Detailed information for compound 1343195

Basic information

Technical information
  • TDR Targets ID: 1343195
  • Name: (6E)-5-imino-6-[(4-methoxyphenyl)methylidene] -2-(2-morpholin-4-yl-2-oxoethyl)-[1,3,4]thiad iazolo[3,2-a]pyrimidin-7-one
  • MW: 413.45 | Formula: C19H19N5O4S
  • H donors: 0 H acceptors: 2 LogP: 1.48 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)/C=C\1/C(=O)N=c2n(C1=N)nc(s2)CC(=O)N1CCOCC1
  • InChi: 1S/C19H19N5O4S/c1-27-13-4-2-12(3-5-13)10-14-17(20)24-19(21-18(14)26)29-15(22-24)11-16(25)23-6-8-28-9-7-23/h2-5,10,20H,6-9,11H2,1H3/b14-10+,20-17?
  • InChiKey: CTFRSMCCTGNKFV-KPZJPCGCSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (6E)-5-imino-6-[(4-methoxyphenyl)methylene]-2-(2-morpholino-2-oxo-ethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
  • (6E)-5-imino-6-[(4-methoxyphenyl)methylene]-2-(2-morpholino-2-oxoethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
  • (6E)-5-imino-2-(2-keto-2-morpholino-ethyl)-6-(4-methoxybenzylidene)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
  • (6E)-5-imino-6-[(4-methoxyphenyl)methylidene]-2-(2-morpholin-4-yl-2-oxo-ethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
  • STOCK4S-44758
  • ZINC05176762

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TAR-binding protein 0.0071 0.3439 0.801
Trypanosoma cruzi ISWI complex protein 0.0018 0.0547 0.1541
Trypanosoma brucei ISWI complex protein 0.0018 0.0547 0.3322
Schistosoma mansoni bromodomain containing protein 0.0078 0.3875 0.3875
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0783 0.0783
Giardia lamblia DINP protein human, muc B family 0.0023 0.0816 1
Brugia malayi PHD-finger family protein 0.0032 0.1302 0.2406
Brugia malayi CXXC zinc finger family protein 0.0035 0.1447 0.2735
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0497 0.0497
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.3329 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.2604 0.5351
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0816 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0783 0.9179
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0497 0.0586
Schistosoma mansoni tar DNA-binding protein 0.0071 0.3439 0.3439
Loa Loa (eye worm) hypothetical protein 0.0053 0.2491 0.5725
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0499 0.0499
Loa Loa (eye worm) hypothetical protein 0.0018 0.0497 0.0916
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.1931 0.1931
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0816 1
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0816 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0783 0.5
Echinococcus granulosus zinc finger protein 0.0026 0.0944 0.0944
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0706 0.142
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0783 0.5
Schistosoma mansoni hypothetical protein 0.0025 0.0905 0.0905
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0816 0.0816
Loa Loa (eye worm) hypothetical protein 0.0049 0.2253 0.5151
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0497 0.0497
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0707 0.0707
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0816 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0707 0.0707
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0499 0.2106
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0707 0.0707
Entamoeba histolytica hypothetical protein 0.004 0.1746 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.1931 0.1931
Loa Loa (eye worm) RNA binding protein 0.0071 0.3439 0.801
Loa Loa (eye worm) hypothetical protein 0.0085 0.4264 1
Brugia malayi RNA binding protein 0.0071 0.3439 0.7238
Entamoeba histolytica hypothetical protein 0.004 0.1746 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0816 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0816 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.1143 0.1143
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0783 0.896
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0816 1
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0816 0.0816
Leishmania major hypothetical protein, conserved 0.0018 0.0547 0.1541
Loa Loa (eye worm) hypothetical protein 0.0021 0.0707 0.1422
Schistosoma mansoni hypothetical protein 0.0189 1 1
Echinococcus multilocularis dna polymerase eta 0.0023 0.0816 0.0816
Brugia malayi hypothetical protein 0.004 0.1746 0.3411
Brugia malayi isocitrate dehydrogenase 0.0018 0.0499 0.059
Schistosoma mansoni tar DNA-binding protein 0.0071 0.3439 0.3439
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0783 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.1746 0.1746
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0783 0.896
Schistosoma mansoni ap endonuclease 0.0023 0.0783 0.0783
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0816 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.2604 0.5998
Schistosoma mansoni hypothetical protein 0.0018 0.0497 0.0497
Echinococcus multilocularis GPCR, family 2 0.0018 0.0497 0.0497
Schistosoma mansoni hypothetical protein 0.0018 0.0497 0.0497
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0816 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0816 1
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0905 0.19
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0816 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0497 0.0497
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0816 0.0816
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0816 1
Toxoplasma gondii exonuclease III APE 0.0023 0.0783 0.1004
Schistosoma mansoni hypothetical protein 0.004 0.1746 0.1746
Brugia malayi Bromodomain containing protein 0.0046 0.209 0.4187
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0665 0.0665
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0499 0.0499
Schistosoma mansoni tar DNA-binding protein 0.0071 0.3439 0.3439
Schistosoma mansoni ap endonuclease 0.0023 0.0783 0.0783
Echinococcus multilocularis geminin 0.0189 1 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0665 0.0665
Schistosoma mansoni tar DNA-binding protein 0.0071 0.3439 0.3439
Entamoeba histolytica hypothetical protein 0.004 0.1746 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0816 1
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.1629 0.3145
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0665 0.0665
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0816 0.0816
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0499 0.0499
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0816 1
Schistosoma mansoni zinc finger protein 0.0026 0.0944 0.0944
Schistosoma mansoni hypothetical protein 0.0189 1 1
Schistosoma mansoni hypothetical protein 0.0018 0.0547 0.0547
Loa Loa (eye worm) hypothetical protein 0.0038 0.1629 0.3645
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0816 1
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0497 0.0586
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.1143 0.1143
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.3634 0.3634
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.3439 0.7238
Brugia malayi TAR-binding protein 0.0071 0.3439 0.7238
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0117 0.0117
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0816 1
Echinococcus granulosus dna polymerase eta 0.0023 0.0816 0.0816
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0816 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0497 0.0916
Schistosoma mansoni hypothetical protein 0.0038 0.1629 0.1629
Schistosoma mansoni zinc finger protein 0.0018 0.0547 0.0547
Leishmania major DNA polymerase eta, putative 0.0023 0.0816 1
Schistosoma mansoni tar DNA-binding protein 0.0071 0.3439 0.3439
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0499 0.0499
Onchocerca volvulus 0.0035 0.1447 0.5
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0499 0.059
Schistosoma mansoni cpg binding protein 0.0039 0.1685 0.1685
Schistosoma mansoni DNA polymerase eta 0.0023 0.0816 0.0816
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0056 0.2604 0.5998
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.2604 0.5351
Echinococcus multilocularis zinc finger protein 0.0026 0.0944 0.0944
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.1746 0.1746
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0783 0.0783
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.3606 0.3606
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0816 0.0816
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0783 0.1232
Loa Loa (eye worm) hypothetical protein 0.0023 0.0816 0.1684
Echinococcus multilocularis tar DNA binding protein 0.0071 0.3439 0.3439
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0816 1
Schistosoma mansoni hypothetical protein 0.0018 0.0497 0.0497
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.3439 0.801
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0499 0.0919
Echinococcus granulosus cpg binding protein 0.0039 0.1685 0.1685
Brugia malayi Bromodomain containing protein 0.0093 0.466 1
Echinococcus granulosus tar DNA binding protein 0.0071 0.3439 0.3439
Leishmania major DNA polymerase kappa, putative 0.0023 0.0816 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0816 0.0342
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0816 0.1684
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0816 1
Echinococcus multilocularis cpg binding protein 0.0039 0.1685 0.1685
Echinococcus granulosus dna polymerase kappa 0.0023 0.0816 0.0816
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0783 0.896
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0816 1
Schistosoma mansoni cpg binding protein 0.0039 0.1685 0.1685
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0499 0.0499
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.3634 0.3634
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0816 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.2094 0.4768
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0665 0.0665
Schistosoma mansoni hypothetical protein 0.0018 0.0497 0.0497
Trypanosoma cruzi ISWI complex protein 0.0018 0.0547 0.1541
Schistosoma mansoni cpg binding protein 0.0035 0.1447 0.1447
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0816 0.1306
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0499 0.2106
Trypanosoma brucei unspecified product 0.0023 0.0816 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0783 1
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0816 0.1306
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0783 0.896
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0497 0.0497
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0499 0.0499
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0816 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0816 1
Echinococcus granulosus GPCR family 2 0.0018 0.0497 0.0497
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0816 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0816 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.1447 0.3207
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.1143 0.1143
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0707 0.0707
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0499 0.0499
Schistosoma mansoni transcription factor LCR-F1 0.004 0.1746 0.1746
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0783 0.1604
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0816 1
Entamoeba histolytica hypothetical protein 0.004 0.1746 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1889 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 1.5849 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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