Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Polypeptide deformylase 1 | 0.3527 | 0.3771 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.015 | 0.2514 |
Brugia malayi | Hemopexin family protein | 0.024 | 0.0189 | 0.5059 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0615 | 0.0598 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0375 | 0.0336 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0615 | 0.0598 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.0239 | 0.1826 |
Brugia malayi | Matrixin family protein | 0.0169 | 0.0112 | 0.2995 |
Echinococcus granulosus | geminin | 0.0205 | 0.015 | 0.2514 |
Onchocerca volvulus | 0.0286 | 0.0239 | 0.5664 | |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0375 | 0.0336 | 1 |
Echinococcus multilocularis | adam 17 protease | 0.0384 | 0.0345 | 0.5774 |
Plasmodium falciparum | peptide deformylase | 0.9243 | 1 | 0.5 |
Onchocerca volvulus | 0.024 | 0.0189 | 0.3431 | |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.9243 | 1 | 1 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0131 | 0.007 | 0.2026 |
Echinococcus granulosus | adam 17 protease | 0.0422 | 0.0387 | 0.6471 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.0239 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.3527 | 0.3771 | 0.5 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0241 | 0.019 | 0.317 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0169 | 0.0112 | 0.3238 |
Loa Loa (eye worm) | hypothetical protein | 0.0806 | 0.0806 | 1 |
Brugia malayi | Matrixin family protein | 0.0409 | 0.0373 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0375 | 0.0336 | 0.3238 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0181 | 0.0125 | 0.3612 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0181 | 0.0125 | 0.2085 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3527 | 0.3771 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0169 | 0.0112 | 0.2995 |
Brugia malayi | Matrixin family protein | 0.0169 | 0.0112 | 0.2995 |
Mycobacterium ulcerans | peptide deformylase | 0.9243 | 1 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3527 | 0.3771 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.9243 | 1 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3527 | 0.3771 | 0.5 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0206 | 0.0152 | 0.4071 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0181 | 0.0125 | 0.2085 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.015 | 0.4354 |
Brugia malayi | Matrixin family protein | 0.0169 | 0.0112 | 0.2995 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.9243 | 1 | 0.5 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0241 | 0.019 | 0.317 |
Schistosoma mansoni | hypothetical protein | 0.024 | 0.0189 | 0.547 |
Brugia malayi | hypothetical protein | 0.0286 | 0.0239 | 0.6389 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.0201 | 0.539 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.0239 | 0.3989 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.0201 | 0.1289 |
Plasmodium vivax | peptide deformylase, putative | 0.9243 | 1 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0409 | 0.0373 | 0.377 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0384 | 0.0345 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.3527 | 0.3771 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.0152 | 0.0579 |
Toxoplasma gondii | hypothetical protein | 0.9243 | 1 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.0239 | 0.3989 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.015 | 0.4354 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.9243 | 1 | 1 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0181 | 0.0125 | 0.334 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3527 | 0.3771 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1413 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.