Detailed information for compound 1342597

Basic information

Technical information
  • TDR Targets ID: 1342597
  • Name: NCGC00074474-01
  • MW: 471.548 | Formula: C28H29N3O4
  • H donors: 1 H acceptors: 3 LogP: 3.55 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)[C@@]1(Cc2ccccc2)[C@@H]2[C@H](CN1C(=O)c1ccccc1)Cc1c2cc([nH]1)C(=O)N(C)C
  • InChi: 1S/C28H29N3O4/c1-30(2)26(33)23-15-21-22(29-23)14-20-17-31(25(32)19-12-8-5-9-13-19)28(24(20)21,27(34)35-3)16-18-10-6-4-7-11-18/h4-13,15,20,24,29H,14,16-17H2,1-3H3/t20-,24+,28+/m0/s1
  • InChiKey: KAFZPGLWPPWEBJ-MUXSNRJPSA-N  


Substructure search Similarity search

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Synonyms

  • UPCMLD02ASTW001086
  • CMLD1_000196

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tar DNA binding protein 0.0056 0.0653 0.0725
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0252 0.3298 0.3662
Echinococcus granulosus survival motor neuron protein 1 0.0207 0.2696 0.2994
Loa Loa (eye worm) hypothetical protein 0.0012 0.0066 0.018
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0158 0.0431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0177 0.3641
Loa Loa (eye worm) nuclear receptor NHR-67 0.0092 0.1144 0.3119
Entamoeba histolytica cysteine protease, putative 0.001 0.0045 0.109
Schistosoma mansoni DNA polymerase eta 0.0019 0.0158 0.0176
Brugia malayi photoreceptor-specific nuclear receptor 0.0195 0.2532 0.6901
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0011 0.0051 0.0057
Onchocerca volvulus 0.002 0.0177 0.0701
Brugia malayi nuclear receptor NHR-67 0.0092 0.1144 0.3119
Echinococcus multilocularis survival motor neuron protein 1 0.0207 0.2696 0.2696
Entamoeba histolytica cysteine protease, putative 0.001 0.0045 0.109
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0177 0.0177
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0011 0.0051 0.0057
Loa Loa (eye worm) hypothetical protein 0.0103 0.1293 0.3524
Schistosoma mansoni hypothetical protein 0.0013 0.0078 0.0086
Echinococcus granulosus FTZ F1 alpha 0.0195 0.2532 0.2812
Onchocerca volvulus 0.0042 0.0475 0.1874
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0045 0.0482
Loa Loa (eye worm) hypothetical protein 0.0092 0.1144 0.3119
Schistosoma mansoni lamin 0.0026 0.0252 0.028
Echinococcus multilocularis mitogen activated protein kinase 0.0043 0.0487 0.0487
Schistosoma mansoni hypothetical protein 0.003 0.0309 0.0343
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0177 0.3641
Trypanosoma cruzi cysteine protease, putative 0.001 0.0045 0.0482
Onchocerca volvulus Bile acid receptor homolog 0.0195 0.2532 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0464 0.7974
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0045 0.005
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0177 0.4253
Schistosoma mansoni ap endonuclease 0.0035 0.0374 0.0416
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0011 0.0051 0.0057
Trichomonas vaginalis ap endonuclease, putative 0.0035 0.0374 0.7687
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.008 0.0845
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0177 0.0483
Echinococcus multilocularis expressed protein 0.0011 0.0051 0.0051
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0195 0.2532 0.6901
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0942 1
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0011 0.0051 0.1047
Echinococcus granulosus mitogen activated protein kinase 0.0043 0.0487 0.0541
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0252 0.0686
Loa Loa (eye worm) hypothetical protein 0.0014 0.0087 0.0238
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0045 0.109
Brugia malayi Cytochrome P450 family protein 0.0013 0.0078 0.0212
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0095 0.1182 0.322
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0011 0.0051 0.0057
Brugia malayi Cathepsin L-like precursor 0.002 0.0177 0.0483
Loa Loa (eye worm) hypothetical protein 0.0025 0.0245 0.0669
Schistosoma mansoni hypothetical protein 0.003 0.0309 0.0343
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0195 0.2532 0.6901
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0177 0.3641
Loa Loa (eye worm) fibroinase 0.002 0.0177 0.0483
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0013 0.0078 0.0826
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0195 0.2532 0.2532
Schistosoma mansoni thyroid hormone receptor 0.0195 0.2532 0.2812
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.008 0.0845
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.022 0.2337
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0013 0.0078 0.2078
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0177 0.3641
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0158 0.1678
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.003 0.0309 0.0842
Mycobacterium leprae Conserved hypothetical protein 0.0013 0.0078 0.5
Loa Loa (eye worm) hypothetical protein 0.0092 0.1144 0.3119
Loa Loa (eye worm) hypothetical protein 0.0103 0.1293 0.3524
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0942 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.1678
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0177 0.3641
Schistosoma mansoni survival motor neuron protein 0.0042 0.0475 0.0527
Loa Loa (eye worm) hypothetical protein 0.0012 0.0064 0.0175
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0195 0.2532 0.2812
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0056 0.0653 0.1779
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0011 0.0051 0.1047
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0011 0.0051 0.0051
Trypanosoma brucei unspecified product 0.0013 0.008 0.0845
Schistosoma mansoni GTP-binding protein alpha subunit 0.0011 0.0051 0.0057
Echinococcus multilocularis cysteine protease 0.002 0.0177 0.0177
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0177 0.3641
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0177 0.0197
Trichomonas vaginalis alpha-glucosidase, putative 0.0012 0.0064 0.1318
Echinococcus granulosus mitogen activated protein kinase 3 0.0043 0.0487 0.0541
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0177 0.0197
Loa Loa (eye worm) hypothetical protein 0.003 0.0309 0.0842
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0011 0.0051 0.0139
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0013 0.0078 0.2078
Loa Loa (eye worm) hypothetical protein 0.0095 0.1182 0.322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0195 0.2532 0.6901
Schistosoma mansoni hypothetical protein 0.0065 0.0778 0.0864
Echinococcus multilocularis FTZ F1 alpha 0.0195 0.2532 0.2532
Leishmania major cathepsin L-like protease 0.002 0.0177 0.1883
Loa Loa (eye worm) latrophilin receptor protein 2 0.003 0.0309 0.0842
Loa Loa (eye worm) hypothetical protein 0.0011 0.0051 0.0139
Entamoeba histolytica cysteine protease, putative 0.002 0.0177 0.4253
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0012 0.0064 0.0681
Trypanosoma brucei unspecified product 0.0013 0.008 0.0845
Plasmodium vivax vivapain-2 0.002 0.0177 0.3827
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0158 0.379
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0158 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.1678
Echinococcus granulosus geminin 0.0676 0.9005 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0087 0.0238
Schistosoma mansoni tar DNA-binding protein 0.0056 0.0653 0.0725
Echinococcus granulosus ecdysone induced protein 78C 0.0195 0.2532 0.2812
Brugia malayi Cathepsin L-like precursor 0.002 0.0177 0.0483
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0195 0.2532 0.2812
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0195 0.2532 0.6901
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0045 0.0124
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0011 0.0051 0.0139
Loa Loa (eye worm) cysteine protease 0.002 0.0177 0.0483
Brugia malayi hypothetical protein 0.0207 0.2696 0.7348
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0195 0.2532 0.2812
Entamoeba histolytica cysteine protease, putative 0.001 0.0045 0.109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0177 0.3641
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0011 0.0051 0.0051
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0103 0.1293 0.1436
Schistosoma mansoni tar DNA-binding protein 0.0056 0.0653 0.0725
Entamoeba histolytica cysteine protease, putative 0.001 0.0045 0.109
Loa Loa (eye worm) hypothetical protein 0.0092 0.1144 0.3119
Toxoplasma gondii histone lysine methyltransferase SET1 0.005 0.0581 1
Brugia malayi hypothetical protein 0.0011 0.0051 0.0139
Loa Loa (eye worm) hypothetical protein 0.0103 0.1293 0.3524
Onchocerca volvulus Protein ultraspiracle homolog 0.0195 0.2532 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0032 0.0332 0.0369
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0158 0.4221
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0158 0.1678
Schistosoma mansoni coup transcription factor 0.0195 0.2532 0.2812
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0032 0.0332 0.6814
Brugia malayi cytochrome P450 0.0013 0.0078 0.0212
Loa Loa (eye worm) hypothetical protein 0.0092 0.1144 0.3119
Mycobacterium leprae putative cytochrome p450 0.0013 0.0078 0.5
Loa Loa (eye worm) nuclear hormone receptor 0.0092 0.1144 0.3119
Loa Loa (eye worm) steroid hormone receptor 0.0195 0.2532 0.6901
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.001 0.0045 0.0482
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0177 0.3641
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0195 0.2532 0.2532
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0011 0.0051 0.0051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0177 0.3641
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0177 0.4253
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0012 0.0064 0.0254
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0252 0.3298 0.8988
Entamoeba histolytica cysteine protease, putative 0.001 0.0045 0.109
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0158 0.2705
Brugia malayi Cytochrome P450 family protein 0.0059 0.0698 0.1902
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0332 0.6814
Trypanosoma brucei unspecified product 0.0019 0.0158 0.1678
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0942 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0032 0.0332 0.5711
Onchocerca volvulus Cathepsin F homolog 0.002 0.0177 0.0701
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0043 0.0487 0.5171
Trichomonas vaginalis alpha-glucosidase, putative 0.0012 0.0064 0.1318
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0011 0.0051 0.1047
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0195 0.2532 0.2812
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0195 0.2532 0.2812
Echinococcus multilocularis ecdysone induced protein 78C 0.0195 0.2532 0.2532
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0035 0.0374 1
Schistosoma mansoni nuclear receptor 0.0092 0.1144 0.1271
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0177 0.4253
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0012 0.0064 0.1318
Echinococcus multilocularis neutral alpha glucosidase AB 0.0032 0.0332 0.0332
Onchocerca volvulus 0.0083 0.1017 0.4018
Echinococcus multilocularis lysosomal alpha glucosidase 0.0143 0.1828 0.1828
Onchocerca volvulus 0.002 0.0177 0.0701
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0011 0.0051 0.0057
Brugia malayi nuclear receptor NHR-88 0.0092 0.1144 0.3119
Echinococcus multilocularis geminin 0.0676 0.9005 0.9005
Brugia malayi intermediate filament protein 0.0026 0.0252 0.0686
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0013 0.0078 0.2078
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0013 0.0078 0.2078
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0092 0.1144 0.1144
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0013 0.0078 0.2078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0087 0.1795
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0013 0.0078 0.2078
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0092 0.1144 0.452
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0195 0.2532 0.2812
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0252 0.3298 0.3662
Leishmania major DNA polymerase eta, putative 0.0019 0.0158 0.1678
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0195 0.2532 0.2812
Loa Loa (eye worm) hypothetical protein 0.0092 0.1144 0.3119
Leishmania major cathepsin L-like protease 0.0077 0.0942 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0252 0.3298 0.3298
Loa Loa (eye worm) hypothetical protein 0.0195 0.2532 0.6901
Leishmania major cathepsin L-like protease 0.0077 0.0942 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.3669 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0195 0.2532 0.2532
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0045 0.0482
Loa Loa (eye worm) acetyltransferase 0.0141 0.1804 0.4916
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.1678
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0045 0.005
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0092 0.1144 0.1144
Echinococcus multilocularis dna polymerase eta 0.0019 0.0158 0.0158
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0087 0.2096
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0158 0.0431
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0195 0.2532 0.6901
Plasmodium vivax vivapain-3 0.001 0.0045 0.098
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0103 0.1293 0.3524
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0095 0.1182 0.322
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0045 0.109
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0332 0.6814
Giardia lamblia Kinase, CMGC MAPK 0.0043 0.0487 1
Entamoeba histolytica cysteine protease, putative 0.001 0.0045 0.109
Leishmania major cytochrome p450-like protein 0.0023 0.022 0.2337
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0032 0.0332 0.796
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0942 1
Echinococcus granulosus intermediate filament protein 0.0026 0.0252 0.028
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0464 0.9515
Leishmania major alpha glucosidase II subunit, putative 0.0032 0.0332 0.3524
Brugia malayi hypothetical protein 0.0092 0.1144 0.3119
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0177 0.0197
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0103 0.1293 0.1436
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.072 0.7644
Schistosoma mansoni hypothetical protein 0.0676 0.9005 1
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0011 0.0051 0.0057
Schistosoma mansoni hypothetical protein 0.0042 0.0475 0.0527
Schistosoma mansoni lamin 0.0026 0.0252 0.028
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0042 0.0475 0.1293
Echinococcus granulosus lamin dm0 0.0026 0.0252 0.028
Loa Loa (eye worm) hypothetical protein 0.0011 0.0051 0.0139
Brugia malayi exodeoxyribonuclease III family protein 0.0035 0.0374 0.1021
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0043 0.0487 0.5171
Schistosoma mansoni steroid hormone receptor ad4bp 0.0195 0.2532 0.2812
Brugia malayi Cathepsin L-like precursor 0.002 0.0177 0.0483
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0035 0.0374 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0091 0.0248
Echinococcus granulosus cathepsin l1 0.0014 0.0087 0.0097
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0942 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0012 0.0064 0.0175
Brugia malayi Nuclear hormone receptor-like 1 0.0103 0.1293 0.3524
Brugia malayi conserved hypotetical protein 0.0092 0.1144 0.3119
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0195 0.2532 0.2532
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0158 0.0176
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0011 0.0051 0.0139
Brugia malayi hypothetical protein 0.0103 0.1293 0.3524
Loa Loa (eye worm) hypothetical protein 0.0019 0.0158 0.0431
Echinococcus multilocularis cathepsin L 0.001 0.0045 0.0045
Brugia malayi nuclear hormone receptor 0.0092 0.1144 0.3119
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0195 0.2532 0.2532
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0177 0.0197
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0177 0.0483
Trypanosoma brucei cytochrome P450, putative 0.0023 0.022 0.2337
Schistosoma mansoni nuclear hormone receptor 0.0195 0.2532 0.2812
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0052 0.061 0.0678
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0011 0.0051 0.0139
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0158 0.1678
Echinococcus multilocularis tar DNA binding protein 0.0056 0.0653 0.0653
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0103 0.1293 0.1436
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0195 0.2532 0.6901
Treponema pallidum exodeoxyribonuclease (exoA) 0.0035 0.0374 1
Brugia malayi CXXC zinc finger family protein 0.0025 0.0238 0.0647
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0045 0.0933
Schistosoma mansoni RAR-like nuclear receptor 0.0195 0.2532 0.2812
Loa Loa (eye worm) DR-78 0.0092 0.1144 0.3119
Onchocerca volvulus 0.0011 0.0051 0.0201
Brugia malayi RNA binding protein 0.0056 0.0653 0.1779
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.013
Brugia malayi Cathepsin L-like precursor 0.002 0.0177 0.0483
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0195 0.2532 0.2812
Trichomonas vaginalis maltase-glucoamylase, putative 0.0012 0.0064 0.1318
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0012 0.0064 0.0681
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0942 1
Entamoeba histolytica cysteine protease, putative 0.001 0.0045 0.109
Plasmodium vivax unspecified product 0.001 0.0045 0.098
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0035 0.0374 0.3975
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0252 0.3298 0.3662
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0158 0.1678
Entamoeba histolytica cysteine proteinase 2 0.001 0.0045 0.109
Schistosoma mansoni tar DNA-binding protein 0.0056 0.0653 0.0725
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0332 0.6814
Loa Loa (eye worm) hypothetical protein 0.0092 0.1144 0.3119
Brugia malayi tailless protein 0.0092 0.1144 0.3119
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0195 0.2532 0.6901
Toxoplasma gondii cathepsin CPL 0.002 0.0177 0.3051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0087 0.1795
Brugia malayi orphan nuclear receptor NR2E1 0.0092 0.1144 0.3119
Entamoeba histolytica cysteine proteinase 1, putative 0.001 0.0045 0.109
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0045 0.0482
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0158 0.3244
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.1804 0.4916
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0252 0.3298 0.3662
Brugia malayi RNA recognition motif domain containing protein 0.0056 0.0653 0.1779
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.1678
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0035 0.0374 0.8979
Echinococcus multilocularis cysteine protease 0.002 0.0177 0.0177
Echinococcus granulosus lysosomal alpha glucosidase 0.0143 0.1828 0.203
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0195 0.2532 0.2812
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0177 0.3641
Loa Loa (eye worm) hypothetical protein 0.0012 0.0072 0.0197
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0332 0.3524
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0013 0.0078 0.0826
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0195 0.2532 0.2532
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0252 0.0686
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0045 0.0124
Leishmania major cysteine peptidase A (CPA) 0.002 0.0177 0.1883
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0043 0.0487 0.5171
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0013 0.0078 0.0826
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0013 0.0078 0.2078
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0143 0.1828 0.4982
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0032 0.0332 0.6814
Schistosoma mansoni thyroid hormone receptor 0.0195 0.2532 0.2812
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0092 0.1144 0.1271
Loa Loa (eye worm) hypothetical protein 0.0065 0.0778 0.212
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0195 0.2532 0.2812
Schistosoma mansoni ap endonuclease 0.0035 0.0374 0.0416
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0195 0.2532 1
Brugia malayi nuclear receptor NHR-88 0.0195 0.2532 0.6901
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0177 0.0483
Toxoplasma gondii exonuclease III APE 0.0035 0.0374 0.6442
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.1804 0.1804
Leishmania major cathepsin L-like protease 0.002 0.0177 0.1883
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0177 0.4253
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0195 0.2532 0.2532
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.003 0.0309 0.0343
Plasmodium falciparum cysteine proteinase falcipain 1 0.001 0.0045 0.109
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0043 0.0487 0.5171
Loa Loa (eye worm) TAR-binding protein 0.0056 0.0653 0.1779
Brugia malayi Nuclear hormone receptor E75 0.0092 0.1144 0.3119
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0011 0.0051 0.0057
Echinococcus granulosus cysteine protease 0.001 0.0045 0.005
Schistosoma mansoni intermediate filament proteins 0.0026 0.0252 0.028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0177 0.3641
Schistosoma mansoni cpg binding protein 0.0026 0.0257 0.0285
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0177 0.0177
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0011 0.0051 0.0139
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0035 0.0374 0.7687
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0158 0.1678
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.008 0.0845
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0013 0.0078 0.2078
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0852 0.9045
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0092 0.1144 0.1271
Brugia malayi nuclear hormone receptor 0.0195 0.2532 0.6901
Entamoeba histolytica cysteine protease, putative 0.001 0.0045 0.109
Brugia malayi follicle stimulating hormone receptor 0.028 0.3669 1
Brugia malayi TAR-binding protein 0.0056 0.0653 0.1779
Loa Loa (eye worm) hypothetical protein 0.002 0.0177 0.0483
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0011 0.0051 0.0051
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.003 0.0309 0.0309
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0195 0.2532 0.6901
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0035 0.0374 0.0416
Schistosoma mansoni nuclear receptor 0.0092 0.1144 0.1271
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0011 0.0051 0.0139
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0013 0.0078 0.2078
Entamoeba histolytica G protein alpha subunit, putative 0.0011 0.0051 0.1223
Brugia malayi Glycosyl hydrolases family 31 protein 0.0032 0.0332 0.0905
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0011 0.0051 0.1047
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0011 0.0051 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0332 0.3524
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0012 0.0064 0.1318
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0011 0.0051 0.1047
Brugia malayi ecdysteroid receptor 0.0195 0.2532 0.6901
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0177 0.3641
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0045 0.109
Schistosoma mansoni hypothetical protein 0.003 0.0309 0.0343
Echinococcus granulosus dna polymerase eta 0.0019 0.0158 0.0176
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0942 1
Brugia malayi Steroid receptor seven-up type 2 0.0195 0.2532 0.6901
Echinococcus granulosus expressed protein 0.0011 0.0051 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0177 0.3641
Brugia malayi nuclear receptor RXR 0.0103 0.1293 0.3524
Entamoeba histolytica cysteine protease, putative 0.001 0.0045 0.109
Brugia malayi hypothetical protein 0.0092 0.1144 0.3119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0195 0.2532 0.6901
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0011 0.0051 0.0057
Trichomonas vaginalis alpha-glucosidase, putative 0.0012 0.0064 0.1318
Schistosoma mansoni tar DNA-binding protein 0.0056 0.0653 0.0725
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0177 0.3641
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.022 0.2337
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0035 0.0374 0.5
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0092 0.1144 0.1144
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0158 0.0158
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0942 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0942 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0045 0.005
Loa Loa (eye worm) hypothetical protein 0.0195 0.2532 0.6901
Schistosoma mansoni GTP-binding protein alpha subunit 0.0011 0.0051 0.0057
Loa Loa (eye worm) hypothetical protein 0.0092 0.1144 0.3119
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0011 0.0051 0.0057
Echinococcus granulosus lamin 0.0026 0.0252 0.028
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0011 0.0051 0.0057
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0011 0.0051 0.1047
Trichomonas vaginalis ap endonuclease, putative 0.0035 0.0374 0.7687
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0012 0.0072 0.008
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0011 0.0051 0.1047
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0043 0.0487 0.5171
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0195 0.2532 0.6901
Loa Loa (eye worm) hypothetical protein 0.0103 0.1293 0.3524
Onchocerca volvulus 0.002 0.0177 0.0701
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0092 0.1144 0.1271
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0043 0.0487 0.5171
Echinococcus multilocularis lamin dm0 0.0026 0.0252 0.0252
Entamoeba histolytica cysteine protease, putative 0.001 0.0045 0.109
Trichomonas vaginalis sucrase-isomaltase, putative 0.0032 0.0332 0.6814
Echinococcus multilocularis mitogen activated protein kinase 3 0.0043 0.0487 0.0487
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.175 0.1944
Brugia malayi Cytochrome P450 family protein 0.0023 0.022 0.06
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0177 0.3641
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0043 0.0487 0.1328
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0177 0.3641
Onchocerca volvulus 0.0026 0.0252 0.0994
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0011 0.0051 0.0139
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0008 0.0009
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0045 0.109
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0158 0.3244
Brugia malayi nuclear receptor RXR 0.0092 0.1144 0.3119
Echinococcus granulosus nuclear receptor nhr 48 0.0092 0.1144 0.1271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0177 0.3641
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.022 0.06
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0013 0.0078 0.0826
Loa Loa (eye worm) hypothetical protein 0.0195 0.2532 0.6901
Brugia malayi MAP kinase sur-1 0.0043 0.0487 0.1328
Loa Loa (eye worm) CXXC zinc finger family protein 0.0025 0.0238 0.0647
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0035 0.0374 0.8078
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0092 0.1144 0.452
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0035 0.0374 0.8979
Schistosoma mansoni tar DNA-binding protein 0.0056 0.0653 0.0725
Brugia malayi Nuclear hormone receptor-like 1 0.0103 0.1293 0.3524
Trichomonas vaginalis maltase-glucoamylase, putative 0.0032 0.0332 0.6814
Onchocerca volvulus 0.0011 0.0051 0.0201
Loa Loa (eye worm) hypothetical protein 0.0011 0.0051 0.0139
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0087 0.0097
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0158 0.2705
Schistosoma mansoni nuclear hormone receptor 0.0092 0.1144 0.1271
Onchocerca volvulus Cathepsin L homolog 0.002 0.0177 0.0701
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0252 0.3298 0.3662
Echinococcus granulosus cpg binding protein 0.0026 0.0257 0.0285
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0158 0.0176
Loa Loa (eye worm) hypothetical protein 0.0195 0.2532 0.6901
Brugia malayi Latrophilin receptor protein 2 0.003 0.0309 0.0842
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0011 0.0051 0.0139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0177 0.3641
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.1678
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0195 0.2532 0.6901
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0043 0.0487 0.838
Loa Loa (eye worm) G protein alpha subunit 3 0.0011 0.0051 0.0139
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0092 0.1144 0.3119
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0013 0.0078 0.2078
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0698 0.1902
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0942 1
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0011 0.0051 0.0057
Leishmania major cathepsin L-like protease 0.002 0.0177 0.1883
Trypanosoma brucei protein kinase, putative 0.0043 0.0487 0.5171
Echinococcus granulosus GPCR family 2 0.003 0.0309 0.0343
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0177 0.3641
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0011 0.0051 0.0057
Schistosoma mansoni alpha-glucosidase 0.0123 0.156 0.1733
Echinococcus multilocularis cpg binding protein 0.0026 0.0257 0.0257
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.0045 0.0482
Loa Loa (eye worm) hypothetical protein 0.0092 0.1144 0.3119
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0158 0.1678
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0464 1
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0011 0.0051 0.1047
Loa Loa (eye worm) ctsf protein 0.002 0.0177 0.0483
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.1678
Brugia malayi cathepsin L-like precursor 0.0014 0.0087 0.0238
Toxoplasma gondii cytochrome p450 superfamily protein 0.0013 0.0078 0.1339
Loa Loa (eye worm) hypothetical protein 0.0012 0.0066 0.018
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0158 0.4221
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0195 0.2532 0.6901
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0177 0.3641
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0487 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0195 0.2532 0.6901
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0195 0.2532 0.2812
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.1804 0.2003
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0487 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0464 0.0515
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0035 0.0374 0.0374
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0035 0.0374 0.3975
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0195 0.2532 0.6901
Loa Loa (eye worm) histone methyltransferase 0.0008 0.0008 0.0022
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0252 0.0686
Loa Loa (eye worm) hypothetical protein 0.0092 0.1144 0.3119
Loa Loa (eye worm) hypothetical protein 0.0092 0.1144 0.3119
Trypanosoma brucei glycosyl hydrolase-like protein 0.0012 0.0064 0.0681
Brugia malayi Cytochrome P450 family protein 0.0023 0.022 0.06
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0252 0.3298 0.8988
Echinococcus multilocularis lysosomal alpha glucosidase 0.0143 0.1828 0.1828
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0045 0.0933
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0091 0.0248
Onchocerca volvulus 0.0026 0.0252 0.0994
Loa Loa (eye worm) cytochrome P450 0.0013 0.0078 0.0212
Onchocerca volvulus 0.002 0.0177 0.0701
Echinococcus multilocularis GPCR, family 2 0.003 0.0309 0.0309
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0942 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.1144 0.3119
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0043 0.0487 0.5171
Brugia malayi hypothetical protein 0.0103 0.1293 0.3524
Loa Loa (eye worm) hypothetical protein 0.0195 0.2532 0.6901
Loa Loa (eye worm) hypothetical protein 0.0092 0.1144 0.3119
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0195 0.2532 0.6901
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.022 0.06
Trypanosoma brucei glucosidase, putative 0.0032 0.0332 0.3524
Onchocerca volvulus 0.0195 0.2532 1
Onchocerca volvulus 0.0025 0.0238 0.0938
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0032 0.0332 0.0905
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0011 0.0051 0.0057
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0007 0.0018
Brugia malayi Calcitonin receptor-like protein seb-1 0.0095 0.1182 0.322
Schistosoma mansoni nuclear receptor nhr-48 0.0092 0.1144 0.1271
Loa Loa (eye worm) hypothetical protein 0.0195 0.2532 0.6901
Schistosoma mansoni hypothetical protein 0.003 0.0309 0.0343
Loa Loa (eye worm) CYP4Cod1 0.0023 0.022 0.06
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0942 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.1144 0.3119
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0092 0.1144 0.1144
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0158 0.1678
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.1678
Echinococcus granulosus Nuclear hormone receptor HR96 0.0092 0.1144 0.1271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0177 0.3641
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0195 0.2532 0.2812
Onchocerca volvulus 0.0092 0.1144 0.452
Onchocerca volvulus 0.002 0.0177 0.0701
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0177 0.0177
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0487 1
Entamoeba histolytica cysteine protease, putative 0.001 0.0045 0.109
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0011 0.0051 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0195 0.2532 0.6901
Leishmania major cathepsin L-like protease 0.0077 0.0942 1
Onchocerca volvulus Cathepsin L homolog 0.002 0.0177 0.0701
Echinococcus multilocularis musashi 0.0026 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0026 0.0252 0.0686
Loa Loa (eye worm) hypothetical protein 0.0011 0.0051 0.0139
Brugia malayi latrophilin 2 splice variant baaae 0.0065 0.0778 0.212
Echinococcus granulosus thyroid hormone receptor alpha 0.0092 0.1144 0.1271
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0487 1
Echinococcus multilocularis lamin 0.0026 0.0252 0.0252
Brugia malayi Glycosyl hydrolases family 31 protein 0.0143 0.1828 0.4982
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0103 0.1293 0.1293
Schistosoma mansoni alpha glucosidase 0.0032 0.0332 0.0369
Echinococcus granulosus dna polymerase kappa 0.0019 0.0158 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.1678
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0011 0.0051 0.0139
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0035 0.0374 0.3975
Echinococcus granulosus Nuclear hormone receptor HR96 0.0092 0.1144 0.1271
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0011 0.0051 0.0057
Schistosoma mansoni nuclear hormone receptor 0.0092 0.1144 0.1271
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0013 0.0078 0.2078
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0012 0.0072 0.0072
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0942 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0195 0.2532 0.6901
Echinococcus granulosus cathepsin L 0.001 0.0045 0.005
Brugia malayi G-protein alpha subunit 0.0011 0.0051 0.0139
Loa Loa (eye worm) hypothetical protein 0.0014 0.0087 0.0238
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0158 0.1678
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0177 0.4253
Onchocerca volvulus 0.002 0.0177 0.0701
Loa Loa (eye worm) RNA binding protein 0.0056 0.0653 0.1779
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0332 0.6814
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.1678
Brugia malayi nuclear hormone receptor family member nhr-6 0.0092 0.1144 0.3119
Loa Loa (eye worm) hypothetical protein 0.0103 0.1293 0.3524
Giardia lamblia DINP protein human, muc B family 0.0019 0.0158 0.3244
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0013 0.0078 0.2078
Plasmodium vivax vivapain-2 0.002 0.0177 0.3827
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0417 0.8561
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0011 0.0051 0.0057
Entamoeba histolytica cysteine protease, putative 0.001 0.0045 0.109
Loa Loa (eye worm) hypothetical protein 0.0207 0.2696 0.7348
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0013 0.0078 0.0826
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.003 0.0309 0.0309
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0942 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0158 0.0158
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0158 0.1678
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0417 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.003 0.0309 0.0343
Echinococcus multilocularis nuclear receptor nhr 48 0.0092 0.1144 0.1144
Schistosoma mansoni cytochrome P450 0.0013 0.0078 0.0086
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0158 0.1678
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0012 0.0064 0.1539
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0013 0.0078 0.2078
Schistosoma mansoni retinoic acid receptor RXR 0.0195 0.2532 0.2812
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0332 0.6814
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0092 0.1144 0.1144
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0013 0.0078 0.2078
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0013 0.0078 0.2078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0177 0.3641
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0035 0.0374 0.3975
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0177 0.3641
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0011 0.0051 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0195 0.2532 0.6901
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.022 0.48
Loa Loa (eye worm) hypothetical protein 0.0011 0.0051 0.0139
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0464 0.7974
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0013 0.0078 0.2078
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0177 0.0177
Echinococcus granulosus cathepsin l1 0.002 0.0177 0.0197
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0195 0.2532 0.2812
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0252 0.3298 0.3298
Onchocerca volvulus 0.0014 0.0087 0.0345
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0013 0.0078 0.2078
Brugia malayi steroid hormone receptor 0.0195 0.2532 0.6901
Onchocerca volvulus 0.0011 0.0051 0.0201
Leishmania major cytochrome p450-like protein 0.0013 0.0078 0.0826
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0177 0.3641
Leishmania major glycosyl hydrolase-like protein 0.0012 0.0064 0.0681
Brugia malayi Cathepsin L-like precursor 0.0014 0.0087 0.0238
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0195 0.2532 0.6901
Schistosoma mansoni cpg binding protein 0.0025 0.0238 0.0264
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0487 0.0541
Brugia malayi Cathepsin L-like precursor 0.002 0.0177 0.0483
Brugia malayi Nuclear hormone receptor E75 0.0092 0.1144 0.3119
Plasmodium vivax vivapain-1 0.001 0.0045 0.098
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0008 0.0008
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0011 0.0051 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0942 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0092 0.1144 0.3119
Leishmania major cathepsin L-like protease 0.002 0.0177 0.1883
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0011 0.0051 0.0139
Echinococcus granulosus cytochrome P450 2K1 0.0013 0.0078 0.0086
Trichomonas vaginalis alpha-glucosidase, putative 0.0012 0.0064 0.1318
Onchocerca volvulus 0.0092 0.1144 0.452
Entamoeba histolytica cysteine protease, putative 0.001 0.0045 0.109
Leishmania major cytochrome p450-like protein 0.0013 0.0078 0.0826
Schistosoma mansoni zinc finger protein 0.0092 0.1144 0.1271
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0035 0.0374 0.1021
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0092 0.1144 0.3119
Brugia malayi Cathepsin L-like precursor 0.0014 0.0087 0.0238
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0177 0.1883
Brugia malayi ecdysone receptor 0.0092 0.1144 0.3119
Leishmania major DNA polymerase kappa, putative 0.0019 0.0158 0.1678
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0087 0.0238
Brugia malayi Cathepsin L-like precursor 0.002 0.0177 0.0483
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0092 0.1144 0.1271
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0195 0.2532 0.6901
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0464 0.9515
Loa Loa (eye worm) hypothetical protein 0.0195 0.2532 0.6901
Schistosoma mansoni alpha-glucosidase 0.0123 0.156 0.1733
Echinococcus multilocularis 0.0013 0.0078 0.0078
Schistosoma mansoni cpg binding protein 0.0026 0.0257 0.0285
Leishmania major cathepsin L-like protease 0.002 0.0177 0.1883
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0013 0.0078 0.2078
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0417 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0158 0.0431
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0011 0.0051 0.0139
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0013 0.0078 0.2078
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0045 0.005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0177 0.3641
Trichomonas vaginalis alpha-glucosidase, putative 0.0012 0.0064 0.1318
Schistosoma mansoni hypothetical protein 0.0676 0.9005 1
Loa Loa (eye worm) hypothetical protein 0.0195 0.2532 0.6901
Onchocerca volvulus 0.002 0.0177 0.0701
Brugia malayi Nuclear hormone receptor-like 1 0.0195 0.2532 0.6901
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.1678
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0032 0.0332 0.796
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0045 0.0482
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0013 0.0078 0.2078

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 0.251188643 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 0.316227766 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 1.995262315 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 31.6227766 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 31.6227766 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (ADMET) = 0.2512 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ] ChEMBL. No reference
Potency (ADMET) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (ADMET) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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