Detailed information for compound 1343114

Basic information

Technical information
  • TDR Targets ID: 1343114
  • Name: 2-[ethyl-(2-methoxy-5-methylphenyl)sulfonylam ino]-N-(4-sulfamoylphenyl)acetamide
  • MW: 441.522 | Formula: C18H23N3O6S2
  • H donors: 2 H acceptors: 5 LogP: 1.24 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(S(=O)(=O)c1cc(C)ccc1OC)CC(=O)Nc1ccc(cc1)S(=O)(=O)N
  • InChi: 1S/C18H23N3O6S2/c1-4-21(29(25,26)17-11-13(2)5-10-16(17)27-3)12-18(22)20-14-6-8-15(9-7-14)28(19,23)24/h5-11H,4,12H2,1-3H3,(H,20,22)(H2,19,23,24)
  • InChiKey: XHIRGVIEXLICHX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[ethyl-(2-methoxy-5-methyl-phenyl)sulfonyl-amino]-N-(4-sulfamoylphenyl)acetamide
  • 2-[ethyl-(2-methoxy-5-methyl-phenyl)sulfonyl-amino]-N-(4-sulfamoylphenyl)ethanamide
  • N~1~-[4-(aminosulfonyl)phenyl]-N~2~-ethyl-N~2~-[(2-methoxy-5-methylphenyl)sulfonyl]glycinamide
  • SMR000082490
  • ZINC02886099
  • MLS000911174
  • MLS000052728

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Kinase, CAMK CAMKL 0.0035 0.0131 0.0397
Brugia malayi Protein kinase domain containing protein 0.0059 0.0512 0.1504
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0103 0.1228 0.2519
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0064 0.0604 0.0604
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0194 0.2702 0.7677
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0055 0.0458 0.1345
Entamoeba histolytica protein kinase domain containing protein 0.0087 0.0966 0.2843
Echinococcus multilocularis casein kinase ii subunit alpha 0.0087 0.0966 0.2742
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0035 0.0131 0.0245
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0111 0.1363 0.1363
Echinococcus granulosus protein kinase C gamma type 0.0168 0.2281 0.2281
Brugia malayi Ras association domain family 1 isoform A 0.0028 0.0012 0.0031
Giardia lamblia Kinase, AGC AKT 0.0106 0.1284 0.394
Entamoeba histolytica PH domain containing protein kinase, putative 0.0125 0.1587 0.4674
Brugia malayi protein kinase C II. 0.015 0.1989 0.586
Leishmania major DNA polymerase eta, putative 0.0054 0.0438 0.0982
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0064 0.0604 0.1516
Echinococcus multilocularis Diacylglycerol kinase theta 0.0028 0.0012 0.003
Echinococcus multilocularis ephrin type A receptor 4 A 0.0076 0.08 0.227
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0111 0.1361 0.3937
Trichomonas vaginalis CAMK family protein kinase 0.0228 0.3255 0.9592
Giardia lamblia Kinase, CMGC GSK 0.0064 0.0604 0.1853
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0131 0.0381
Loa Loa (eye worm) hypothetical protein 0.0137 0.1789 0.3682
Trypanosoma brucei cdc2-related kinase 1 0.0059 0.0512 0.1168
Echinococcus granulosus unc 13 munc13 0.0029 0.0036 0.0036
Toxoplasma gondii aurora kinase 0.0074 0.0762 0.2269
Trichomonas vaginalis CAMK family protein kinase 0.0228 0.3255 0.9592
Schistosoma mansoni diacylglycerol kinase theta 0.0028 0.0012 0.0029
Schistosoma mansoni hypothetical protein 0.0028 0.0012 0.0029
Echinococcus multilocularis protein kinase c iota type 0.0244 0.3519 1
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0074 0.0762 0.0762
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0055 0.0458 0.1002
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0147 0.1937 0.1937
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0131 0.0381
Echinococcus multilocularis hypothetical protein 0.0071 0.0706 0.2003
Schistosoma mansoni serine/threonine protein kinase 0.015 0.1989 0.5474
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0064 0.0604 0.1227
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0059 0.0512 0.1035
Brugia malayi protein kinase C3,putative 0.0133 0.1712 0.5043
Brugia malayi Protein kinase domain containing protein 0.0194 0.2702 0.796
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0131 0.0381
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0218 0.3091 0.6379
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0064 0.0604 0.1714
Echinococcus granulosus Rac GTPase activating protein 1 0.0028 0.0012 0.0012
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0055 0.0458 0.1047
Echinococcus granulosus serine:threonine kinase SAD 1 0.0035 0.0131 0.0131
Trichomonas vaginalis CAMK family protein kinase 0.0228 0.3255 0.9592
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0131 0.0356
Trichomonas vaginalis AGC family protein kinase 0.012 0.1514 0.446
Onchocerca volvulus 0.0029 0.0036 0.0073
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0059 0.0512 0.0512
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0218 0.3091 0.3091
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0055 0.0458 0.1297
Echinococcus granulosus aurora kinase A 0.0074 0.0762 0.0762
Brugia malayi Protein kinase domain containing protein 0.0203 0.2851 0.8402
Brugia malayi C1-like domain containing protein 0.0037 0.0159 0.0465
Schistosoma mansoni serine/threonine protein kinase 0.012 0.1514 0.4166
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0218 0.309 0.6376
Trichomonas vaginalis CMGC family protein kinase 0.0064 0.0604 0.1777
Entamoeba histolytica protein kinase, putative 0.0053 0.0418 0.1226
Trichomonas vaginalis AGC family protein kinase 0.0074 0.0762 0.2241
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0418 0.1145
Trichomonas vaginalis CMGC family protein kinase 0.0087 0.0966 0.2843
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0177 0.0498
Echinococcus granulosus cyclin dependent kinase 1 0.0059 0.0512 0.0512
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0228 0.3255 0.6718
Schistosoma mansoni serine/threonine protein kinase 0.0196 0.2732 0.752
Giardia lamblia Kinase, CAMK CAMKL 0.0035 0.0131 0.0397
Echinococcus granulosus Diacylglycerol kinase theta 0.0028 0.0012 0.0012
Trichomonas vaginalis AGC family protein kinase 0.0074 0.0762 0.2241
Plasmodium vivax unspecified product 0.0087 0.0966 0.6056
Loa Loa (eye worm) AGC/AKT protein kinase 0.0236 0.3393 0.7005
Schistosoma mansoni serine/threonine protein kinase 0.0173 0.2373 0.6532
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.015 0.1989 0.4096
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0064 0.0604 0.1792
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0438 0.094
Entamoeba histolytica protein kinase, putative 0.0032 0.0079 0.0228
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.127 0.3493
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0438 0.0982
Entamoeba histolytica protein kinase, putative 0.0074 0.0762 0.2241
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0111 0.1363 0.387
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0218 0.309 0.8781
Echinococcus granulosus cyclin dependent kinase 5 0.0059 0.0512 0.0512
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1228 0.3616
Echinococcus multilocularis cyclin dependent kinase 1 0.0059 0.0512 0.1451
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0203 0.2851 0.5882
Echinococcus multilocularis protein kinase c eta type 0.0028 0.0012 0.003
Trichomonas vaginalis AGC family protein kinase 0.0236 0.3393 1
Brugia malayi p70 ribosomal S6 kinase beta 0.0232 0.3316 0.9772
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0131 0.0381
Trypanosoma cruzi casein kinase II, putative 0.0087 0.0966 0.2673
Trypanosoma brucei aurora B kinase 0.0074 0.0762 0.1934
Loa Loa (eye worm) hypothetical protein 0.0033 0.009 0.016
Entamoeba histolytica diacylglycerol kinase, putative 0.0028 0.0012 0.0031
Trypanosoma cruzi cdc2-related kinase 3 0.0059 0.0512 0.122
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0029 0.0036 0.0098
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0147 0.1937 0.3987
Echinococcus multilocularis nervana 2 0.0111 0.1363 0.387
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0131 0.0381
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0131 0.0381
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0064 0.0604 0.1227
Trichomonas vaginalis AGC family protein kinase 0.0236 0.3393 1
Schistosoma mansoni serine/threonine-protein kinase 0.0125 0.1587 0.4366
Trichomonas vaginalis CMGC family protein kinase 0.0087 0.0966 0.2843
Echinococcus granulosus serine threonine protein kinase nrc 0.012 0.151 0.151
Trichomonas vaginalis AGC family protein kinase 0.0074 0.0762 0.2241
Trypanosoma brucei protein kinase, putative 0.0064 0.0604 0.1451
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0053 0.0417 0.1182
Plasmodium vivax protein kinase Crk2 0.0059 0.0512 0.2764
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.012 0.151 1
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.012 0.1514 0.4301
Echinococcus multilocularis Rac GTPase activating protein 1 0.0028 0.0012 0.003
Trichomonas vaginalis CAMK family protein kinase 0.0228 0.3255 0.9592
Trichomonas vaginalis AGC family protein kinase 0.012 0.1514 0.446
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0059 0.0512 0.122
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0029 0.0036 0.0036
Echinococcus granulosus myotubularin protein 13 0.0033 0.009 0.009
Toxoplasma gondii AGC kinase 0.0232 0.3316 1
Echinococcus multilocularis calcium activated potassium channel 0.008 0.0853 0.2421
Echinococcus multilocularis protein kinase shaggy 0.0064 0.0604 0.1714
Entamoeba histolytica protein kinase, putative 0.0074 0.0762 0.2241
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0326 0.4839 1
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.012 0.151 0.4288
Leishmania major protein kinase A catalytic subunit 0.0055 0.0458 0.1047
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0064 0.0604 0.166
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0131 0.0381
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0052 0.0139
Entamoeba histolytica protein kinase, putative 0.0232 0.3316 0.9772
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0055 0.0458 0.1047
Plasmodium falciparum glycogen synthase kinase 3 0.0064 0.0604 0.3434
Toxoplasma gondii CMGC kinase, CK2 family 0.0087 0.0966 0.2886
Loa Loa (eye worm) AGC/PKN protein kinase 0.012 0.1514 0.3112
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0458 0.1345
Entamoeba histolytica cell division protein kinase 2, putative 0.0059 0.0512 0.1504
Echinococcus multilocularis serine:threonine protein kinase N2 0.012 0.1514 0.4301
Trichomonas vaginalis CAMK family protein kinase 0.0117 0.1458 0.4294
Trichomonas vaginalis CMGC family protein kinase 0.0064 0.0604 0.1777
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0512 0.1504
Schistosoma mansoni serine/threonine protein kinase 0.012 0.1514 0.4166
Leishmania major casein kinase II, putative 0.0087 0.0966 0.2673
Giardia lamblia Kinase, PLK 0.0228 0.3255 1
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0055 0.0458 0.1348
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0059 0.0512 0.1035
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0762 0.2094
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0087 0.0966 0.1976
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0131 0.0381
Onchocerca volvulus 0.0064 0.0604 0.1826
Brugia malayi serine/threonine-protein kinase plk-2 0.0228 0.3255 0.9592
Entamoeba histolytica casein kinase, putative 0.0087 0.0966 0.2843
Entamoeba histolytica protein kinase, putative 0.012 0.1514 0.446
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0194 0.2702 0.5572
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0131 0.0381
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0059 0.0512 0.122
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0173 0.2373 0.2373
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0131 0.0381
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.012 0.1514 0.1514
Entamoeba histolytica protein kinase domain containing protein 0.0064 0.0604 0.1777
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0027 0.0002 0.0002
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0027 0.0002 0.0002
Loa Loa (eye worm) AGC/PKA protein kinase 0.0055 0.0458 0.0923
Trichomonas vaginalis CMGC family protein kinase 0.0087 0.0966 0.2843
Echinococcus granulosus serine:threonine protein kinase N2 0.012 0.1514 0.1514
Trypanosoma cruzi cdc2-related kinase 3 0.0059 0.0512 0.122
Loa Loa (eye worm) hypothetical protein 0.016 0.2161 0.4451
Onchocerca volvulus 0.016 0.2161 0.6626
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.2702 0.7436
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0059 0.0512 0.1035
Loa Loa (eye worm) hypothetical protein 0.0055 0.0458 0.0923
Trypanosoma cruzi polo-like protein kinase, putative 0.0228 0.3255 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0053 0.0417 0.0417
Brugia malayi Protein kinase domain containing protein 0.012 0.1514 0.446
Schistosoma mansoni serine/threonine protein kinase 0.012 0.1514 0.4166
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.012 0.1514 0.1514
Onchocerca volvulus Serine\/threonine kinase homolog 0.0228 0.3255 1
Trichomonas vaginalis CAMK family protein kinase 0.0228 0.3255 0.9592
Entamoeba histolytica diacylglycerol kinase, putative 0.0028 0.0012 0.0031
Schistosoma mansoni hypothetical protein 0.0071 0.0706 0.194
Trypanosoma cruzi aurora B kinase, putative 0.0074 0.0762 0.202
Trypanosoma cruzi rac serine-threonine kinase, putative 0.012 0.151 0.4414
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0438 0.1285
Loa Loa (eye worm) hypothetical protein 0.016 0.2161 0.4451
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0046 0.0311 0.0879
Entamoeba histolytica cell division protein kinase 2, putative 0.0059 0.0512 0.1504
Entamoeba histolytica p21-activated kinase 0.0032 0.0079 0.0228
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.014 0.1826 0.3758
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0027 0.0002 0.0002
Trichomonas vaginalis CMGC family protein kinase 0.0087 0.0966 0.2843
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0131 0.0381
Trichomonas vaginalis CMGC family protein kinase 0.0087 0.0966 0.2843
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0194 0.2702 0.5572
Schistosoma mansoni atypical protein kinase C 0.0251 0.3633 1
Schistosoma mansoni serine/threonine kinase 0.012 0.1514 0.4166
Trichomonas vaginalis CMGC family protein kinase 0.0087 0.0966 0.2843
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0055 0.0458 0.0458
Brugia malayi Protein kinase c protein 2 0.0084 0.0926 0.2724
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0512 0.1405
Loa Loa (eye worm) TK/EPH protein kinase 0.0097 0.1129 0.2313
Trypanosoma brucei Casein kinase II 0.0087 0.0966 0.2559
Brugia malayi Pleckstrin Homology Domain 0.0033 0.009 0.0259
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0087 0.0966 0.6056
Leishmania major protein kinase A catalytic subunit isoform 1 0.0055 0.0458 0.1047
Trichomonas vaginalis AGC family protein kinase 0.0236 0.3393 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.009 0.016
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0055 0.0458 0.1047
Trichomonas vaginalis CAMK family protein kinase 0.008 0.0853 0.251
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0853 0.2345
Echinococcus granulosus nervana 2 0.0111 0.1363 0.1363
Trichomonas vaginalis AGC family protein kinase 0.0236 0.3393 1
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0173 0.2373 0.6744
Loa Loa (eye worm) AUR protein kinase 0.0074 0.0762 0.1553
Trichomonas vaginalis AGC family protein kinase 0.0074 0.0762 0.2241
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0218 0.309 0.309
Schistosoma mansoni rac gtpase activating protein 0.0028 0.0012 0.0029
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0074 0.0762 0.2241
Echinococcus multilocularis serine:threonine protein kinase 0.0103 0.1228 0.3487
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0228 0.3255 0.925
Echinococcus multilocularis myotubularin protein 13 0.0033 0.009 0.025
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0173 0.2373 0.6744
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0853 0.2345
Echinococcus granulosus serine:threonine protein kinase 0.0103 0.1228 0.1228
Trichomonas vaginalis AGC family protein kinase 0.0236 0.3393 1
Trichomonas vaginalis CAMK family protein kinase 0.0228 0.3255 0.9592
Entamoeba histolytica PH domain containing protein kinase, putative 0.006 0.0535 0.1573
Brugia malayi Protein kinase domain containing protein 0.0103 0.1228 0.3616
Echinococcus multilocularis Glutaredoxin protein 5 0.0111 0.1363 0.387
Schistosoma mansoni kinase 0.012 0.1505 0.414
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0147 0.1937 0.5705
Trichomonas vaginalis AGC family protein kinase 0.0125 0.1592 0.4687
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0055 0.0458 0.2372
Brugia malayi RhoGEF domain containing protein 0.0028 0.0012 0.0031
Brugia malayi diacylglycerol kinase 0.0028 0.0012 0.0031
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0512 0.1405
Loa Loa (eye worm) AGC/NDR protein kinase 0.012 0.1514 0.3112
Brugia malayi Variant SH3 domain containing protein 0.0028 0.0012 0.0031
Entamoeba histolytica protein kinase, putative 0.0064 0.0604 0.1777
Trypanosoma cruzi cdc2-related kinase 1 0.0059 0.0512 0.122
Brugia malayi RhoGAP domain containing protein 0.0028 0.0012 0.0031
Schistosoma mansoni protein kinase C mu 0.0037 0.0159 0.0434
Echinococcus granulosus protein kinase c epsilon type 0.015 0.1989 0.1989
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.012 0.151 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0125 0.1587 0.4674
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0131 0.0381
Onchocerca volvulus 0.0074 0.076 0.2306
Trichomonas vaginalis CAMK family protein kinase 0.0117 0.1458 0.4294
Echinococcus granulosus serine/threonine protein kinase 0.0125 0.1587 0.1587
Brugia malayi serine/threonine kinase 12 0.0074 0.0762 0.2241
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0055 0.0458 0.1297
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0203 0.2851 0.2851
Giardia lamblia Kinase, CMGC CK2 0.0087 0.0966 0.2964
Schistosoma mansoni protein kinase C mu 0.0028 0.0012 0.0029
Echinococcus granulosus Protein kinase C brain isozyme 0.0196 0.2732 0.2732
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0028 0.0012 0.0029
Giardia lamblia Kinase, AGC PKA 0.012 0.151 0.4635
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0028 0.0012 0.003
Echinococcus multilocularis serine threonine protein kinase 0.0168 0.2281 0.648
Echinococcus granulosus cyclin dependent kinase 0.0059 0.0512 0.0512
Echinococcus multilocularis cyclin dependent kinase 0.0059 0.0512 0.1451
Loa Loa (eye worm) hypothetical protein 0.0029 0.0036 0.0049
Trypanosoma cruzi cdc2-related kinase 1 0.0059 0.0512 0.122
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0218 0.3091 0.8785
Trichomonas vaginalis AGC family protein kinase 0.0236 0.3393 1
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0173 0.2373 0.2373
Trypanosoma cruzi Protein kinase B 0.0125 0.1587 0.4661
Entamoeba histolytica serine/threonine protein kinase, putative 0.0035 0.0131 0.0381
Toxoplasma gondii histone kinase SNF1, putative 0.0035 0.0131 0.0359
Loa Loa (eye worm) hypothetical protein 0.0074 0.0755 0.1539
Brugia malayi map kinase activated protein kinase protein 2 0.0218 0.3091 0.911
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0194 0.2702 0.2702
Plasmodium vivax glycogen synthase kinase 3, putative 0.0064 0.0604 0.3434
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0131 0.0356
Leishmania major protein kinase, putative 0.0074 0.0762 0.202
Entamoeba histolytica hypothetical protein 0.0028 0.0012 0.0031
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0028 0.0012 0.0029
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0055 0.0458 0.1002
Brugia malayi Casein kinase II, alpha chain 0.0087 0.0966 0.2843
Giardia lamblia Kinase, CMGC CDK 0.0059 0.0512 0.1568
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.008 0.0853 0.1742
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0059 0.0512 0.1512
Echinococcus granulosus nervana 2 0.0111 0.1363 0.1363
Loa Loa (eye worm) hypothetical protein 0.005 0.0365 0.0731
Trypanosoma brucei rac serine-threonine kinase, putative 0.0236 0.3393 1
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0147 0.1937 0.5501
Loa Loa (eye worm) hypothetical protein 0.0054 0.0438 0.0881
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.127 0.3493
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0105 0.127 0.127
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0074 0.0762 0.2241
Leishmania major protein kinase A catalytic subunit isoform 2 0.0055 0.0458 0.1047
Echinococcus granulosus dna polymerase eta 0.0054 0.0438 0.0438
Loa Loa (eye worm) AUR protein kinase 0.0074 0.0762 0.1553
Entamoeba histolytica protein kinase domain containing protein 0.0064 0.0604 0.1777
Echinococcus multilocularis unc 13 (munc13) 0.0029 0.0036 0.0098
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0105 0.127 0.3606
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0512 0.1504
Echinococcus multilocularis raf serine:threonine protein kinase 0.003 0.0052 0.0143
Giardia lamblia Aurora kinase 0.0074 0.0762 0.2337
Loa Loa (eye worm) AGC/PKA protein kinase 0.0055 0.0458 0.0923
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0131 0.0356
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0053 0.0418 0.0418
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0074 0.0762 0.2161
Echinococcus granulosus RNA directed DNA polymerase 0.0046 0.0304 0.0304
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0228 0.3255 0.3255
Onchocerca volvulus 0.0033 0.009 0.0238
Trichomonas vaginalis CAMK family protein kinase 0.0228 0.3255 0.9592
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0055 0.0458 0.1297
Brugia malayi Protein kinase domain containing protein 0.0174 0.2388 0.7035
Toxoplasma gondii AGC kinase 0.0055 0.0458 0.1348
Schistosoma mansoni protein kinase C 0.0029 0.0036 0.0094
Toxoplasma gondii AGC kinase 0.0055 0.0458 0.1348
Giardia lamblia Kinase, CMGC CDK 0.0059 0.0512 0.1568
Brugia malayi Protein kinase domain containing protein 0.012 0.1514 0.446
Trypanosoma cruzi polo-like protein kinase, putative 0.0228 0.3255 1
Entamoeba histolytica protein kinase 2, putative 0.012 0.151 0.4446
Trichomonas vaginalis AGC family protein kinase 0.012 0.1514 0.446
Echinococcus granulosus N chimaerin 0.0028 0.0012 0.0012
Entamoeba histolytica protein kinase, putative 0.0236 0.3393 1
Schistosoma mansoni ephrin receptor 0.0076 0.08 0.2199
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0196 0.2732 0.7763
Loa Loa (eye worm) hypothetical protein 0.0281 0.4114 0.8498
Brugia malayi serine/threonine protein kinase 6 0.0074 0.0762 0.2241
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.0762 0.2241
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.1937 0.5329
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0131 0.0381
Schistosoma mansoni vav2 0.0033 0.009 0.0242
Brugia malayi putative serine/threonine kinase SADA gamma 0.0035 0.0131 0.0381
Brugia malayi diacylglycerol kinase 0.0028 0.0012 0.0031
Echinococcus granulosus protein kinase c eta type 0.0028 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0071 0.0706 0.1437
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0035 0.0131 0.0367
Entamoeba histolytica protein kinase, putative 0.0236 0.3393 1
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0055 0.0458 0.2372
Loa Loa (eye worm) hypothetical protein 0.016 0.2161 0.4451
Loa Loa (eye worm) hypothetical protein 0.0046 0.0304 0.0604
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0194 0.2702 0.796
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0131 0.0381
Schistosoma mansoni unc-13 (munc13) 0.0029 0.0036 0.0094
Schistosoma mansoni serine/threonine protein kinase 0.0218 0.3091 0.8509
Echinococcus multilocularis nervana 2 0.0111 0.1363 0.387
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0074 0.0762 0.2241
Echinococcus granulosus casein kinase ii subunit alpha 0.0087 0.0966 0.0966
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0055 0.0458 0.1002
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0512 0.1504
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0055 0.0458 0.1047
Brugia malayi serine/threonine-protein kinase 6 0.0074 0.0762 0.2241
Trichomonas vaginalis CMGC family protein kinase 0.0087 0.0966 0.2843
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0228 0.3255 1
Echinococcus multilocularis serine:threonine protein kinase 0.0103 0.1228 0.3487
Echinococcus granulosus NDR protein kinase 0.012 0.1514 0.1514
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0458 0.1256
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0046 0.0311 0.0311
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0131 0.0381
Loa Loa (eye worm) hypothetical protein 0.0074 0.076 0.155
Trypanosoma brucei polo-like protein kinase 0.0228 0.3255 0.9576
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0074 0.0762 0.4576
Schistosoma mansoni serine/threonine protein kinase 0.0218 0.309 0.8505
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.012 0.1514 0.3112
Schistosoma mansoni DNA polymerase eta 0.0054 0.0438 0.12
Schistosoma mansoni unc-13 (munc13) 0.0029 0.0036 0.0094
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.012 0.151 0.151
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0131 0.0381
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0055 0.0458 0.0458
Leishmania major DNA polymerase eta, putative 0.0038 0.0177 0.0148
Echinococcus multilocularis dna polymerase eta 0.0054 0.0438 0.1239
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0053 0.0418 0.1183
Brugia malayi Temporarily assigned gene name protein 59 0.0149 0.1978 0.5826
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0458 0.1256
Schistosoma mansoni serine/threonine protein kinase 0.0173 0.2373 0.6532
Brugia malayi Kinase associated domain 1 family protein 0.0071 0.0706 0.2077
Schistosoma mansoni serine/threonine-protein kinase 0.0125 0.1587 0.4366
Trypanosoma brucei cdc2-related kinase 3 0.0059 0.0512 0.1168
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0131 0.0356
Brugia malayi intracellular kinase 0.0064 0.0604 0.1777
Brugia malayi RhoGAP domain containing protein 0.0028 0.0012 0.0031
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.012 0.1514 0.4301
Echinococcus multilocularis serine:threonine protein kinase 38 0.012 0.1514 0.4301
Entamoeba histolytica protein kinase , putative 0.0074 0.0762 0.2241
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0194 0.2702 0.8293
Giardia lamblia Kinase, AGC PKA 0.0055 0.0458 0.1402
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0131 0.0381
Loa Loa (eye worm) AUR protein kinase 0.0074 0.0762 0.1553
Brugia malayi ephrin receptor 1 precursor 0.0037 0.0166 0.0484
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0853 0.2345
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0111 0.1367 0.4026
Brugia malayi Hr1 repeat family protein 0.012 0.1514 0.446
Schistosoma mansoni serine/threonine protein kinase 0.0196 0.2732 0.752
Echinococcus multilocularis cyclin dependent kinase 5 0.0059 0.0512 0.1451
Echinococcus granulosus Glutaredoxin protein 5 0.0111 0.1363 0.1363
Echinococcus multilocularis serine:threonine protein kinase N2 0.012 0.1514 0.4301
Echinococcus granulosus serine:threonine protein kinase 0.0103 0.1228 0.1228
Brugia malayi serine/threonine-protein kinase PAK 7 0.0221 0.3144 0.9266
Echinococcus granulosus ephrin type A receptor 4 A 0.0076 0.08 0.08
Brugia malayi Protein kinase domain containing protein 0.0236 0.3393 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0232 0.3316 0.6845
Echinococcus granulosus protein kinase c iota type 0.0244 0.3519 0.3519
Plasmodium falciparum serine/threonine protein kinase, putative 0.0074 0.0762 0.4576
Echinococcus multilocularis RNA directed DNA polymerase 0.0046 0.0304 0.0859
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0055 0.0458 0.1297
Schistosoma mansoni protein kinase 0.0074 0.0762 0.2094
Echinococcus multilocularis N chimaerin 0.0028 0.0012 0.003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0131 0.0245
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0037 0.0159 0.0304
Schistosoma mansoni serine/threonine protein kinase 0.0203 0.2851 0.7848
Schistosoma mansoni diacylglycerol kinase theta 0.0028 0.0012 0.0029
Echinococcus multilocularis rac serine:threonine kinase 0.0125 0.1587 0.4508
Giardia lamblia Kinase, CMGC GSK 0.0064 0.0604 0.1853
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0056 0.0474 0.0957
Loa Loa (eye worm) hypothetical protein 0.0103 0.1228 0.2519
Loa Loa (eye worm) hypothetical protein 0.0188 0.2612 0.5386
Entamoeba histolytica protein kinase, putative 0.0032 0.0079 0.0228
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0221 0.3144 0.6489
Brugia malayi cell division control protein 2 homolog 0.0059 0.0512 0.1504
Plasmodium falciparum casein kinase 2, alpha subunit 0.0087 0.0966 0.6056
Plasmodium falciparum protein kinase 5 0.0059 0.0512 0.2764
Trichomonas vaginalis AGC family protein kinase 0.0236 0.3393 1
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0106 0.1284 0.3779
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0046 0.0304 0.0859
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0458 0.1256
Echinococcus multilocularis protein kinase c epsilon type 0.015 0.1989 0.5651
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0064 0.0604 0.1516
Loa Loa (eye worm) hypothetical protein 0.0038 0.0171 0.0329
Echinococcus granulosus raf serine:threonine protein kinase 0.003 0.0052 0.0052
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0203 0.2851 0.81
Echinococcus multilocularis aurora kinase A 0.0074 0.0762 0.2161
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0028 0.0012 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0228 0.3255 0.896
Schistosoma mansoni serine/threonine kinase 0.008 0.0853 0.2345
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0055 0.0458 0.0458
Schistosoma mansoni hypothetical protein 0.0071 0.0706 0.194
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0125 0.1587 0.4661
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0177 0.0148
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0037 0.0159 0.0465
Echinococcus granulosus calcium activated potassium channel 0.008 0.0853 0.0853
Brugia malayi Protein kinase domain containing protein 0.008 0.0853 0.251
Entamoeba histolytica serine/threonine protein kinase, putative 0.0228 0.3255 0.9592
Entamoeba histolytica protein kinase, putative 0.0053 0.0418 0.1226
Echinococcus granulosus protein kinase shaggy 0.0064 0.0604 0.0604
Schistosoma mansoni protein kinase 0.0087 0.0966 0.2655
Echinococcus multilocularis cyclin dependent kinase 1 0.0059 0.0512 0.1451
Entamoeba histolytica PH domain containing protein kinase, putative 0.006 0.0535 0.1573

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2512 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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