Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | thioredoxin reductase, putative | 0.0054 | 0.2369 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.3553 | 1 |
Treponema pallidum | NADH oxidase | 0.0019 | 0.0091 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0138 | 0.7722 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0124 | 0.6835 | 0.8837 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0124 | 0.6835 | 0.8837 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0124 | 0.6835 | 0.8837 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0124 | 0.6835 | 0.8837 |
Plasmodium falciparum | glutathione reductase | 0.0054 | 0.2369 | 1 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.3553 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0968 | 0.2725 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0019 | 0.0091 | 0.5 |
Schistosoma mansoni | lamin | 0.0033 | 0.0968 | 0.0886 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0019 | 0.0091 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.3553 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0019 | 0.0091 | 0.5 |
Brugia malayi | RNA binding protein | 0.0073 | 0.3553 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.3553 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0968 | 0.2725 |
Schistosoma mansoni | lamin | 0.0033 | 0.0968 | 0.0886 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3553 | 0.3494 |
Toxoplasma gondii | thioredoxin reductase | 0.0054 | 0.2369 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0138 | 0.7722 | 1 |
Leishmania major | trypanothione reductase | 0.0054 | 0.2369 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0054 | 0.2369 | 0.6667 |
Echinococcus granulosus | lamin | 0.0033 | 0.0968 | 0.2535 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0968 | 0.2535 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0019 | 0.0091 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0124 | 0.6835 | 0.8837 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0138 | 0.7722 | 1 |
Onchocerca volvulus | 0.0033 | 0.0968 | 0.5 | |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0019 | 0.0091 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0968 | 0.2725 |
Plasmodium vivax | glutathione reductase, putative | 0.0054 | 0.2369 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.093 | 0.2618 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3553 | 0.3494 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3553 | 0.3494 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0054 | 0.2369 | 0.658 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.3553 | 1 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0968 | 0.2535 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0054 | 0.2369 | 0.2985 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0019 | 0.0091 | 0.5 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0968 | 0.2535 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0124 | 0.6835 | 0.8837 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0138 | 0.7722 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0054 | 0.2369 | 1 |
Onchocerca volvulus | 0.0033 | 0.0968 | 0.5 | |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0054 | 0.2369 | 0.658 |
Brugia malayi | glutathione reductase | 0.0054 | 0.2369 | 0.6667 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0019 | 0.0091 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0968 | 0.2725 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0019 | 0.0091 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0054 | 0.2369 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.3553 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0968 | 0.2725 |
Loa Loa (eye worm) | glutathione reductase | 0.0054 | 0.2369 | 0.6667 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0019 | 0.0091 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0019 | 0.0091 | 0.0255 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3553 | 0.3494 |
Trypanosoma brucei | trypanothione reductase | 0.0054 | 0.2369 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0054 | 0.2369 | 0.6667 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.3553 | 0.3494 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0968 | 0.0886 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0968 | 0.2535 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.3553 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0968 | 0.2535 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.01 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 21.1923 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.