Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.5328 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.5328 | 0.5 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Onchocerca volvulus | Basement membrane proteoglycan homolog | 0.0006 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.5328 | 0.5328 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.5328 | 0.5328 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.5328 | 0.5 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.5328 | 0.5328 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0073 | 1 | 1 |
Onchocerca volvulus | Arrow homolog | 0.0006 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.5328 | 0.5 |
Onchocerca volvulus | Terribly reduced optic lobes homolog | 0.0006 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0042 | 0.5328 | 0.5328 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.5328 | 0.5328 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Onchocerca volvulus | 0.0006 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1312 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.