 0.1031
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0249 0.9555
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0032 0.0341
Schistosoma mansoni smad 0.0018 0.0058 0.0242
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0149 0.2803
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Schistosoma mansoni hypothetical protein 0.0042 0.0179 0.0772
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0106 0.0496 0.0539
Toxoplasma gondii selenide, water dikinase 0.001 0.0016 0.0003
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Schistosoma mansoni smad 0.0008 0.0009 0.0024
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.001 0.0016 0.0627
Trichomonas vaginalis glutamate synthase, putative 0.001 0.0016 0.0627
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0056 0.0249 0.027
Echinococcus granulosus thioredoxin glutathione reductase 0.0104 0.0489 0.2136
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0249 0.4934
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.0496 0.2168
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0017 0.0901
Brugia malayi CXXC zinc finger family protein 0.0028 0.0108 0.0498
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0017 0.0063
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0149 0.2816
Echinococcus granulosus dnaJ subfamily B 0.0396 0.1949 0.8557
Brugia malayi nuclear receptor NHR-88 0.001 0.0017 0.0045
Schistosoma mansoni glutamate synthase 0.001 0.0016 0.0059
Brugia malayi MH2 domain containing protein 0.0018 0.0058 0.0249
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0017 0.0063
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0064 0.1018
Plasmodium vivax ataxin-2 like protein, putative 0.0058 0.0259 0.5147
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0249 0.4934
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0056 0.0249 0.1062
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0175 0.0158
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0462 0.2277 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.0496 0.2168
Trichomonas vaginalis apoptosis inducing factor, putative 0.001 0.0016 0.0627
Echinococcus multilocularis tar DNA binding protein 0.0072 0.0327 0.0355
Mycobacterium tuberculosis Probable dehydrogenase 0.0238 0.1155 0.1592
Schistosoma mansoni hypothetical protein 0.0026 0.0099 0.0421
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.0259 0.5138
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Treponema pallidum NADH oxidase 0.0036 0.0149 0.0133
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0039
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0264 0.1288 0.1777
Loa Loa (eye worm) hypothetical protein 0.0013 0.0032 0.0106
Leishmania major DNA damage repair protein, putative 0.0013 0.0032 0.0341
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0058 0.0242
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0111 0.1995
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0175 0.3349
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0042
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.0249 0.4934
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0406 0.1996 0.218
Loa Loa (eye worm) hypothetical protein 0.0462 0.2277 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0017 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0017 0.0045
Leishmania major DNA polymerase eta, putative 0.0068 0.0311 0.6228
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0056 0.0249 0.027
Echinococcus multilocularis thioredoxin glutathione reductase 0.0104 0.0489 0.0532
Plasmodium falciparum phosphodiesterase delta, putative 0.0056 0.0249 0.4934
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0462 0.2277 0.8131
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0058 0.026 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0056 0.0249 0.1212
Echinococcus multilocularis GPCR, family 2 0.0018 0.0058 0.006
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0249 0.1212
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0175 0.3349
Trypanosoma brucei hypothetical protein, conserved 0.0056 0.0249 0.4934
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0058 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0017 0.0039
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.001 0.0016 0.0003
Schistosoma mansoni hypothetical protein 0.001 0.0016 0.0059
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.003 0.0284
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0406 0.1996 0.8764
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.4934
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.001 0.0016 0.0059
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Entamoeba histolytica disulphide oxidoreductase, putative 0.001 0.0016 0.0034
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0016 0.0627
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0017 0.0016
Plasmodium vivax glutathione reductase, putative 0.0104 0.0489 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0249 0.1084
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Echinococcus multilocularis cpg binding protein 0.0029 0.0115 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0149 0.2803
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.4934
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0017 0.0063
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.4942
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0017 0.0045
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.001 0.0016 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0017 0.0039
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0058 0.026 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0039
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0566 0.2797 0.2785
Trichomonas vaginalis conserved hypothetical protein 0.004 0.017 0.6511
Echinococcus granulosus tar DNA binding protein 0.0072 0.0327 0.1426
Toxoplasma gondii LsmAD domain-containing protein 0.0058 0.0259 0.0876
Echinococcus granulosus dna polymerase kappa 0.0041 0.0175 0.0754
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0056 0.0249 0.027
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0017 0.0016
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0249 0.4934
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.001 0.0016 0.0627
Trichomonas vaginalis pc-MYB2, putative 0.0058 0.026 0.9947
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0017 0.0063
Loa Loa (eye worm) PDE1B protein 0.0056 0.0249 0.1062
Loa Loa (eye worm) MH2 domain-containing protein 0.0263 0.1282 0.5615
Echinococcus granulosus expressed protein 0.004 0.017 0.0734
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0064 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0111 0.1995
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0056 0.0249 0.1084
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0056 0.0249 0.1084
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0149 0.2803
Giardia lamblia DINP protein human, muc B family 0.0041 0.0175 0.07
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Leishmania major hypothetical protein, conserved 0.0058 0.0259 0.5138
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0149 0.0586
Schistosoma mansoni sulfide quinone reductase 0.001 0.0016 0.0059
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0149 0.2803
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Schistosoma mansoni hypothetical protein 0.0039 0.0162 0.0697
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0327 0.1426
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0327 0.1426
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.001 0.0016 0.0015
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0064 0.0281
Leishmania major DNA polymerase kappa, putative 0.0013 0.0032 0.0341
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0036 0.0149 0.0133
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0039
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0149 0.2803
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0064 0.1018
Mycobacterium tuberculosis Probable oxidoreductase 0.0264 0.1288 0.1777
Schistosoma mansoni hypothetical protein 0.0018 0.0058 0.0241
Loa Loa (eye worm) thioredoxin reductase 0.0104 0.0489 0.2118
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0056 0.0249 0.1084
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0058 0.0241
Echinococcus granulosus cpg binding protein 0.0029 0.0115 0.0494
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0056 0.0249 0.027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.0496 0.2168
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0149 0.0133
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0064 0.027
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0058 0.006
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0462 0.2277 1
Brugia malayi Thioredoxin reductase 0.0104 0.0489 0.2417
Brugia malayi nuclear hormone receptor 0.001 0.0017 0.0045
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0175 0.0754
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0149 0.0133
Trichomonas vaginalis MYB3r3, putative 0.0058 0.026 0.9947
Plasmodium falciparum glutathione reductase 0.0036 0.0149 0.2803
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0249 0.4934
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1836 0.9143 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0149 0.0133
Echinococcus granulosus bloom syndrome protein 0.0019 0.0064 0.027
Leishmania major trypanothione reductase 0.0104 0.0489 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0058 0.0248
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.0327 0.1406
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0249 0.4934
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0249 0.1212
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0056 0.0249 0.1084
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0058 0.026 1
Plasmodium vivax phosphodiesterase gamma, putative 0.0056 0.0249 0.4942
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0175 0.3349
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0039
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0032 0.0061
Echinococcus granulosus sulfide:quinone oxidoreductase 0.001 0.0016 0.0059
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0064 0.027
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Schistosoma mansoni cpg binding protein 0.0029 0.0115 0.0494
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.001 0.0016 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0017 0.0045
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0017 0.0045
Echinococcus granulosus glutamate synthase 0.001 0.0016 0.0059
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0249 0.1084
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0149 0.0479
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.0327 0.1604
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0149 0.0159
Leishmania major DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Schistosoma mansoni DNA helicase recq1 0.0019 0.0064 0.027
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0238 0.1155 0.1592
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0175 0.0836
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0566 0.2797 0.3885
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0462 0.2277 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0165 0.3151
Loa Loa (eye worm) hypothetical protein 0.0058 0.0259 0.1105
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0017 0.0045
Trichomonas vaginalis C-MYB, putative 0.0058 0.026 0.9947
Loa Loa (eye worm) hypothetical protein 0.0039 0.0162 0.0675
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0249 0.4934
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.001 0.0016 0.0015
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0162 0.077
Schistosoma mansoni thyroid hormone receptor 0.001 0.0017 0.0063
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0168 0.322
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0017 0.0063
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0149 0.0641
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.4942
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0017 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0017 0.0045
Brugia malayi MH2 domain containing protein 0.0263 0.1282 0.6409
Echinococcus multilocularis dna polymerase eta 0.0068 0.0311 0.0337
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.0249 0.4934
Brugia malayi polk-prov protein 0.0013 0.0032 0.0121
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0056 0.0249 0.027
Leishmania major hypothetical protein, conserved 0.0056 0.0249 0.4934
Leishmania major cAMP-specific phosphodiesterase, putative 0.0056 0.0249 0.4934
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0249 0.9555
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0149 0.2803
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0058 0.006
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0012 0.003 0.0013
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0017 0.0901
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0056 0.0249 0.1084
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.001 0.0016 0.0003
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0017 0.0063
Onchocerca volvulus 0.0028 0.0108 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0064 0.1018
Brugia malayi hypothetical protein 0.0042 0.0179 0.0856
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0106 0.0496 0.2168
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0175 0.0732
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0263 0.1145
Trypanosoma brucei DNA polymerase eta, putative 0.0068 0.0311 0.6228
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0406 0.1996 0.8761
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0175 0.0188
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0039
Entamoeba histolytica hypothetical protein 0.0042 0.0179 0.6682
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0327 0.1426
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0149 0.2803
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.001 0.0016 0.0059
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0058 0.0242
Schistosoma mansoni thyroid hormone receptor 0.001 0.0017 0.0063
Echinococcus granulosus Smad4 0.0018 0.0058 0.0242
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0012 0.0009
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0058 0.0218
Schistosoma mansoni smad1 5 8 and 0.0018 0.0058 0.0242
Brugia malayi Smad1 0.0018 0.0058 0.0249
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2008 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0149 0.2803
Echinococcus granulosus dna polymerase eta 0.0068 0.0311 0.1353
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0032 0.0341
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0017 0.0063
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.001 0.0016 0.0015
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.0249 0.4934
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0462 0.2277 0.2488
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0064 0.0281
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0064 0.2468
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Entamoeba histolytica glutamate synthase beta subunit, putative 0.001 0.0016 0.0034
Brugia malayi hypothetical protein 0.0058 0.0259 0.1261
Plasmodium vivax thioredoxin reductase, putative 0.0104 0.0489 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0064 0.0176
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0232 0.0778
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0064 0.0281
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0165 0.0538
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0165 0.3151
Toxoplasma gondii thioredoxin reductase 0.0104 0.0489 0.1702
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0032 0.0341
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0017 0.0039
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0238 0.1155 0.1592
Loa Loa (eye worm) hypothetical protein 0.0018 0.0058 0.0218
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1442 0.7172 1
Echinococcus multilocularis smad 0.0018 0.0058 0.006
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0017 0.0016
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.0259 0.5138
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0327 0.1426
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.001 0.0016 0.0627
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0017 0.0045
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0175 0.0221
Schistosoma mansoni cpg binding protein 0.0028 0.0108 0.046
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0249 0.4934
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0149 0.0133
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0017 0.0045
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0165 0.6132
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0104 0.0489 0.066
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0056 0.0249 0.1084
Schistosoma mansoni rotamase 0.004 0.017 0.0734
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Brugia malayi RNA binding protein 0.0072 0.0327 0.1604
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0039
Schistosoma mansoni hypothetical protein 0.0373 0.1833 0.8049
Leishmania major hypothetical protein, conserved 0.0056 0.0249 0.4934
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.0259 0.5138
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0064 0.0176
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0017 0.0063
Onchocerca volvulus 0.001 0.0017 0.0901
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0011 0.0012
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0056 0.0249 0.4934
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0175 0.0158
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0058 0.0218
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0175 0.6687
Trichomonas vaginalis pc-MYB2, putative 0.0058 0.026 0.9947
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0056 0.0249 0.027
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Trypanosoma brucei unspecified product 0.0028 0.0111 0.1995
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0149 0.2803
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0175 0.3349
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2008 1 1
Schistosoma mansoni smad1 5 8 and 0.0018 0.0058 0.0242
Entamoeba histolytica thioredoxin reductase, putative 0.001 0.0016 0.0034
Plasmodium falciparum phosphodiesterase gamma, putative 0.0056 0.0249 0.4934
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0249 0.9555
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Onchocerca volvulus 0.001 0.0016 0.0793
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0016 0.0627
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0056 0.0249 0.1212
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.003 0.0284
Brugia malayi ImpB/MucB/SamB family protein 0.0068 0.0311 0.152
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0017 0.0022
Mycobacterium tuberculosis Probable reductase 0.0238 0.1155 0.1592
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.001 0.0016 0.004
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0039
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Loa Loa (eye worm) TAR-binding protein 0.0072 0.0327 0.1406
Schistosoma mansoni disulfide oxidoreductase 0.001 0.0016 0.0059
Schistosoma mansoni nuclear hormone receptor 0.001 0.0017 0.0063
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0247
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0056 0.0249 0.1084
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.1949 0.2129
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0249 0.1084
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0012 0.003 0.0051
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Schistosoma mansoni glutamate synthase 0.001 0.0016 0.0059
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0017 0.0039
Trypanosoma cruzi trypanothione reductase, putative 0.0104 0.0489 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0056 0.0249 0.1084
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0056 0.0249 0.4934
Trichomonas vaginalis MYB, putative 0.0059 0.0261 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0149 0.2803
Echinococcus multilocularis expressed protein 0.004 0.017 0.0183
Loa Loa (eye worm) hypothetical protein 0.0068 0.0311 0.1332
Echinococcus granulosus mothers against decapentaplegic 2 0.0008 0.0009 0.0024
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0017 0.0045
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0249 0.1084
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0064 0.0213
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0056 0.0249 0.4934
Plasmodium falciparum glutathione reductase 0.0104 0.0489 1
Schistosoma mansoni sulfide quinone reductase 0.001 0.0016 0.0059
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0165 0.3151
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0249 0.1212
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0251 0.122
Brugia malayi MH1 domain containing protein 0.0018 0.0058 0.0249
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0017 0.0039
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.001 0.0016 0.0015
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0064 0.0247
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0175 0.6687
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0327 0.1426
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0149 0.2803
Loa Loa (eye worm) RNA binding protein 0.0072 0.0327 0.1406
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0149 0.57
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1442 0.7172 1
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0017 0.0063
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0064 0.0067
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0249 0.4934
Trichomonas vaginalis C-MYB, putative 0.0058 0.026 0.9947
Echinococcus multilocularis Smad4 0.0018 0.0058 0.006
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0017 0.0007
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.9555
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0149 0.2803
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0249 0.1084
Brugia malayi steroid hormone receptor 0.001 0.0017 0.0045
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0012 0.003 0.0284
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0058 0.026 0.9947
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Trypanosoma brucei PAB1-binding protein , putative 0.0058 0.0259 0.5138
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0249 0.9555
Plasmodium vivax ferrodoxin reductase, putative 0.001 0.0016 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0017 0.0045
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0249 0.9555
Brugia malayi MH2 domain containing protein 0.0018 0.0058 0.0249
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0027 0.0101 0.0465
Echinococcus granulosus geminin 0.0373 0.1833 0.8049
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0149 0.0185
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.001 0.0016 0.0059
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0064 0.1018
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0462 0.2277 0.2488
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.001 0.0016 0.004
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0106 0.0496 0.2452
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0017 0.0063
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0017 0.0063
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0058 0.006
Entamoeba histolytica recQ family DNA helicase 0.001 0.0017 0.0076
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Loa Loa (eye worm) nuclear factor I 0.001 0.0018 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0032 0.0341
Loa Loa (eye worm) hypothetical protein 0.0056 0.0249 0.1062
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.001 0.0016 0.0034
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0017 0.0022
Echinococcus multilocularis mothers against decapentaplegic 2 0.0008 0.0009 0.0006
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.001 0.0016 0.0059
Entamoeba histolytica hypothetical protein 0.0042 0.0179 0.6682
Trichomonas vaginalis MYB72, putative 0.0058 0.026 0.9947
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0017 0.0063
Schistosoma mansoni blooms syndrome DNA helicase 0.0009 0.0016 0.0055
Brugia malayi MH1 domain containing protein 0.0018 0.0058 0.0249
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0016 0.0627
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0238 0.1155 0.1592
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0179 0.0772
Loa Loa (eye worm) hypothetical protein 0.0056 0.0249 0.1062
Loa Loa (eye worm) hypothetical protein 0.0056 0.0249 0.1062
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0017 0.0016
Brugia malayi ecdysteroid receptor 0.001 0.0017 0.0045
Schistosoma mansoni cpg binding protein 0.0029 0.0115 0.0494
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0017 0.0045
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.4934
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0249 0.9555
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0035
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0175 0.6514
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0249 0.4934
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0017 0.0039
Schistosoma mansoni glutamate synthase 0.001 0.0016 0.0059
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0017 0.0901
Giardia lamblia Myb 1-like protein 0.0059 0.0261 0.1082
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0017 0.0045
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0017 0.0063
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.001 0.0016 0.0035
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0566 0.2797 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0058 0.026 1
Schistosoma mansoni Smad4 0.0018 0.0058 0.0242
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0017 0.0063
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0175 0.0754
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0175 0.0754
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0056 0.0249 0.4934
Echinococcus multilocularis geminin 0.0373 0.1833 0.2002
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0064 0.0067
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0027 0.0101 0.0465
Echinococcus multilocularis mothers against decapentaplegic 6 0.0008 0.0009 0.0006
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0064 0.2468
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0249 0.0841
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0238 0.1155 0.1592
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0149 0.0479
Loa Loa (eye worm) RecQ helicase 0.0019 0.0064 0.0247
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0056 0.0249 0.1084
Trichomonas vaginalis glutamate synthase, putative 0.001 0.0016 0.0627
Brugia malayi MH1 domain containing protein 0.001 0.0018 0.0048
Brugia malayi TAR-binding protein 0.0072 0.0327 0.1604
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0058 0.026 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.0249 0.4934
Plasmodium falciparum thioredoxin reductase 0.0104 0.0489 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0249 0.4934
Trypanosoma brucei unspecified product 0.0028 0.0111 0.1995
Entamoeba histolytica glutamate synthase beta subunit, putative 0.001 0.0016 0.0034
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.001 0.0016 0.0017
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0264 0.1288 0.1777

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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