Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.4504 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.4504 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0023 | 0.4504 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.9646 | 0.9646 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 0.5 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.4504 | 0.4504 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.4504 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 0.5 |
Echinococcus multilocularis | musashi | 0.0033 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 1 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.4504 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0023 | 0.4504 | 0.4504 |
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.4504 | 0.5 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.4504 | 0.4504 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.4504 | 0.5 |
Onchocerca volvulus | 0.0033 | 1 | 0.5 | |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0023 | 0.4504 | 0.4504 |
Schistosoma mansoni | lamin | 0.0033 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.4504 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.4504 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.4504 | 0.3875 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0023 | 0.4504 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.4504 | 0.4504 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 1 | 0.5 | |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.4504 | 0.5 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 0.4504 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.4504 | 0.4504 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.4504 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.4504 | 0.4504 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.1026 | 0.1026 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.4504 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.4504 | 0.3875 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4504 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 0.4504 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.4504 | 1 |
Echinococcus multilocularis | lamin | 0.0033 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 1 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.4504 | 0.4504 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.2818 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.3696 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.