Detailed information for compound 1342265

Basic information

Technical information
  • TDR Targets ID: 1342265
  • Name: 4-methyl-N-[2-[6-(3-propan-2-yloxypropylamino )-[1,2,4]triazolo[5,4-f]pyridazin-3-yl]ethyl] benzenesulfonamide
  • MW: 432.54 | Formula: C20H28N6O3S
  • H donors: 2 H acceptors: 5 LogP: 2.39 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(OCCCNc1ccc2n(n1)c(CCNS(=O)(=O)c1ccc(cc1)C)nn2)C
  • InChi: 1S/C20H28N6O3S/c1-15(2)29-14-4-12-21-18-9-10-19-23-24-20(26(19)25-18)11-13-22-30(27,28)17-7-5-16(3)6-8-17/h5-10,15,22H,4,11-14H2,1-3H3,(H,21,25)
  • InChiKey: VCMBZNPZRXJTEX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-[6-(3-isopropoxypropylamino)-[1,2,4]triazolo[5,4-f]pyridazin-3-yl]ethyl]-4-methyl-benzenesulfonamide
  • N-[2-[6-(3-isopropoxypropylamino)-[1,2,4]triazolo[5,4-f]pyridazin-3-yl]ethyl]-4-methylbenzenesulfonamide
  • SMR000324887
  • MLS000684932

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Giardia lamblia U5 small nuclear ribonucleoprotein 200 kDa helicase, putative RecQ helicase-like 649 aa 521 aa 19.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Nuclear hormone receptor HR96 0.0138 0.4488 0.4248
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0294 1 1
Brugia malayi Nuclear hormone receptor E75 0.0138 0.4488 0.4248
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0138 0.4488 0.4488
Loa Loa (eye worm) hypothetical protein 0.0138 0.4488 0.4488
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0417 0.5
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0024 0.0417 0.0417
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0138 0.4488 0.4488
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0155 0.5078 0.4864
Schistosoma mansoni DNA helicase recq1 0.0024 0.0417 0.0417
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0155 0.5078 0.5078
Loa Loa (eye worm) hypothetical protein 0.0138 0.4488 0.4488
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0294 1 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0294 1 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0138 0.4488 0.4248
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0417 1
Loa Loa (eye worm) steroid hormone receptor 0.0294 1 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0155 0.5078 0.4864
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0138 0.4488 0.4248
Onchocerca volvulus 0.0294 1 1
Loa Loa (eye worm) hypothetical protein 0.0294 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0294 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0294 1 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.4488 0.4488
Loa Loa (eye worm) hypothetical protein 0.0155 0.5078 0.5078
Brugia malayi hypothetical protein 0.0155 0.5078 0.4864
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0138 0.4488 0.4248
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0294 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0294 1 1
Brugia malayi nuclear receptor NHR-67 0.0138 0.4488 0.4248
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0294 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0294 1 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0417 0.5
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0294 1 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0138 0.4488 0.4248
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0294 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0417 0.0417
Schistosoma mansoni nuclear receptor 0.0138 0.4488 0.4488
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0417 0.5
Schistosoma mansoni nuclear hormone receptor 0.0294 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0294 1 1
Loa Loa (eye worm) RecQ helicase 0.0024 0.0417 0.0417
Brugia malayi hypothetical protein 0.0138 0.4488 0.4248
Onchocerca volvulus Bile acid receptor homolog 0.0294 1 1
Loa Loa (eye worm) hypothetical protein 0.0294 1 1
Loa Loa (eye worm) hypothetical protein 0.0294 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0294 1 1
Loa Loa (eye worm) hypothetical protein 0.0294 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0294 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0294 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0155 0.5078 0.5078
Brugia malayi hypothetical protein 0.0155 0.5078 0.4864
Brugia malayi tailless protein 0.0138 0.4488 0.4248
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0294 1 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.4488 0.4488
Loa Loa (eye worm) hypothetical protein 0.0138 0.4488 0.4488
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0294 1 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.00000000073812 0.5
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0294 1 1
Brugia malayi nuclear hormone receptor 0.0294 1 1
Giardia lamblia Sgs1 DNA helicase, putative 0.0024 0.0417 0.5
Brugia malayi nuclear receptor NHR-88 0.0138 0.4488 0.4248
Onchocerca volvulus Protein ultraspiracle homolog 0.0294 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0294 1 1
Echinococcus granulosus ecdysone induced protein 78C 0.0294 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.0294 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0294 1 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.4488 0.4488
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0155 0.5078 0.5078
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0294 1 1
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0417 0.5
Loa Loa (eye worm) hypothetical protein 0.0294 1 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0417 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0294 1 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0138 0.4488 0.4248
Echinococcus granulosus Nuclear hormone receptor HR96 0.0138 0.4488 0.4248
Schistosoma mansoni nuclear hormone receptor 0.0138 0.4488 0.4488
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0138 0.4488 0.4488
Loa Loa (eye worm) hypothetical protein 0.0294 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0294 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0138 0.4488 0.4488
Loa Loa (eye worm) hypothetical protein 0.0012 0.00000000035074 0.00000000035074
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0294 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0294 1 1
Brugia malayi orphan nuclear receptor NR2E1 0.0138 0.4488 0.4248
Brugia malayi hypothetical protein 0.0138 0.4488 0.4248
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0294 1 1
Loa Loa (eye worm) hypothetical protein 0.0294 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0294 1 1
Brugia malayi ecdysone receptor 0.0138 0.4488 0.4248
Brugia malayi conserved hypotetical protein 0.0138 0.4488 0.4248
Schistosoma mansoni zinc finger protein 0.0138 0.4488 0.4488
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0024 0.0417 0.5
Brugia malayi nuclear hormone receptor 0.0138 0.4488 0.4248
Brugia malayi Nuclear hormone receptor E75 0.0138 0.4488 0.4248
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0294 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0138 0.4488 0.4248
Loa Loa (eye worm) hypothetical protein 0.0155 0.5078 0.5078
Loa Loa (eye worm) hypothetical protein 0.0138 0.4488 0.4488
Echinococcus multilocularis ecdysone induced protein 78C 0.0294 1 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.4488 0.4488
Brugia malayi nuclear receptor RXR 0.0138 0.4488 0.4248
Loa Loa (eye worm) nuclear hormone receptor 0.0138 0.4488 0.4488
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0294 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.5078 0.5078
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0294 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0138 0.4488 0.4248
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0417 0.5
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0138 0.4488 0.4248
Brugia malayi nuclear receptor NHR-88 0.0294 1 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0138 0.4488 0.4248
Brugia malayi Nuclear hormone receptor-like 1 0.0155 0.5078 0.4864
Brugia malayi nuclear receptor RXR 0.0155 0.5078 0.4864
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0294 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0294 1 1
Schistosoma mansoni nuclear hormone receptor 0.0138 0.4488 0.4488
Loa Loa (eye worm) hypothetical protein 0.0138 0.4488 0.4488
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0417 1
Schistosoma mansoni nuclear receptor 0.0138 0.4488 0.4488
Schistosoma mansoni coup transcription factor 0.0294 1 1
Echinococcus multilocularis FTZ F1 alpha 0.0294 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0294 1 1
Schistosoma mansoni nuclear receptor nhr-48 0.0138 0.4488 0.4488
Echinococcus granulosus FTZ F1 alpha 0.0294 1 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0294 1 1
Schistosoma mansoni thyroid hormone receptor 0.0294 1 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0138 0.4488 0.4248
Loa Loa (eye worm) hypothetical protein 0.0155 0.5078 0.5078
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0294 1 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0138 0.4488 0.4248
Loa Loa (eye worm) hypothetical protein 0.0138 0.4488 0.4488
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0294 1 1
Treponema pallidum ATP-dependent DNA helicase 0.0012 0.00000000035074 0.5
Loa Loa (eye worm) hypothetical protein 0.0138 0.4488 0.4488
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0294 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0294 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0294 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0294 1 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0417 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0294 1 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0417 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0138 0.4488 0.4248
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0294 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0155 0.5078 0.4864
Brugia malayi steroid hormone receptor 0.0294 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0294 1 1
Schistosoma mansoni thyroid hormone receptor 0.0294 1 1
Loa Loa (eye worm) hypothetical protein 0.0294 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.5078 0.5078
Loa Loa (eye worm) hypothetical protein 0.0138 0.4488 0.4488
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0294 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0294 1 1
Schistosoma mansoni DNA helicase recq5 0.0024 0.0417 0.0417
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0294 1 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.4488 0.4488
Echinococcus granulosus nuclear receptor nhr 48 0.0138 0.4488 0.4248
Loa Loa (eye worm) DR-78 0.0138 0.4488 0.4488

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0093 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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