TDR Targets

Basic information

Technical information

TDR Targets ID: 134264
Name: (2R)-1-(4-benzylpiperazin-1-yl)-3,3,3-trifluo ro-2-hydroxy-2-methylpropan-1-one
MW: 316.319 | Formula: C15H19F3N2O2
H donors: 1 H acceptors: 2 LogP: 1.71 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C([C@](C(F)(F)F)(O)C)N1CCN(CC1)Cc1ccccc1
InChi: 1S/C15H19F3N2O2/c1-14(22,15(16,17)18)13(21)20-9-7-19(8-10-20)11-12-5-3-2-4-6-12/h2-6,22H,7-11H2,1H3/t14-/m1/s1
InChiKey: KWYSLQQFPJNQKB-CQSZACIVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2R)-1-(4-benzylpiperazin-1-yl)-3,3,3-trifluoro-2-hydroxy-2-methyl-propan-1-one
(2R)-1-(4-benzyl-1-piperazinyl)-3,3,3-trifluoro-2-hydroxy-2-methyl-1-propanone
(2R)-3,3,3-trifluoro-2-hydroxy-2-methyl-1-[4-(phenylmethyl)piperazin-1-yl]propan-1-one
(2R)-1-(4-benzylpiperazino)-3,3,3-trifluoro-2-hydroxy-2-methyl-propan-1-one
(2R)-3,3,3-trifluoro-2-hydroxy-2-methyl-1-[4-(phenylmethyl)-1-piperazinyl]propan-1-one
(2R)-1-[4-(benzyl)piperazin-1-yl]-3,3,3-trifluoro-2-hydroxy-2-methyl-propan-1-one

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Pyruvate dehydrogenase kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	Get druggable targets OG5_127409	All targets in OG5_127409
Trypanosoma brucei gambiense	developmentally regulated phosphoprotein	Get druggable targets OG5_127409	All targets in OG5_127409
Schistosoma japonicum	ko:K00898 pyruvate dehydrogenase kinase [EC2.7.11.2], putative	Get druggable targets OG5_127409	All targets in OG5_127409
Trypanosoma cruzi	developmentally regulated phosphoprotein, putative	Get druggable targets OG5_127409	All targets in OG5_127409
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127409	All targets in OG5_127409
Leishmania donovani	developmentally regulated phosphoprotein-like protein	Get druggable targets OG5_127409	All targets in OG5_127409
Schistosoma mansoni	pyruvate dehydrogenase	Get druggable targets OG5_127409	All targets in OG5_127409
Candida albicans	similar to S. pombe SPAC644.11c predicted pyruvate dehydrogenase kinase	Get druggable targets OG5_127409	All targets in OG5_127409
Leishmania braziliensis	developmentally regulated phosphoprotein-like protein	Get druggable targets OG5_127409	All targets in OG5_127409
Leishmania mexicana	developmentally regulated phosphoprotein-like protein	Get druggable targets OG5_127409	All targets in OG5_127409
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	Get druggable targets OG5_127409	All targets in OG5_127409
Leishmania infantum	developmentally regulated phosphoprotein-like protein	Get druggable targets OG5_127409	All targets in OG5_127409
Schistosoma mansoni	pyruvate dehydrogenase	Get druggable targets OG5_127409	All targets in OG5_127409
Schistosoma japonicum	[Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial precursor, putative	Get druggable targets OG5_127409	All targets in OG5_127409
Schistosoma mansoni	pyruvate dehydrogenase	Get druggable targets OG5_127409	All targets in OG5_127409
Trypanosoma brucei	developmentally regulated phosphoprotein	Get druggable targets OG5_127409	All targets in OG5_127409
Brugia malayi	kinase, mitochondrial precursor	Get druggable targets OG5_127409	All targets in OG5_127409
Leishmania major	developmentally regulated phosphoprotein-like protein	Get druggable targets OG5_127409	All targets in OG5_127409
Echinococcus granulosus	Pyruvate dehydrogenase lipoamide kinase	Get druggable targets OG5_127409	All targets in OG5_127409
Trypanosoma congolense	developmentally regulated phosphoprotein, putative	Get druggable targets OG5_127409	All targets in OG5_127409

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Leishmania mexicana	pyruvate dehydrogenase (lipoamide) kinase, putative	Pyruvate dehydrogenase kinase	407 aa	373 aa	22.5 %
Leishmania donovani	pyruvate dehydrogenase (lipoamide) kinase, putative	Pyruvate dehydrogenase kinase	407 aa	373 aa	23.3 %
Leishmania infantum	pyruvate dehydrogenase (lipoamide) kinase, putative	Pyruvate dehydrogenase kinase	407 aa	373 aa	23.3 %
Trypanosoma brucei gambiense	pyruvate dehydrogenase (lipoamide) kinase, putative	Pyruvate dehydrogenase kinase	407 aa	348 aa	22.4 %
Leishmania major	pyruvate dehydrogenase (lipoamide) kinase, putative	Pyruvate dehydrogenase kinase	407 aa	373 aa	23.1 %
Trypanosoma cruzi	pyruvate dehydrogenase (lipoamide) kinase, putative	Pyruvate dehydrogenase kinase	407 aa	337 aa	22.3 %
Trypanosoma congolense	pyruvate dehydrogenase (lipoamide) kinase, putative	Pyruvate dehydrogenase kinase	407 aa	339 aa	22.7 %
Trypanosoma brucei	pyruvate dehydrogenase (lipoamide) kinase, putative	Pyruvate dehydrogenase kinase	407 aa	348 aa	22.4 %
Leishmania braziliensis	pyruvate dehydrogenase (lipoamide) kinase, putative	Pyruvate dehydrogenase kinase	407 aa	373 aa	22.3 %
Neospora caninum	3-methyl-2-oxobutanoate dehydrogenase (lipoamide) kinase, putative	Pyruvate dehydrogenase kinase	407 aa	377 aa	28.1 %
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	Pyruvate dehydrogenase kinase	407 aa	374 aa	28.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	esterase/lipase LipP	0.0078	0.0802	1
Loa Loa (eye worm)	PHD-finger family protein	0.0024	0.0048	0.0054
Loa Loa (eye worm)	beta-lactamase	0.0078	0.0802	0.0907
Brugia malayi	MH1 domain containing protein	0.0045	0.0336	0.0316
Brugia malayi	beta-lactamase family protein	0.0078	0.0802	0.0847
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0664	0.1909
Leishmania major	cathepsin L-like protease	0.0068	0.0664	0.1909
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1205	0.1363
Mycobacterium tuberculosis	Probable hydrolase	0.0078	0.0802	0.0356
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0045	0.0336	0.0306
Brugia malayi	intermediate filament protein	0.0055	0.0484	0.0486
Brugia malayi	beta-lactamase	0.0078	0.0802	0.0847
Trichomonas vaginalis	penicillin-binding protein, putative	0.0078	0.0802	0.5
Loa Loa (eye worm)	nuclear factor I	0.0025	0.0058	0.0065
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0069	0.0682	0.0653
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0062	0.0586	0.1306
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0085	0.0097
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0045	0.0336	0.0306
Echinococcus multilocularis	smad	0.0045	0.0336	0.0306
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0664	0.1909
Mycobacterium tuberculosis	Conserved protein	0.0078	0.0802	0.0356
Brugia malayi	Intermediate filament tail domain containing protein	0.0055	0.0484	0.0486
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0664	0.1909
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0045	0.0336	0.0306
Mycobacterium tuberculosis	Probable lipase LipD	0.0078	0.0802	0.0356
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0498	0.6669	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0664	0.1909
Trypanosoma brucei	developmentally regulated phosphoprotein	0.0144	0.1721	1
Schistosoma mansoni	smad	0.0045	0.0336	0.0306
Brugia malayi	MH1 domain containing protein	0.0045	0.0336	0.0316
Echinococcus granulosus	lamin dm0	0.0055	0.0484	0.0455
Echinococcus granulosus	tumor protein p63	0.073	0.9905	0.9905
Onchocerca volvulus		0.0078	0.0802	0.4409
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0256	0.3284	0.3714
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0664	0.1909
Leishmania major	cathepsin L-like protease	0.0068	0.0664	0.1909
Trichomonas vaginalis	D-aminoacylase, putative	0.0078	0.0802	0.5
Mycobacterium tuberculosis	Conserved protein	0.0078	0.0802	0.0356
Trypanosoma brucei	hypothetical protein, conserved	0.0078	0.0802	0.2964
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0078	0.0802	0.0356
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.0664	0.1909
Mycobacterium tuberculosis	Probable esterase LipL	0.0078	0.0802	0.0356
Plasmodium vivax	hypothetical protein, conserved	0.0078	0.0802	0.5
Brugia malayi	RNA binding protein	0.0256	0.3284	0.3673
Toxoplasma gondii	ABC1 family protein	0.0078	0.0802	1
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0802	0.0907
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0078	0.0802	0.0774
Mycobacterium leprae	Probable lipase LipE	0.0078	0.0802	0.5
Loa Loa (eye worm)	MH2 domain-containing protein	0.0045	0.0336	0.0379
Schistosoma mansoni	tar DNA-binding protein	0.0256	0.3284	0.3264
Brugia malayi	Smad1	0.0045	0.0336	0.0316
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0055	0.0484	0.0548
Brugia malayi	beta-lactamase family protein	0.0078	0.0802	0.0847
Schistosoma mansoni	pyruvate dehydrogenase	0.0144	0.1721	0.1695
Trypanosoma cruzi	cruzipain precursor, putative	0.0068	0.0664	0.1909
Onchocerca volvulus		0.0078	0.0802	0.4409
Echinococcus multilocularis	musashi	0.0055	0.0484	0.0455
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0078	0.0802	0.0907
Brugia malayi	MH2 domain containing protein	0.0045	0.0336	0.0316
Echinococcus granulosus	Pyruvate dehydrogenase lipoamide kinase	0.0144	0.1721	0.1695
Brugia malayi	kinase, mitochondrial precursor	0.0144	0.1721	0.1893
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0026	0.0079	0.0048
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0664	0.1909
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0078	0.0802	0.0356
Schistosoma mansoni	tar DNA-binding protein	0.0256	0.3284	0.3264
Echinococcus granulosus	fetal alzheimer antigen falz	0.0026	0.0079	0.0048
Echinococcus multilocularis	tar DNA binding protein	0.0256	0.3284	0.3264
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.0664	0.1909
Echinococcus granulosus	smad	0.0045	0.0336	0.0306
Schistosoma mansoni	Smad4	0.0045	0.0336	0.0306
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0078	0.0802	0.0774
Onchocerca volvulus		0.0078	0.0802	0.4409
Echinococcus granulosus	Smad4	0.0045	0.0336	0.0306
Loa Loa (eye worm)	MH1 domain-containing protein	0.0045	0.0336	0.0379
Trichomonas vaginalis	penicillin-binding protein, putative	0.0078	0.0802	0.5
Leishmania major	cathepsin L-like protease	0.0068	0.0664	0.1909
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0027	0.0085	0.0055
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0078	0.0802	1
Schistosoma mansoni	microtubule-associated protein tau	0.0736	1	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0654	0.8844	1
Loa Loa (eye worm)	TAR-binding protein	0.0256	0.3284	0.3714
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0802	0.0907
Loa Loa (eye worm)	RNA binding protein	0.0256	0.3284	0.3714
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0861	0.0973
Echinococcus multilocularis	lamin dm0	0.0055	0.0484	0.0455
Echinococcus multilocularis	microtubule associated protein 2	0.0736	1	1
Echinococcus granulosus	lamin	0.0055	0.0484	0.0455
Echinococcus granulosus	mothers against decapentaplegic 5	0.0045	0.0336	0.0306
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0586	0.0556
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0062	0.0582	0.1277
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0802	0.0907
Echinococcus multilocularis	lamin	0.0055	0.0484	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0374	0.0423
Schistosoma mansoni	tar DNA-binding protein	0.0256	0.3284	0.3264
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0586	0.0556
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0484	0.0548
Echinococcus granulosus	beta LACTamase domain containing family member	0.0078	0.0802	0.0774
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0042	0.0296	0.0266
Loa Loa (eye worm)	hypothetical protein	0.005	0.0405	0.0458
Schistosoma mansoni	pyruvate dehydrogenase	0.0136	0.1609	0.1583
Trichomonas vaginalis	D-aminoacylase, putative	0.0078	0.0802	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0078	0.0802	0.2964
Trichomonas vaginalis	D-aminoacylase, putative	0.0078	0.0802	0.5
Schistosoma mansoni	smad1 5 8 and	0.0045	0.0336	0.0306
Echinococcus multilocularis	Smad4	0.0045	0.0336	0.0306
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0045	0.0336	0.0306
Schistosoma mansoni	smad1 5 8 and	0.0045	0.0336	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0058	0.0065
Loa Loa (eye worm)	intermediate filament protein	0.0055	0.0484	0.0548
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0062	0.0586	0.0556
Schistosoma mansoni	cellular tumor antigen P53	0.0107	0.1205	0.1178
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0058	0.0527	0.2885
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0664	0.1909
Loa Loa (eye worm)	hypothetical protein	0.0144	0.1721	0.1946
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0069	0.0682	0.0653
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0078	0.0802	0.0847
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0026	0.0079	0.0048
Brugia malayi	Bromodomain containing protein	0.0044	0.0335	0.0315
Mycobacterium leprae	conserved hypothetical protein	0.0078	0.0802	0.5
Echinococcus multilocularis	tumor protein p63	0.073	0.9905	0.9905
Trypanosoma cruzi	major cysteine proteinase, putative	0.0054	0.0461	0.035
Schistosoma mansoni	hypothetical protein	0.0024	0.0048	0.0017
Trypanosoma cruzi	hypothetical protein, conserved	0.0078	0.0802	0.2964
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0802	0.0907
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0664	0.1909
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.0664	0.1909
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0027	0.0085	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0071	0.0081
Schistosoma mansoni	tar DNA-binding protein	0.0256	0.3284	0.3264
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0802	0.0907
Leishmania major	developmentally regulated phosphoprotein-like protein	0.0144	0.1721	1
Schistosoma mansoni	lamin	0.0055	0.0484	0.0455
Schistosoma mansoni	intermediate filament proteins	0.0055	0.0484	0.0455
Brugia malayi	MH2 domain containing protein	0.0045	0.0336	0.0316
Loa Loa (eye worm)	hypothetical protein	0.0054	0.047	0.0532
Mycobacterium ulcerans	beta-lactamase	0.0078	0.0802	1
Schistosoma mansoni	lamin	0.0055	0.0484	0.0455
Mycobacterium tuberculosis	Conserved protein	0.0078	0.0802	0.0356
Mycobacterium ulcerans	hypothetical protein	0.0078	0.0802	1
Trichomonas vaginalis	esterase, putative	0.0078	0.0802	0.5
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0078	0.0802	0.0356
Brugia malayi	TAR-binding protein	0.0256	0.3284	0.3673
Onchocerca volvulus		0.0107	0.1205	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.003	0.0126	0.0143
Echinococcus granulosus	intermediate filament protein	0.0055	0.0484	0.0455
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0078	0.0802	0.0774
Schistosoma mansoni	tar DNA-binding protein	0.0256	0.3284	0.3264
Brugia malayi	MH2 domain containing protein	0.0654	0.8844	1
Brugia malayi	Bromodomain containing protein	0.0087	0.093	0.0993
Toxoplasma gondii	aldehyde dehydrogenase	0.0062	0.0586	0.4405
Schistosoma mansoni	pyruvate dehydrogenase	0.0136	0.1609	0.1583
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0336	0.038
Brugia malayi	PHD-finger family protein	0.0029	0.0118	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0071	0.0081
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0062	0.0586	0.0556
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0664	0.1909
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0664	0.1909
Loa Loa (eye worm)	Smad1	0.0045	0.0336	0.0379
Leishmania major	hypothetical protein, conserved	0.0078	0.0802	0.2964
Schistosoma mansoni	bromodomain containing protein	0.0073	0.074	0.0711
Loa Loa (eye worm)	transcription factor SMAD2	0.0654	0.8844	1
Mycobacterium ulcerans	lipase LipD	0.0078	0.0802	1
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0802	0.0907
Schistosoma mansoni	smad1 5 8 and	0.0045	0.0336	0.0306
Echinococcus granulosus	tar DNA binding protein	0.0256	0.3284	0.3264
Mycobacterium tuberculosis	Probable lipase LipE	0.0078	0.0802	0.0356
Brugia malayi	cytoplasmic intermediate filament protein	0.003	0.0126	0.0078
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0664	0.1909
Brugia malayi	RNA recognition motif domain containing protein	0.0256	0.3284	0.3673
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0144	0.1721	0.1695
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0144	0.1721	0.1695
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0042	0.0296	0.0266
Trypanosoma cruzi	developmentally regulated phosphoprotein, putative	0.0144	0.1721	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 19.9 uM	Inhibitory activity tested against Pyruvate Dehydrogenase Kinase (PDHK) receptor from rats.	ChEMBL.	10649979
IC50 (binding)	= 19.9 uM	Inhibitory activity tested against Pyruvate Dehydrogenase Kinase (PDHK) receptor from rats.	ChEMBL.	10649979

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10805348

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 134264