Detailed information for compound 1342598

Basic information

Technical information
  • TDR Targets ID: 1342598
  • Name: tert-butyl 4-[2-[4-[3-[bis[(2-methylpropan-2- yl)oxycarbonylamino]methylideneamino]propyl]t riazol-1-yl]acetyl]piperazine-1-carboxylate
  • MW: 594.704 | Formula: C27H46N8O7
  • H donors: 2 H acceptors: 6 LogP: 3.49 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(OC(C)(C)C)N/C(=N/C(=O)OC(C)(C)C)/NCCCc1nnn(c1)CC(=O)N1CCN(CC1)C(=O)OC(C)(C)C
  • InChi: 1S/C27H46N8O7/c1-25(2,3)40-22(37)29-21(30-23(38)41-26(4,5)6)28-12-10-11-19-17-35(32-31-19)18-20(36)33-13-15-34(16-14-33)24(39)42-27(7,8)9/h17H,10-16,18H2,1-9H3,(H2,28,29,30,37,38)
  • InChiKey: BEEUXSVKXNUYLF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • tert-butyl 4-[2-[4-[3-[bis(tert-butoxycarbonylamino)methyleneamino]propyl]triazol-1-yl]acetyl]piperazine-1-carboxylate
  • 4-[2-[4-[3-[bis[(tert-butoxy-oxomethyl)amino]methyleneamino]propyl]-1-triazolyl]-1-oxoethyl]-1-piperazinecarboxylic acid tert-butyl ester
  • 4-[2-[4-[3-[bis(tert-butoxycarbonylamino)methyleneamino]propyl]triazol-1-yl]acetyl]piperazine-1-carboxylic acid tert-butyl ester
  • tert-butyl 4-[2-[4-[3-[bis[(2-methylpropan-2-yl)oxycarbonylamino]methylideneamino]propyl]-1,2,3-triazol-1-yl]ethanoyl]piperazine-1-carboxylate
  • MLS000560469
  • SMR000327410
  • Yu-mono-GR

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0214 0.0204
Onchocerca volvulus 0.0084 0.162 0.3443
Brugia malayi Nuclear hormone receptor-like 1 0.0094 0.1826 0.5134
Echinococcus multilocularis FTZ F1 alpha 0.0178 0.3548 0.3542
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0284 0.5
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0084 0.162 0.162
Loa Loa (eye worm) hypothetical protein 0.0084 0.162 0.4551
Schistosoma mansoni hypothetical protein 0.0015 0.0214 0.0214
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0284 1
Loa Loa (eye worm) hypothetical protein 0.0178 0.3548 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0084 0.162 0.4551
Trypanosoma brucei unspecified product 0.0013 0.0165 0.55
Schistosoma mansoni nuclear receptor 0.0084 0.162 0.162
Trypanosoma brucei unspecified product 0.0019 0.0284 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0608 0.1689
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0178 0.3548 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0813 0.0804
Loa Loa (eye worm) nuclear receptor NHR-67 0.0084 0.162 0.4551
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0214 0.0204
Brugia malayi nuclear receptor NHR-88 0.0178 0.3548 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0084 0.162 0.1612
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0214 0.0204
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0178 0.3548 0.3548
Echinococcus granulosus thyroid hormone receptor alpha 0.0084 0.162 0.1612
Onchocerca volvulus 0.0084 0.162 0.3443
Schistosoma mansoni hypothetical protein 0.0015 0.0214 0.0214
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0284 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0178 0.3548 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0094 0.1826 0.5134
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0118 0.0108
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0178 0.3548 0.3542
Giardia lamblia DINP protein human, muc B family 0.0019 0.0284 0.4023
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1403 0.1403
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0751 0.5659
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0074 0.0065
Schistosoma mansoni coup transcription factor 0.0178 0.3548 0.3548
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0284 1
Echinococcus multilocularis dna polymerase eta 0.0019 0.0284 0.0275
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0284 0.3257
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0284 1
Brugia malayi Steroid receptor seven-up type 2 0.0178 0.3548 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0813 0.0804
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0178 0.3548 0.3548
Loa Loa (eye worm) hypothetical protein 0.0178 0.3548 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0178 0.3548 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0284 1
Brugia malayi ecdysone receptor 0.0084 0.162 0.4551
Brugia malayi Nuclear hormone receptor E75 0.0084 0.162 0.4551
Echinococcus multilocularis ecdysone induced protein 78C 0.0178 0.3548 0.3542
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0751 0.5659
Loa Loa (eye worm) hypothetical protein 0.0178 0.3548 1
Schistosoma mansoni RAR-like nuclear receptor 0.0178 0.3548 0.3548
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0165 0.55
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0813 0.0813
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0178 0.3548 0.3542
Brugia malayi ecdysteroid receptor 0.0178 0.3548 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.162 0.4551
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0165 0.55
Schistosoma mansoni hypothetical protein 0.0015 0.0214 0.0214
Loa Loa (eye worm) acetyltransferase 0.0142 0.2798 0.7879
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0084 0.162 0.1612
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0284 0.0275
Onchocerca volvulus Bile acid receptor homolog 0.0178 0.3548 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0178 0.3548 0.3542
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0178 0.3548 0.3542
Loa Loa (eye worm) hypothetical protein 0.0178 0.3548 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0284 0.5
Loa Loa (eye worm) hypothetical protein 0.0178 0.3548 1
Brugia malayi hypothetical protein 0.0094 0.1826 0.5134
Loa Loa (eye worm) hypothetical protein 0.0049 0.0896 0.2503
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0896 0.2503
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0284 1
Schistosoma mansoni zinc finger protein 0.0084 0.162 0.162
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.058 0.1612
Brugia malayi nuclear receptor NHR-67 0.0084 0.162 0.4551
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0084 0.162 0.4551
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0284 0.3257
Echinococcus granulosus Nuclear hormone receptor HR96 0.0084 0.162 0.1612
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0084 0.162 0.3443
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0284 0.0275
Loa Loa (eye worm) hypothetical protein 0.0094 0.1826 0.5134
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0084 0.162 0.1612
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0118 0.0305
Loa Loa (eye worm) hypothetical protein 0.0084 0.162 0.4551
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.2716 0.2709
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0178 0.3548 0.3542
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.068 1
Loa Loa (eye worm) hypothetical protein 0.0178 0.3548 1
Brugia malayi nuclear receptor RXR 0.0094 0.1826 0.5134
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0284 1
Schistosoma mansoni hypothetical protein 0.0494 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0178 0.3548 0.3542
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0284 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0178 0.3548 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0178 0.3548 1
Schistosoma mansoni nuclear receptor nhr-48 0.0084 0.162 0.162
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0284 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0284 0.0776
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0094 0.1826 0.1826
Loa Loa (eye worm) hypothetical protein 0.0015 0.0214 0.0577
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0178 0.3548 1
Echinococcus multilocularis GPCR, family 2 0.0015 0.0214 0.0204
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0178 0.3548 0.3548
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0284 1
Echinococcus granulosus GPCR family 2 0.0015 0.0214 0.0204
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0896 0.2503
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0024
Brugia malayi Nuclear hormone receptor E75 0.0084 0.162 0.4551
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0178 0.3548 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0284 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.162 0.4551
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0178 0.3548 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0084 0.162 0.3443
Loa Loa (eye worm) hypothetical protein 0.0178 0.3548 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0178 0.3548 0.3542
Brugia malayi CXXC zinc finger family protein 0.0035 0.0608 0.1689
Brugia malayi polk-prov protein 0.0006 0.0018 0.0024
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0178 0.3548 0.3542
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0284 0.0275
Schistosoma mansoni DNA polymerase eta 0.0019 0.0284 0.0284
Schistosoma mansoni cpg binding protein 0.0037 0.0648 0.0648
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0178 0.3548 0.3542
Echinococcus multilocularis nuclear receptor nhr 48 0.0084 0.162 0.1612
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0751 0.0742
Loa Loa (eye worm) DR-78 0.0084 0.162 0.4551
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0074 0.0065
Onchocerca volvulus 0.0178 0.3548 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0178 0.3548 0.3542
Brugia malayi hypothetical protein 0.0084 0.162 0.4551
Echinococcus granulosus dna polymerase eta 0.0019 0.0284 0.0275
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0178 0.3548 1
Echinococcus granulosus nuclear receptor nhr 48 0.0084 0.162 0.1612
Loa Loa (eye worm) hypothetical protein 0.0084 0.162 0.4551
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0084 0.162 0.162
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0178 0.3548 0.3548
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0284 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0214 0.0577
Brugia malayi hypothetical protein 0.0084 0.162 0.4551
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0165 0.55
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0284 0.0284
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0084 0.162 0.1612
Brugia malayi nuclear receptor RXR 0.0084 0.162 0.4551
Brugia malayi steroid hormone receptor 0.0178 0.3548 1
Trypanosoma brucei unspecified product 0.0013 0.0165 0.55
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0074 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0284 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.162 0.4551
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0214 0.0204
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.2798 0.7879
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0284 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0813 0.0813
Loa Loa (eye worm) hypothetical protein 0.0178 0.3548 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0178 0.3548 0.3548
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0178 0.3548 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0284 0.0776
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0813 0.0804
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0284 1
Brugia malayi nuclear receptor NHR-88 0.0084 0.162 0.4551
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0178 0.3548 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0284 0.0776
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0178 0.3548 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0284 1
Brugia malayi nuclear hormone receptor 0.0178 0.3548 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0178 0.3548 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0284 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.162 0.4551
Loa Loa (eye worm) hypothetical protein 0.0094 0.1826 0.5134
Loa Loa (eye worm) hypothetical protein 0.0084 0.162 0.4551
Schistosoma mansoni zinc finger protein 0.0005 0.001 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0813 0.0804
Brugia malayi tailless protein 0.0084 0.162 0.4551
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0094 0.1826 0.1818
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0178 0.3548 0.3542
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0084 0.162 0.1612
Echinococcus granulosus ecdysone induced protein 78C 0.0178 0.3548 0.3542
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0214 0.0577
Loa Loa (eye worm) hypothetical protein 0.0084 0.162 0.4551
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0284 0.0284
Schistosoma mansoni thyroid hormone receptor 0.0178 0.3548 0.3548
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0084 0.162 0.1612
Brugia malayi orphan nuclear receptor NR2E1 0.0084 0.162 0.4551
Schistosoma mansoni nuclear hormone receptor 0.0084 0.162 0.162
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0094 0.1826 0.1818
Loa Loa (eye worm) hypothetical protein 0.0094 0.1826 0.5134
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0178 0.3548 1
Schistosoma mansoni cpg binding protein 0.0035 0.0608 0.0608
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0813 0.2271
Schistosoma mansoni cpg binding protein 0.0037 0.0648 0.0648
Leishmania major DNA polymerase eta, putative 0.0019 0.0284 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0751 1
Echinococcus granulosus cpg binding protein 0.0037 0.0648 0.0639
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0178 0.3548 1
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.068 1
Brugia malayi conserved hypotetical protein 0.0084 0.162 0.4551
Loa Loa (eye worm) steroid hormone receptor 0.0178 0.3548 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.162 0.4551
Loa Loa (eye worm) nuclear hormone receptor 0.0084 0.162 0.4551
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0178 0.3548 1
Schistosoma mansoni thyroid hormone receptor 0.0178 0.3548 0.3548
Brugia malayi Nuclear hormone receptor-like 1 0.0094 0.1826 0.5134
Schistosoma mansoni bromodomain containing protein 0.0005 0.001 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0178 0.3548 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0284 0.0776
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0094 0.1826 0.1826
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0214 0.0577
Echinococcus multilocularis thyroid hormone receptor alpha 0.0178 0.3548 0.3542
Echinococcus granulosus FTZ F1 alpha 0.0178 0.3548 0.3542
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0084 0.162 0.1612
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0018 0.0018
Brugia malayi nuclear hormone receptor 0.0084 0.162 0.4551
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.2798 0.2798
Echinococcus multilocularis cpg binding protein 0.0037 0.0648 0.0639
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0178 0.3548 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.068 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0813 0.2271
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0074 0.0065
Echinococcus granulosus Nuclear hormone receptor HR96 0.0084 0.162 0.1612
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0284 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0178 0.3548 0.3548
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0178 0.3548 0.3542
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0115 0.0297
Schistosoma mansoni nuclear receptor 0.0084 0.162 0.162
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0074 0.0074
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0284 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.1313 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.162 0.4551
Loa Loa (eye worm) hypothetical protein 0.0094 0.1826 0.5134
Schistosoma mansoni nuclear hormone receptor 0.0178 0.3548 0.3548
Brugia malayi Nuclear hormone receptor-like 1 0.0178 0.3548 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0178 0.3548 1
Schistosoma mansoni nuclear hormone receptor 0.0084 0.162 0.162
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0178 0.3548 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0813 0.0813
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0284 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.162 0.4551
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0178 0.3548 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.058 0.1612
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0084 0.162 0.4551
Brugia malayi nuclear hormone receptor family member odr-7 0.0084 0.162 0.4551
Schistosoma mansoni hypothetical protein 0.0015 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0094 0.1826 0.5134
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0751 1
Leishmania major DNA polymerase kappa, putative 0.0019 0.0284 1
Schistosoma mansoni retinoic acid receptor RXR 0.0178 0.3548 0.3548
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0751 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0178 0.3548 0.3542
Loa Loa (eye worm) hypothetical protein 0.0084 0.162 0.4551
Schistosoma mansoni bromodomain containing protein 0.0005 0.001 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0284 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0178 0.3548 1
Echinococcus granulosus dna polymerase kappa 0.0019 0.0284 0.0275
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0896 0.2503
Brugia malayi hypothetical protein 0.0094 0.1826 0.5134
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0118 0.0108
Schistosoma mansoni hypothetical protein 0.0033 0.058 0.058
Schistosoma mansoni steroid hormone receptor ad4bp 0.0178 0.3548 0.3548
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.2798 0.2791
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0178 0.3548 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0284 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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